iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Xma-133862

Ensembl Protein ID

ENSXMAP00000001670.1

UniProt Accession

M3ZHH8; M3ZHH8_XIPMA

Genbank Protein ID

ENSXMAP00000001670

Protein Name

Ubiquitin-related modifier 1

Genbank Nucleotide ID

AGAJ01008086

Gene Name

urm1; URM1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSXMAG00000001680.1	ENSXMAT00000001673.1	ENSXMAP00000001670.1

Status

Unreviewed

Classification

Family	Identity	E-Value	Score	Source Orthology
ULD/UDP/UBQ/UBQ_Other	40.40	9.00e-15	72.80	IUUC-Sce-106366

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Organism

Xiphophorus maculatus

Functional Description
(View)

Acts as a sulfur carrier required for 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Serves as sulfur donor in tRNA 2-thiolation reaction by being thiocarboxylated (-COSH) at its C-terminus by MOCS3. The sulfur is then transferred to tRNA to form 2-thiolation of mcm(5)S(2)U. Also acts as a ubiquitin-like protein (UBL) that is covalently conjugated via an isopeptide bond to lysine residues of target proteins. The thiocarboxylated form serves as substrate for conjugation and oxidative stress specifically induces the formation of UBL-protein conjugates.

Protein Sequence
(Fasta)

MAAPVAVHLE FGGGAELLFD GVKEHHVTLP SQSEPWDMKQ LLVWIQRNLL KERPELFVQG 60
DTVRPGILVL INDADWELMG ELDYQLLDQD NIVFISTLHG G 101

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Nucleotide Sequence
(Fasta)

TTCGCCTTCC GTCACTTCCT GCATGTGCGG ACAACATGGC AGCCCCCGTT GCTGTTCATC 60
TGGAGTTTGG GTAGGTACAT TTTAAACTTT CCTCGATTGT ATGTGTTTAG TTTTCTGAAA 120

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Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-1017--Isopeptide bond
KW-1185--Reference proteome
KW-0819--tRNA processing
KW-0833--Ubl conjugation pathway

Interpro

IPR012675--Beta-grasp_dom
IPR016155--Mopterin_synth/thiamin_S_b
IPR015221--Urm1

Pfam

PF09138--Urm1

Gene Ontology

GO:0005829--C:cytosol
GO:0032447--P:protein urmylation
GO:0034227--P:tRNA thio-modification
GO:0002098--P:tRNA wobble uridine modification

KEGG

xma:102232018

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002254	Ailuropoda melanoleuca	78.22	8.00e-46	174.00
IUUC-Atr-003089	Amborella trichopoda	62.11	2.00e-30	123.00
IUUC-Apl-003382	Anas platyrhynchos	81.32	1.00e-40	157.00
IUUC-Aca-004981	Anolis carolinensis	82.18	4.00e-47	179.00
IUUC-Aly-005517	Arabidopsis lyrata	60.87	2.00e-28	116.00
IUUC-Ath-006718	Arabidopsis thaliana	60.71	5.00e-25	105.00
IUUC-Ago-007917	Ashbya gossypii	40.40	1.00e-17	80.90
IUUC-Acl-008054	Aspergillus clavatus	70.00	1.00e-15	74.30
IUUC-Afl-008704	Aspergillus flavus	54.44	5.00e-20	88.60
IUUC-Aor-009890	Aspergillus oryzae	53.92	2.00e-23	100.00
IUUC-Bta-012448	Bos taurus	79.21	5.00e-46	175.00
IUUC-Bci-013865	Botrytis cinerea	45.54	3.00e-20	89.70
IUUC-Bdi-014980	Brachypodium distachyon	63.38	1.00e-23	100.00
IUUC-Bol-016055	Brassica oleracea	60.53	3.00e-24	102.00
IUUC-Bra-016845	Brassica rapa	60.53	3.00e-24	102.00
IUUC-Cel-018485	Caenorhabditis elegans	33.98	4.00e-10	55.80
IUUC-Cja-019587	Callithrix jacchus	80.20	4.00e-46	175.00
IUUC-Cfa-020653	Canis familiaris	80.20	4.00e-46	175.00
IUUC-Cpo-021622	Cavia porcellus	80.20	4.00e-46	175.00
IUUC-Cre-023015	Chlamydomonas reinhardtii	55.10	2.00e-25	106.00
IUUC-Csa-023756	Chlorocebus sabaeus	78.48	2.00e-34	137.00
IUUC-Cgl-026518	Colletotrichum gloeosporioides	44.55	5.00e-20	89.40
IUUC-Cne-026953	Cryptococcus neoformans	57.43	3.00e-27	114.00
IUUC-Cme-027314	Cyanidioschyzon merolae	44.44	1.00e-18	84.00
IUUC-Dre-027884	Danio rerio	86.14	2.00e-48	183.00
IUUC-Dno-029262	Dasypus novemcinctus	78.75	2.00e-35	141.00
IUUC-Dor-030601	Dipodomys ordii	52.48	2.00e-22	96.30
IUUC-Dme-031893	Drosophila melanogaster	58.82	9.00e-30	121.00
IUUC-Ete-032773	Echinops telfairi	75.25	3.00e-42	162.00
IUUC-Eca-034187	Equus caballus	81.19	2.00e-46	176.00
IUUC-Eeu-034808	Erinaceus europaeus	77.23	9.00e-45	171.00
IUUC-Fca-036107	Felis catus	80.20	1.00e-46	176.00
IUUC-Fal-036607	Ficedula albicollis	79.12	5.00e-40	155.00
IUUC-Fox-037698	Fusarium oxysporum	45.19	7.00e-21	92.00
IUUC-Gmo-039492	Gadus morhua	87.13	7.00e-49	184.00
IUUC-Ggr-039965	Gaeumannomyces graminis	46.15	9.00e-19	85.90
IUUC-Gga-041268	Gallus gallus	80.20	7.00e-46	174.00
IUUC-Gac-042111	Gasterosteus aculeatus	90.10	4.00e-51	192.00
IUUC-Gma-043240	Glycine max	57.14	1.00e-23	100.00
IUUC-Ggo-045176	Gorilla gorilla	77.22	2.00e-27	114.00
IUUC-Hsa-046077	Homo sapiens	78.22	5.00e-39	151.00
IUUC-Itr-048111	Ictidomys tridecemlineatus	80.90	1.00e-33	133.00
IUUC-Kpa-049157	Komagataella pastoris	46.46	1.00e-18	84.00
IUUC-Lch-049889	Latimeria chalumnae	80.20	1.00e-46	177.00
IUUC-Lpe-050783	Leersia perrieri	66.67	1.00e-21	94.40
IUUC-Loc-052400	Lepisosteus oculatus	86.14	3.00e-49	185.00
IUUC-Lma-053259	Leptosphaeria maculans	47.52	1.00e-20	90.90
IUUC-Laf-053596	Loxodonta africana	77.67	3.00e-44	169.00
IUUC-Mcc-054845	Macaca mulatta	74.49	1.00e-40	157.00
IUUC-Meu-055968	Macropus eugenii	83.17	1.00e-47	180.00
IUUC-Mor-057126	Magnaporthe oryzae	42.31	2.00e-16	78.20
IUUC-Mpo-057311	Magnaporthe poae	47.52	4.00e-20	90.10
IUUC-Mtr-058266	Medicago truncatula	53.49	2.00e-22	97.10
IUUC-Mla-058847	Melampsora laricipopulina	38.83	3.00e-11	60.10
IUUC-Mga-059468	Meleagris gallopavo	81.32	7.00e-41	157.00
IUUC-Mvi-060235	Microbotryum violaceum	35.76	3.00e-18	84.30
IUUC-Mdo-061948	Monodelphis domestica	82.18	7.00e-47	177.00
IUUC-Mmu-063946	Mus musculus	80.20	9.00e-46	174.00
IUUC-Mac-064812	Musa acuminata	68.75	2.00e-24	103.00
IUUC-Mpu-066763	Mustela putorius furo	80.20	3.00e-45	172.00
IUUC-Mlu-066970	Myotis lucifugus	79.75	5.00e-35	138.00
IUUC-Ncr-068824	Neurospora crassa	44.55	2.00e-18	84.00
IUUC-Nle-069849	Nomascus leucogenys	78.48	2.00e-34	137.00
IUUC-Opr-070227	Ochotona princeps	80.20	4.00e-46	175.00
IUUC-Ont-072530	Oreochromis niloticus	91.09	6.00e-51	191.00
IUUC-Oan-073191	Ornithorhynchus anatinus	85.39	1.00e-41	160.00
IUUC-Ocu-074460	Oryctolagus cuniculus	80.61	7.00e-45	171.00
IUUC-Oba-075499	Oryza barthii	67.19	4.00e-22	97.10
IUUC-Obr-076896	Oryza brachyantha	64.06	4.00e-21	94.40
IUUC-Ogl-077834	Oryza glaberrima	67.19	1.00e-22	97.40
IUUC-Ogu-078622	Oryza glumaepatula	67.19	1.00e-22	97.40
IUUC-Oin-079358	Oryza indica	67.19	4.00e-22	97.80
IUUC-Olo-081035	Oryza longistaminata	53.40	2.00e-23	101.00
IUUC-Oni-082425	Oryza nivara	67.19	1.00e-22	97.40
IUUC-Opu-083461	Oryza punctata	66.67	8.00e-22	95.90
IUUC-Oru-084875	Oryza rufipogon	60.56	2.00e-20	90.10
IUUC-Oga-089128	Otolemur garnettii	81.19	3.00e-46	176.00
IUUC-Oar-089896	Ovis aries	79.21	5.00e-46	175.00
IUUC-Ptr-091618	Pan troglodytes	77.22	3.00e-27	114.00
IUUC-Pan-092238	Papio anubis	78.48	1.00e-34	138.00
IUUC-Psi-093879	Pelodiscus sinensis	79.21	2.00e-45	173.00
IUUC-Pma-094484	Petromyzon marinus	75.25	8.00e-35	137.00
IUUC-Ppa-095801	Physcomitrella patens	56.41	2.00e-21	93.60
IUUC-Pfo-097192	Poecilia formosa	100.00	4.00e-55	205.00
IUUC-Pab-098203	Pongo abelii	78.22	7.00e-39	151.00
IUUC-Pop-099614	Populus trichocarpa	57.14	1.00e-23	100.00
IUUC-Pca-100507	Procavia capensis	78.48	8.00e-35	137.00
IUUC-Ppe-101174	Prunus persica	61.05	3.00e-29	119.00
IUUC-Pva-102735	Pteropus vampyrus	79.21	9.00e-43	164.00
IUUC-Pgr-103510	Puccinia graminis	35.92	5.00e-10	56.20
IUUC-Ptt-103918	Puccinia triticina	34.95	5.00e-10	56.20
IUUC-Pte-104173	Pyrenophora teres	48.54	3.00e-22	96.30
IUUC-Pyt-104806	Pyrenophora triticirepentis	48.54	2.00e-22	96.70
IUUC-Rno-105820	Rattus norvegicus	81.19	7.00e-46	174.00
IUUC-Sce-106366	Saccharomyces cerevisiae	40.40	3.00e-15	72.80
IUUC-Sja-107727	Schizosaccharomyces japonicus	40.62	6.00e-16	75.50
IUUC-Spo-108074	Schizosaccharomyces pombe	39.80	3.00e-10	55.80
IUUC-Smo-108944	Selaginella moellendorffii	60.67	2.00e-25	106.00
IUUC-Sit-110277	Setaria italica	68.75	7.00e-23	98.20
IUUC-Sly-111505	Solanum lycopersicum	54.76	6.00e-24	101.00
IUUC-Stu-112076	Solanum tuberosum	55.95	2.00e-24	103.00
IUUC-Sbi-114274	Sorghum bicolor	60.53	3.00e-23	100.00
IUUC-Sre-114953	Sporisorium reilianum	56.86	5.00e-26	108.00
IUUC-Ssc-115418	Sus scrofa	81.19	3.00e-46	176.00
IUUC-Tgu-117311	Taeniopygia guttata	79.12	5.00e-40	154.00
IUUC-Tru-118598	Takifugu rubripes	88.76	1.00e-42	163.00
IUUC-Tni-120109	Tetraodon nigroviridis	89.22	5.00e-48	181.00
IUUC-Tca-120942	Theobroma cacao	54.22	8.00e-23	97.80
IUUC-Tre-122099	Trichoderma reesei	48.94	6.00e-15	71.60
IUUC-Tvi-122285	Trichoderma virens	50.00	2.00e-18	84.00
IUUC-Tae-125193	Triticum aestivum	67.19	2.00e-22	96.70
IUUC-Tur-126677	Triticum urartu	56.58	8.00e-20	88.60
IUUC-Tme-127120	Tuber melanosporum	48.08	2.00e-23	100.00
IUUC-Tbe-128050	Tupaia belangeri	59.41	2.00e-28	116.00
IUUC-Ttr-129019	Tursiops truncatus	78.22	4.00e-43	165.00
IUUC-Uma-129483	Ustilago maydis	53.92	2.00e-23	100.00
IUUC-Vda-129690	Verticillium dahliae	41.96	2.00e-16	77.00
IUUC-Vvi-131174	Vitis vinifera	59.04	1.00e-23	100.00
IUUC-Yli-134398	Yarrowia lipolytica	44.33	1.00e-16	77.80
IUUC-Zma-134964	Zea mays	59.21	7.00e-22	95.10

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence