iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSLACG00000009365.2	ENSLACT00000010708.1	ENSLACP00000010629.1
ENSLACG00000009365.2	ENSLACT00000010709.2	ENSLACP00000010630.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	2.10e-87	293.8	1644	2023

Active Site

Position(s)	Description	Evidence
1990	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 6    kkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnp..dsglknp..................ehlklFe 72
           ++ le+++++E g++l G+t+ef+al+s+elq++dl+l++ +e   ++ + n+  ++++++p                  ++   F+
   Q: 1644 RAMLEIQYENEVGTGL-GPTLEFYALVSQELQRADLSLWRGEEITLTNPKGNQegTKYIHSPqglfavpfgrttkpahiaKVKMKFR 1729
           56899***********.**********************555443333322221134444457777788**********9999**** PP
   S: 73   flGrllgkalqdgrlldlplsksfyklllgk..............................klsledleevdpelykslkeikenae 129
           flG+l++ka++d rl+ +++  + y   l++                              k +l+d ++  + l + l++++ n  
   Q: 1730 FLGKLMAKAIMDFRLVSYHIYIMHYGFQLNQtsctitrlslwhnssiteqeqvamftiillKSELSDGSKSRECLQQALESLNMN-G 1815
           ***********************99987777677777544444444444443333333333344444444444444444444444.3 PP
   S: 130  sdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvklvveyrlkegikeqveafreGfneviplellslFteeelel 216
            ++e+lgld+t       l+   + eLk gG++ipVt+ N+eeY +lvv ++l+eg+++q+e+fr+Gf++v+pl++l++F +eel++
   Q: 1816 CSVEDLGLDFT-------LPGFPNIELKKGGKDIPVTIHNLEEYLRLVVYWTLNEGVTRQFESFRDGFESVFPLHHLQYFYPEELDQ 1895
           35555555555.......7899999************************************************************** PP
   S: 217  licGe..eeidvedlkketkykggytedspaiqwFwevleefsseerkafLqFvTgssrlPlgGfaelkprlfvirk.....dasdd 296
           l+cG+  e++dv++l + ++ ++gyt+ds+a+++++e+l++f++e+++ fLqFvTgs+rlP+gGf++l+p l+++rk     ++ dd
   Q: 1896 LLCGSksETWDVKTLMECCRPDHGYTHDSRAVKFLFEILSSFDAEQQRLFLQFVTGSPRLPVGGFRSLNPPLTIVRKtfestENPDD 1982
           ****98889***********************************************************************988888* PP
   S: 297  rlPssnTCfnyLkLPeYsskeilkekLlyAieet.kgFels 336
            lPs++TC+nyLkLP+Yss ei++ekL++A +e+ ++F+ls
   Q: 1983 FLPSVMTCVNYLKLPDYSSIEIMREKLIMAAREGqQSFHLS 2023
           **************************************985 PP

Organism

Latimeria chalumnae

Protein Sequence
(Fasta)

MSNRPNSNPG GSLRRSQRNT AGAQPQDNAA GGRGCTSSTT LIPQQEDTDK NSTSERQRPG 60
QTHKRDSSRG LKRRASPEDS SSSSPSAAKK PKALQHTETS SETNRTKSKK KSQVQDQDKL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AGATTTTTTA AAAAGTGCTA AAACAATATT AAATTATTTA AAATCTTTTT TTCCATTACT 60
TACTTCACTT TTAGTGACGG CAAACTGAAA GAAATCTTTG CTAGGAGCTG GAGCTTGGGC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR011989--ARM-like
IPR016024--ARM-type_fold
IPR000569--HECT_dom
IPR004170--WWE-dom
IPR018123--WWE-dom_subgr

PROSITE

PS50237--HECT
PS50918--WWE

Pfam

PF00632--HECT
PF02825--WWE

SMART

SM00119--HECTc
SM00678--WWE

Gene Ontology

GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000750	Aegilops tauschii	36.39	2.00e-116	414.00
IUUC-Aml-001502	Ailuropoda melanoleuca	84.47	0.00e+00	3088.00
IUUC-Atr-002821	Amborella trichopoda	37.18	2.00e-110	394.00
IUUC-Apl-003531	Anas platyrhynchos	84.52	0.00e+00	3027.00
IUUC-Aly-005962	Arabidopsis lyrata	37.36	2.00e-106	381.00
IUUC-Ath-006636	Arabidopsis thaliana	37.66	1.00e-106	381.00
IUUC-Ago-007875	Ashbya gossypii	35.46	5.00e-80	293.00
IUUC-Acl-008242	Aspergillus clavatus	35.64	3.00e-110	394.00
IUUC-Afl-008736	Aspergillus flavus	39.16	8.00e-111	395.00
IUUC-Afu-008812	Aspergillus fumigatus	36.24	1.00e-112	402.00
IUUC-Ani-009407	Aspergillus nidulans	36.95	3.00e-111	397.00
IUUC-Ang-009763	Aspergillus niger	39.12	5.00e-105	376.00
IUUC-Aor-009941	Aspergillus oryzae	31.00	4.00e-114	406.00
IUUC-Ate-010459	Aspergillus terreus	37.04	2.00e-85	311.00
IUUC-Ame-011761	Astyanax mexicanus	87.48	0.00e+00	2930.00
IUUC-Bgr-012265	Blumeria graminis	33.58	1.00e-100	361.00
IUUC-Bta-013070	Bos taurus	85.33	0.00e+00	3107.00
IUUC-Bci-013890	Botrytis cinerea	38.20	8.00e-98	352.00
IUUC-Bdi-014046	Brachypodium distachyon	37.21	2.00e-113	404.00
IUUC-Bol-015942	Brassica oleracea	43.18	2.00e-105	378.00
IUUC-Bra-016849	Brassica rapa	41.76	4.00e-105	377.00
IUUC-Cja-019046	Callithrix jacchus	82.89	0.00e+00	3090.00
IUUC-Cfa-020521	Canis familiaris	82.78	0.00e+00	2981.00
IUUC-Cpo-021639	Cavia porcellus	80.88	0.00e+00	2981.00
IUUC-Cre-022767	Chlamydomonas reinhardtii	39.39	2.00e-87	315.00
IUUC-Csa-023231	Chlorocebus sabaeus	84.32	0.00e+00	3165.00
IUUC-Cho-024380	Choloepus hoffmanni	81.67	0.00e+00	1884.00
IUUC-Cin-025482	Ciona intestinalis	50.37	2.00e-152	532.00
IUUC-Csv-026121	Ciona savignyi	48.20	0.00e+00	1521.00
IUUC-Cgl-026716	Colletotrichum gloeosporioides	34.27	2.00e-103	371.00
IUUC-Cne-026857	Cryptococcus neoformans	38.86	2.00e-90	328.00
IUUC-Cme-027226	Cyanidioschyzon merolae	32.93	4.00e-71	264.00
IUUC-Dre-028174	Danio rerio	87.37	0.00e+00	2971.00
IUUC-Dor-030939	Dipodomys ordii	78.53	0.00e+00	2474.00
IUUC-Dse-031444	Dothistroma septosporum	37.15	1.00e-100	362.00
IUUC-Dme-032162	Drosophila melanogaster	66.89	1.00e-170	595.00
IUUC-Ete-032345	Echinops telfairi	80.59	0.00e+00	2030.00
IUUC-Eca-033229	Equus caballus	84.03	0.00e+00	3052.00
IUUC-Eeu-035205	Erinaceus europaeus	75.38	0.00e+00	2647.00
IUUC-Fca-036444	Felis catus	83.61	0.00e+00	3075.00
IUUC-Fal-037131	Ficedula albicollis	86.34	0.00e+00	3157.00
IUUC-Fox-038035	Fusarium oxysporum	39.07	5.00e-103	368.00
IUUC-Fso-038320	Fusarium solani	38.69	2.00e-103	371.00
IUUC-Gmo-039497	Gadus morhua	85.64	0.00e+00	2920.00
IUUC-Ggr-040057	Gaeumannomyces graminis	37.85	4.00e-104	374.00
IUUC-Gga-041021	Gallus gallus	86.00	0.00e+00	3160.00
IUUC-Gac-042474	Gasterosteus aculeatus	80.66	0.00e+00	2966.00
IUUC-Gma-043060	Glycine max	36.49	2.00e-112	401.00
IUUC-Ggo-044855	Gorilla gorilla	82.89	0.00e+00	3091.00
IUUC-Hsa-046147	Homo sapiens	84.24	0.00e+00	3099.00
IUUC-Hvu-047775	Hordeum vulgare	37.65	1.00e-115	411.00
IUUC-Itr-048131	Ictidomys tridecemlineatus	85.88	0.00e+00	3129.00
IUUC-Kpa-049098	Komagataella pastoris	36.54	3.00e-80	294.00
IUUC-Lpe-051017	Leersia perrieri	36.47	3.00e-109	390.00
IUUC-Loc-051777	Lepisosteus oculatus	86.34	0.00e+00	3235.00
IUUC-Lma-052990	Leptosphaeria maculans	35.57	2.00e-110	394.00
IUUC-Laf-053727	Loxodonta africana	84.03	0.00e+00	3083.00
IUUC-Mcc-055799	Macaca mulatta	90.25	0.00e+00	2975.00
IUUC-Meu-056065	Macropus eugenii	84.29	0.00e+00	1886.00
IUUC-Mor-057054	Magnaporthe oryzae	37.78	2.00e-100	361.00
IUUC-Mpo-057417	Magnaporthe poae	36.79	2.00e-102	367.00
IUUC-Mtr-057849	Medicago truncatula	36.17	2.00e-105	377.00
IUUC-Mla-058870	Melampsora laricipopulina	40.48	2.00e-100	360.00
IUUC-Mga-059580	Meleagris gallopavo	84.66	0.00e+00	2656.00
IUUC-Mvi-060507	Microbotryum violaceum	40.69	1.00e-110	395.00
IUUC-Mmr-060816	Microcebus murinus	85.39	0.00e+00	3153.00
IUUC-Mdo-062866	Monodelphis domestica	82.03	0.00e+00	2969.00
IUUC-Mmu-063906	Mus musculus	86.85	0.00e+00	3168.00
IUUC-Mac-064675	Musa acuminata	38.44	2.00e-103	370.00
IUUC-Mpu-066199	Mustela putorius furo	83.16	0.00e+00	3039.00
IUUC-Mlu-067110	Myotis lucifugus	87.00	0.00e+00	3141.00
IUUC-Nfi-068482	Neosartorya fischeri	36.39	1.00e-113	405.00
IUUC-Ncr-068906	Neurospora crassa	38.69	1.00e-104	375.00
IUUC-Nle-069410	Nomascus leucogenys	82.73	0.00e+00	3077.00
IUUC-Opr-070401	Ochotona princeps	76.14	0.00e+00	1701.00
IUUC-Ont-072100	Oreochromis niloticus	81.59	0.00e+00	3035.00
IUUC-Oan-073121	Ornithorhynchus anatinus	85.87	0.00e+00	3207.00
IUUC-Ocu-074623	Oryctolagus cuniculus	84.52	0.00e+00	3085.00
IUUC-Oba-075380	Oryza barthii	35.02	2.00e-105	377.00
IUUC-Obr-076915	Oryza brachyantha	35.77	7.00e-109	389.00
IUUC-Ogl-077055	Oryza glaberrima	36.74	4.00e-110	393.00
IUUC-Ogu-078892	Oryza glumaepatula	38.57	1.00e-104	374.00
IUUC-Oin-079256	Oryza indica	36.71	9.00e-109	389.00
IUUC-Olo-080343	Oryza longistaminata	36.71	8.00e-109	389.00
IUUC-Ome-081422	Oryza meridionalis	36.71	6.00e-108	386.00
IUUC-Oni-083047	Oryza nivara	38.79	6.00e-107	382.00
IUUC-Opu-083641	Oryza punctata	34.72	1.00e-102	368.00
IUUC-Oru-084439	Oryza rufipogon	38.75	4.00e-105	376.00
IUUC-Osa-085972	Oryza sativa	36.60	1.00e-108	387.00
IUUC-Ola-087173	Oryzias latipes	82.37	0.00e+00	3014.00
IUUC-Olu-087871	Ostreococcus lucimarinus	35.66	5.00e-79	288.00
IUUC-Oga-087908	Otolemur garnettii	84.29	0.00e+00	3080.00
IUUC-Oar-090277	Ovis aries	86.61	0.00e+00	3184.00
IUUC-Ptr-091543	Pan troglodytes	84.34	0.00e+00	3101.00
IUUC-Pan-092243	Papio anubis	90.25	0.00e+00	2975.00
IUUC-Psi-093150	Pelodiscus sinensis	85.76	0.00e+00	3177.00
IUUC-Pno-094891	Phaeosphaeria nodorum	39.55	2.00e-106	381.00
IUUC-Ppa-095181	Physcomitrella patens	40.43	1.00e-98	353.00
IUUC-Pfo-096267	Poecilia formosa	87.31	0.00e+00	2978.00
IUUC-Pab-098072	Pongo abelii	83.02	0.00e+00	3090.00
IUUC-Pop-099190	Populus trichocarpa	36.95	1.00e-108	388.00
IUUC-Pca-100311	Procavia capensis	79.70	0.00e+00	2824.00
IUUC-Ppe-101284	Prunus persica	36.99	9.00e-108	385.00
IUUC-Pva-102215	Pteropus vampyrus	79.64	0.00e+00	1058.00
IUUC-Pgr-103694	Puccinia graminis	35.68	2.00e-100	361.00
IUUC-Ptt-103916	Puccinia triticina	38.36	2.00e-95	344.00
IUUC-Pte-104346	Pyrenophora teres	40.55	2.00e-107	384.00
IUUC-Pyt-104508	Pyrenophora triticirepentis	40.75	3.00e-108	387.00
IUUC-Rno-105315	Rattus norvegicus	82.13	0.00e+00	3014.00
IUUC-Sce-106273	Saccharomyces cerevisiae	34.53	1.00e-68	255.00
IUUC-Sha-106835	Sarcophilus harrisii	85.87	0.00e+00	3222.00
IUUC-Sja-107943	Schizosaccharomyces japonicus	37.70	3.00e-94	340.00
IUUC-Spo-108081	Schizosaccharomyces pombe	37.12	5.00e-94	340.00
IUUC-Ssl-108560	Sclerotinia sclerotiorum	38.40	4.00e-101	363.00
IUUC-Smo-109590	Selaginella moellendorffii	41.85	2.00e-103	371.00
IUUC-Sit-110717	Setaria italica	36.13	2.00e-110	394.00
IUUC-Sly-111469	Solanum lycopersicum	39.02	1.00e-112	401.00
IUUC-Stu-112896	Solanum tuberosum	36.64	1.00e-95	343.00
IUUC-Sar-113224	Sorex araneus	78.50	0.00e+00	1640.00
IUUC-Sbi-114313	Sorghum bicolor	36.87	4.00e-115	410.00
IUUC-Sre-114993	Sporisorium reilianum	33.67	8.00e-100	359.00
IUUC-Ssc-115535	Sus scrofa	83.86	0.00e+00	3042.00
IUUC-Tgu-117493	Taeniopygia guttata	86.60	0.00e+00	2512.00
IUUC-Tru-118669	Takifugu rubripes	79.14	0.00e+00	2908.00
IUUC-Tsy-119373	Tarsius syrichta	82.21	0.00e+00	1616.00
IUUC-Tni-120049	Tetraodon nigroviridis	72.89	0.00e+00	778.00
IUUC-Tca-121779	Theobroma cacao	37.77	4.00e-106	380.00
IUUC-Tre-122195	Trichoderma reesei	35.80	2.00e-102	368.00
IUUC-Tvi-122650	Trichoderma virens	35.03	1.00e-103	372.00
IUUC-Tae-123580	Triticum aestivum	37.81	6.00e-115	408.00
IUUC-Tur-126295	Triticum urartu	37.76	9.00e-117	415.00
IUUC-Tme-126964	Tuber melanosporum	34.71	3.00e-103	370.00
IUUC-Tbe-128149	Tupaia belangeri	73.51	0.00e+00	1082.00
IUUC-Ttr-128165	Tursiops truncatus	86.05	0.00e+00	2751.00
IUUC-Uma-129365	Ustilago maydis	35.93	6.00e-84	306.00
IUUC-Vda-129725	Verticillium dahliae	39.24	1.00e-101	365.00
IUUC-Vpa-130678	Vicugna pacos	86.79	0.00e+00	2399.00
IUUC-Vvi-131147	Vitis vinifera	38.21	4.00e-113	403.00
IUUC-Xtr-132636	Xenopus tropicalis	83.63	0.00e+00	2993.00
IUUC-Xma-133458	Xiphophorus maculatus	87.31	0.00e+00	3001.00
IUUC-Yli-134481	Yarrowia lipolytica	38.50	7.00e-97	349.00
IUUC-Zma-135782	Zea mays	43.62	3.00e-109	390.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence