iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Ont-072488

Ensembl Protein ID

ENSONIP00000019097.1

UniProt Accession

I3KDA2; I3KDA2_ORENI

Genbank Protein ID

ENSONIP00000019097

Protein Name

Coatomer subunit alpha

Genbank Nucleotide ID

AERX01017817

Gene Name

copa

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSONIG00000015174.1	ENSONIT00000019114.1	ENSONIP00000019097.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	3.60e-35	118.9	133	163
UBD/Beta-Prp	3.10e-75	253.5	3	324

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 1    gHtdsvtclaf.sd.tllvsGsdDgtikvWD 29
           gH+  v c +f ++ +l+vsGs D t++vWD
   Q: 133  GHNHYVMCAQFhPSeDLVVSGSLDQTVRVWD 163
           8***********666**************** PP

UBD/Beta-Prp

   S: 4    tlkghhksvitcvkfspdksllatgsrdgtikvwdvttgkllrslsgheaevtavkfspdgkilvtgseDrtikvwdlstgkcvhtlkg 92
           t +++++++++ + f+p++++++++  +g i++wd+++ +l+ ++ +h+++v+ ++f+++++++v+g++D+ ikvw+++ + c+ tl g
   Q: 3    TKFETKSARVKGLSFHPKRPWVLASLHNGVIQLWDYRMCTLIDKFDEHDGPVRGIDFHKQQPLFVSGGDDYKIKVWNYKLRRCLFTLLG 91
           67889999********************************************************************************* PP
   S: 93   hedsvlslsfspsgdklvsGshdrtirvwdletgqcleetlsghdgvvncvvvhpdgnllvsGslDrtvrlWdl............... 166
           h d+++++ f+ +  +++s+s+d+tir+w++++++c+  +l+gh++ v+c+++hp+++l+vsGslD+tvr+Wd+               
   Q: 92   HLDYIRTTFFHHEYPWILSASDDQTIRIWNWQSRTCVC-VLTGHNHYVMCAQFHPSEDLVVSGSLDQTVRVWDIsglrkknlspgavet 179
           **************************************.************************************************** PP
   S: 167  ............ktgkllrtltgghtdsvyslsfdsngkelvsgsldgtvklwdlqtgec..vrtlnghtdnvksvrfspnderlvsgs 241
                       +++ ++++  +gh++ v++ +f+++++ +vsg++d++vk+w + +++   ++t++gh +nv++  f+p++e+++s s
   Q: 180  dvrgisgvdlfgASDAVVKHVLEGHDRGVNWAAFHPSMPLIVSGADDRQVKIWRMNESKAweLDTCRGHYNNVSCAIFHPRQELILSNS 268
           ************888888877777********************************8888789************************** PP
   S: 242  sDgsiriWdlrsgdllktlqlhnssvisvavlsfgdnvlvlgsedskvniwklkknep 299
           +D+sir+Wd+ +++ ++t+ + +++++   + +++ n +++g  ds   ++kl++++p
   Q: 269  EDKSIRVWDMSKRTGVQTFRRDHDRFWVLGA-HPNLNLFAAG-HDSGMIVFKLERERP 324
           ***************************9999.5544444433.589999999988765 PP

Organism

Oreochromis niloticus

Functional Description
(View)

The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network.

Protein Sequence
(Fasta)

MLTKFETKSA RVKGLSFHPK RPWVLASLHN GVIQLWDYRM CTLIDKFDEH DGPVRGIDFH 60
KQQPLFVSGG DDYKIKVWNY KLRRCLFTLL GHLDYIRTTF FHHEYPWILS ASDDQTIRIW 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATTTTTACCG CTTTTTTAAA GAAACGAACG ACTCTTTATC CGAGTACGTA TATTTATTTC 60
ATACGTCTAA GGAGTGCTTG GAAATATACA GATTAGATTT GTTATGACGG CATTTAGTCG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0931--ER-Golgi transport
KW-0333--Golgi apparatus
KW-0472--Membrane
KW-0653--Protein transport
KW-1185--Reference proteome
KW-0813--Transport
KW-0853--WD repeat

Interpro

IPR016391--Coatomer_asu
IPR010714--Coatomer_asu_C
IPR006692--Coatomer_WD-assoc_reg
IPR020472--G-protein_beta_WD-40_rep
IPR011990--TPR-like_helical_dom
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF04053--Coatomer_WDAD
PF06957--COPI_C
PF00400--WD40

PRINTS

PR00320--GPROTEINBRPT

SMART

SM00320--WD40

Gene Ontology

GO:0030126--C:COPI vesicle coat
GO:0000139--C:Golgi membrane
GO:0005198--F:structural molecule activity
GO:0006886--P:intracellular protein transport
GO:0030903--P:notochord development
GO:0061053--P:somite development
GO:0016192--P:vesicle-mediated transport

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000064	Aegilops tauschii	61.44	0.00e+00	1090.00
IUUC-Aml-001758	Ailuropoda melanoleuca	87.67	0.00e+00	2251.00
IUUC-Atr-002493	Amborella trichopoda	54.34	0.00e+00	1320.00
IUUC-Apl-003385	Anas platyrhynchos	85.97	0.00e+00	1904.00
IUUC-Aca-005154	Anolis carolinensis	93.24	2.00e-118	417.00
IUUC-Aly-006020	Arabidopsis lyrata	53.71	0.00e+00	1294.00
IUUC-Ath-007058	Arabidopsis thaliana	61.39	0.00e+00	1075.00
IUUC-Ago-007992	Ashbya gossypii	44.61	0.00e+00	1028.00
IUUC-Acl-008027	Aspergillus clavatus	56.44	0.00e+00	999.00
IUUC-Afl-008644	Aspergillus flavus	56.71	0.00e+00	993.00
IUUC-Afu-008964	Aspergillus fumigatus	56.89	0.00e+00	1004.00
IUUC-Ani-009379	Aspergillus nidulans	56.24	0.00e+00	1010.00
IUUC-Ang-009756	Aspergillus niger	57.04	0.00e+00	1010.00
IUUC-Aor-010174	Aspergillus oryzae	56.71	0.00e+00	994.00
IUUC-Ate-010302	Aspergillus terreus	48.02	0.00e+00	1193.00
IUUC-Ame-011229	Astyanax mexicanus	93.22	0.00e+00	2326.00
IUUC-Bgr-012300	Blumeria graminis	47.52	0.00e+00	1116.00
IUUC-Bta-012524	Bos taurus	88.40	0.00e+00	2240.00
IUUC-Bci-013781	Botrytis cinerea	48.22	0.00e+00	1182.00
IUUC-Bdi-014549	Brachypodium distachyon	53.68	0.00e+00	1329.00
IUUC-Bol-015925	Brassica oleracea	52.79	0.00e+00	1276.00
IUUC-Bra-016978	Brassica rapa	52.67	0.00e+00	1263.00
IUUC-Cel-018115	Caenorhabditis elegans	62.34	0.00e+00	1120.00
IUUC-Cja-019107	Callithrix jacchus	85.32	0.00e+00	2177.00
IUUC-Cfa-020675	Canis familiaris	87.55	0.00e+00	2216.00
IUUC-Cpo-021813	Cavia porcellus	88.32	0.00e+00	2257.00
IUUC-Cre-022969	Chlamydomonas reinhardtii	64.24	0.00e+00	1102.00
IUUC-Csa-023523	Chlorocebus sabaeus	88.32	0.00e+00	2262.00
IUUC-Cho-024704	Choloepus hoffmanni	75.63	0.00e+00	1733.00
IUUC-Cin-025572	Ciona intestinalis	72.32	0.00e+00	1867.00
IUUC-Csv-025864	Ciona savignyi	75.60	0.00e+00	1302.00
IUUC-Cgl-026510	Colletotrichum gloeosporioides	57.14	0.00e+00	1015.00
IUUC-Cne-027053	Cryptococcus neoformans	59.62	0.00e+00	1047.00
IUUC-Cme-027222	Cyanidioschyzon merolae	40.17	2.00e-144	507.00
IUUC-Dre-027421	Danio rerio	93.46	0.00e+00	2318.00
IUUC-Dno-029303	Dasypus novemcinctus	88.03	0.00e+00	2251.00
IUUC-Dor-030290	Dipodomys ordii	82.12	0.00e+00	934.00
IUUC-Dse-031543	Dothistroma septosporum	46.76	0.00e+00	1116.00
IUUC-Dme-031945	Drosophila melanogaster	75.48	0.00e+00	1288.00
IUUC-Ete-032873	Echinops telfairi	83.29	0.00e+00	1956.00
IUUC-Eca-033773	Equus caballus	86.35	0.00e+00	2193.00
IUUC-Eeu-034874	Erinaceus europaeus	74.83	0.00e+00	1336.00
IUUC-Fca-035739	Felis catus	90.43	0.00e+00	1648.00
IUUC-Fal-037263	Ficedula albicollis	81.71	0.00e+00	2021.00
IUUC-Fox-037738	Fusarium oxysporum	48.23	0.00e+00	1201.00
IUUC-Fso-038153	Fusarium solani	48.78	0.00e+00	1179.00
IUUC-Gmo-039602	Gadus morhua	89.07	0.00e+00	2196.00
IUUC-Ggr-039931	Gaeumannomyces graminis	56.77	0.00e+00	1011.00
IUUC-Gga-040590	Gallus gallus	87.66	0.00e+00	2259.00
IUUC-Gac-041318	Gasterosteus aculeatus	95.88	0.00e+00	2390.00
IUUC-Gma-043894	Glycine max	54.65	0.00e+00	1347.00
IUUC-Ggo-045029	Gorilla gorilla	87.67	0.00e+00	2255.00
IUUC-Hsa-046078	Homo sapiens	87.67	0.00e+00	2254.00
IUUC-Hvu-047556	Hordeum vulgare	54.37	0.00e+00	1350.00
IUUC-Itr-048881	Ictidomys tridecemlineatus	84.41	0.00e+00	1518.00
IUUC-Kpa-049256	Komagataella pastoris	45.06	0.00e+00	1083.00
IUUC-Lch-049706	Latimeria chalumnae	88.48	0.00e+00	2231.00
IUUC-Lpe-051316	Leersia perrieri	61.92	0.00e+00	1093.00
IUUC-Loc-051867	Lepisosteus oculatus	70.95	0.00e+00	1228.00
IUUC-Lma-053138	Leptosphaeria maculans	55.67	0.00e+00	1011.00
IUUC-Laf-053510	Loxodonta africana	89.03	0.00e+00	2298.00
IUUC-Mcc-055836	Macaca mulatta	87.00	0.00e+00	2252.00
IUUC-Meu-056238	Macropus eugenii	82.49	0.00e+00	1133.00
IUUC-Mor-057172	Magnaporthe oryzae	48.38	0.00e+00	1179.00
IUUC-Mpo-057300	Magnaporthe poae	48.47	0.00e+00	1165.00
IUUC-Mtr-058248	Medicago truncatula	54.87	0.00e+00	1358.00
IUUC-Mla-059019	Melampsora laricipopulina	51.94	0.00e+00	1270.00
IUUC-Mga-059499	Meleagris gallopavo	87.52	0.00e+00	2253.00
IUUC-Mvi-060336	Microbotryum violaceum	52.67	0.00e+00	1263.00
IUUC-Mmr-061102	Microcebus murinus	87.83	0.00e+00	2222.00
IUUC-Mdo-062594	Monodelphis domestica	88.40	0.00e+00	2287.00
IUUC-Mmu-063736	Mus musculus	87.59	0.00e+00	2243.00
IUUC-Mac-065398	Musa acuminata	51.46	0.00e+00	1226.00
IUUC-Mpu-066701	Mustela putorius furo	88.11	0.00e+00	2251.00
IUUC-Mlu-067392	Myotis lucifugus	87.10	0.00e+00	2254.00
IUUC-Nfi-068270	Neosartorya fischeri	57.09	0.00e+00	1002.00
IUUC-Ncr-068892	Neurospora crassa	48.63	0.00e+00	1172.00
IUUC-Nle-069634	Nomascus leucogenys	93.64	0.00e+00	1324.00
IUUC-Opr-070952	Ochotona princeps	75.63	0.00e+00	1595.00
IUUC-Oan-073184	Ornithorhynchus anatinus	43.89	1.00e-67	249.00
IUUC-Ocu-074211	Oryctolagus cuniculus	88.48	0.00e+00	2261.00
IUUC-Oba-075761	Oryza barthii	61.68	0.00e+00	1090.00
IUUC-Obr-076429	Oryza brachyantha	61.68	0.00e+00	1088.00
IUUC-Ogl-077364	Oryza glaberrima	61.68	0.00e+00	1092.00
IUUC-Ogu-078257	Oryza glumaepatula	61.68	0.00e+00	1089.00
IUUC-Oin-080029	Oryza indica	61.92	0.00e+00	1089.00
IUUC-Olo-080466	Oryza longistaminata	61.94	0.00e+00	1080.00
IUUC-Ome-081993	Oryza meridionalis	63.99	0.00e+00	1019.00
IUUC-Oni-082874	Oryza nivara	61.68	0.00e+00	1091.00
IUUC-Opu-083370	Oryza punctata	54.17	0.00e+00	1315.00
IUUC-Oru-084274	Oryza rufipogon	61.68	0.00e+00	1091.00
IUUC-Osa-085565	Oryza sativa	61.68	0.00e+00	1091.00
IUUC-Ola-086921	Oryzias latipes	94.32	0.00e+00	2329.00
IUUC-Olu-087639	Ostreococcus lucimarinus	54.49	0.00e+00	1333.00
IUUC-Oga-087991	Otolemur garnettii	83.31	0.00e+00	2120.00
IUUC-Oar-089590	Ovis aries	88.32	0.00e+00	2259.00
IUUC-Ptr-090808	Pan troglodytes	87.75	0.00e+00	2256.00
IUUC-Pan-092475	Papio anubis	87.92	0.00e+00	2248.00
IUUC-Psi-093044	Pelodiscus sinensis	74.38	0.00e+00	1593.00
IUUC-Pno-094839	Phaeosphaeria nodorum	54.48	0.00e+00	947.00
IUUC-Ppa-095254	Physcomitrella patens	55.56	0.00e+00	1388.00
IUUC-Pfo-097493	Poecilia formosa	96.97	0.00e+00	2352.00
IUUC-Pab-098497	Pongo abelii	88.40	0.00e+00	2263.00
IUUC-Pop-099992	Populus trichocarpa	55.46	0.00e+00	1330.00
IUUC-Pca-100413	Procavia capensis	83.48	0.00e+00	966.00
IUUC-Ppe-101899	Prunus persica	54.53	0.00e+00	1325.00
IUUC-Pva-102126	Pteropus vampyrus	84.51	0.00e+00	2152.00
IUUC-Pgr-103376	Puccinia graminis	52.22	0.00e+00	1278.00
IUUC-Ptt-103978	Puccinia triticina	46.73	0.00e+00	1065.00
IUUC-Pte-104126	Pyrenophora teres	54.77	0.00e+00	966.00
IUUC-Pyt-104778	Pyrenophora triticirepentis	45.23	7.00e-176	611.00
IUUC-Rno-105428	Rattus norvegicus	88.48	0.00e+00	2256.00
IUUC-Sce-106464	Saccharomyces cerevisiae	43.27	0.00e+00	993.00
IUUC-Sha-107301	Sarcophilus harrisii	88.36	0.00e+00	2240.00
IUUC-Sja-107961	Schizosaccharomyces japonicus	45.62	0.00e+00	1082.00
IUUC-Spo-108217	Schizosaccharomyces pombe	46.45	0.00e+00	1110.00
IUUC-Ssl-108643	Sclerotinia sclerotiorum	48.46	0.00e+00	1187.00
IUUC-Smo-109582	Selaginella moellendorffii	64.09	0.00e+00	1149.00
IUUC-Sit-109697	Setaria italica	61.56	0.00e+00	1088.00
IUUC-Sly-111447	Solanum lycopersicum	54.99	0.00e+00	1368.00
IUUC-Stu-112564	Solanum tuberosum	54.74	0.00e+00	1360.00
IUUC-Sar-113313	Sorex araneus	77.35	0.00e+00	1297.00
IUUC-Sbi-114388	Sorghum bicolor	53.88	0.00e+00	1329.00
IUUC-Sre-115209	Sporisorium reilianum	57.88	0.00e+00	1042.00
IUUC-Ssc-115933	Sus scrofa	88.32	0.00e+00	2257.00
IUUC-Tgu-117109	Taeniopygia guttata	75.00	0.00e+00	707.00
IUUC-Tru-117772	Takifugu rubripes	94.58	0.00e+00	2311.00
IUUC-Tsy-119105	Tarsius syrichta	75.91	0.00e+00	1933.00
IUUC-Tni-120556	Tetraodon nigroviridis	79.18	0.00e+00	1655.00
IUUC-Tca-121046	Theobroma cacao	53.96	0.00e+00	1345.00
IUUC-Tre-121951	Trichoderma reesei	48.59	0.00e+00	1172.00
IUUC-Tvi-122359	Trichoderma virens	57.47	0.00e+00	1018.00
IUUC-Tae-123688	Triticum aestivum	54.45	0.00e+00	1349.00
IUUC-Tur-126754	Triticum urartu	61.20	0.00e+00	1088.00
IUUC-Tme-127170	Tuber melanosporum	49.80	0.00e+00	1210.00
IUUC-Tbe-127882	Tupaia belangeri	67.96	0.00e+00	768.00
IUUC-Ttr-128217	Tursiops truncatus	85.40	0.00e+00	2177.00
IUUC-Uma-129337	Ustilago maydis	58.12	0.00e+00	1043.00
IUUC-Vda-129828	Verticillium dahliae	47.94	0.00e+00	1164.00
IUUC-Vpa-130537	Vicugna pacos	87.19	0.00e+00	2206.00
IUUC-Vvi-130958	Vitis vinifera	62.99	0.00e+00	1104.00
IUUC-Xtr-132857	Xenopus tropicalis	83.91	0.00e+00	2115.00
IUUC-Xma-133138	Xiphophorus maculatus	96.81	0.00e+00	2350.00
IUUC-Yli-134399	Yarrowia lipolytica	51.39	0.00e+00	866.00
IUUC-Zma-135612	Zea mays	53.70	0.00e+00	1323.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence