iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Fal-037071

Ensembl Protein ID

ENSFALP00000006150.1

UniProt Accession

U3JTP6; U3JTP6_FICAL

Genbank Protein ID

ENSFALP00000006150

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AGTO01020794

Gene Name

UBR5

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSFALG00000005901.1	ENSFALT00000006177.1	ENSFALP00000006150.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	4.70e-79	265.9	2461	2783

Active Site

Position(s)	Description	Evidence
2753	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 17   egldlgGvtreflallskelqnpd..lglf.lysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlldlplsksfykll 100
           e+ + +G++r ++++ ++++ + d  ++lf +  +++ +t +p +++      +l++F+ +Gr+lg++l +++l++++l+++++k l
   Q: 2461 ENRKRHGSSRSVVDMELDDTDDGDdnAPLFyQPGKRGFYTPRPGKNTE----ARLNCFRNIGRILGLCLLQNELCPITLNRHVIKVL 2543
           556777999999999999999988777888234444777777777765....89********************************* PP
   S: 101  lgkklsledleevdpelyks.lkeikena..esdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvklvveyrlke 184
           lg+k++++d++ +dp +y+s  + i++++  ++d   +++dl+f ++ ++ +   ++eL+++G nipVt +N +eYv++++e+r+  
   Q: 2544 LGRKVNWHDFAFFDPVMYESlRQLILASQsaDADAVFAAMDLAFAIDLCKEEGGGQVELISNGVNIPVTPQNVYEYVRKYAEHRMLV 2630
           ********************555566555556699999************************************************* PP
   S: 185  gikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspai....qwFwevleefsseerkafLqF 267
             ++ ++a+r+G+ +v+p+++l+ +t+e+++ll++G+ e++v++l ++t+++++  e+ +++    +wFw+++e++s++er++++ F
   Q: 2631 VAEQPLHAMRKGLLDVLPKNSLEDLTAEDFRLLVNGCGEVNVQMLISFTSFNDESGENAEKLlqfkRWFWSIVEKMSMTERQDLVYF 2717
           ***************************************************9999999999989999******************** PP
   S: 268  vTgssrlPl..gGfaelkprlfvirkdasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFel 335
           +T+s++lP+  +Gf++++  +++ir   +d++lP++nTC+++L +P Yssk+ilk+kLl+Ai++ k+F++
   Q: 2718 WTSSPSLPAseEGFQPMP--SITIRP-PDDQHLPTANTCISRLYVPLYSSKQILKQKLLLAIKT-KNFGF 2783
           *********999******..799999.99**********************************9.99875 PP

Organism

Ficedula albicollis

Protein Sequence
(Fasta)

MSSSNSLISF CFRLREVSEK LNKYNLNSHP PLNVLEQATI KQCVVGPNHA AFLLEDGRVC 60
RIGFSVQPDR LELGKPENSD GSKLSSGSGA GRTSRPGRTS DSPWFLSGSE TLGRLAGNTL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TGTTGGGGGA CTGTGGAGTA TGTCATCAAG TAACAGCTTA ATTTCTTTCT GTTTCAGATT 60
AAGGGAAGTT TCAGAGAAGC TGAACAAATA TAATTTAAAC AGGTAAGGCA TATCACATGC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR024725--E3_UbLigase_EDD_UBA
IPR000569--HECT_dom
IPR002004--PABP_HYD
IPR009091--RCC1/BLIP-II
IPR003126--Znf_UBR

PROSITE

PS50237--HECT
PS51309--PABC
PS51157--ZF_UBR

Pfam

PF11547--E3_UbLigase_EDD
PF00632--HECT
PF00658--PABP

SMART

SM00119--HECTc
SM00517--PolyA
SM00396--ZnF_UBR1

Gene Ontology

GO:0005829--C:cytosol
GO:0016020--C:membrane
GO:0005654--C:nucleoplasm
GO:0048471--C:perinuclear region of cytoplasm
GO:0043234--C:protein complex
GO:0003723--F:RNA binding
GO:0034450--F:ubiquitin-ubiquitin ligase activity
GO:0008270--F:zinc ion binding
GO:0006974--P:cellular response to DNA damage stimulus
GO:2000780--P:negative regulation of double-strand break repair
GO:1901315--P:negative regulation of histone H2A K63-linked ubiquitination
GO:0090263--P:positive regulation of canonical Wnt signaling pathway
GO:0035413--P:positive regulation of catenin import into nucleus
GO:0010628--P:positive regulation of gene expression
GO:0033160--P:positive regulation of protein import into nucleus, translocation
GO:0050847--P:progesterone receptor signaling pathway
GO:0000209--P:protein polyubiquitination

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002217	Ailuropoda melanoleuca	98.27	0.00e+00	4539.00
IUUC-Apl-004165	Anas platyrhynchos	98.70	0.00e+00	4551.00
IUUC-Aca-004577	Anolis carolinensis	97.13	0.00e+00	3952.00
IUUC-Ame-010702	Astyanax mexicanus	84.67	0.00e+00	2492.00
IUUC-Bta-012313	Bos taurus	97.26	0.00e+00	4540.00
IUUC-Cel-018165	Caenorhabditis elegans	35.10	8.00e-69	256.00
IUUC-Cja-019858	Callithrix jacchus	97.12	0.00e+00	4556.00
IUUC-Cfa-020973	Canis familiaris	97.41	0.00e+00	4543.00
IUUC-Cpo-022108	Cavia porcellus	96.96	0.00e+00	1917.00
IUUC-Csa-023985	Chlorocebus sabaeus	98.16	0.00e+00	4575.00
IUUC-Cho-025034	Choloepus hoffmanni	88.59	0.00e+00	982.00
IUUC-Cin-025715	Ciona intestinalis	40.46	0.00e+00	939.00
IUUC-Csv-026088	Ciona savignyi	40.47	4.00e-160	558.00
IUUC-Dre-027730	Danio rerio	87.51	0.00e+00	4002.00
IUUC-Dno-029123	Dasypus novemcinctus	94.65	0.00e+00	4368.00
IUUC-Dor-030757	Dipodomys ordii	92.17	0.00e+00	2851.00
IUUC-Dme-032192	Drosophila melanogaster	51.67	3.00e-173	603.00
IUUC-Ete-032292	Echinops telfairi	94.81	0.00e+00	2175.00
IUUC-Eca-034347	Equus caballus	97.08	0.00e+00	4499.00
IUUC-Eeu-034873	Erinaceus europaeus	92.62	0.00e+00	4309.00
IUUC-Fca-036485	Felis catus	95.98	0.00e+00	4438.00
IUUC-Gmo-039589	Gadus morhua	89.45	0.00e+00	4006.00
IUUC-Gga-041195	Gallus gallus	97.01	0.00e+00	4456.00
IUUC-Gac-042538	Gasterosteus aculeatus	89.39	0.00e+00	4020.00
IUUC-Ggo-045351	Gorilla gorilla	96.30	0.00e+00	4585.00
IUUC-Hsa-045941	Homo sapiens	97.16	0.00e+00	4582.00
IUUC-Itr-048635	Ictidomys tridecemlineatus	97.05	0.00e+00	4532.00
IUUC-Lch-050480	Latimeria chalumnae	93.75	0.00e+00	4335.00
IUUC-Loc-052664	Lepisosteus oculatus	89.49	0.00e+00	4116.00
IUUC-Laf-053935	Loxodonta africana	97.76	0.00e+00	1593.00
IUUC-Mcc-054703	Macaca mulatta	98.16	0.00e+00	4578.00
IUUC-Meu-056431	Macropus eugenii	88.10	0.00e+00	803.00
IUUC-Mga-059289	Meleagris gallopavo	98.74	0.00e+00	3650.00
IUUC-Mmr-061737	Microcebus murinus	96.76	0.00e+00	4467.00
IUUC-Mdo-062499	Monodelphis domestica	97.45	0.00e+00	4525.00
IUUC-Mmu-063273	Mus musculus	96.18	0.00e+00	4447.00
IUUC-Mpu-066907	Mustela putorius furo	98.31	0.00e+00	4209.00
IUUC-Mlu-067942	Myotis lucifugus	97.84	0.00e+00	4558.00
IUUC-Nle-069527	Nomascus leucogenys	97.16	0.00e+00	4587.00
IUUC-Opr-070626	Ochotona princeps	85.89	0.00e+00	1430.00
IUUC-Ont-071951	Oreochromis niloticus	88.12	0.00e+00	3949.00
IUUC-Oan-072958	Ornithorhynchus anatinus	98.82	0.00e+00	4204.00
IUUC-Ocu-074503	Oryctolagus cuniculus	95.53	0.00e+00	4427.00
IUUC-Ola-086757	Oryzias latipes	88.88	0.00e+00	4032.00
IUUC-Oga-088781	Otolemur garnettii	97.05	0.00e+00	4523.00
IUUC-Oar-089274	Ovis aries	98.02	0.00e+00	4534.00
IUUC-Ptr-090669	Pan troglodytes	97.82	0.00e+00	3996.00
IUUC-Pan-092226	Papio anubis	97.02	0.00e+00	4537.00
IUUC-Psi-093502	Pelodiscus sinensis	97.99	0.00e+00	4537.00
IUUC-Pma-094454	Petromyzon marinus	77.51	0.00e+00	736.00
IUUC-Pfo-096173	Poecilia formosa	87.95	0.00e+00	3759.00
IUUC-Pab-098355	Pongo abelii	97.01	0.00e+00	3164.00
IUUC-Pca-100570	Procavia capensis	97.76	0.00e+00	1170.00
IUUC-Pva-102572	Pteropus vampyrus	93.83	0.00e+00	1354.00
IUUC-Rno-104916	Rattus norvegicus	95.36	0.00e+00	3935.00
IUUC-Sha-106653	Sarcophilus harrisii	97.63	0.00e+00	4534.00
IUUC-Sar-113517	Sorex araneus	87.19	0.00e+00	1263.00
IUUC-Ssc-115470	Sus scrofa	98.48	0.00e+00	2522.00
IUUC-Tgu-116932	Taeniopygia guttata	99.53	0.00e+00	4560.00
IUUC-Tru-117682	Takifugu rubripes	88.35	0.00e+00	2591.00
IUUC-Tsy-119417	Tarsius syrichta	93.82	0.00e+00	2464.00
IUUC-Tni-120442	Tetraodon nigroviridis	84.03	0.00e+00	3656.00
IUUC-Tbe-127456	Tupaia belangeri	85.45	0.00e+00	2088.00
IUUC-Ttr-128606	Tursiops truncatus	91.57	0.00e+00	1524.00
IUUC-Vpa-130112	Vicugna pacos	95.48	0.00e+00	3727.00
IUUC-Xtr-131929	Xenopus tropicalis	95.03	0.00e+00	4433.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence