iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Details
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Basic Information

Integrated Annotations

Tag

Content

iUUCD ID

IUUC-Spo-108075

UUCD1 version

UUC-ScP-00037

Ensembl Protein ID

SPAC821.08c.1:pep

UniProt Accession

P78972; SLP1_SCHPO

Genbank Protein ID

AAC49621.1; CAB57442.1

Protein Name

WD repeat-containing protein slp1

Genbank Nucleotide ID

U77983; CU329670

Gene Name

slp1; SPAC821.08c

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
SPAC821.08c	SPAC821.08c.1	SPAC821.08c.1:pep

Annotation

mRNA Expression
GEO
Protein-protein Interaction
iRefIndex	Mentha
Protein 3D Structure
PDB	MMDB
Protein Expression/Proteomics

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E3 adaptor/Cullin RING/DCX/DWD	WD_repeat	15791259; 18082611
E3 adaptor/Cullin RING/APC_C/CDC20	CDC20	15791259; 18082611

Classification

Family	E-value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	1.00e-22	77.4	302	334
E3 adaptor/Cullin RING/APC_C/CDC20	8.40e-140	463.4	168	472

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 1    gHtdsvtclaf.sd.tllvsGsdDgtikvWDlr 31
           gH+++v++la+ sd   l+sG++D+++++WD r
   Q: 302  GHSSEVCGLAWrSDgLQLASGGNDNVVQIWDAR 334
           8***********99788**************76 PP

E3 adaptor/Cullin RING/APC_C/CDC20

   S: 1    pekvldapelrddfylnLldWssknvlavaLgssvylwsaktgdvskladleekdlvtsvswieegtllavGtkkgeveiyDveekkkvrtl 92
           pe+vldap + dd+ylnLldWs+ nv+avaL+++vy+w+a++g+vs+la+++e+++v+sv+w+++g++l+vG  +g v+iyDve+++k+rt+
   Q: 168  PERVLDAPGIIDDYYLNLLDWSNLNVVAVALERNVYVWNADSGSVSALAETDESTYVASVKWSHDGSFLSVGLGNGLVDIYDVESQTKLRTM 259
           689***************************************************************************************** PP
   S: 93   tghsarvgaLsWnaevlssGsrdgeilhrdvrvkelklstlqahaqevCGlkwnedaklLasGGnDnsvsvwdasssePlkkfkehkaavka 184
           +gh+arvg+LsWn++vlssGsr+g+i+h+dvr++++++ tlq+h++evCGl w++d+ +LasGGnDn+v++wda+ss P +++++h+aavka
   Q: 260  AGHQARVGCLSWNRHVLSSGSRSGAIHHHDVRIANHQIGTLQGHSSEVCGLAWRSDGLQLASGGNDNVVQIWDARSSIPKFTKTNHNAAVKA 351
           ******************************************************************************************** PP
   S: 185  iawsPwqkslLasGGGtaDrcikfwntltgalleeidtgsqvcsllwskkskelvsthGfaenkitlwkyps..lskvaelkgheaRvlsla 274
           +aw+Pwq++lLa+GGGt+D++i+fwn++tga+++++d+gsqv+sl+ws++ske++sthGf++n++++w+y+s  l+k++++ +h++Rvl++a
   Q: 352  VAWCPWQSNLLATGGGTMDKQIHFWNAATGARVNTVDAGSQVTSLIWSPHSKEIMSTHGFPDNNLSIWSYSSsgLTKQVDIPAHDTRVLYSA 443
           **********************************************************************99889***************** PP
   S: 275  lspdgeaivtaagDetlrfwklfdkkkak 303
           lspdg+ + taa+De+l+fw+++d +++k
   Q: 444  LSPDGRILSTAASDENLKFWRVYDGDHVK 472
           ************************99876 PP

Organism

Schizosaccharomyces pombe

Functional Description
(View)

Required for mad2-dependent spindle checkpoint activation. Promotes ubiquitin-dependent degradation of cdc13 by the anaphase promoting complex/cyclosome (APC/C).

Protein Sequence
(Fasta)

MEIAGNSSTI SPTFSTPTKK RNLVFPNSPI TPLHQQALLG RNGRSSKRCS PKSSFIRNSP 60
KIDVVNTDWS IPLCGSPRNK SRPASRSDRF IPSRPNTANA FVNSISSDVP FDYSESVAEA 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CATCTAAACA CTTTGAATTT CAACGTTACA AAGTTTTAGT ATCTTCGGAT CCTTTTTCTT 60
TGATATATTA GGCTGGTCCT ATATTGTTTG TCTTAAGGAA AAGACTGGTA TCTCTTCCTT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0002--3D-structure
KW-0131--Cell cycle
KW-0132--Cell division
KW-0181--Complete proteome
KW-0498--Mitosis
KW-1185--Reference proteome
KW-0677--Repeat
KW-0853--WD repeat

Interpro

IPR024977--Apc4_WD40_dom
IPR033010--Cdc20/Fizzy
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF12894--ANAPC4_WD40
PF00400--WD40

SMART

SM00320--WD40

Gene Ontology

GO:0032153--C:cell division site
GO:0033597--C:mitotic checkpoint complex
GO:0072686--C:mitotic spindle
GO:0044732--C:mitotic spindle pole body
GO:0005634--C:nucleus
GO:0010997--F:anaphase-promoting complex binding
GO:1990757--F:ubiquitin ligase activator activity
GO:0031145--P:anaphase-promoting complex-dependent catabolic process
GO:0051301--P:cell division
GO:0034613--P:cellular protein localization
GO:0000070--P:mitotic sister chromatid segregation
GO:1905188--P:positive regulation of metaphase/anaphase transition of meiosis I
GO:1905191--P:positive regulation of metaphase/anaphase transition of meiosis II

KEGG

spo:SPAC821.08c

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000974	Aegilops tauschii	41.57	5.00e-92	329.00
IUUC-Aml-001545	Ailuropoda melanoleuca	51.76	5.00e-88	316.00
IUUC-Apl-003255	Anas platyrhynchos	43.22	2.00e-96	344.00
IUUC-Aca-004920	Anolis carolinensis	42.58	3.00e-90	323.00
IUUC-Aly-006253	Arabidopsis lyrata	44.71	2.00e-93	334.00
IUUC-Ath-006868	Arabidopsis thaliana	44.47	3.00e-93	333.00
IUUC-Ago-007962	Ashbya gossypii	41.75	9.00e-94	335.00
IUUC-Acl-008043	Aspergillus clavatus	62.95	3.00e-132	463.00
IUUC-Afl-008593	Aspergillus flavus	63.51	1.00e-134	471.00
IUUC-Afu-008793	Aspergillus fumigatus	63.79	2.00e-133	467.00
IUUC-Ani-009158	Aspergillus nidulans	64.07	6.00e-135	472.00
IUUC-Ang-009786	Aspergillus niger	64.35	4.00e-135	473.00
IUUC-Aor-010163	Aspergillus oryzae	63.51	1.00e-134	471.00
IUUC-Ate-010479	Aspergillus terreus	62.67	5.00e-133	466.00
IUUC-Bgr-012059	Blumeria graminis	63.51	1.00e-142	498.00
IUUC-Bta-012625	Bos taurus	45.05	9.00e-89	318.00
IUUC-Bci-013607	Botrytis cinerea	64.35	5.00e-144	502.00
IUUC-Bdi-014344	Brachypodium distachyon	42.20	1.00e-91	328.00
IUUC-Bol-015368	Brassica oleracea	46.00	8.00e-96	343.00
IUUC-Bra-016738	Brassica rapa	45.22	5.00e-95	340.00
IUUC-Cja-019132	Callithrix jacchus	52.40	2.00e-89	320.00
IUUC-Cfa-020780	Canis familiaris	44.91	6.00e-89	319.00
IUUC-Cpo-022223	Cavia porcellus	52.08	3.00e-78	283.00
IUUC-Cre-022701	Chlamydomonas reinhardtii	43.49	8.00e-91	325.00
IUUC-Csa-023666	Chlorocebus sabaeus	45.79	2.00e-89	320.00
IUUC-Cgl-026465	Colletotrichum gloeosporioides	64.07	9.00e-143	498.00
IUUC-Cne-026872	Cryptococcus neoformans	45.09	3.00e-107	380.00
IUUC-Dre-028026	Danio rerio	43.52	1.00e-94	337.00
IUUC-Dno-028865	Dasypus novemcinctus	43.07	2.00e-87	314.00
IUUC-Dor-030958	Dipodomys ordii	45.45	4.00e-85	306.00
IUUC-Dse-031391	Dothistroma septosporum	62.40	5.00e-141	492.00
IUUC-Dme-031905	Drosophila melanogaster	45.01	1.00e-91	328.00
IUUC-Ete-032387	Echinops telfairi	45.71	2.00e-80	291.00
IUUC-Eeu-035059	Erinaceus europaeus	39.85	6.00e-69	252.00
IUUC-Fca-036346	Felis catus	54.72	2.00e-78	284.00
IUUC-Fal-037558	Ficedula albicollis	42.93	3.00e-94	337.00
IUUC-Fox-037850	Fusarium oxysporum	63.23	5.00e-142	495.00
IUUC-Fso-038375	Fusarium solani	63.79	8.00e-143	498.00
IUUC-Gmo-039284	Gadus morhua	43.56	7.00e-94	335.00
IUUC-Ggr-039864	Gaeumannomyces graminis	62.95	6.00e-141	492.00
IUUC-Gga-040790	Gallus gallus	43.92	4.00e-94	336.00
IUUC-Gac-041431	Gasterosteus aculeatus	41.77	1.00e-83	301.00
IUUC-Ggo-045052	Gorilla gorilla	45.54	4.00e-89	320.00
IUUC-Hsa-046305	Homo sapiens	45.54	4.00e-89	320.00
IUUC-Hvu-047227	Hordeum vulgare	42.15	9.00e-92	328.00
IUUC-Itr-048461	Ictidomys tridecemlineatus	52.40	8.00e-79	285.00
IUUC-Lpe-050954	Leersia perrieri	41.59	6.00e-83	299.00
IUUC-Loc-052638	Lepisosteus oculatus	45.60	1.00e-82	298.00
IUUC-Lma-052998	Leptosphaeria maculans	62.67	5.00e-141	492.00
IUUC-Laf-053742	Loxodonta africana	44.67	3.00e-88	317.00
IUUC-Mcc-054948	Macaca mulatta	45.79	2.00e-89	320.00
IUUC-Mor-057277	Magnaporthe oryzae	62.67	6.00e-139	485.00
IUUC-Mpo-057624	Magnaporthe poae	62.12	3.00e-138	483.00
IUUC-Mtr-058044	Medicago truncatula	47.95	2.00e-88	317.00
IUUC-Mla-059066	Melampsora laricipopulina	47.54	1.00e-109	387.00
IUUC-Mga-060102	Meleagris gallopavo	43.67	1.00e-93	334.00
IUUC-Mvi-060422	Microbotryum violaceum	46.97	4.00e-103	366.00
IUUC-Mmr-061615	Microcebus murinus	52.40	2.00e-89	321.00
IUUC-Mdo-061982	Monodelphis domestica	46.50	6.00e-76	278.00
IUUC-Mmu-063864	Mus musculus	51.74	1.00e-83	301.00
IUUC-Mpu-066502	Mustela putorius furo	51.12	5.00e-95	339.00
IUUC-Mlu-067277	Myotis lucifugus	45.57	3.00e-90	323.00
IUUC-Nfi-068375	Neosartorya fischeri	64.07	7.00e-134	468.00
IUUC-Ncr-068951	Neurospora crassa	62.29	6.00e-139	485.00
IUUC-Nle-070149	Nomascus leucogenys	52.08	3.00e-87	313.00
IUUC-Ont-071660	Oreochromis niloticus	45.03	4.00e-83	300.00
IUUC-Oan-073677	Ornithorhynchus anatinus	53.02	7.00e-89	319.00
IUUC-Ocu-073797	Oryctolagus cuniculus	52.40	2.00e-89	321.00
IUUC-Oba-075514	Oryza barthii	44.42	1.00e-83	301.00
IUUC-Obr-076018	Oryza brachyantha	44.20	7.00e-91	325.00
IUUC-Ogl-077254	Oryza glaberrima	44.03	5.00e-83	299.00
IUUC-Ogu-078562	Oryza glumaepatula	43.78	2.00e-82	297.00
IUUC-Oin-080094	Oryza indica	44.03	5.00e-83	299.00
IUUC-Olo-080449	Oryza longistaminata	43.41	1.00e-83	301.00
IUUC-Ome-081186	Oryza meridionalis	43.95	5.00e-90	324.00
IUUC-Oni-082243	Oryza nivara	44.03	5.00e-83	299.00
IUUC-Opu-084007	Oryza punctata	43.78	1.00e-82	298.00
IUUC-Oru-084357	Oryza rufipogon	44.03	1.00e-82	298.00
IUUC-Osa-086094	Oryza sativa	44.03	1.00e-82	298.00
IUUC-Ola-086907	Oryzias latipes	42.40	2.00e-83	301.00
IUUC-Oga-088184	Otolemur garnettii	52.40	4.00e-87	313.00
IUUC-Oar-090023	Ovis aries	44.42	3.00e-86	310.00
IUUC-Ptr-090935	Pan troglodytes	45.54	4.00e-89	319.00
IUUC-Pan-091845	Papio anubis	45.79	2.00e-89	320.00
IUUC-Psi-093188	Pelodiscus sinensis	43.46	1.00e-94	338.00
IUUC-Pma-094187	Petromyzon marinus	42.38	2.00e-85	307.00
IUUC-Pno-094809	Phaeosphaeria nodorum	62.40	1.00e-139	488.00
IUUC-Ppa-095687	Physcomitrella patens	44.20	2.00e-95	341.00
IUUC-Pfo-097429	Poecilia formosa	40.55	3.00e-75	273.00
IUUC-Pab-098603	Pongo abelii	45.79	3.00e-89	320.00
IUUC-Pop-098890	Populus trichocarpa	43.84	1.00e-90	324.00
IUUC-Pca-101062	Procavia capensis	44.91	2.00e-89	320.00
IUUC-Pva-102925	Pteropus vampyrus	44.72	5.00e-89	319.00
IUUC-Pgr-103627	Puccinia graminis	45.71	2.00e-98	351.00
IUUC-Pte-104142	Pyrenophora teres	62.12	2.00e-139	486.00
IUUC-Pyt-104693	Pyrenophora triticirepentis	62.12	2.00e-139	487.00
IUUC-Rno-106005	Rattus norvegicus	51.72	3.00e-84	303.00
IUUC-Sce-106360	Saccharomyces cerevisiae	43.84	2.00e-99	354.00
IUUC-Sha-107472	Sarcophilus harrisii	45.21	3.00e-87	313.00
IUUC-Sja-107919	Schizosaccharomyces japonicus	69.42	0.00e+00	688.00
IUUC-Ssl-108507	Sclerotinia sclerotiorum	64.07	2.00e-143	500.00
IUUC-Smo-108922	Selaginella moellendorffii	43.78	8.00e-92	328.00
IUUC-Sit-110732	Setaria italica	43.78	3.00e-91	327.00
IUUC-Sly-111202	Solanum lycopersicum	44.20	4.00e-90	323.00
IUUC-Stu-112024	Solanum tuberosum	44.10	1.00e-92	331.00
IUUC-Sar-113092	Sorex araneus	50.49	2.00e-78	284.00
IUUC-Sbi-114207	Sorghum bicolor	42.28	2.00e-91	327.00
IUUC-Sre-114976	Sporisorium reilianum	42.56	5.00e-86	309.00
IUUC-Ssc-115710	Sus scrofa	52.08	2.00e-88	317.00
IUUC-Tgu-117100	Taeniopygia guttata	42.18	1.00e-92	331.00
IUUC-Tru-118184	Takifugu rubripes	42.93	8.00e-82	295.00
IUUC-Tsy-118931	Tarsius syrichta	41.12	4.00e-62	230.00
IUUC-Tni-120326	Tetraodon nigroviridis	44.77	7.00e-86	308.00
IUUC-Tca-120949	Theobroma cacao	43.58	2.00e-90	323.00
IUUC-Tre-122211	Trichoderma reesei	62.18	9.00e-140	488.00
IUUC-Tvi-122531	Trichoderma virens	62.95	8.00e-141	491.00
IUUC-Tae-123765	Triticum aestivum	41.57	3.00e-92	330.00
IUUC-Tur-126193	Triticum urartu	42.48	3.00e-91	327.00
IUUC-Tme-126905	Tuber melanosporum	64.75	2.00e-143	500.00
IUUC-Tbe-127384	Tupaia belangeri	55.09	1.00e-85	308.00
IUUC-Ttr-128511	Tursiops truncatus	43.75	5.00e-88	316.00
IUUC-Uma-129318	Ustilago maydis	38.43	3.00e-85	307.00
IUUC-Vda-129993	Verticillium dahliae	63.79	3.00e-142	496.00
IUUC-Vpa-130775	Vicugna pacos	40.72	2.00e-60	224.00
IUUC-Vvi-131277	Vitis vinifera	44.53	3.00e-91	326.00
IUUC-Xtr-131993	Xenopus tropicalis	43.52	3.00e-93	333.00
IUUC-Xma-133332	Xiphophorus maculatus	43.52	1.00e-87	315.00
IUUC-Yli-134501	Yarrowia lipolytica	58.41	6.00e-136	475.00
IUUC-Zma-135135	Zea mays	42.33	9.00e-89	318.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence