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Basic Information Integrated Annotations
Tag Content
UUCD2 ID IUUC-Ath-006681
UUCD1 version UUC-ArT-00098
Ensembl Protein ID AT5G05970.2
UniProt Accession B3H5K9; B6EUA6; Q9FI89; NEDD1_ARATH
Genbank Protein ID BAB10802.1; AED90947.1; AED90948.1; AT5G05970.2
Protein Name Protein NEDD1; Neural precursor cell expressed developmentally down-regulated protein 1 homolog; Protein GCP-WD
Genbank Nucleotide ID AB017060; CP002688; CP002688; AY093770
Gene Name NEDD1; GCP-WD; At5g05970; K18J17.16
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
AT5G05970 AT5G05970.2 AT5G05970.2
AT5G05970 AT5G05970.1 AT5G05970.1
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO
Protein Expression/Proteomics
GPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
E3 adaptor/Cullin RING/DCX/DWD 1.60e-21 76.4 186 208
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 adaptor/Cullin RING/DCX/DWD
   S: 11   f..sd.tllvsGsdDgtikvWDl 30
           +  s+ +llv+++dDgt+++WD+
   Q: 186  YsrSSrHLLVTAGDDGTVHLWDT 208
           465556889*************6 PP
   
Organism Arabidopsis thaliana
Functional Description
(View)

Functional Description


     Regulates microtubules organization in a centrosome-independent manner. Required for the spindle to be positioned correctly and for the function of gamma-tubulin in organizing phragmoplast microtubules (PubMed:19383896). Component of active gamma-tubulin ring complexes (gamma-TuRCs) associated with cortical microtubules in interphase cells (PubMed:25438942). Mediates gamma-TuRC recruitment to the nucleation sites and is important for determining the ratio of branched to parallel nucleation (PubMed:25438942). May mediate the localization of GCP2 and GCP3 to the nuclear envelope (PubMed:19383896).
 Regulates microtubules organization in a centrosome-independent manner. Required for the spindle to be positioned correctly and for the function of gamma-tubulin in organizing phragmoplast microtubules (PubMed:19383896). Component of active gamma-tubulin ring complexes (gamma-TuRCs) associated with cortical microtubules in interphase cells (PubMed:25438942). Mediates gamma-TuRC recruitment to the nucleation sites and is important for determining the ratio of branched to parallel nucleation (PubMed:25438942). May mediate the localization of GCP2 and GCP3 to the nuclear envelope (PubMed:19383896).
Protein Sequence
(Fasta)
MMSNLVEPSW RLLAASGGDT VKLFDVSADS GDPCVLSYTP SPGCAVNSVK WNHTNLVVAS 60
TGEDKKISLW RKNGQSLGTV PVTGKDGGDS AEECLSAISF SKKGSRYICS GGTGQIVKIW 120
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Protein Fasta Sequence


>IUUC-Ath-006681|E3,WD_repeat|Arabidopsis thaliana
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Nucleotide Sequence
(Fasta)
CTGTCATTTC GAATCTGTCT CTAATCTCAT AGGGTTCAAA ATTTGGTTTC TGCTGTTCTC 60
TCGAGAAAAA AGTACAGTTC CCGCATTGTT CAGATTCTCT AAGATTCATT CATCAATCTG 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Ath-006681|E3,WD_repeat|Arabidopsis thaliana
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Sequence Source Ensembl
Keyword

KW-0025--Alternative splicing
KW-0137--Centromere
KW-0158--Chromosome
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0206--Cytoskeleton
KW-0995--Kinetochore
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0677--Repeat
KW-0853--WD repeat
Interpro

IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom
PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION
Pfam

PF00400--WD40
SMART

SM00320--WD40
Gene Ontology

GO:0000777--C:condensed chromosome kinetochore
GO:0005828--C:kinetochore microtubule
GO:0005635--C:nuclear envelope
GO:0009524--C:phragmoplast
GO:0000919--P:cell plate assembly
GO:0009553--P:embryo sac development
GO:0009555--P:pollen development
GO:0032467--P:positive regulation of cytokinesis
GO:0060236--P:regulation of mitotic spindle organization
GO:2000694--P:regulation of phragmoplast microtubule organization
KEGG ath:AT5G05970
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-000871 Aegilops tauschii 63.98 8.00e-89 321.00
IUUC-Aml-002397 Ailuropoda melanoleuca 28.45 4.00e-41 162.00
IUUC-Atr-002464 Amborella trichopoda 59.55 2.00e-173 602.00
IUUC-Apl-003870 Anas platyrhynchos 31.94 1.00e-37 150.00
IUUC-Aca-004925 Anolis carolinensis 33.11 9.00e-41 160.00
IUUC-Aly-005931 Arabidopsis lyrata 95.77 0.00e+00 1461.00
IUUC-Ame-010906 Astyanax mexicanus 29.77 2.00e-28 120.00
IUUC-Bta-013389 Bos taurus 31.83 3.00e-41 162.00
IUUC-Bdi-014340 Brachypodium distachyon 60.49 1.00e-168 585.00
IUUC-Bol-016282 Brassica oleracea 72.08 0.00e+00 1049.00
IUUC-Bra-017178 Brassica rapa 74.17 0.00e+00 1080.00
IUUC-Cja-019541 Callithrix jacchus 28.73 4.00e-39 155.00
IUUC-Cfa-021218 Canis familiaris 29.12 9.00e-41 161.00
IUUC-Cpo-021697 Cavia porcellus 29.00 4.00e-40 159.00
IUUC-Csa-023620 Chlorocebus sabaeus 28.89 1.00e-40 160.00
IUUC-Cho-025105 Choloepus hoffmanni 27.59 1.00e-30 127.00
IUUC-Cin-025293 Ciona intestinalis 27.84 3.00e-26 113.00
IUUC-Csv-026234 Ciona savignyi 30.48 2.00e-25 108.00
IUUC-Dre-028251 Danio rerio 33.84 3.00e-31 129.00
IUUC-Dno-029281 Dasypus novemcinctus 32.18 2.00e-38 152.00
IUUC-Ete-033113 Echinops telfairi 33.05 2.00e-37 149.00
IUUC-Eca-034230 Equus caballus 33.02 2.00e-39 156.00
IUUC-Eeu-034671 Erinaceus europaeus 29.86 6.00e-38 151.00
IUUC-Fca-035775 Felis catus 31.25 3.00e-39 156.00
IUUC-Fal-037557 Ficedula albicollis 29.59 3.00e-32 132.00
IUUC-Gmo-038586 Gadus morhua 30.97 2.00e-28 119.00
IUUC-Gga-040153 Gallus gallus 31.38 3.00e-36 146.00
IUUC-Gac-041385 Gasterosteus aculeatus 33.55 1.00e-33 137.00
IUUC-Gma-042844 Glycine max 60.40 0.00e+00 885.00
IUUC-Ggo-044576 Gorilla gorilla 28.47 5.00e-40 158.00
IUUC-Hsa-046198 Homo sapiens 28.70 1.00e-40 160.00
IUUC-Hvu-047794 Hordeum vulgare 72.67 4.00e-70 256.00
IUUC-Lch-050561 Latimeria chalumnae 26.48 5.00e-17 82.40
IUUC-Lpe-051469 Leersia perrieri 59.03 3.00e-173 601.00
IUUC-Loc-052816 Lepisosteus oculatus 32.41 2.00e-27 117.00
IUUC-Laf-053880 Loxodonta africana 31.53 4.00e-37 149.00
IUUC-Mcc-054977 Macaca mulatta 28.70 7.00e-41 161.00
IUUC-Meu-056141 Macropus eugenii 34.91 2.00e-36 146.00
IUUC-Mtr-058441 Medicago truncatula 57.28 0.00e+00 850.00
IUUC-Mga-060141 Meleagris gallopavo 32.46 2.00e-34 140.00
IUUC-Mmr-061201 Microcebus murinus 31.95 1.00e-39 157.00
IUUC-Mdo-061855 Monodelphis domestica 31.58 4.00e-36 145.00
IUUC-Mmu-064342 Mus musculus 31.43 7.00e-38 151.00
IUUC-Mac-065368 Musa acuminata 60.54 1.00e-167 582.00
IUUC-Mpu-066191 Mustela putorius furo 28.31 7.00e-40 158.00
IUUC-Mlu-067310 Myotis lucifugus 32.17 1.00e-39 157.00
IUUC-Nle-069990 Nomascus leucogenys 28.47 4.00e-40 159.00
IUUC-Opr-070336 Ochotona princeps 33.80 8.00e-37 147.00
IUUC-Ont-071675 Oreochromis niloticus 28.57 9.00e-35 141.00
IUUC-Oan-072772 Ornithorhynchus anatinus 34.12 9.00e-38 150.00
IUUC-Ocu-074095 Oryctolagus cuniculus 31.95 6.00e-39 155.00
IUUC-Oba-075327 Oryza barthii 49.43 0.00e+00 660.00
IUUC-Obr-076119 Oryza brachyantha 48.59 0.00e+00 675.00
IUUC-Ogl-077820 Oryza glaberrima 49.39 0.00e+00 675.00
IUUC-Ogu-078679 Oryza glumaepatula 49.43 0.00e+00 659.00
IUUC-Oin-079891 Oryza indica 49.43 0.00e+00 661.00
IUUC-Olo-080414 Oryza longistaminata 48.17 4.00e-173 600.00
IUUC-Ome-081888 Oryza meridionalis 47.67 0.00e+00 639.00
IUUC-Oni-082417 Oryza nivara 49.26 0.00e+00 674.00
IUUC-Opu-083393 Oryza punctata 48.28 0.00e+00 686.00
IUUC-Oru-084698 Oryza rufipogon 49.50 0.00e+00 662.00
IUUC-Osa-086121 Oryza sativa 49.26 0.00e+00 674.00
IUUC-Ola-086806 Oryzias latipes 32.92 9.00e-35 141.00
IUUC-Olu-087591 Ostreococcus lucimarinus 30.60 4.00e-22 98.60
IUUC-Oga-088622 Otolemur garnettii 32.70 3.00e-40 159.00
IUUC-Oar-090391 Ovis aries 31.55 2.00e-40 160.00
IUUC-Ptr-091036 Pan troglodytes 28.47 6.00e-40 158.00
IUUC-Pan-092576 Papio anubis 28.70 2.00e-40 160.00
IUUC-Psi-093450 Pelodiscus sinensis 31.80 6.00e-40 158.00
IUUC-Pma-094101 Petromyzon marinus 32.39 1.00e-31 129.00
IUUC-Ppa-095804 Physcomitrella patens 41.67 9.00e-167 580.00
IUUC-Pfo-097142 Poecilia formosa 28.92 3.00e-35 142.00
IUUC-Pab-097829 Pongo abelii 28.74 7.00e-41 161.00
IUUC-Pop-099687 Populus trichocarpa 60.75 0.00e+00 860.00
IUUC-Pca-100217 Procavia capensis 28.53 5.00e-32 132.00
IUUC-Ppe-101502 Prunus persica 59.75 0.00e+00 861.00
IUUC-Pva-102736 Pteropus vampyrus 29.73 2.00e-40 159.00
IUUC-Rno-104977 Rattus norvegicus 32.06 2.00e-38 153.00
IUUC-Sha-107003 Sarcophilus harrisii 35.19 9.00e-39 154.00
IUUC-Smo-109002 Selaginella moellendorffii 50.58 8.00e-140 490.00
IUUC-Sit-109796 Setaria italica 58.10 5.00e-173 600.00
IUUC-Sly-110941 Solanum lycopersicum 57.03 0.00e+00 788.00
IUUC-Stu-112314 Solanum tuberosum 57.54 0.00e+00 790.00
IUUC-Sar-112926 Sorex araneus 26.38 4.00e-31 129.00
IUUC-Sbi-113822 Sorghum bicolor 45.93 2.00e-134 472.00
IUUC-Ssc-116242 Sus scrofa 32.58 4.00e-38 151.00
IUUC-Tgu-116765 Taeniopygia guttata 29.41 1.00e-33 137.00
IUUC-Tru-117738 Takifugu rubripes 31.52 1.00e-34 140.00
IUUC-Tsy-118856 Tarsius syrichta 29.19 1.00e-37 150.00
IUUC-Tni-120871 Tetraodon nigroviridis 31.96 3.00e-37 149.00
IUUC-Tca-120965 Theobroma cacao 66.30 0.00e+00 683.00
IUUC-Tae-123957 Triticum aestivum 59.87 8.00e-168 583.00
IUUC-Tur-126840 Triticum urartu 65.09 7.00e-166 577.00
IUUC-Ttr-128551 Tursiops truncatus 28.31 9.00e-33 134.00
IUUC-Vpa-130324 Vicugna pacos 32.80 6.00e-41 161.00
IUUC-Vvi-131699 Vitis vinifera 60.75 0.00e+00 866.00
IUUC-Xtr-131956 Xenopus tropicalis 30.84 5.00e-39 155.00
IUUC-Xma-132982 Xiphophorus maculatus 29.89 9.00e-35 141.00
Created Date 25-Jun-2017

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