iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Mpu-065836

Ensembl Protein ID

ENSMPUP00000017394.1

UniProt Accession

M3Z1D2; M3Z1D2_MUSPF

Genbank Protein ID

ENSMPUP00000017394

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AEYP01031532

Gene Name

MDM2

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMPUG00000017505.1	ENSMPUT00000017651.1	ENSMPUP00000017394.1

Status

Unreviewed

Classification

Family	Identity	E-Value	Score	Source Orthology
E3 activity/RING/RING	93.28	0.00e+00	819.00	IUUC-Hsa-046376
E3 activity/RING/RING	78.43	0.00e+00	671.00	IUUC-Mmu-063207
E3 activity/RING/RING	80.61	0.00e+00	688.00	IUUC-Rno-105641

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Organism

Mustela putorius furo

Protein Sequence
(Fasta)

MCNTNMSVST DGAVSTSQMP ASEQETLVRP KPLLLKLLKS VGAQKDTYTM KEVIFYLGQY 60
IMTKRLYDEK QQHIVYCSND LLGDLFGVPS FSVKEHRKIY TMIYRNLVVV NQHESSDSGT 120

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Nucleotide Sequence
(Fasta)

GCAAATGTGC AATACCAACA TGTCTGTGTC TACTGATGGT GCTGTAAGCA CCTCACAGAT 60
GCCAGCTTCG GAACAAGAGA CCCTGGTTGG TATCTTTGTC TCAAGTGTAA CTTTTAAGAT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0479--Metal-binding
KW-1185--Reference proteome

Interpro

IPR028340--Mdm2
IPR015459--MDM2_E3_ligase
IPR016495--p53_neg-reg_MDM_2/4
IPR003121--SWIB_MDM2_domain
IPR001876--Znf_RanBP2
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD

PROSITE

PS01358--ZF_RANBP2_1
PS50199--ZF_RANBP2_2
PS50089--ZF_RING_2

Pfam

PF02201--SWIB
PF00641--zf-RanBP

Gene Ontology

GO:0005737--C:cytoplasm
GO:0016604--C:nuclear body
GO:0005730--C:nucleolus
GO:0043234--C:protein complex
GO:0016874--F:ligase activity
GO:0061630--F:ubiquitin protein ligase activity
GO:0008270--F:zinc ion binding
GO:0003283--P:atrial septum development
GO:0003181--P:atrioventricular valve morphogenesis
GO:0001568--P:blood vessel development
GO:0001974--P:blood vessel remodeling
GO:0060411--P:cardiac septum morphogenesis
GO:0071456--P:cellular response to hypoxia
GO:0006977--P:DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
GO:0003203--P:endocardial cushion morphogenesis
GO:0045184--P:establishment of protein localization
GO:0043066--P:negative regulation of apoptotic process
GO:0071157--P:negative regulation of cell cycle arrest
GO:0043518--P:negative regulation of DNA damage response, signal transduction by p53 class mediator
GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter
GO:0018205--P:peptidyl-lysine modification
GO:0032436--P:positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0051865--P:protein autoubiquitination
GO:0006461--P:protein complex assembly
GO:0031648--P:protein destabilization
GO:0034504--P:protein localization to nucleus
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0002027--P:regulation of heart rate
GO:0046677--P:response to antibiotic
GO:0007089--P:traversing start control point of mitotic cell cycle
GO:0003281--P:ventricular septum development

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002039	Ailuropoda melanoleuca	96.51	0.00e+00	862.00
IUUC-Apl-003193	Anas platyrhynchos	65.37	4.00e-160	557.00
IUUC-Aca-004305	Anolis carolinensis	57.46	4.00e-121	428.00
IUUC-Ame-010675	Astyanax mexicanus	44.66	3.00e-83	302.00
IUUC-Bta-013270	Bos taurus	92.68	0.00e+00	792.00
IUUC-Cja-019744	Callithrix jacchus	91.08	0.00e+00	788.00
IUUC-Cfa-020807	Canis familiaris	95.34	0.00e+00	803.00
IUUC-Cpo-022182	Cavia porcellus	86.94	0.00e+00	729.00
IUUC-Cre-022828	Chlamydomonas reinhardtii	35.42	9.00e-06	41.20
IUUC-Csa-023541	Chlorocebus sabaeus	92.87	0.00e+00	793.00
IUUC-Cho-024831	Choloepus hoffmanni	74.63	1.00e-86	312.00
IUUC-Cin-025448	Ciona intestinalis	28.37	8.00e-21	93.60
IUUC-Csv-026151	Ciona savignyi	31.17	2.00e-11	62.40
IUUC-Dre-028419	Danio rerio	43.12	2.00e-50	193.00
IUUC-Dno-028950	Dasypus novemcinctus	91.24	0.00e+00	795.00
IUUC-Dor-031048	Dipodomys ordii	70.33	7.00e-168	583.00
IUUC-Ete-032264	Echinops telfairi	68.36	6.00e-170	590.00
IUUC-Eca-033301	Equus caballus	83.30	0.00e+00	725.00
IUUC-Eeu-035005	Erinaceus europaeus	82.75	0.00e+00	676.00
IUUC-Fca-035454	Felis catus	96.13	0.00e+00	839.00
IUUC-Fal-036720	Ficedula albicollis	61.46	3.00e-73	268.00
IUUC-Gmo-039296	Gadus morhua	42.44	8.00e-46	177.00
IUUC-Gga-040251	Gallus gallus	65.78	2.00e-155	542.00
IUUC-Gac-041528	Gasterosteus aculeatus	39.32	4.00e-33	135.00
IUUC-Ggo-044948	Gorilla gorilla	84.73	0.00e+00	717.00
IUUC-Hsa-046376	Homo sapiens	93.28	0.00e+00	798.00
IUUC-Itr-048328	Ictidomys tridecemlineatus	89.63	0.00e+00	745.00
IUUC-Lch-050037	Latimeria chalumnae	56.26	3.00e-117	415.00
IUUC-Loc-051837	Lepisosteus oculatus	50.60	2.00e-112	399.00
IUUC-Laf-053483	Loxodonta africana	84.15	0.00e+00	724.00
IUUC-Mcc-055294	Macaca mulatta	93.08	0.00e+00	796.00
IUUC-Mga-060007	Meleagris gallopavo	64.59	1.00e-147	516.00
IUUC-Mmr-060673	Microcebus murinus	92.67	0.00e+00	820.00
IUUC-Mdo-063057	Monodelphis domestica	75.46	0.00e+00	670.00
IUUC-Mmu-063207	Mus musculus	79.03	9.00e-180	622.00
IUUC-Mlu-068193	Myotis lucifugus	89.86	0.00e+00	784.00
IUUC-Nle-069927	Nomascus leucogenys	92.87	0.00e+00	795.00
IUUC-Opr-070590	Ochotona princeps	84.29	0.00e+00	700.00
IUUC-Ont-071984	Oreochromis niloticus	42.63	2.00e-50	193.00
IUUC-Oan-072744	Ornithorhynchus anatinus	72.15	4.00e-166	577.00
IUUC-Ocu-074071	Oryctolagus cuniculus	91.67	0.00e+00	783.00
IUUC-Ola-087329	Oryzias latipes	39.73	6.00e-67	248.00
IUUC-Oga-088135	Otolemur garnettii	82.83	0.00e+00	738.00
IUUC-Oar-090078	Ovis aries	92.26	0.00e+00	822.00
IUUC-Ptr-091399	Pan troglodytes	93.28	0.00e+00	798.00
IUUC-Pan-092720	Papio anubis	93.08	0.00e+00	796.00
IUUC-Psi-093591	Pelodiscus sinensis	65.78	3.00e-133	468.00
IUUC-Pma-094500	Petromyzon marinus	34.27	8.00e-26	109.00
IUUC-Pfo-096316	Poecilia formosa	40.78	7.00e-72	264.00
IUUC-Pab-097696	Pongo abelii	92.67	0.00e+00	789.00
IUUC-Pca-100974	Procavia capensis	81.71	0.00e+00	741.00
IUUC-Pva-102488	Pteropus vampyrus	88.39	0.00e+00	716.00
IUUC-Rno-105641	Rattus norvegicus	80.61	0.00e+00	659.00
IUUC-Sha-107314	Sarcophilus harrisii	73.67	0.00e+00	693.00
IUUC-Sar-112938	Sorex araneus	85.31	0.00e+00	754.00
IUUC-Ssc-115495	Sus scrofa	92.67	0.00e+00	783.00
IUUC-Tgu-116623	Taeniopygia guttata	64.73	3.00e-151	528.00
IUUC-Tru-117820	Takifugu rubripes	38.11	2.00e-68	253.00
IUUC-Tsy-119162	Tarsius syrichta	65.76	8.00e-88	317.00
IUUC-Tni-119793	Tetraodon nigroviridis	41.96	9.00e-42	164.00
IUUC-Tbe-127816	Tupaia belangeri	87.22	8.00e-117	413.00
IUUC-Ttr-129194	Tursiops truncatus	82.11	0.00e+00	652.00
IUUC-Vpa-130326	Vicugna pacos	88.19	0.00e+00	741.00
IUUC-Xtr-132216	Xenopus tropicalis	56.60	1.00e-119	422.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence