iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO
DNA & RNA Element
TRANSFAC
Post-translational Modifications (PTMs)
dbPPT
Protein Expression/Proteomics

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/BCR/BTB_Other: BTB	1.00e-08	36.3	120	178

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/BCR/BTB_Other: BTB

   S: 10   eeffahkivLaasSsvFyalflmeleesksklmveik.d.vqpevfrallkFlYtgklde 67
           +e +   ++Laa S++Fy+lf++++ es+ ++ +++k d  + +++ +llkF+Y+++l+ 
   Q: 120  QELHISSAILAAKSPFFYKLFSNGMLESE-QKQMTLKiDaSEETAVMELLKFMYSNSLSV 178
           56677789******************998.77777777879**************99875 PP

Organism

Arabidopsis thaliana

Functional Description
(View)

May act as a substrate-specific adapter of an E3 ubiquitin-protein ligase complex (CUL3-RBX1-BTB) which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.

Protein Sequence
(Fasta)

MDLSLSGGDF RFAFNNVNFS DRLLRIEITQ SSGEGEVICS SIVDWARDRK RRREDVTNHT 60
NDATCHVESD LNKNSCEIVN ENSNNKTQVL VTAAEQEPKS GGEDENERLT NNNTSVLSVQ 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGATCTCT CACTCTCCGG TGGTGATTTT AGGTTTGCTT TCAACAACGT TAATTTTTCT 60
GATCGTCTTC TTCGGATCGA GATCACCCAA AGCAGCGGTG AGGGTGAGGT TATCTGTTCT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0833--Ubl conjugation pathway

Interpro

IPR011705--BACK
IPR000210--BTB/POZ_dom
IPR011333--SKP1/BTB/POZ

PROSITE

PS50097--BTB

Pfam

PF07707--BACK
PF00651--BTB

SMART

SM00875--BACK
SM00225--BTB

Gene Ontology

GO:0031463--C:Cul3-RING ubiquitin ligase complex
GO:0005634--C:nucleus
GO:0016567--P:protein ubiquitination
GO:0010114--P:response to red light

KEGG

ath:AT4G01160

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Apl-003748	Anas platyrhynchos	31.07	1.00e-14	73.90
IUUC-Aly-006525	Arabidopsis lyrata	84.34	0.00e+00	850.00
IUUC-Fal-037632	Ficedula albicollis	28.99	4.00e-13	68.90
IUUC-Gga-040525	Gallus gallus	30.58	1.00e-13	70.90
IUUC-Mga-059451	Meleagris gallopavo	30.58	1.00e-13	71.20

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence