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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Cel-018434
UUCD1 version UUC-CaE-00679
Ensembl Protein ID C08B6.9
UniProt Accession Q17820; SAE1_CAEEL
Genbank Protein ID CAA96591.1
Protein Name SUMO-activating enzyme subunit aos-1
Genbank Nucleotide ID Z72502
Gene Name aos-1; C08B6.9
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
WBGene00000142 C08B6.9 C08B6.9
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO
DNA & RNA Element
microRNARAID2
Protein-protein Interaction
IIDiRefIndexPINAMentha
Protein Expression/Proteomics
GPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
E1 E1_ThiF 11806825
Classification
Family E-value Score Start End
E1 1.90e-68 231.9 11 163
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E1
   S: 1    YDRQirlwGeeaqeklksakvllvGagglGcEllKnLvlaGvgsitvvDmdtvevsnlnrqFLfraedv..gksKAevaaealkelnpdvnveaheesitel 100
           YDRQirlwG+eaq+k++++kvl++G ++lG+E++K+L laGv ++++vD++ v++++++++FL++a+    +++K+ +++++l +ln++v++ ++ee++  +
   Q: 11   YDRQIRLWGMEAQNKIRNSKVLIIGGKQLGAEVAKTLSLAGVDEMHLVDHRLVDTEEIGMNFLYDASVDnsKMTKWAASYNFLYNLNRNVKLFIVEEDVLSK 112
           ******************************************************************76666******************************* PP
   S: 101  eeeiv..FfkkfdvVvlaldnrearrkvnrlclnarvpliesgtlGllGqv 149
           ++++   +++kf++Vv++++++e   kvn++c+++++++i+++++G++G++
   Q: 113  NDSEIeeYLTKFTLVVVLDESYERTAKVNNICRKHHIRFISGAIYGWIGYA 163
           999889********************************************8 PP
   
Organism Caenorhabditis elegans
Functional Description
(View)

Functional Description


     The dimeric enzyme acts as an E1 ligase for smo-1. It mediates ATP-dependent activation of smo-1 and formation of a thioester with a conserved cysteine residue on uba-2 (Probable).
 The dimeric enzyme acts as an E1 ligase for smo-1. It mediates ATP-dependent activation of smo-1 and formation of a thioester with a conserved cysteine residue on uba-2 (Probable).
Protein Sequence
(Fasta)
MEVSKAEQAI YDRQIRLWGM EAQNKIRNSK VLIIGGKQLG AEVAKTLSLA GVDEMHLVDH 60
RLVDTEEIGM NFLYDASVDN SKMTKWAASY NFLYNLNRNV KLFIVEEDVL SKNDSEIEEY 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Cel-018434|E1,E1_ThiF|Caenorhabditis elegans
Please wait for a moment...
Nucleotide Sequence
(Fasta)
AATGTCCGAA GCAAAAGAAA ATATGGAGGT CAGCAAAGCT GAACAGGCGA TTTACGATCG 60
ACAAATTCGT TTATGGGGAA TGGAAGCTCA AAATAAGTAA GTTTAAATTT TTTCGAATAA 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Cel-018434|E1,E1_ThiF|Caenorhabditis elegans
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0181--Complete proteome
KW-0436--Ligase
KW-1185--Reference proteome
KW-0833--Ubl conjugation pathway
Interpro

IPR016040--NAD(P)-bd_dom
IPR000594--ThiF_NAD_FAD-bd
Pfam

PF00899--ThiF
Gene Ontology

GO:0031510--C:SUMO activating enzyme complex
GO:0008641--F:small protein activating enzyme activity
GO:0016925--P:protein sumoylation
KEGG cel:CELE_C08B6.9
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-000695 Aegilops tauschii 24.52 5.00e-21 93.60
IUUC-Aml-001477 Ailuropoda melanoleuca 29.88 7.00e-36 142.00
IUUC-Atr-002536 Amborella trichopoda 28.28 1.00e-25 108.00
IUUC-Apl-003982 Anas platyrhynchos 30.45 2.00e-21 94.40
IUUC-Aca-004868 Anolis carolinensis 32.21 5.00e-37 147.00
IUUC-Aly-005588 Arabidopsis lyrata 28.78 1.00e-24 105.00
IUUC-Ath-006677 Arabidopsis thaliana 28.49 2.00e-23 101.00
IUUC-Ago-007891 Ashbya gossypii 27.46 1.00e-25 108.00
IUUC-Acl-008197 Aspergillus clavatus 28.12 2.00e-32 131.00
IUUC-Afl-008520 Aspergillus flavus 28.37 3.00e-33 134.00
IUUC-Afu-009107 Aspergillus fumigatus 25.14 2.00e-23 102.00
IUUC-Ani-009143 Aspergillus nidulans 26.89 2.00e-27 115.00
IUUC-Ang-009804 Aspergillus niger 27.82 3.00e-31 127.00
IUUC-Aor-010190 Aspergillus oryzae 28.37 3.00e-33 134.00
IUUC-Ate-010519 Aspergillus terreus 22.43 8.00e-12 63.20
IUUC-Ame-011043 Astyanax mexicanus 31.83 3.00e-32 131.00
IUUC-Bgr-012084 Blumeria graminis 27.11 2.00e-29 121.00
IUUC-Bta-012723 Bos taurus 31.07 3.00e-38 150.00
IUUC-Bci-013809 Botrytis cinerea 27.76 4.00e-31 127.00
IUUC-Bdi-014800 Brachypodium distachyon 26.69 1.00e-23 102.00
IUUC-Bol-015744 Brassica oleracea 28.03 3.00e-21 94.40
IUUC-Bra-016683 Brassica rapa 27.62 7.00e-21 93.20
IUUC-Cja-019815 Callithrix jacchus 30.64 6.00e-39 153.00
IUUC-Cfa-020329 Canis familiaris 30.18 7.00e-36 143.00
IUUC-Cpo-022208 Cavia porcellus 29.97 1.00e-36 145.00
IUUC-Csa-023592 Chlorocebus sabaeus 31.29 2.00e-30 125.00
IUUC-Cin-025351 Ciona intestinalis 29.97 1.00e-35 142.00
IUUC-Cgl-026491 Colletotrichum gloeosporioides 26.80 8.00e-27 113.00
IUUC-Cne-026970 Cryptococcus neoformans 23.30 1.00e-15 75.90
IUUC-Dre-028263 Danio rerio 31.40 6.00e-33 133.00
IUUC-Dno-030055 Dasypus novemcinctus 28.49 5.00e-35 140.00
IUUC-Dor-030864 Dipodomys ordii 27.55 8.00e-31 125.00
IUUC-Dse-031565 Dothistroma septosporum 23.80 1.00e-23 103.00
IUUC-Dme-032011 Drosophila melanogaster 30.15 2.00e-25 108.00
IUUC-Ete-032982 Echinops telfairi 40.16 3.00e-19 87.80
IUUC-Eca-034164 Equus caballus 27.61 1.00e-28 119.00
IUUC-Fca-035564 Felis catus 30.18 1.00e-36 145.00
IUUC-Fox-037928 Fusarium oxysporum 25.70 3.00e-25 108.00
IUUC-Fso-038404 Fusarium solani 25.76 6.00e-25 107.00
IUUC-Gmo-038867 Gadus morhua 29.59 2.00e-30 124.00
IUUC-Ggr-040068 Gaeumannomyces graminis 26.96 2.00e-27 115.00
IUUC-Gga-041197 Gallus gallus 31.40 9.00e-26 109.00
IUUC-Gac-042609 Gasterosteus aculeatus 30.26 9.00e-31 126.00
IUUC-Gma-044135 Glycine max 29.23 3.00e-26 111.00
IUUC-Ggo-044600 Gorilla gorilla 30.77 4.00e-38 150.00
IUUC-Hsa-046731 Homo sapiens 30.77 4.00e-38 150.00
IUUC-Itr-049038 Ictidomys tridecemlineatus 30.18 5.00e-37 147.00
IUUC-Kpa-049371 Komagataella pastoris 25.66 2.00e-22 98.60
IUUC-Lch-050045 Latimeria chalumnae 33.03 9.00e-43 166.00
IUUC-Lpe-051620 Leersia perrieri 25.79 9.00e-24 102.00
IUUC-Loc-051749 Lepisosteus oculatus 29.60 2.00e-34 138.00
IUUC-Lma-053150 Leptosphaeria maculans 26.30 5.00e-28 117.00
IUUC-Laf-053875 Loxodonta africana 29.67 1.00e-37 149.00
IUUC-Mcc-055163 Macaca mulatta 28.79 2.00e-31 127.00
IUUC-Meu-056076 Macropus eugenii 59.32 4.00e-16 77.40
IUUC-Mor-057029 Magnaporthe oryzae 26.84 9.00e-29 119.00
IUUC-Mtr-058633 Medicago truncatula 28.32 3.00e-24 104.00
IUUC-Mvi-060367 Microbotryum violaceum 26.96 4.00e-28 117.00
IUUC-Mmr-061294 Microcebus murinus 26.80 2.00e-25 108.00
IUUC-Mdo-062827 Monodelphis domestica 30.90 2.00e-40 157.00
IUUC-Mmu-063568 Mus musculus 30.86 8.00e-37 146.00
IUUC-Mac-064495 Musa acuminata 25.57 5.00e-21 93.60
IUUC-Mpu-065826 Mustela putorius furo 29.88 2.00e-35 141.00
IUUC-Mlu-067751 Myotis lucifugus 27.90 1.00e-28 119.00
IUUC-Nfi-068597 Neosartorya fischeri 28.37 2.00e-33 135.00
IUUC-Ncr-068768 Neurospora crassa 26.29 2.00e-26 112.00
IUUC-Nle-069882 Nomascus leucogenys 38.65 1.00e-27 114.00
IUUC-Ont-072576 Oreochromis niloticus 30.81 1.00e-30 125.00
IUUC-Oan-073560 Ornithorhynchus anatinus 28.99 3.00e-27 114.00
IUUC-Ocu-074732 Oryctolagus cuniculus 27.86 8.00e-28 116.00
IUUC-Oba-075956 Oryza barthii 25.81 3.00e-25 107.00
IUUC-Obr-076004 Oryza brachyantha 25.81 1.00e-23 102.00
IUUC-Ogu-078335 Oryza glumaepatula 26.59 1.00e-24 105.00
IUUC-Oin-079177 Oryza indica 25.81 3.00e-24 104.00
IUUC-Ome-081880 Oryza meridionalis 25.81 3.00e-24 104.00
IUUC-Oni-082688 Oryza nivara 25.81 3.00e-24 104.00
IUUC-Opu-083231 Oryza punctata 25.86 2.00e-26 111.00
IUUC-Oru-084759 Oryza rufipogon 25.81 3.00e-24 104.00
IUUC-Osa-085601 Oryza sativa 24.93 2.00e-23 101.00
IUUC-Ola-086496 Oryzias latipes 31.12 3.00e-29 120.00
IUUC-Oga-089005 Otolemur garnettii 29.12 1.00e-32 132.00
IUUC-Oar-089611 Ovis aries 31.07 4.00e-38 150.00
IUUC-Ptr-091337 Pan troglodytes 30.77 4.00e-38 150.00
IUUC-Pan-092401 Papio anubis 31.56 4.00e-39 153.00
IUUC-Pma-094210 Petromyzon marinus 32.65 8.00e-42 162.00
IUUC-Pno-094975 Phaeosphaeria nodorum 26.15 8.00e-27 113.00
IUUC-Ppa-095925 Physcomitrella patens 26.74 2.00e-27 114.00
IUUC-Pfo-096890 Poecilia formosa 30.64 2.00e-29 122.00
IUUC-Pab-098173 Pongo abelii 30.77 5.00e-38 150.00
IUUC-Pop-099145 Populus trichocarpa 27.91 2.00e-26 111.00
IUUC-Pca-100899 Procavia capensis 64.00 1.00e-14 72.80
IUUC-Ppe-101274 Prunus persica 25.63 4.00e-17 80.50
IUUC-Pva-102625 Pteropus vampyrus 29.88 2.00e-36 145.00
IUUC-Pgr-103426 Puccinia graminis 28.32 4.00e-26 110.00
IUUC-Pte-104082 Pyrenophora teres 25.82 2.00e-27 115.00
IUUC-Pyt-104818 Pyrenophora triticirepentis 25.63 2.00e-27 115.00
IUUC-Rno-106129 Rattus norvegicus 30.09 6.00e-40 156.00
IUUC-Sha-107120 Sarcophilus harrisii 28.53 1.00e-28 119.00
IUUC-Sja-107996 Schizosaccharomyces japonicus 26.74 2.00e-24 104.00
IUUC-Spo-108321 Schizosaccharomyces pombe 25.69 4.00e-21 94.00
IUUC-Ssl-108608 Sclerotinia sclerotiorum 28.61 2.00e-32 131.00
IUUC-Smo-109539 Selaginella moellendorffii 24.15 3.00e-17 80.90
IUUC-Sit-110166 Setaria italica 25.85 3.00e-23 100.00
IUUC-Sly-111116 Solanum lycopersicum 27.98 1.00e-22 99.40
IUUC-Stu-112638 Solanum tuberosum 27.33 3.00e-23 100.00
IUUC-Sar-113506 Sorex araneus 24.78 1.00e-23 102.00
IUUC-Sbi-114548 Sorghum bicolor 25.36 8.00e-23 99.80
IUUC-Ssc-115891 Sus scrofa 30.47 2.00e-37 148.00
IUUC-Tru-118469 Takifugu rubripes 30.92 2.00e-33 135.00
IUUC-Tsy-119304 Tarsius syrichta 25.87 5.00e-22 97.10
IUUC-Tni-119803 Tetraodon nigroviridis 25.72 4.00e-27 114.00
IUUC-Tca-121747 Theobroma cacao 27.49 4.00e-23 100.00
IUUC-Tre-122060 Trichoderma reesei 28.03 8.00e-28 116.00
IUUC-Tvi-122324 Trichoderma virens 26.80 7.00e-29 119.00
IUUC-Tae-125474 Triticum aestivum 25.64 1.00e-25 108.00
IUUC-Tur-126224 Triticum urartu 26.09 6.00e-23 100.00
IUUC-Tme-126939 Tuber melanosporum 29.12 4.00e-33 134.00
IUUC-Tbe-127982 Tupaia belangeri 28.78 2.00e-34 138.00
IUUC-Ttr-128758 Tursiops truncatus 30.77 8.00e-38 149.00
IUUC-Vda-129664 Verticillium dahliae 26.74 8.00e-27 113.00
IUUC-Vpa-130778 Vicugna pacos 33.76 2.00e-28 118.00
IUUC-Vvi-131399 Vitis vinifera 26.45 7.00e-22 96.70
IUUC-Xtr-131919 Xenopus tropicalis 30.97 3.00e-39 154.00
IUUC-Xma-133482 Xiphophorus maculatus 30.64 7.00e-29 119.00
IUUC-Yli-134596 Yarrowia lipolytica 25.36 1.00e-23 102.00
IUUC-Zma-135688 Zea mays 25.36 3.00e-23 101.00
Created Date 25-Jun-2017

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