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Tag Content
iUUCD ID IUUC-Afl-008704
Ensembl Protein ID EED51225
UniProt Accession B8ND17; B8ND17_ASPFN
Genbank Protein ID EED51225.1
Protein Name Ubiquitin-related modifier 1
Genbank Nucleotide ID EQ963477
Gene Name URM1; AFLA_054880
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
AFLA_054880 EED51225 EED51225
Status Unreviewed
Classification
Family Identity E-Value Score Source Orthology
ULD/UDP/UBQ/UBQ_Other 37.63 2.00e-13 68.60 IUUC-Sce-106366
Active Site
Position(s) Description Evidence
N/A N/A N/A
Organism Aspergillus flavus
Functional Description
(View)

Functional Description


     Acts as a sulfur carrier required for 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Serves as sulfur donor in tRNA 2-thiolation reaction by being thiocarboxylated (-COSH) at its C-terminus by the MOCS3 homolog UBA4. The sulfur is then transferred to tRNA to form 2-thiolation of mcm(5)S(2)U. Prior mcm(5) tRNA modification by the elongator complex is required for 2-thiolation. Also acts as a ubiquitin-like protein (UBL) that is covalently conjugated via an isopeptide bond to lysine residues of target proteins such as AHP1. The thiocarboxylated form serves as substrate for conjugation and oxidative stress specifically induces the formation of UBL-protein conjugates.
 Acts as a sulfur carrier required for 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Serves as sulfur donor in tRNA 2-thiolation reaction by being thiocarboxylated (-COSH) at its C-terminus by the MOCS3 homolog UBA4. The sulfur is then transferred to tRNA to form 2-thiolation of mcm(5)S(2)U. Prior mcm(5) tRNA modification by the elongator complex is required for 2-thiolation. Also acts as a ubiquitin-like protein (UBL) that is covalently conjugated via an isopeptide bond to lysine residues of target proteins such as AHP1. The thiocarboxylated form serves as substrate for conjugation and oxidative stress specifically induces the formation of UBL-protein conjugates.
Protein Sequence
(Fasta)
MLFSNERKHS VTLPARLSDG GRPSISFLLE YLVKNVMKDE RKELFMLEDN VRPGILVLIN 60
DADWELEGEE KYELQPADNI VFVSTLHGG 89
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Protein Fasta Sequence


>IUUC-Afl-008704|ULD,UBQ_Other|Aspergillus flavus
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Nucleotide Sequence
(Fasta)
ATGCTGTTCT CCAATGAGCG CAAGCATAGT GTCACACTAC CTGCTCGGCT GAGTGACGGT 60
GGCCGGCCGA GTATAAGCTT CCTCCTCGAA TACCTTGTCA AAAATGTGAT GAAGGATGAG 120
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Nucleotide Fasta Sequence


>IUUC-Afl-008704|ULD,UBQ_Other|Aspergillus flavus
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Sequence Source Ensembl
Keyword

KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-1017--Isopeptide bond
KW-1185--Reference proteome
KW-0819--tRNA processing
KW-0833--Ubl conjugation pathway
Interpro

IPR012675--Beta-grasp_dom
IPR016155--Mopterin_synth/thiamin_S_b
IPR015221--Urm1
Pfam

PF09138--Urm1
Gene Ontology

GO:0005829--C:cytosol
GO:0032447--P:protein urmylation
GO:0034227--P:tRNA thio-modification
GO:0002098--P:tRNA wobble uridine modification
KEGG afv:AFLA_054880
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-002254 Ailuropoda melanoleuca 53.93 9.00e-21 89.70
IUUC-Atr-003089 Amborella trichopoda 46.07 1.00e-18 82.00
IUUC-Apl-003382 Anas platyrhynchos 55.06 2.00e-21 91.70
IUUC-Aca-004981 Anolis carolinensis 53.93 7.00e-21 90.10
IUUC-Aly-005517 Arabidopsis lyrata 58.06 3.00e-16 74.30
IUUC-Ath-006718 Arabidopsis thaliana 50.68 5.00e-16 73.90
IUUC-Ago-007917 Ashbya gossypii 45.56 9.00e-20 86.30
IUUC-Acl-008054 Aspergillus clavatus 86.79 7.00e-24 99.40
IUUC-Aor-009890 Aspergillus oryzae 100.00 7.00e-49 183.00
IUUC-Bta-012448 Bos taurus 53.93 5.00e-21 90.50
IUUC-Bci-013865 Botrytis cinerea 59.55 1.00e-29 119.00
IUUC-Bdi-014980 Brachypodium distachyon 52.78 2.00e-17 79.00
IUUC-Bol-016055 Brassica oleracea 54.84 2.00e-15 71.60
IUUC-Bra-016845 Brassica rapa 54.84 2.00e-15 71.60
IUUC-Cel-018485 Caenorhabditis elegans 36.92 1.00e-06 42.70
IUUC-Cja-019587 Callithrix jacchus 55.06 5.00e-21 90.50
IUUC-Cfa-020653 Canis familiaris 55.06 3.00e-21 90.90
IUUC-Cpo-021622 Cavia porcellus 55.06 5.00e-21 90.50
IUUC-Cre-023015 Chlamydomonas reinhardtii 42.70 3.00e-17 77.80
IUUC-Csa-023756 Chlorocebus sabaeus 54.55 9.00e-13 63.90
IUUC-Cgl-026518 Colletotrichum gloeosporioides 65.17 3.00e-32 128.00
IUUC-Cne-026953 Cryptococcus neoformans 54.35 2.00e-20 89.70
IUUC-Cme-027314 Cyanidioschyzon merolae 46.27 2.00e-13 65.10
IUUC-Dre-027884 Danio rerio 56.67 2.00e-21 91.70
IUUC-Dno-029262 Dasypus novemcinctus 47.44 9.00e-12 60.80
IUUC-Dor-030601 Dipodomys ordii 54.84 2.00e-11 58.50
IUUC-Dme-031893 Drosophila melanogaster 50.56 3.00e-20 87.80
IUUC-Ete-032773 Echinops telfairi 52.81 8.00e-21 89.70
IUUC-Eca-034187 Equus caballus 56.18 3.00e-21 90.90
IUUC-Eeu-034808 Erinaceus europaeus 53.93 3.00e-20 87.80
IUUC-Fca-036107 Felis catus 56.18 2.00e-21 92.00
IUUC-Fal-036607 Ficedula albicollis 53.93 3.00e-21 90.50
IUUC-Fox-037698 Fusarium oxysporum 64.04 2.00e-32 128.00
IUUC-Gmo-039492 Gadus morhua 54.44 3.00e-21 91.30
IUUC-Ggr-039965 Gaeumannomyces graminis 59.55 4.00e-29 118.00
IUUC-Gga-041268 Gallus gallus 55.06 1.00e-21 92.80
IUUC-Gac-042111 Gasterosteus aculeatus 53.33 6.00e-21 90.10
IUUC-Gma-043240 Glycine max 54.84 1.00e-15 72.40
IUUC-Ggo-045176 Gorilla gorilla 50.00 1.00e-09 53.50
IUUC-Hsa-046077 Homo sapiens 51.69 6.00e-18 80.10
IUUC-Itr-048111 Ictidomys tridecemlineatus 51.69 2.00e-18 81.30
IUUC-Kpa-049157 Komagataella pastoris 49.44 1.00e-18 82.40
IUUC-Lch-049889 Latimeria chalumnae 53.33 2.00e-20 88.20
IUUC-Lpe-050783 Leersia perrieri 55.74 3.00e-14 68.20
IUUC-Loc-052400 Lepisosteus oculatus 54.44 2.00e-20 89.00
IUUC-Lma-053259 Leptosphaeria maculans 57.30 1.00e-27 112.00
IUUC-Laf-053596 Loxodonta africana 53.85 3.00e-20 87.80
IUUC-Mcc-054845 Macaca mulatta 55.06 5.00e-21 90.10
IUUC-Meu-055968 Macropus eugenii 57.30 2.00e-22 95.10
IUUC-Mor-057126 Magnaporthe oryzae 56.67 4.00e-26 108.00
IUUC-Mpo-057311 Magnaporthe poae 61.80 6.00e-31 124.00
IUUC-Mtr-058266 Medicago truncatula 51.52 2.00e-15 72.40
IUUC-Mla-058847 Melampsora laricipopulina 41.43 3.00e-08 48.50
IUUC-Mga-059468 Meleagris gallopavo 55.06 1.00e-21 92.40
IUUC-Mvi-060235 Microbotryum violaceum 55.07 2.00e-16 76.30
IUUC-Mdo-061948 Monodelphis domestica 55.56 9.00e-22 92.80
IUUC-Mmu-063946 Mus musculus 55.06 1.00e-20 89.40
IUUC-Mac-064812 Musa acuminata 59.68 2.00e-16 75.10
IUUC-Mpu-066763 Mustela putorius furo 56.18 4.00e-21 90.50
IUUC-Mlu-066970 Myotis lucifugus 54.55 7.00e-13 62.80
IUUC-Ncr-068824 Neurospora crassa 52.81 7.00e-27 110.00
IUUC-Nle-069849 Nomascus leucogenys 54.55 1.00e-12 63.50
IUUC-Opr-070227 Ochotona princeps 55.06 5.00e-21 90.50
IUUC-Ont-072530 Oreochromis niloticus 55.56 7.00e-22 93.20
IUUC-Oan-073191 Ornithorhynchus anatinus 55.06 2.00e-21 91.30
IUUC-Ocu-074460 Oryctolagus cuniculus 56.18 1.00e-21 92.00
IUUC-Oba-075499 Oryza barthii 47.06 4.00e-15 72.00
IUUC-Obr-076896 Oryza brachyantha 50.72 2.00e-14 70.50
IUUC-Ogl-077834 Oryza glaberrima 47.06 9.00e-16 72.80
IUUC-Ogu-078622 Oryza glumaepatula 47.06 9.00e-16 72.80
IUUC-Oin-079358 Oryza indica 49.38 6.00e-15 72.00
IUUC-Olo-081035 Oryza longistaminata 44.94 3.00e-15 72.80
IUUC-Oni-082425 Oryza nivara 47.06 9.00e-16 72.80
IUUC-Opu-083461 Oryza punctata 51.47 2.00e-14 69.70
IUUC-Oru-084875 Oryza rufipogon 50.72 4.00e-13 63.50
IUUC-Oga-089128 Otolemur garnettii 56.18 3.00e-21 90.90
IUUC-Oar-089896 Ovis aries 53.93 5.00e-21 90.50
IUUC-Ptr-091618 Pan troglodytes 50.00 1.00e-09 53.50
IUUC-Pan-092238 Papio anubis 54.55 1.00e-12 63.90
IUUC-Psi-093879 Pelodiscus sinensis 56.18 5.00e-22 93.60
IUUC-Pma-094484 Petromyzon marinus 58.11 2.00e-17 79.00
IUUC-Ppa-095801 Physcomitrella patens 43.53 3.00e-15 71.20
IUUC-Pfo-097192 Poecilia formosa 54.44 2.00e-20 88.60
IUUC-Pab-098203 Pongo abelii 51.69 6.00e-18 80.10
IUUC-Pop-099614 Populus trichocarpa 54.84 2.00e-15 71.60
IUUC-Pca-100507 Procavia capensis 53.03 1.00e-12 62.40
IUUC-Ppe-101174 Prunus persica 41.57 2.00e-15 72.00
IUUC-Pva-102735 Pteropus vampyrus 56.10 9.00e-18 79.70
IUUC-Pgr-103510 Puccinia graminis 38.30 2.00e-09 52.40
IUUC-Ptt-103918 Puccinia triticina 34.04 5.00e-08 47.80
IUUC-Pte-104173 Pyrenophora teres 59.55 3.00e-30 121.00
IUUC-Pyt-104806 Pyrenophora triticirepentis 58.43 1.00e-29 119.00
IUUC-Rno-105820 Rattus norvegicus 55.06 1.00e-20 89.40
IUUC-Sce-106366 Saccharomyces cerevisiae 37.63 2.00e-14 68.60
IUUC-Sja-107727 Schizosaccharomyces japonicus 39.77 2.00e-16 75.90
IUUC-Spo-108074 Schizosaccharomyces pombe 43.82 2.00e-13 65.10
IUUC-Smo-108944 Selaginella moellendorffii 42.70 2.00e-15 71.20
IUUC-Sit-110277 Setaria italica 47.13 1.00e-16 75.50
IUUC-Sly-111505 Solanum lycopersicum 54.55 1.00e-16 76.30
IUUC-Stu-112076 Solanum tuberosum 54.55 1.00e-16 75.90
IUUC-Sbi-114274 Sorghum bicolor 45.35 8.00e-16 73.60
IUUC-Sre-114953 Sporisorium reilianum 57.65 3.00e-24 101.00
IUUC-Ssc-115418 Sus scrofa 55.56 4.00e-21 90.90
IUUC-Tgu-117311 Taeniopygia guttata 52.81 9.00e-21 89.40
IUUC-Tru-118598 Takifugu rubripes 53.33 1.00e-20 89.00
IUUC-Tni-120109 Tetraodon nigroviridis 52.22 5.00e-19 84.00
IUUC-Tca-120942 Theobroma cacao 48.48 5.00e-15 70.50
IUUC-Tre-122099 Trichoderma reesei 66.29 3.00e-27 110.00
IUUC-Tvi-122285 Trichoderma virens 69.66 4.00e-28 114.00
IUUC-Tae-125193 Triticum aestivum 48.78 7.00e-16 73.20
IUUC-Tur-126677 Triticum urartu 42.55 3.00e-13 65.10
IUUC-Tme-127120 Tuber melanosporum 61.80 2.00e-29 119.00
IUUC-Tbe-128050 Tupaia belangeri 41.57 5.00e-14 67.00
IUUC-Ttr-129019 Tursiops truncatus 56.18 9.00e-22 92.80
IUUC-Uma-129483 Ustilago maydis 54.12 8.00e-23 96.70
IUUC-Vda-129690 Verticillium dahliae 53.57 3.00e-30 121.00
IUUC-Vvi-131174 Vitis vinifera 46.91 8.00e-16 73.20
IUUC-Xma-133862 Xiphophorus maculatus 54.44 2.00e-20 88.60
IUUC-Yli-134398 Yarrowia lipolytica 46.15 4.00e-20 87.40
IUUC-Zma-134964 Zea mays 45.35 1.00e-17 79.30
Created Date 25-Jun-2017

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