iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMMUG00000003149.3	ENSMMUT00000047334.2	ENSMMUP00000040363.1
ENSMMUG00000003149.3	ENSMMUT00000004466.3	ENSMMUP00000004215.3

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	3.40e-28	97.6	307	336
E3 adaptor/Cullin RING/APC_C/CDC20	1.20e-147	492.2	172	478

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 1    gHtdsvtclaf.sd.tllvsGsdDgtikvW 28
           gH+ +v++l++ +d ++l+sG++D+ + vW
   Q: 307  GHSQEVCGLRWaPDgRHLASGGNDNLVNVW 336
           8***********999*************** PP

E3 adaptor/Cullin RING/APC_C/CDC20

   S: 1    pekvldapelrddfylnLldWssknvlavaLgssvylwsaktgdvskladl.eekdlvtsvswieegtllavGtkkgeveiyDveekkk 88
           p+++ldape+r+d+ylnL+dWss nvlavaL++svylwsa++gd+ +l ++ +++++v+sv+wi+eg++lavGt+++ev+++Dv+++k+
   Q: 172  PDRILDAPEIRNDYYLNLVDWSSGNVLAVALDNSVYLWSASSGDILQLLQMeQPGEYVSSVAWIKEGNYLAVGTSSAEVQLWDVQQQKR 260
           689************************************************899*********************************** PP
   S: 89   vrtltghsarvgaLsWnaevlssGsrdgeilhrdvrvkelklstlqahaqevCGlkwnedaklLasGGnDnsvsvwdassse....Plk 173
           +r++t+hsarvg+LsWn+++lssGsr+g+i+h+dvrv+e++++tl++h+qevCGl+w+ d+++LasGGnDn v+vw ++  e    Pl+
   Q: 261  LRNMTSHSARVGSLSWNSYILSSGSRSGHIHHHDVRVAEHHVATLSGHSQEVCGLRWAPDGRHLASGGNDNLVNVWPSAPGEggwvPLQ 349
           ********************************************************************************9999***** PP
   S: 174  kfkehkaavkaiawsPwqkslLasGGGtaDrcikfwntltgalleeidtgsqvcsllwskkskelvsthGfaenkitlwkypslskvae 262
           +f++h++avka+aw+Pwq+++La+GGGt+Dr+i++wn+++ga+l+++d++sqvcs+lws+++kel+s+hGfa+n++++wkyp+++kvae
   Q: 350  TFTQHQGAVKAVAWCPWQSNVLATGGGTSDRHIRIWNVCSGACLSAVDAHSQVCSILWSPHYKELISGHGFAQNQLVIWKYPTMAKVAE 438
           ***************************************************************************************** PP
   S: 263  lkgheaRvlslalspdgeaivtaagDetlrfwklfdkkka 302
           lkgh++Rvlsl++spdg+++++aa+Detlr+w++f+ ++a
   Q: 439  LKGHTSRVLSLTMSPDGATVASAAADETLRLWRCFELDPA 478
           ***********************************99876 PP

Organism

Macaca mulatta

Protein Sequence
(Fasta)

MAQFAFESDL HSLLQLDAPI PNAPPARWQR KAKEASGPAP SPMRAANRSH SAGRTPGRTP 60
GKSSSKVQTT PSKPGGDRYI PHRSAAQMEV ASFLLSKENQ PENSQTPTKK EHQKAWALNL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GGCTCCGCAG GCACCAACTG CAAGGACCCC TCCCGCTGCG GGCGTTCCCA TGGCACAATT 60
CGCGTTCGAG AGTGACCTGC ACTCGCTGCT TCAGCTGGAT GCACCCATCC CCAATGCACC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0131--Cell cycle
KW-0132--Cell division
KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0677--Repeat
KW-0853--WD repeat

Interpro

IPR024977--Apc4_WD40_dom
IPR033187--CDC20
IPR033010--Cdc20/Fizzy
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF12894--ANAPC4_WD40
PF00400--WD40

SMART

SM00320--WD40

Gene Ontology

GO:0005680--C:anaphase-promoting complex
GO:0097027--F:ubiquitin-protein transferase activator activity
GO:0031145--P:anaphase-promoting complex-dependent catabolic process
GO:0051301--P:cell division
GO:0007064--P:mitotic sister chromatid cohesion
GO:0090307--P:mitotic spindle assembly
GO:0090129--P:positive regulation of synapse maturation
GO:0031915--P:positive regulation of synaptic plasticity
GO:1904668--P:positive regulation of ubiquitin protein ligase activity
GO:0040020--P:regulation of meiotic nuclear division

KEGG

mcc:702317

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000638	Aegilops tauschii	46.55	4.00e-111	395.00
IUUC-Aml-001545	Ailuropoda melanoleuca	97.39	0.00e+00	946.00
IUUC-Atr-003103	Amborella trichopoda	46.68	3.00e-109	388.00
IUUC-Apl-003255	Anas platyrhynchos	80.45	0.00e+00	754.00
IUUC-Aca-004920	Anolis carolinensis	75.83	0.00e+00	775.00
IUUC-Aly-006012	Arabidopsis lyrata	49.26	1.00e-109	390.00
IUUC-Ath-006795	Arabidopsis thaliana	46.95	4.00e-108	384.00
IUUC-Ate-010479	Aspergillus terreus	48.70	4.00e-92	332.00
IUUC-Ame-010850	Astyanax mexicanus	60.35	4.00e-91	327.00
IUUC-Bgr-012059	Blumeria graminis	49.51	2.00e-95	342.00
IUUC-Bta-012625	Bos taurus	97.19	0.00e+00	949.00
IUUC-Bci-013607	Botrytis cinerea	48.25	5.00e-99	355.00
IUUC-Bdi-014344	Brachypodium distachyon	48.43	5.00e-110	391.00
IUUC-Bol-015368	Brassica oleracea	46.12	1.00e-106	381.00
IUUC-Bra-016738	Brassica rapa	46.60	4.00e-106	379.00
IUUC-Cja-019132	Callithrix jacchus	98.80	0.00e+00	963.00
IUUC-Cfa-020780	Canis familiaris	97.19	0.00e+00	945.00
IUUC-Cpo-022223	Cavia porcellus	97.39	0.00e+00	901.00
IUUC-Cre-022701	Chlamydomonas reinhardtii	49.77	2.00e-116	412.00
IUUC-Csa-023666	Chlorocebus sabaeus	100.00	0.00e+00	967.00
IUUC-Cho-024920	Choloepus hoffmanni	97.16	4.00e-161	561.00
IUUC-Cin-025675	Ciona intestinalis	51.79	2.00e-136	479.00
IUUC-Csv-026019	Ciona savignyi	51.51	7.00e-132	464.00
IUUC-Cgl-026465	Colletotrichum gloeosporioides	41.00	3.00e-97	349.00
IUUC-Cme-027234	Cyanidioschyzon merolae	52.19	8.00e-106	377.00
IUUC-Dre-028026	Danio rerio	59.76	0.00e+00	630.00
IUUC-Dno-028865	Dasypus novemcinctus	96.60	0.00e+00	934.00
IUUC-Dor-030958	Dipodomys ordii	96.19	0.00e+00	942.00
IUUC-Dse-031391	Dothistroma septosporum	39.05	6.00e-97	348.00
IUUC-Dme-031905	Drosophila melanogaster	49.44	1.00e-143	503.00
IUUC-Ete-032387	Echinops telfairi	91.58	0.00e+00	902.00
IUUC-Eca-033522	Equus caballus	87.58	0.00e+00	852.00
IUUC-Eeu-035059	Erinaceus europaeus	84.60	0.00e+00	796.00
IUUC-Fca-036346	Felis catus	97.73	0.00e+00	868.00
IUUC-Fal-037558	Ficedula albicollis	80.16	0.00e+00	800.00
IUUC-Fox-037850	Fusarium oxysporum	45.57	2.00e-98	353.00
IUUC-Fso-038375	Fusarium solani	44.81	4.00e-99	355.00
IUUC-Gmo-039284	Gadus morhua	62.10	0.00e+00	631.00
IUUC-Ggr-039864	Gaeumannomyces graminis	48.84	4.00e-99	355.00
IUUC-Gga-040790	Gallus gallus	79.96	0.00e+00	816.00
IUUC-Gac-041431	Gasterosteus aculeatus	61.63	1.00e-179	622.00
IUUC-Gma-043489	Glycine max	47.22	3.00e-107	382.00
IUUC-Ggo-045052	Gorilla gorilla	99.60	0.00e+00	965.00
IUUC-Hsa-046305	Homo sapiens	99.60	0.00e+00	965.00
IUUC-Hvu-047476	Hordeum vulgare	45.80	1.00e-110	393.00
IUUC-Itr-048461	Ictidomys tridecemlineatus	97.60	0.00e+00	904.00
IUUC-Lch-050174	Latimeria chalumnae	61.39	2.00e-173	601.00
IUUC-Lpe-050954	Leersia perrieri	48.05	2.00e-101	362.00
IUUC-Loc-052638	Lepisosteus oculatus	63.12	0.00e+00	634.00
IUUC-Lma-052998	Leptosphaeria maculans	43.27	2.00e-100	360.00
IUUC-Laf-053742	Loxodonta africana	97.80	0.00e+00	948.00
IUUC-Meu-056013	Macropus eugenii	86.57	1.00e-142	499.00
IUUC-Mor-057277	Magnaporthe oryzae	46.19	1.00e-96	347.00
IUUC-Mpo-057624	Magnaporthe poae	51.79	4.00e-97	348.00
IUUC-Mtr-057725	Medicago truncatula	46.05	4.00e-100	358.00
IUUC-Mga-060102	Meleagris gallopavo	80.20	0.00e+00	818.00
IUUC-Mmr-061615	Microcebus murinus	98.96	0.00e+00	955.00
IUUC-Mdo-061982	Monodelphis domestica	89.34	0.00e+00	778.00
IUUC-Mmu-063864	Mus musculus	94.59	0.00e+00	934.00
IUUC-Mac-064861	Musa acuminata	47.94	6.00e-111	394.00
IUUC-Mpu-066502	Mustela putorius furo	97.19	0.00e+00	937.00
IUUC-Mlu-067277	Myotis lucifugus	90.02	0.00e+00	885.00
IUUC-Ncr-068951	Neurospora crassa	46.13	8.00e-96	344.00
IUUC-Nle-070149	Nomascus leucogenys	99.60	0.00e+00	959.00
IUUC-Opr-070778	Ochotona princeps	95.54	0.00e+00	687.00
IUUC-Ont-071660	Oreochromis niloticus	60.96	2.00e-178	618.00
IUUC-Oan-073677	Ornithorhynchus anatinus	77.69	0.00e+00	711.00
IUUC-Ocu-073797	Oryctolagus cuniculus	97.38	0.00e+00	947.00
IUUC-Oba-075946	Oryza barthii	48.42	1.00e-108	386.00
IUUC-Obr-076018	Oryza brachyantha	46.61	6.00e-109	387.00
IUUC-Ogl-077254	Oryza glaberrima	48.05	1.00e-101	363.00
IUUC-Ogu-078521	Oryza glumaepatula	48.65	6.00e-109	388.00
IUUC-Oin-079145	Oryza indica	48.42	8.00e-109	387.00
IUUC-Olo-080798	Oryza longistaminata	48.40	2.00e-108	387.00
IUUC-Ome-081186	Oryza meridionalis	48.40	9.00e-109	388.00
IUUC-Oni-082243	Oryza nivara	48.05	1.00e-101	363.00
IUUC-Opu-084007	Oryza punctata	48.05	2.00e-101	362.00
IUUC-Oru-084562	Oryza rufipogon	48.65	1.00e-108	387.00
IUUC-Osa-086094	Oryza sativa	48.05	1.00e-101	363.00
IUUC-Ola-086907	Oryzias latipes	60.63	2.00e-166	578.00
IUUC-Olu-087647	Ostreococcus lucimarinus	48.84	2.00e-119	422.00
IUUC-Oga-088184	Otolemur garnettii	97.40	0.00e+00	944.00
IUUC-Oar-090023	Ovis aries	91.88	0.00e+00	841.00
IUUC-Ptr-090935	Pan troglodytes	98.52	0.00e+00	897.00
IUUC-Pan-091845	Papio anubis	100.00	0.00e+00	967.00
IUUC-Psi-093188	Pelodiscus sinensis	80.54	0.00e+00	843.00
IUUC-Pma-094187	Petromyzon marinus	54.36	3.00e-149	521.00
IUUC-Pno-094809	Phaeosphaeria nodorum	40.98	3.00e-101	362.00
IUUC-Ppa-095457	Physcomitrella patens	46.99	9.00e-111	393.00
IUUC-Pfo-097429	Poecilia formosa	58.37	2.00e-160	558.00
IUUC-Pab-098603	Pongo abelii	99.80	0.00e+00	966.00
IUUC-Pop-099654	Populus trichocarpa	46.63	2.00e-103	369.00
IUUC-Pca-101062	Procavia capensis	96.79	0.00e+00	926.00
IUUC-Ppe-101865	Prunus persica	46.99	3.00e-97	348.00
IUUC-Pva-102925	Pteropus vampyrus	96.39	0.00e+00	971.00
IUUC-Pte-104142	Pyrenophora teres	42.42	7.00e-99	354.00
IUUC-Pyt-104693	Pyrenophora triticirepentis	42.26	9.00e-99	354.00
IUUC-Rno-106005	Rattus norvegicus	94.79	0.00e+00	933.00
IUUC-Sha-107472	Sarcophilus harrisii	89.80	0.00e+00	894.00
IUUC-Sja-107919	Schizosaccharomyces japonicus	43.06	1.00e-94	340.00
IUUC-Spo-108075	Schizosaccharomyces pombe	45.59	3.00e-97	348.00
IUUC-Ssl-108507	Sclerotinia sclerotiorum	49.56	3.00e-98	352.00
IUUC-Smo-108922	Selaginella moellendorffii	49.68	4.00e-124	438.00
IUUC-Sit-110732	Setaria italica	47.25	9.00e-110	390.00
IUUC-Sly-111202	Solanum lycopersicum	44.87	3.00e-106	378.00
IUUC-Stu-112676	Solanum tuberosum	45.56	8.00e-98	350.00
IUUC-Sar-113092	Sorex araneus	91.18	0.00e+00	880.00
IUUC-Sbi-114558	Sorghum bicolor	45.93	1.00e-109	390.00
IUUC-Ssc-115710	Sus scrofa	98.20	0.00e+00	955.00
IUUC-Tgu-117100	Taeniopygia guttata	79.37	0.00e+00	799.00
IUUC-Tru-118184	Takifugu rubripes	57.58	1.00e-139	489.00
IUUC-Tsy-118892	Tarsius syrichta	97.87	6.00e-164	569.00
IUUC-Tni-120474	Tetraodon nigroviridis	59.41	1.00e-168	586.00
IUUC-Tca-120949	Theobroma cacao	46.75	3.00e-107	381.00
IUUC-Tre-122211	Trichoderma reesei	41.16	9.00e-98	350.00
IUUC-Tvi-122531	Trichoderma virens	40.97	7.00e-98	351.00
IUUC-Tae-122784	Triticum aestivum	45.92	7.00e-111	394.00
IUUC-Tur-126193	Triticum urartu	46.02	6.00e-111	394.00
IUUC-Tbe-127384	Tupaia belangeri	99.33	7.00e-178	616.00
IUUC-Ttr-128511	Tursiops truncatus	97.19	0.00e+00	943.00
IUUC-Vda-129993	Verticillium dahliae	41.25	7.00e-99	354.00
IUUC-Vvi-131245	Vitis vinifera	47.42	7.00e-95	340.00
IUUC-Xtr-131993	Xenopus tropicalis	73.49	0.00e+00	759.00
IUUC-Xma-133332	Xiphophorus maculatus	61.54	4.00e-177	614.00
IUUC-Zma-135135	Zea mays	47.88	2.00e-108	386.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence