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Tag Content
iUUCD ID IUUC-Aca-005291
Ensembl Protein ID ENSACAP00000011188.3
UniProt Accession H9GHK8; H9GHK8_ANOCA
Protein Name Phosphoinositide phospholipase C
Gene Name PLCG1
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSACAG00000011128.3 ENSACAT00000011422.3 ENSACAP00000011188.3
Status Unreviewed
Classification
Family E-Value Score Start End
UBD/SH3 2.60e-12 46.5 783 841
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   UBD/SH3
   S: 2    skekvqvlydyeaqnddeLtlkkGdvvlviekeeqdegWlkgvkelegkrGl.fPenFvekle 63
           +k  v++l+dy+aq +deLt++k  v++ +  e+q++gW++g  +  gk+ l fP+n+ve++ 
   Q: 783  FKCAVKALFDYKAQREDELTFTKNAVIQNV--EKQEGGWWRG--DYGGKKQLwFPSNYVEEIT 841
           56789************************9..9*********..676666655*******985 PP
   
Organism Anolis carolinensis
Protein Sequence
(Fasta)
MASLFTNGPC IQSEAEVVHL YRSLEVGTVM TLFYSKKSQR PERKTFQVKL ETRQVIWSRG 60
SEKIEGAIDI REIQEIRLGR NSRDFDRYQE DPSFRPDPAH CFVILYGMEF RLKTLSLQAT 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Aca-005291|UBD,SH3|Anolis carolinensis
Please wait for a moment...
Nucleotide Sequence
(Fasta)
TGGGATTCCT CGCCAGAGGT TTGCAGAGGT GCCCACTCCC CACTCCCCTC CGTTCCCCTT 60
GCTTTCCCTG CCAGTCTCTC TTCCCTTCTT CCAGCCATTG CAAACCCACA CACATCAGCC 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Aca-005291|UBD,SH3|Anolis carolinensis
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0106--Calcium
KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0442--Lipid degradation
KW-0443--Lipid metabolism
KW-1185--Reference proteome
KW-0727--SH2 domain
KW-0728--SH3 domain
KW-0807--Transducer
Interpro

IPR000008--C2_dom
IPR011992--EF-hand-dom_pair
IPR018247--EF_Hand_1_Ca_BS
IPR002048--EF_hand_dom
IPR011993--PH_dom-like
IPR001849--PH_domain
IPR001192--PI-PLC_fam
IPR016279--PLC-gamma
IPR028380--PLC-gamma1
IPR017946--PLC-like_Pdiesterase_TIM-brl
IPR000909--PLipase_C_PInositol-sp_X_dom
IPR001711--PLipase_C_Pinositol-sp_Y
IPR000980--SH2
IPR001452--SH3_domain
PROSITE

PS50004--C2
PS00018--EF_HAND_1
PS50222--EF_HAND_2
PS50003--PH_DOMAIN
PS50007--PIPLC_X_DOMAIN
PS50008--PIPLC_Y_DOMAIN
PS50001--SH2
PS50002--SH3
Pfam

PF00168--C2
PF00388--PI-PLC-X
PF00387--PI-PLC-Y
PF00017--SH2
PF00018--SH3_1
PRINTS

PR00390--PHPHLIPASEC
PR00401--SH2DOMAIN
PR00452--SH3DOMAIN
SMART

SM00239--C2
SM00233--PH
SM00148--PLCXc
SM00149--PLCYc
SM00252--SH2
SM00326--SH3
Gene Ontology

GO:0005911--C:cell-cell junction
GO:0008180--C:COP9 signalosome
GO:0005829--C:cytosol
GO:0030027--C:lamellipodium
GO:0005886--C:plasma membrane
GO:0001726--C:ruffle
GO:0005509--F:calcium ion binding
GO:0004435--F:phosphatidylinositol phospholipase C activity
GO:0004871--F:signal transducer activity
GO:0019722--P:calcium-mediated signaling
GO:0016477--P:cell migration
GO:0071364--P:cellular response to epidermal growth factor stimulus
GO:0007173--P:epidermal growth factor receptor signaling pathway
GO:0009395--P:phospholipid catabolic process
GO:0045766--P:positive regulation of angiogenesis
GO:0043536--P:positive regulation of blood vessel endothelial cell migration
GO:0051281--P:positive regulation of release of sequestered calcium ion into cytosol
GO:0050852--P:T cell receptor signaling pathway
KEGG acs:100559347
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001452 Ailuropoda melanoleuca 86.30 0.00e+00 2293.00
IUUC-Apl-003541 Anas platyrhynchos 69.58 0.00e+00 1757.00
IUUC-Ame-011004 Astyanax mexicanus 68.69 0.00e+00 1808.00
IUUC-Bta-012660 Bos taurus 86.64 0.00e+00 2177.00
IUUC-Cja-019206 Callithrix jacchus 86.10 0.00e+00 2281.00
IUUC-Cfa-020257 Canis familiaris 86.72 0.00e+00 2198.00
IUUC-Cpo-022391 Cavia porcellus 81.40 0.00e+00 2120.00
IUUC-Csa-024170 Chlorocebus sabaeus 87.69 0.00e+00 1667.00
IUUC-Cin-025520 Ciona intestinalis 47.85 0.00e+00 1114.00
IUUC-Dre-027944 Danio rerio 72.19 0.00e+00 1897.00
IUUC-Dno-029440 Dasypus novemcinctus 86.03 0.00e+00 2092.00
IUUC-Dor-031001 Dipodomys ordii 85.79 0.00e+00 2281.00
IUUC-Eca-033809 Equus caballus 86.64 0.00e+00 2199.00
IUUC-Fca-036510 Felis catus 86.48 0.00e+00 2195.00
IUUC-Fal-037541 Ficedula albicollis 89.46 0.00e+00 2129.00
IUUC-Gmo-038630 Gadus morhua 65.82 0.00e+00 1442.00
IUUC-Gga-040142 Gallus gallus 89.25 0.00e+00 2310.00
IUUC-Ggo-045063 Gorilla gorilla 86.64 0.00e+00 2303.00
IUUC-Hsa-046428 Homo sapiens 86.56 0.00e+00 2301.00
IUUC-Itr-048245 Ictidomys tridecemlineatus 86.72 0.00e+00 2268.00
IUUC-Lch-049766 Latimeria chalumnae 80.48 0.00e+00 1965.00
IUUC-Loc-052285 Lepisosteus oculatus 78.48 0.00e+00 2064.00
IUUC-Laf-053365 Loxodonta africana 85.92 0.00e+00 2175.00
IUUC-Mcc-054871 Macaca mulatta 86.33 0.00e+00 2287.00
IUUC-Meu-056724 Macropus eugenii 82.96 0.00e+00 2053.00
IUUC-Mga-059329 Meleagris gallopavo 88.57 0.00e+00 2180.00
IUUC-Mmr-061110 Microcebus murinus 86.68 0.00e+00 2300.00
IUUC-Mdo-062448 Monodelphis domestica 87.34 0.00e+00 2316.00
IUUC-Mmu-063565 Mus musculus 86.02 0.00e+00 2270.00
IUUC-Mpu-066683 Mustela putorius furo 86.72 0.00e+00 2300.00
IUUC-Mlu-067779 Myotis lucifugus 86.31 0.00e+00 2185.00
IUUC-Nle-069219 Nomascus leucogenys 87.23 0.00e+00 1910.00
IUUC-Opr-070766 Ochotona princeps 83.84 0.00e+00 1331.00
IUUC-Ont-072524 Oreochromis niloticus 74.58 0.00e+00 1961.00
IUUC-Oan-073214 Ornithorhynchus anatinus 86.02 2.00e-43 167.00
IUUC-Ocu-074361 Oryctolagus cuniculus 84.54 0.00e+00 2244.00
IUUC-Ola-086820 Oryzias latipes 73.73 0.00e+00 1992.00
IUUC-Oga-088172 Otolemur garnettii 86.95 0.00e+00 2306.00
IUUC-Oar-090306 Ovis aries 84.19 0.00e+00 2110.00
IUUC-Ptr-090682 Pan troglodytes 86.64 0.00e+00 2303.00
IUUC-Pan-092835 Papio anubis 87.91 0.00e+00 1677.00
IUUC-Psi-093344 Pelodiscus sinensis 87.18 0.00e+00 2296.00
IUUC-Pfo-096984 Poecilia formosa 72.71 0.00e+00 1905.00
IUUC-Pab-097871 Pongo abelii 86.72 0.00e+00 2272.00
IUUC-Pca-100772 Procavia capensis 79.92 0.00e+00 2088.00
IUUC-Pva-102790 Pteropus vampyrus 86.89 0.00e+00 2241.00
IUUC-Rno-105974 Rattus norvegicus 86.09 0.00e+00 2290.00
IUUC-Sar-112995 Sorex araneus 84.83 0.00e+00 2220.00
IUUC-Ssc-115360 Sus scrofa 86.09 0.00e+00 2285.00
IUUC-Tgu-116585 Taeniopygia guttata 86.25 0.00e+00 2189.00
IUUC-Tru-117742 Takifugu rubripes 74.15 0.00e+00 1997.00
IUUC-Tsy-119259 Tarsius syrichta 88.12 0.00e+00 781.00
IUUC-Tni-120833 Tetraodon nigroviridis 66.61 0.00e+00 1700.00
IUUC-Tbe-127504 Tupaia belangeri 73.59 0.00e+00 1227.00
IUUC-Ttr-128650 Tursiops truncatus 86.39 0.00e+00 1144.00
IUUC-Xtr-132862 Xenopus tropicalis 78.17 0.00e+00 2008.00
Created Date 25-Jun-2017

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