iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress
Protein-protein Interaction
HINT
Post-translational Modifications (PTMs)
dbPPT
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	7.30e-29	101.9	1235	1566

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/USP

   S: 1    tGlkNl..gNtCYmNSvLQcLsnipelrelllekkkeklneenpkepkgellkslqklfeelw....kskkkavsprellkalkkeaee...fsgy 87
           tGl+N      C++N ++Q+L+n+  +r  +l+  +++l++      + ++++sl  +f++l     +++k+ v+p++l  al+++ +    f++ 
   Q: 1235 TGLQNEvgEYNCFLNVIIQSLWNLGMFRAEFLR--SSTLEHH--HFGDPCVVCSLYAIFTALStassETRKEPVAPSSLRIALSNLYPDssfFQEA 1326
           57888733347**********************..5555444..3466799999999999997777799999********999999887556889* PP
   S: 88   eqqDaqEflaflldqleeelkkeknkpkeeeeeedkselsdeaeekkkkknkslisdlFqgqlksqikclecdnvssreepfldlslpvpgkeetk 183
           + +Da+E+la+++d l++++   ++++++++e+++    s++  + +    +++ + lF++ +++q+ c +c+ +s r+ + +++  +++ +  + 
   Q: 1327 QMNDASEVLAVIFDCLHRSF--AQSSSVSDTESAE----SNSTGSWDCANRSCIAHSLFGMDVSEQLNCYSCGLES-RHLKYTSFFHNINASALRT 1415
           ********************..3444444443333....33444557778889********************998.6667788888888655544 PP
   S: 184  ke......slqdcLesftkeeelegenkyycekckkkqeaekklklkklPevLilhLkRfsfseeqksrekinkkvefpleLdlspfctspeekqk 273
           ++      s++++L+    +++l ++   +   c k+      + l++ P+v+++ L + +  e   ++    +   ++ e+d+s +       ++
   Q: 1416 MKvtcaenSFDELLNLVEMNHQLACDR--EAGGCGKRN--HIHHILTTPPHVFTIVLGWQNTCE--TVEDIAATLAALNTEIDISIMYRG----VD 1501
           444555559999999999999998865..666676555..4567899*************5444..677788888888889***954444....34 PP
   S: 274  ekkkYeLiavvvHsGslssGHYvayvknekgk.WllfdDskVtev.keeevleetg...staYvlfYkr 337
            k++Y+L++vv+++G     HY++++++++++ W+ +dD++V+++ ++++vl++++    ++ vl+Y++
   Q: 1502 PKNTYSLVSVVCYYG----QHYHCFAYSHEHDqWIMYDDQNVKVIgSWSDVLSMCKrghLQPQVLLYEK 1566
           489************....9*******955545************779*****9988888899999987 PP

Organism

Arabidopsis thaliana

Protein Sequence
(Fasta)

MGQKKKAPAP LDSALIKLEC EKALKSFGRG SYNKAIRLIK DSCSRHQDSA LIHRVQGTIC 60
VKVAAVYEDL ATKQKYLRNA IESARKAVEL SPDSIEFGHF YANLLYEAAN DGKREYDEVV 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GCGGTTCAAT TCGCAAACCG AGTAGTTCGC TTCGTCTGGT AAAGTAAACC ATAAAATACC 60
GATGGTTCAA CTAGAAATAA TTACTAATCG AAGTAAACCG GTTTGTAATC GCTAATGTAA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0378--Hydrolase
KW-1185--Reference proteome

Interpro

IPR006866--DUF627_N
IPR006865--DUF629
IPR001394--Peptidase_C19_UCH
IPR011990--TPR-like_helical_dom
IPR028889--USP_dom
IPR013087--Znf_C2H2_type

PROSITE

PS50235--USP_3
PS00028--ZINC_FINGER_C2H2_1

Pfam

PF04781--DUF627
PF04780--DUF629
PF00443--UCH

Gene Ontology

GO:0046872--F:metal ion binding
GO:0036459--F:thiol-dependent ubiquitinyl hydrolase activity
GO:0016579--P:protein deubiquitination

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001414	Ailuropoda melanoleuca	33.14	3.00e-42	167.00
IUUC-Apl-003843	Anas platyrhynchos	33.04	5.00e-40	159.00
IUUC-Aca-004351	Anolis carolinensis	32.94	4.00e-41	163.00
IUUC-Aly-005859	Arabidopsis lyrata	92.81	0.00e+00	2775.00
IUUC-Ame-011525	Astyanax mexicanus	34.11	1.00e-42	168.00
IUUC-Bol-015670	Brassica oleracea	76.06	0.00e+00	725.00
IUUC-Bra-016731	Brassica rapa	76.11	0.00e+00	2302.00
IUUC-Cja-018724	Callithrix jacchus	33.24	2.00e-42	167.00
IUUC-Cfa-021222	Canis familiaris	33.14	4.00e-42	167.00
IUUC-Cpo-021795	Cavia porcellus	32.94	1.00e-42	168.00
IUUC-Cre-022697	Chlamydomonas reinhardtii	32.49	3.00e-43	171.00
IUUC-Csa-023262	Chlorocebus sabaeus	33.24	3.00e-42	167.00
IUUC-Cho-024422	Choloepus hoffmanni	31.96	9.00e-38	152.00
IUUC-Csv-026063	Ciona savignyi	28.66	1.00e-33	136.00
IUUC-Dre-028438	Danio rerio	32.77	3.00e-43	169.00
IUUC-Dno-029317	Dasypus novemcinctus	31.87	1.00e-39	158.00
IUUC-Dor-030249	Dipodomys ordii	32.75	2.00e-39	157.00
IUUC-Dme-032071	Drosophila melanogaster	32.01	3.00e-38	154.00
IUUC-Ete-032403	Echinops telfairi	32.27	7.00e-40	159.00
IUUC-Eeu-035319	Erinaceus europaeus	26.46	5.00e-18	86.30
IUUC-Fal-037089	Ficedula albicollis	32.36	3.00e-42	167.00
IUUC-Gmo-039688	Gadus morhua	31.14	2.00e-39	155.00
IUUC-Gac-042157	Gasterosteus aculeatus	34.21	9.00e-44	171.00
IUUC-Gma-043691	Glycine max	55.90	0.00e+00	1611.00
IUUC-Ggo-045626	Gorilla gorilla	33.24	3.00e-42	167.00
IUUC-Hsa-045767	Homo sapiens	33.24	2.00e-42	167.00
IUUC-Lch-049712	Latimeria chalumnae	34.11	2.00e-41	162.00
IUUC-Lpe-051572	Leersia perrieri	38.13	0.00e+00	879.00
IUUC-Laf-054578	Loxodonta africana	33.14	9.00e-42	166.00
IUUC-Meu-056802	Macropus eugenii	27.04	4.00e-28	119.00
IUUC-Mtr-058682	Medicago truncatula	54.00	0.00e+00	1486.00
IUUC-Mga-059684	Meleagris gallopavo	30.41	4.00e-34	139.00
IUUC-Mmu-063480	Mus musculus	33.53	2.00e-42	168.00
IUUC-Mac-064469	Musa acuminata	46.64	5.00e-165	575.00
IUUC-Nle-070110	Nomascus leucogenys	32.94	1.00e-42	168.00
IUUC-Opr-070676	Ochotona princeps	29.86	2.00e-19	92.00
IUUC-Ont-072449	Oreochromis niloticus	30.47	4.00e-41	162.00
IUUC-Oan-073551	Ornithorhynchus anatinus	32.27	2.00e-41	164.00
IUUC-Oba-075174	Oryza barthii	36.56	2.00e-141	497.00
IUUC-Ogl-077138	Oryza glaberrima	36.51	4.00e-142	499.00
IUUC-Ogu-078705	Oryza glumaepatula	36.33	3.00e-142	499.00
IUUC-Oin-079125	Oryza indica	36.22	4.00e-142	499.00
IUUC-Ome-081864	Oryza meridionalis	36.48	1.00e-141	498.00
IUUC-Oni-082109	Oryza nivara	36.00	5.00e-141	495.00
IUUC-Opu-083823	Oryza punctata	37.30	6.00e-143	501.00
IUUC-Oru-084310	Oryza rufipogon	36.69	2.00e-146	513.00
IUUC-Ola-086742	Oryzias latipes	32.68	2.00e-41	163.00
IUUC-Oga-088920	Otolemur garnettii	33.24	2.00e-42	167.00
IUUC-Oar-089644	Ovis aries	33.14	4.00e-42	167.00
IUUC-Ptr-091530	Pan troglodytes	32.94	1.00e-42	168.00
IUUC-Pan-092190	Papio anubis	33.24	2.00e-42	167.00
IUUC-Psi-094022	Pelodiscus sinensis	33.24	9.00e-42	166.00
IUUC-Ppa-095930	Physcomitrella patens	36.58	1.00e-148	521.00
IUUC-Pfo-096167	Poecilia formosa	32.27	8.00e-42	165.00
IUUC-Pop-099539	Populus trichocarpa	57.12	0.00e+00	1636.00
IUUC-Rno-105463	Rattus norvegicus	32.56	3.00e-41	164.00
IUUC-Sit-110021	Setaria italica	38.73	2.00e-151	529.00
IUUC-Sar-113376	Sorex araneus	33.71	5.00e-21	96.30
IUUC-Ssc-115969	Sus scrofa	31.29	1.00e-38	154.00
IUUC-Tgu-116521	Taeniopygia guttata	32.36	5.00e-43	169.00
IUUC-Tru-118240	Takifugu rubripes	30.39	3.00e-36	145.00
IUUC-Tsy-119297	Tarsius syrichta	29.08	6.00e-29	122.00
IUUC-Tni-120116	Tetraodon nigroviridis	30.95	1.00e-39	155.00
IUUC-Tca-121692	Theobroma cacao	60.76	0.00e+00	1793.00
IUUC-Tbe-127607	Tupaia belangeri	32.75	3.00e-40	160.00
IUUC-Ttr-128647	Tursiops truncatus	30.41	5.00e-36	145.00
IUUC-Xtr-131831	Xenopus tropicalis	33.82	1.00e-43	172.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence