iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	GXD
DNA & RNA Element
AREsite	microRNA	TRANSFAC	RepTar
miRNAMap	RAID2
Protein-protein Interaction
IID
Post-translational Modifications (PTMs)
dbPAF	PhosphositePlus
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	1.60e-24	86.0	182	220

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 1    gHtdsvtclaf.sdtllvsGsdDgtikvWDlrtgvllks 38
           gH+d+++++a+ +dt+ vsGs+Dg++ +W+++++vl+ks
   Q: 182  GHKDWIFSIAWiNDTMAVSGSRDGSMGLWEVTDDVLTKS 220
           8**********************************9986 PP

Organism

Mus musculus

Functional Description
(View)

May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex.

Protein Sequence
(Fasta)

MARKAVSRKR KASASPGAGS DAQGPQFGWD HSLHKRKRLP PVKRSLVYYL KNREVRLQNE 60
TSYSRLLHGY AAQQLPSLLK EREFHLGTLN KVFASQWLNH RQVVCGTKCN TLFVVDVQTG 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GCAGGAGTGA CGGGGCGCGG GCGAGTGGGA GGGGGGTGTT TTGGTTCTCG CCGCTCGCCG 60
TCCTTTCCAG ACACGGCGGT AGGAAAGCTG CTTGTTCCTG CTTTTCCTTC CCCTTCCCTT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0206--Cytoskeleton
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0833--Ubl conjugation pathway
KW-0853--WD repeat

Interpro

IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

SMART

SM00320--WD40

Gene Ontology

GO:0005813--C:centrosome
GO:0080008--C:Cul4-RING E3 ubiquitin ligase complex
GO:0005737--C:cytoplasm
GO:0016567--P:protein ubiquitination

KEGG

mmu:68970

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002102	Ailuropoda melanoleuca	97.79	0.00e+00	924.00
IUUC-Apl-003794	Anas platyrhynchos	91.86	0.00e+00	825.00
IUUC-Aca-004264	Anolis carolinensis	85.35	0.00e+00	740.00
IUUC-Ame-011254	Astyanax mexicanus	69.26	0.00e+00	668.00
IUUC-Bta-012923	Bos taurus	96.91	0.00e+00	917.00
IUUC-Cja-019590	Callithrix jacchus	98.25	0.00e+00	702.00
IUUC-Cfa-021123	Canis familiaris	98.23	0.00e+00	927.00
IUUC-Cpo-021733	Cavia porcellus	93.57	0.00e+00	664.00
IUUC-Csa-023339	Chlorocebus sabaeus	98.23	0.00e+00	929.00
IUUC-Cho-024837	Choloepus hoffmanni	76.68	1.00e-147	516.00
IUUC-Dre-027571	Danio rerio	70.35	0.00e+00	673.00
IUUC-Dno-029106	Dasypus novemcinctus	98.02	0.00e+00	895.00
IUUC-Dme-031774	Drosophila melanogaster	40.27	5.00e-80	291.00
IUUC-Ete-033140	Echinops telfairi	72.82	4.00e-115	407.00
IUUC-Eca-034316	Equus caballus	97.35	0.00e+00	922.00
IUUC-Eeu-034641	Erinaceus europaeus	90.94	0.00e+00	640.00
IUUC-Fca-036150	Felis catus	98.13	0.00e+00	882.00
IUUC-Fal-036636	Ficedula albicollis	90.11	0.00e+00	849.00
IUUC-Gmo-038736	Gadus morhua	74.19	0.00e+00	664.00
IUUC-Gga-040896	Gallus gallus	84.65	0.00e+00	765.00
IUUC-Gac-042623	Gasterosteus aculeatus	72.47	0.00e+00	674.00
IUUC-Ggo-044968	Gorilla gorilla	98.83	0.00e+00	706.00
IUUC-Hsa-046020	Homo sapiens	98.45	0.00e+00	931.00
IUUC-Itr-048766	Ictidomys tridecemlineatus	97.79	0.00e+00	927.00
IUUC-Lch-050244	Latimeria chalumnae	81.24	0.00e+00	774.00
IUUC-Loc-052777	Lepisosteus oculatus	75.27	0.00e+00	683.00
IUUC-Laf-054505	Loxodonta africana	96.03	0.00e+00	913.00
IUUC-Mcc-055187	Macaca mulatta	98.13	0.00e+00	880.00
IUUC-Meu-056026	Macropus eugenii	90.16	0.00e+00	802.00
IUUC-Mga-059618	Meleagris gallopavo	56.98	6.00e-127	447.00
IUUC-Mmr-061121	Microcebus murinus	90.57	0.00e+00	825.00
IUUC-Mdo-062823	Monodelphis domestica	93.38	0.00e+00	864.00
IUUC-Mpu-066157	Mustela putorius furo	98.23	0.00e+00	927.00
IUUC-Mlu-067146	Myotis lucifugus	96.69	0.00e+00	918.00
IUUC-Nle-069179	Nomascus leucogenys	96.25	0.00e+00	900.00
IUUC-Opr-070970	Ochotona princeps	95.61	0.00e+00	679.00
IUUC-Ont-072013	Oreochromis niloticus	69.57	0.00e+00	635.00
IUUC-Oan-072810	Ornithorhynchus anatinus	83.46	2.00e-61	227.00
IUUC-Ocu-074646	Oryctolagus cuniculus	96.25	0.00e+00	912.00
IUUC-Ola-087062	Oryzias latipes	70.36	0.00e+00	660.00
IUUC-Olu-087756	Ostreococcus lucimarinus	28.01	4.00e-16	79.30
IUUC-Oga-089071	Otolemur garnettii	97.79	0.00e+00	926.00
IUUC-Oar-089522	Ovis aries	96.69	0.00e+00	915.00
IUUC-Ptr-091042	Pan troglodytes	93.38	0.00e+00	877.00
IUUC-Pan-092832	Papio anubis	98.01	0.00e+00	926.00
IUUC-Psi-093131	Pelodiscus sinensis	92.33	0.00e+00	827.00
IUUC-Pma-094151	Petromyzon marinus	57.50	5.00e-60	223.00
IUUC-Pfo-096970	Poecilia formosa	69.94	0.00e+00	664.00
IUUC-Pab-098019	Pongo abelii	98.45	0.00e+00	931.00
IUUC-Pca-100401	Procavia capensis	79.53	1.00e-155	542.00
IUUC-Pva-103128	Pteropus vampyrus	98.23	0.00e+00	932.00
IUUC-Rno-105945	Rattus norvegicus	85.43	0.00e+00	774.00
IUUC-Sha-107518	Sarcophilus harrisii	94.75	0.00e+00	677.00
IUUC-Smo-108742	Selaginella moellendorffii	33.01	1.00e-51	196.00
IUUC-Sar-113026	Sorex araneus	75.28	0.00e+00	662.00
IUUC-Ssc-115446	Sus scrofa	96.72	0.00e+00	852.00
IUUC-Tgu-117240	Taeniopygia guttata	83.20	0.00e+00	660.00
IUUC-Tru-118560	Takifugu rubripes	68.78	0.00e+00	662.00
IUUC-Tsy-119344	Tarsius syrichta	90.95	0.00e+00	847.00
IUUC-Tni-119714	Tetraodon nigroviridis	72.28	0.00e+00	677.00
IUUC-Tbe-127634	Tupaia belangeri	98.81	1.00e-96	347.00
IUUC-Ttr-128503	Tursiops truncatus	98.01	0.00e+00	926.00
IUUC-Vpa-130126	Vicugna pacos	96.86	2.00e-165	575.00
IUUC-Xtr-132744	Xenopus tropicalis	50.99	4.00e-109	388.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence