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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Hsa-045665
UUCD1 version UUC-HoS-00064
Ensembl Protein ID ENSP00000473391.1
UniProt Accession P35226; Q16030; Q5T8Z3; Q96F37; BMI1_HUMAN
Genbank Protein ID AAA19873.1; BAG36046.1; CAI15958.1; EAW86148.1; EAW86150.1; EAW86151.1; EAW86154.1; AAH11652.1; AAB27059.1
Protein Name Polycomb complex protein BMI-1; Polycomb group RING finger protein 4; RING finger protein 51
Genbank Nucleotide ID L13689; AK313235; AL158211; CH471072; CH471072; CH471072; CH471072; BC011652; AH004292
Gene Name BMI1; PCGF4; RNF51
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000269897.5 ENST00000475460.6 ENSP00000473382.1
ENSG00000269897.5 ENST00000602390.5 ENSP00000473391.1
ENSG00000269897.5 ENST00000489125.2 ENSP00000473495.1
ENSG00000269897.5 ENST00000417470.1 ENSP00000398759.2
Annotation
Cancer Mutation
ICGC
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOTCGAICGCTHPA
HPM
DNA & RNA Element
circBaseCircNetmiRTarBaseTargetScan
SomamiRRAID2
Protein-protein Interaction
IIDiRefIndexPINAMentha
Protein 3D Structure
PDBMMDB
Drug and target
TTD
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
HPRD
Protein Expression/Proteomics
THPAGPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
E3 activity/RING/RING RING 19956605
ULD/UDP/UFD/RAWUL RAWUL 9009205; 9121482; 18588675; 22325352; 23523425
Classification
Family E-value Score Start End
E3 activity/RING/RING 1.30e-05 27.3 161 200
ULD/UDP/UFD/RAWUL 5.00e-30 105.5 274 369
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 activity/RING/RING
   S: 1    CaiCledfkdgplvlpCgHvfhadClqkwpglknssskefrCPlCr 46
           C +C   f d + +  C H f+++C+ ++        ++ +CP+C+
   Q: 161  CVLCGGYFIDATTIIECLHSFCKTCIVRY------LETSKYCPICD 200
           ********99999****************......**********5 PP
   

   ULD/UDP/UFD/RAWUL
   S: 1    islsLeplesnkakddsk..........lkkkylrcsarltVkhlkkflaeklklsssyevdllcedevLednetLeeikyifiwkkegpLv 82
           isls+e++++n+ +++ +          ++k+ylrc+a++tV+hl+kfl++k+++++++++d+++e+e+L+d++tL++i+yi++w+++gpL+
   Q: 274  ISLSIEFFDQNRLDRKVNkdkekskeevNDKRYLRCPAAMTVMHLRKFLRSKMDIPNTFQIDVMYEEEPLKDYYTLMDIAYIYTWRRNGPLP 365
           7899999999998887768888899999**************************************************************** PP
   S: 83   LqYr 86
           L+Yr
   Q: 366  LKYR 369
           ***9 PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. In the PRC1 complex, it is required to stimulate the E3 ubiquitin-protein ligase activity of RNF2/RING2.
 Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. In the PRC1 complex, it is required to stimulate the E3 ubiquitin-protein ligase activity of RNF2/RING2.
Protein Sequence
(Fasta)
MELSESVQKG FQMLADPRSF DSNAFTLLLR AAFQSLLDAQ ADEAVLDHPD LKHIDPVVLK 60
HCHAAAATYI LEAGKHRADK STLSTYLEDC KFDRERIELF CTEYQNNKNS LEILLGRTLI 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-045665|E3,RING;ULD,RAWUL|Homo sapiens
Please wait for a moment...
Nucleotide Sequence
(Fasta)
GTGCGTGTCG AAGGTCACGG CGCGCTCACA ATGGAGCTCT CGGAGTCTGT GCAGAAAGGC 60
TTCCAGATGC TGGCGGATCC CCGCTCCTTC GACTCCAACG CCTTCACGCT TCTCCTCCGG 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-045665|E3,RING;ULD,RAWUL|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0156--Chromatin regulator
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0479--Metal-binding
KW-0539--Nucleus
KW-0621--Polymorphism
KW-0656--Proto-oncogene
KW-1185--Reference proteome
KW-0678--Repressor
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0832--Ubl conjugation
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR032443--RAWUL
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS
PROSITE

PS00518--ZF_RING_1
PS50089--ZF_RING_2
Pfam

PF16207--RAWUL
SMART

SM00184--RING
Gene Ontology

GO:0005829--C:cytosol
GO:0016604--C:nuclear body
GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0031519--C:PcG protein complex
GO:0035102--C:PRC1 complex
GO:0000151--C:ubiquitin ligase complex
GO:1990841--F:promoter-specific chromatin binding
GO:0071535--F:RING-like zinc finger domain binding
GO:0008270--F:zinc ion binding
GO:0016569--P:covalent chromatin modification
GO:0030097--P:hemopoiesis
GO:0045814--P:negative regulation of gene expression, epigenetic
GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter
GO:0048146--P:positive regulation of fibroblast proliferation
GO:0051443--P:positive regulation of ubiquitin-protein transferase activity
GO:0010468--P:regulation of gene expression
GO:0007379--P:segment specification
GO:0006351--P:transcription, DNA-templated
KEGG hsa:100532731; hsa:648
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-000603 Aegilops tauschii 40.85 5.00e-12 65.90
IUUC-Aml-001498 Ailuropoda melanoleuca 98.77 2.00e-170 591.00
IUUC-Apl-004208 Anas platyrhynchos 95.14 7.00e-136 476.00
IUUC-Aca-004661 Anolis carolinensis 83.44 5.00e-140 490.00
IUUC-Ath-007649 Arabidopsis thaliana 42.50 3.00e-12 67.00
IUUC-Ame-010610 Astyanax mexicanus 72.21 1.00e-138 486.00
IUUC-Bta-012606 Bos taurus 99.08 2.00e-171 595.00
IUUC-Bol-015090 Brassica oleracea 36.63 9.00e-14 71.60
IUUC-Cja-019482 Callithrix jacchus 99.68 0.00e+00 629.00
IUUC-Cfa-020482 Canis familiaris 98.77 2.00e-170 591.00
IUUC-Cpo-022061 Cavia porcellus 99.68 0.00e+00 629.00
IUUC-Csa-024102 Chlorocebus sabaeus 95.19 0.00e+00 868.00
IUUC-Cho-025081 Choloepus hoffmanni 81.93 9.00e-113 399.00
IUUC-Cin-025612 Ciona intestinalis 49.07 3.00e-52 199.00
IUUC-Dre-027929 Danio rerio 79.75 2.00e-142 498.00
IUUC-Dno-029797 Dasypus novemcinctus 98.09 0.00e+00 648.00
IUUC-Dor-030256 Dipodomys ordii 96.50 4.00e-169 587.00
IUUC-Dme-031904 Drosophila melanogaster 45.02 1.00e-52 202.00
IUUC-Ete-033148 Echinops telfairi 64.71 3.00e-83 301.00
IUUC-Eca-033318 Equus caballus 99.39 6.00e-172 596.00
IUUC-Eeu-034547 Erinaceus europaeus 86.31 2.00e-150 525.00
IUUC-Fca-035866 Felis catus 99.39 2.00e-171 594.00
IUUC-Fal-036660 Ficedula albicollis 96.01 3.00e-161 560.00
IUUC-Gmo-039341 Gadus morhua 82.31 7.00e-126 443.00
IUUC-Gga-040611 Gallus gallus 95.54 2.00e-166 578.00
IUUC-Gac-041888 Gasterosteus aculeatus 72.49 4.00e-129 454.00
IUUC-Gma-042798 Glycine max 39.51 5.00e-12 65.50
IUUC-Ggo-045027 Gorilla gorilla 100.00 0.00e+00 630.00
IUUC-Itr-049045 Ictidomys tridecemlineatus 99.36 1.00e-179 621.00
IUUC-Lch-049714 Latimeria chalumnae 86.24 1.00e-164 572.00
IUUC-Loc-052161 Lepisosteus oculatus 81.35 5.00e-144 503.00
IUUC-Laf-054108 Loxodonta africana 97.80 2.00e-179 621.00
IUUC-Mcc-055562 Macaca mulatta 99.56 0.00e+00 923.00
IUUC-Meu-056709 Macropus eugenii 97.85 2.00e-174 604.00
IUUC-Mtr-058158 Medicago truncatula 43.42 4.00e-10 57.00
IUUC-Mga-060104 Meleagris gallopavo 92.77 2.00e-120 424.00
IUUC-Mmr-061191 Microcebus murinus 97.23 0.00e+00 903.00
IUUC-Mdo-062711 Monodelphis domestica 93.17 4.00e-154 537.00
IUUC-Mmu-064255 Mus musculus 95.22 3.00e-167 580.00
IUUC-Mpu-066466 Mustela putorius furo 98.47 1.00e-170 592.00
IUUC-Mlu-067622 Myotis lucifugus 99.36 0.00e+00 627.00
IUUC-Nle-069253 Nomascus leucogenys 93.00 0.00e+00 847.00
IUUC-Opr-070511 Ochotona princeps 99.04 5.00e-180 623.00
IUUC-Ont-072177 Oreochromis niloticus 84.23 6.00e-130 456.00
IUUC-Oan-073336 Ornithorhynchus anatinus 97.55 7.00e-172 596.00
IUUC-Ocu-074113 Oryctolagus cuniculus 99.36 4.00e-171 593.00
IUUC-Oba-075690 Oryza barthii 42.25 7.00e-12 65.10
IUUC-Ogl-077513 Oryza glaberrima 42.25 8.00e-12 65.10
IUUC-Ogu-078755 Oryza glumaepatula 42.25 9.00e-12 65.10
IUUC-Oni-082398 Oryza nivara 42.25 8.00e-12 65.50
IUUC-Oru-084965 Oryza rufipogon 42.25 8.00e-12 65.50
IUUC-Osa-086282 Oryza sativa 42.25 5.00e-12 65.90
IUUC-Ola-087057 Oryzias latipes 85.19 4.00e-124 437.00
IUUC-Oga-088346 Otolemur garnettii 100.00 0.00e+00 630.00
IUUC-Oar-089843 Ovis aries 99.08 2.00e-171 595.00
IUUC-Ptr-090486 Pan troglodytes 100.00 0.00e+00 630.00
IUUC-Pan-092667 Papio anubis 94.58 0.00e+00 790.00
IUUC-Psi-093469 Pelodiscus sinensis 95.40 1.00e-173 602.00
IUUC-Pma-094481 Petromyzon marinus 74.04 4.00e-90 323.00
IUUC-Pfo-097156 Poecilia formosa 80.41 2.00e-133 468.00
IUUC-Pab-097670 Pongo abelii 100.00 0.00e+00 630.00
IUUC-Pop-098807 Populus trichocarpa 37.08 1.00e-12 67.80
IUUC-Pva-102800 Pteropus vampyrus 100.00 0.00e+00 630.00
IUUC-Rno-105128 Rattus norvegicus 94.59 1.00e-170 592.00
IUUC-Sha-106747 Sarcophilus harrisii 97.85 2.00e-163 568.00
IUUC-Sar-113416 Sorex araneus 99.36 0.00e+00 627.00
IUUC-Ssc-115864 Sus scrofa 99.68 0.00e+00 630.00
IUUC-Tgu-116851 Taeniopygia guttata 95.14 1.00e-136 479.00
IUUC-Tru-117698 Takifugu rubripes 86.18 1.00e-124 439.00
IUUC-Tsy-119590 Tarsius syrichta 99.36 0.00e+00 627.00
IUUC-Tni-120170 Tetraodon nigroviridis 83.85 6.00e-129 453.00
IUUC-Tae-123760 Triticum aestivum 37.21 7.00e-12 65.50
IUUC-Tur-126396 Triticum urartu 40.85 6.00e-12 65.50
IUUC-Tbe-127790 Tupaia belangeri 99.68 0.00e+00 629.00
IUUC-Ttr-129316 Tursiops truncatus 99.39 0.00e+00 627.00
IUUC-Vpa-130669 Vicugna pacos 99.69 3.00e-172 597.00
IUUC-Xtr-131912 Xenopus tropicalis 87.77 5.00e-148 516.00
Created Date 25-Jun-2017

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