iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Oga-088036

Ensembl Protein ID

ENSOGAP00000006265.2

UniProt Accession

H0WVD4; H0WVD4_OTOGA

Genbank Protein ID

ENSOGAP00000006265

Protein Name

Phosphoinositide phospholipase C

Genbank Nucleotide ID

AAQR03081229

Gene Name

PLCG2

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSOGAG00000006986.2	ENSOGAT00000007000.2	ENSOGAP00000006265.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/SH3	1.00e-10	41.4	422	478

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/SH3

   S: 4    ekvqvlydyeaqnddeLtlkkGdvvlviekeeqdegWlkgvkelegkrGlfPenFvekle 63
           ++v++lydy+a+++deL++ +G  ++ +   ++ +gW+kg    +  +  fP+n+ve ++
   Q: 422  RTVKALYDYKAKQSDELSFCRGALIHNV--SKEPGGWWKGD-YGTRIQQYFPSNYVEDIS 478
           789************************9..77889*****6.55556679******9985 PP

Organism

Otolemur garnettii

Protein Sequence
(Fasta)

MGCRCIELDC WDGPDGKPII YHGWTRTTKI KFDDVVQAIK DHAFVTSSFP VILSIEEHCS 60
VEQQRHMAKT FKEVFGDLLL MKPTEASADQ LPSPSQLREK ILIKHKKLGP RGDVDVNVDD 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GGGGGCGGCT GCGCTCGGGA CCCCGGAGCC CGGACCCGGG GCAGGAGGGC GGCTGCGCCC 60
CGGCGGCACG GCCACGGCCA GGTGAGCAAG TGACCAGGCC GGGCGGGAGC GCGCACGGGG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0442--Lipid degradation
KW-0443--Lipid metabolism
KW-1185--Reference proteome
KW-0728--SH3 domain
KW-0807--Transducer

Interpro

IPR000008--C2_dom
IPR001192--PI-PLC_fam
IPR028381--PLC-gamma2
IPR017946--PLC-like_Pdiesterase_TIM-brl
IPR000909--PLipase_C_PInositol-sp_X_dom
IPR001711--PLipase_C_Pinositol-sp_Y
IPR000980--SH2
IPR001452--SH3_domain

PROSITE

PS50004--C2
PS50007--PIPLC_X_DOMAIN
PS50008--PIPLC_Y_DOMAIN
PS50001--SH2
PS50002--SH3

Pfam

PF00168--C2
PF00388--PI-PLC-X
PF00387--PI-PLC-Y
PF00017--SH2
PF00018--SH3_1

PRINTS

PR00390--PHPHLIPASEC
PR00401--SH2DOMAIN
PR00452--SH3DOMAIN

SMART

SM00239--C2
SM00148--PLCXc
SM00149--PLCYc
SM00252--SH2
SM00326--SH3

Gene Ontology

GO:0005829--C:cytosol
GO:0070062--C:extracellular exosome
GO:0005886--C:plasma membrane
GO:0004435--F:phosphatidylinositol phospholipase C activity
GO:0004871--F:signal transducer activity
GO:0032237--P:activation of store-operated calcium channel activity
GO:0050853--P:B cell receptor signaling pathway
GO:0002316--P:follicular B cell differentiation
GO:0032959--P:inositol trisphosphate biosynthetic process
GO:0035556--P:intracellular signal transduction
GO:0016042--P:lipid catabolic process
GO:0043069--P:negative regulation of programmed cell death
GO:0006661--P:phosphatidylinositol biosynthetic process
GO:0002092--P:positive regulation of receptor internalization
GO:0032481--P:positive regulation of type I interferon production
GO:0010468--P:regulation of gene expression
GO:0051209--P:release of sequestered calcium ion into cytosol
GO:0032496--P:response to lipopolysaccharide
GO:0050852--P:T cell receptor signaling pathway

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Apl-003345	Anas platyrhynchos	81.57	0.00e+00	1431.00
IUUC-Aca-004266	Anolis carolinensis	78.28	0.00e+00	1502.00
IUUC-Bta-013196	Bos taurus	93.77	0.00e+00	1820.00
IUUC-Cpo-021890	Cavia porcellus	92.17	0.00e+00	1799.00
IUUC-Csa-024233	Chlorocebus sabaeus	96.07	0.00e+00	1844.00
IUUC-Dno-028871	Dasypus novemcinctus	93.99	0.00e+00	1825.00
IUUC-Eca-033458	Equus caballus	95.52	0.00e+00	1832.00
IUUC-Eeu-035329	Erinaceus europaeus	88.00	0.00e+00	1700.00
IUUC-Fal-037390	Ficedula albicollis	81.99	0.00e+00	1576.00
IUUC-Gga-040918	Gallus gallus	82.31	0.00e+00	1562.00
IUUC-Ggo-045625	Gorilla gorilla	94.32	0.00e+00	1828.00
IUUC-Hsa-046129	Homo sapiens	95.85	0.00e+00	1869.00
IUUC-Itr-048240	Ictidomys tridecemlineatus	94.36	0.00e+00	1044.00
IUUC-Mcc-054831	Macaca mulatta	96.04	0.00e+00	1782.00
IUUC-Mga-059368	Meleagris gallopavo	82.64	0.00e+00	1567.00
IUUC-Mmr-060898	Microcebus murinus	96.94	0.00e+00	1853.00
IUUC-Mmu-064334	Mus musculus	93.44	0.00e+00	1785.00
IUUC-Mlu-067230	Myotis lucifugus	94.64	0.00e+00	1843.00
IUUC-Nle-069318	Nomascus leucogenys	88.18	0.00e+00	1651.00
IUUC-Opr-070718	Ochotona princeps	93.98	0.00e+00	959.00
IUUC-Ocu-073814	Oryctolagus cuniculus	93.44	0.00e+00	1798.00
IUUC-Oar-089556	Ovis aries	93.15	0.00e+00	1812.00
IUUC-Ptr-091001	Pan troglodytes	95.85	0.00e+00	1867.00
IUUC-Pan-092744	Papio anubis	96.28	0.00e+00	1848.00
IUUC-Psi-093987	Pelodiscus sinensis	81.44	0.00e+00	1583.00
IUUC-Pab-098268	Pongo abelii	92.46	0.00e+00	1779.00
IUUC-Pva-102939	Pteropus vampyrus	91.15	0.00e+00	1749.00
IUUC-Sre-115229	Sporisorium reilianum	43.33	7.00e-10	60.50
IUUC-Ssc-115308	Sus scrofa	94.99	0.00e+00	1669.00
IUUC-Tgu-116811	Taeniopygia guttata	82.31	0.00e+00	1580.00
IUUC-Tsy-119139	Tarsius syrichta	95.90	1.00e-157	551.00
IUUC-Ttr-128392	Tursiops truncatus	90.27	0.00e+00	1704.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence