iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Bta-012664

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

DAAA02026758

Gene Name

TNFAIP3

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSBTAG00000000436.1	ENSBTAT00000000557.1	ENSBTAP00000000557.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/OTU	1.40e-39	135.8	93	263
UBD/ZnF/ZnF_A20	3.10e-24	84.7	747	780

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/OTU

   S: 2    lilktkgDGnCLlrAvsqsllgvfddds.lsdalveaLreltseyl....qkesdffsefieek........edekefcqklvepe... 74
           ++lkt+gDGnCL++A+sq+++gv+d+d+ l++al+++L+e+ ++++    q es + +ef+e++         de++ + k+++ +   
   Q: 93   VALKTNGDGNCLMHAASQYMWGVQDTDLvLRKALFSTLKETDTRNFkfrwQLESLKSQEFVETGlcydtrnwTDEWDSLVKMASADtpa 181
           789**********************************************9*******************99999999999999998775 PP
   S: 75   akg.......eeihifaLaqiLsrpiivvdvdsles..........kvggillpllfpeek.lkkpivLlYrsgHYdaLval 138
           a+g       eeihif+L++iL+rpiiv+++++l+s          kvggi+lpl++p+++ +++pivL+Y+s H+ +Lv++
   Q: 182  ARGglqyqslEEIHIFVLCNILRRPIIVISDKMLRSlesgsnfaplKVGGIYLPLHWPAQEcYRYPIVLGYDSQHFVPLVTM 263
           5557***************************************************************************986 PP

UBD/ZnF/ZnF_A20

   S: 2    pskllCkk.gCgfYGnpetngyCSkCyreelrrr 34
           p+ ++C++ +C+++Gn+++ngyC++C++++++++
   Q: 747  PPTQRCRApACDHFGNAKCNGYCNECFQFKQMYG 780
           99******************************96 PP

Organism

Bos taurus

Protein Sequence
(Fasta)

MAEQLLPLAL YLSNMRKAVK IRERTPADIF KPANGIIHHF KSMHRYTLEM FRTCQFCPQF 60
REIIHNALID RNIQASLESQ KKLNWCREVR RLVALKTNGD GNCLMHAASQ YMWGVQDTDL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGCTGAGC AACTCCTTCC TCTGGCCTTG TATTTGAGCA ATATGCGGAA AGCTGTGAAG 60
ATACGAGAGA GAACGCCAGC AGATATTTTT AAACCTGCCA ATGGAATCAT TCACCATTTT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome

Interpro

IPR033478--A20
IPR003323--OTU_dom
IPR002653--Znf_A20

PROSITE

PS50802--OTU
PS51036--ZF_A20

Pfam

PF02338--OTU
PF01754--zf-A20

SMART

SM00259--ZnF_A20

Gene Ontology

GO:0005737--C:cytoplasm
GO:0070062--C:extracellular exosome
GO:0005634--C:nucleus
GO:0003677--F:DNA binding
GO:0070530--F:K63-linked polyubiquitin binding
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0001922--P:B-1 B cell homeostasis
GO:0070301--P:cellular response to hydrogen peroxide
GO:0072666--P:establishment of protein localization to vacuole
GO:0006955--P:immune response
GO:0050869--P:negative regulation of B cell activation
GO:2000349--P:negative regulation of CD40 signaling pathway
GO:0002677--P:negative regulation of chronic inflammatory response
GO:0045736--P:negative regulation of cyclin-dependent protein serine/threonine kinase activity
GO:2000352--P:negative regulation of endothelial cell apoptotic process
GO:1902042--P:negative regulation of extrinsic apoptotic signaling pathway via death domain receptors
GO:0043124--P:negative regulation of I-kappaB kinase/NF-kappaB signaling
GO:0045824--P:negative regulation of innate immune response
GO:0032691--P:negative regulation of interleukin-1 beta production
GO:0032703--P:negative regulation of interleukin-2 production
GO:0032715--P:negative regulation of interleukin-6 production
GO:0032088--P:negative regulation of NF-kappaB transcription factor activity
GO:0070429--P:negative regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway
GO:0070433--P:negative regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway
GO:0031397--P:negative regulation of protein ubiquitination
GO:0048662--P:negative regulation of smooth muscle cell proliferation
GO:0034140--P:negative regulation of toll-like receptor 3 signaling pathway
GO:0034148--P:negative regulation of toll-like receptor 5 signaling pathway
GO:0032720--P:negative regulation of tumor necrosis factor production
GO:1903364--P:positive regulation of cellular protein catabolic process
GO:2000347--P:positive regulation of hepatocyte proliferation
GO:0071947--P:protein deubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0035871--P:protein K11-linked deubiquitination
GO:0071108--P:protein K48-linked deubiquitination
GO:0070936--P:protein K48-linked ubiquitination
GO:0070536--P:protein K63-linked deubiquitination
GO:0002634--P:regulation of germinal center formation
GO:0050727--P:regulation of inflammatory response
GO:0045088--P:regulation of innate immune response
GO:0032495--P:response to muramyl dipeptide
GO:0072573--P:tolerance induction to lipopolysaccharide

KEGG

bta:508105

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001825	Ailuropoda melanoleuca	88.23	0.00e+00	1446.00
IUUC-Apl-003501	Anas platyrhynchos	64.69	0.00e+00	1021.00
IUUC-Aca-004245	Anolis carolinensis	62.16	0.00e+00	1024.00
IUUC-Afu-008991	Aspergillus fumigatus	31.71	8.00e+00	25.00
IUUC-Ame-011789	Astyanax mexicanus	47.05	0.00e+00	702.00
IUUC-Cja-019895	Callithrix jacchus	85.95	0.00e+00	1404.00
IUUC-Cfa-020754	Canis familiaris	88.35	0.00e+00	1447.00
IUUC-Cpo-021780	Cavia porcellus	85.34	0.00e+00	1389.00
IUUC-Csa-023568	Chlorocebus sabaeus	86.33	0.00e+00	1423.00
IUUC-Cho-024300	Choloepus hoffmanni	88.34	0.00e+00	645.00
IUUC-Dre-028577	Danio rerio	48.81	0.00e+00	691.00
IUUC-Dno-029382	Dasypus novemcinctus	81.04	0.00e+00	1297.00
IUUC-Dor-030874	Dipodomys ordii	82.91	0.00e+00	1335.00
IUUC-Ete-032721	Echinops telfairi	90.19	0.00e+00	799.00
IUUC-Eca-033596	Equus caballus	84.05	0.00e+00	1364.00
IUUC-Eeu-035159	Erinaceus europaeus	82.80	0.00e+00	1064.00
IUUC-Fca-035847	Felis catus	87.59	0.00e+00	1431.00
IUUC-Fal-036681	Ficedula albicollis	63.85	0.00e+00	1030.00
IUUC-Gmo-038521	Gadus morhua	59.71	1.00e-146	513.00
IUUC-Gga-040975	Gallus gallus	63.07	0.00e+00	1035.00
IUUC-Gac-042216	Gasterosteus aculeatus	61.74	6.00e-153	534.00
IUUC-Ggo-045258	Gorilla gorilla	85.44	0.00e+00	1409.00
IUUC-Hsa-046071	Homo sapiens	85.57	0.00e+00	1413.00
IUUC-Itr-048386	Ictidomys tridecemlineatus	86.08	0.00e+00	1400.00
IUUC-Lch-050326	Latimeria chalumnae	57.21	0.00e+00	894.00
IUUC-Loc-051945	Lepisosteus oculatus	46.91	4.00e-175	608.00
IUUC-Laf-053722	Loxodonta africana	84.18	0.00e+00	1378.00
IUUC-Mcc-055503	Macaca mulatta	86.08	0.00e+00	1419.00
IUUC-Meu-056481	Macropus eugenii	71.96	0.00e+00	1118.00
IUUC-Mga-059690	Meleagris gallopavo	61.47	0.00e+00	965.00
IUUC-Mmr-061233	Microcebus murinus	85.10	0.00e+00	1383.00
IUUC-Mdo-062446	Monodelphis domestica	77.79	0.00e+00	1248.00
IUUC-Mmu-063436	Mus musculus	85.10	0.00e+00	1351.00
IUUC-Mpu-066808	Mustela putorius furo	87.85	0.00e+00	1438.00
IUUC-Mlu-067339	Myotis lucifugus	86.20	0.00e+00	1398.00
IUUC-Nle-069888	Nomascus leucogenys	85.70	0.00e+00	1413.00
IUUC-Opr-070303	Ochotona princeps	84.24	0.00e+00	1371.00
IUUC-Ont-072283	Oreochromis niloticus	59.81	2.00e-148	519.00
IUUC-Oan-072925	Ornithorhynchus anatinus	74.19	0.00e+00	1193.00
IUUC-Ocu-073889	Oryctolagus cuniculus	85.71	0.00e+00	1371.00
IUUC-Ola-087417	Oryzias latipes	59.81	5.00e-148	518.00
IUUC-Oga-088708	Otolemur garnettii	83.67	0.00e+00	1312.00
IUUC-Oar-089271	Ovis aries	96.82	0.00e+00	1530.00
IUUC-Ptr-091296	Pan troglodytes	85.57	0.00e+00	1412.00
IUUC-Pan-092474	Papio anubis	86.20	0.00e+00	1420.00
IUUC-Psi-093447	Pelodiscus sinensis	66.16	0.00e+00	1066.00
IUUC-Pfo-096511	Poecilia formosa	60.29	4.00e-150	525.00
IUUC-Pab-098700	Pongo abelii	85.70	0.00e+00	1413.00
IUUC-Pca-100246	Procavia capensis	76.84	0.00e+00	909.00
IUUC-Pva-102606	Pteropus vampyrus	76.40	3.00e-177	615.00
IUUC-Rno-105818	Rattus norvegicus	84.86	0.00e+00	1380.00
IUUC-Sha-106559	Sarcophilus harrisii	76.29	0.00e+00	1221.00
IUUC-Sar-113454	Sorex araneus	91.46	0.00e+00	637.00
IUUC-Ssc-116064	Sus scrofa	90.70	0.00e+00	1446.00
IUUC-Tgu-117212	Taeniopygia guttata	64.13	0.00e+00	1030.00
IUUC-Tru-118230	Takifugu rubripes	60.53	1.00e-151	530.00
IUUC-Tsy-119066	Tarsius syrichta	84.78	0.00e+00	1378.00
IUUC-Tni-119825	Tetraodon nigroviridis	48.35	0.00e+00	684.00
IUUC-Tvi-122463	Trichoderma virens	39.47	3.50e+00	27.30
IUUC-Tbe-127601	Tupaia belangeri	95.12	0.00e+00	665.00
IUUC-Ttr-128930	Tursiops truncatus	91.72	0.00e+00	1468.00
IUUC-Vpa-130450	Vicugna pacos	95.76	0.00e+00	808.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence