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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Hsa-046462
UUCD1 version UUC-HoS-00154
Ensembl Protein ID ENSP00000373772.3
UniProt Accession Q5VTR2; A7MCT5; Q2TB34; Q69YL5; Q6P527; Q8N3J4; Q96JD3; Q9H9Y7; Q9HA51; Q9NUR4; Q9NWQ3; Q9NX83; BRE1A_HUMAN
Genbank Protein ID AAK58539.1; BAA91134.1; BAA91326.1; BAA92057.1; BAB14005.1; BAB14081.1; BAG37025.1; CAH69963.1; CAH69963.1; CAI14618.1; CAI14618.1; AAH63115.1; AAI10585.1; AAI10586.1; AAI52310.1; CAH10630.1; CAD38947.1
Protein Name E3 ubiquitin-protein ligase BRE1A; RING finger protein 20; RING-type E3 ubiquitin transferase BRE1A
Genbank Nucleotide ID AF265230; AK000389; AK000697; AK002051; AK022300; AK022532; AK314401; AL591377; AL353621; AL353621; AL591377; BC063115; BC110584; BC110585; BC152309; AL832910; AL834272
Gene Name RNF20; BRE1A
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000155827.11 ENST00000389120.7 ENSP00000373772.3
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPM
DNA & RNA Element
UTRdbAREsitecircBaseCircNet
miRTarBasemicroRNATRANSFACTargetScan
RepTarSomamiRmiRcodeRAID2
Protein-protein Interaction
IIDiRefIndexPINAHINT
MenthaInWeb_IM
Disease-associated Information
ClinVarOMIM
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
HPRDPhospho.ELMUniProtPHOSIDA
BioGRIDmUbiSiDa
DNA Methylation
MethyCancerTCGAICGCCOSMIC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
E3 activity/RING/RING RING 16713563; 16307923; 16627869; 19037095
Classification
Family E-value Score Start End
E3 activity/RING/RING 0.38 13.0 922 961
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 activity/RING/RING
   S: 1    CaiCledfkdgplvlpCgHvfhadCl.qkwpglknssskefrCPlCr 46
           C+ C  + kd  +++ C Hvf+++C+  ++        ++ +CP C+
   Q: 922  CPCCNMRKKD-AVLTKCFHVFCFECVkTRY------DTRQRKCPKCN 961
           9999555566.888************9999......999*******6 PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     Component of the RNF20/40 E3 ubiquitin-protein ligase complex that mediates monoubiquitination of 'Lys-120' of histone H2B (H2BK120ub1). H2BK120ub1 gives a specific tag for epigenetic transcriptional activation and is also prerequisite for histone H3 'Lys-4' and 'Lys-79' methylation (H3K4me and H3K79me, respectively). It thereby plays a central role inb histone code and gene regulation. The RNF20/40 complex forms a H2B ubiquitin ligase complex in cooperation with the E2 enzyme UBE2A or UBE2B; reports about the cooperation with UBE2E1/UBCH are contradictory. Required for transcriptional activation of Hox genes. Recruited to the MDM2 promoter, probably by being recruited by p53/TP53, and thereby acts as a transcriptional coactivator. Mediates the polyubiquitination of isoform 2 of PA2G4 in cancer cells leading to its proteasome-mediated degradation.
 Component of the RNF20/40 E3 ubiquitin-protein ligase complex that mediates monoubiquitination of 'Lys-120' of histone H2B (H2BK120ub1). H2BK120ub1 gives a specific tag for epigenetic transcriptional activation and is also prerequisite for histone H3 'Lys-4' and 'Lys-79' methylation (H3K4me and H3K79me, respectively). It thereby plays a central role inb histone code and gene regulation. The RNF20/40 complex forms a H2B ubiquitin ligase complex in cooperation with the E2 enzyme UBE2A or UBE2B; reports about the cooperation with UBE2E1/UBCH are contradictory. Required for transcriptional activation of Hox genes. Recruited to the MDM2 promoter, probably by being recruited by p53/TP53, and thereby acts as a transcriptional coactivator. Mediates the polyubiquitination of isoform 2 of PA2G4 in cancer cells leading to its proteasome-mediated degradation.
Protein Sequence
(Fasta)
MSGIGNKRAA GEPGTSMPPE KKAAVEDSGT TVETIKLGGV SSTEELDIRT LQTKNRKLAE 60
MLDQRQAIED ELREHIEKLE RRQATDDASL LIVNRYWSQF DENIRIILKR YDLEQGLGDL 120
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Protein Fasta Sequence


>IUUC-Hsa-046462|E3,RING|Homo sapiens
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Nucleotide Sequence
(Fasta)
GGAAGTTCTG CCTTGTCTCC GCCGCGGGTC AGGGGTGAGA GCTGGAATCT CTGCACGGGC 60
CTTGGTGAGT AACTGCTGCG AGTTCTGTTC CCGCGCGGCG CCAGTTCAAA GAACTTAGGT 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-046462|E3,RING|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0007--Acetylation
KW-0156--Chromatin regulator
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0479--Metal-binding
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR015422--PyrdxlP-dep_Trfase_sub2
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS
PROSITE

PS00518--ZF_RING_1
PS50089--ZF_RING_2
SMART

SM00184--RING
Gene Ontology

GO:0033503--C:HULC complex
GO:0005730--C:nucleolus
GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0000151--C:ubiquitin ligase complex
GO:0003682--F:chromatin binding
GO:0042393--F:histone binding
GO:0003730--F:mRNA 3'-UTR binding
GO:0002039--F:p53 binding
GO:0003713--F:transcription coactivator activity
GO:0031625--F:ubiquitin protein ligase binding
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0033523--P:histone H2B ubiquitination
GO:0010390--P:histone monoubiquitination
GO:0030336--P:negative regulation of cell migration
GO:1900364--P:negative regulation of mRNA polyadenylation
GO:2001168--P:positive regulation of histone H2B ubiquitination
GO:0031062--P:positive regulation of histone methylation
GO:0045893--P:positive regulation of transcription, DNA-templated
GO:0000209--P:protein polyubiquitination
GO:0016567--P:protein ubiquitination
GO:0006355--P:regulation of transcription, DNA-templated
GO:0006511--P:ubiquitin-dependent protein catabolic process
KEGG hsa:56254
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001976 Ailuropoda melanoleuca 98.26 0.00e+00 1652.00
IUUC-Apl-003407 Anas platyrhynchos 87.54 0.00e+00 943.00
IUUC-Aca-004246 Anolis carolinensis 87.37 0.00e+00 928.00
IUUC-Ago-007988 Ashbya gossypii 31.69 6.00e-15 76.30
IUUC-Acl-008319 Aspergillus clavatus 25.85 3.00e-14 73.90
IUUC-Aor-010142 Aspergillus oryzae 28.62 2.00e-15 78.20
IUUC-Ate-010547 Aspergillus terreus 26.15 2.00e-14 74.30
IUUC-Ame-011916 Astyanax mexicanus 77.93 2.00e-143 503.00
IUUC-Bta-012357 Bos taurus 98.05 0.00e+00 1615.00
IUUC-Bci-013926 Botrytis cinerea 44.19 5.00e-08 53.50
IUUC-Bdi-015006 Brachypodium distachyon 26.46 6.00e-24 106.00
IUUC-Cel-018659 Caenorhabditis elegans 34.41 8.00e-40 159.00
IUUC-Cja-019244 Callithrix jacchus 98.88 0.00e+00 1028.00
IUUC-Cfa-020320 Canis familiaris 98.46 0.00e+00 1649.00
IUUC-Cpo-021617 Cavia porcellus 95.29 0.00e+00 1664.00
IUUC-Csa-023509 Chlorocebus sabaeus 100.00 0.00e+00 1619.00
IUUC-Cho-024616 Choloepus hoffmanni 81.49 0.00e+00 971.00
IUUC-Cme-027134 Cyanidioschyzon merolae 39.06 1.00e-13 71.60
IUUC-Dno-029537 Dasypus novemcinctus 97.61 0.00e+00 1021.00
IUUC-Dor-030250 Dipodomys ordii 95.90 0.00e+00 1541.00
IUUC-Dse-031300 Dothistroma septosporum 38.46 2.00e-15 77.80
IUUC-Ete-033164 Echinops telfairi 94.26 0.00e+00 1214.00
IUUC-Eca-033347 Equus caballus 98.26 0.00e+00 1612.00
IUUC-Eeu-034801 Erinaceus europaeus 93.61 0.00e+00 635.00
IUUC-Fca-036024 Felis catus 98.56 0.00e+00 1677.00
IUUC-Fal-037622 Ficedula albicollis 88.43 0.00e+00 949.00
IUUC-Gmo-039446 Gadus morhua 77.55 4.00e-132 466.00
IUUC-Ggr-040117 Gaeumannomyces graminis 45.28 2.00e-11 64.30
IUUC-Gga-040412 Gallus gallus 89.48 0.00e+00 902.00
IUUC-Gac-042205 Gasterosteus aculeatus 60.68 6.00e-142 498.00
IUUC-Ggo-044703 Gorilla gorilla 99.90 0.00e+00 1619.00
IUUC-Itr-048298 Ictidomys tridecemlineatus 98.54 0.00e+00 1597.00
IUUC-Lch-049505 Latimeria chalumnae 74.86 0.00e+00 705.00
IUUC-Loc-051951 Lepisosteus oculatus 63.47 7.00e-112 398.00
IUUC-Lma-053312 Leptosphaeria maculans 28.71 6.00e-15 76.30
IUUC-Laf-054122 Loxodonta africana 96.93 0.00e+00 1602.00
IUUC-Mcc-054647 Macaca mulatta 100.00 0.00e+00 1619.00
IUUC-Meu-056559 Macropus eugenii 92.02 0.00e+00 1454.00
IUUC-Mpo-057568 Magnaporthe poae 45.28 2.00e-11 64.30
IUUC-Mga-059731 Meleagris gallopavo 95.18 2.00e-173 603.00
IUUC-Mmr-061495 Microcebus murinus 98.77 0.00e+00 1664.00
IUUC-Mdo-062599 Monodelphis domestica 93.59 0.00e+00 973.00
IUUC-Mmu-063278 Mus musculus 97.42 0.00e+00 1020.00
IUUC-Mpu-065910 Mustela putorius furo 98.15 0.00e+00 1654.00
IUUC-Mlu-067040 Myotis lucifugus 97.54 0.00e+00 1590.00
IUUC-Ncr-068695 Neurospora crassa 27.31 3.00e-12 67.00
IUUC-Nle-069058 Nomascus leucogenys 99.81 0.00e+00 1036.00
IUUC-Opr-071149 Ochotona princeps 96.61 0.00e+00 1006.00
IUUC-Ont-072543 Oreochromis niloticus 75.00 1.00e-133 470.00
IUUC-Oan-072996 Ornithorhynchus anatinus 96.97 0.00e+00 646.00
IUUC-Ocu-074773 Oryctolagus cuniculus 98.36 0.00e+00 1592.00
IUUC-Ola-087287 Oryzias latipes 63.20 0.00e+00 887.00
IUUC-Olu-087683 Ostreococcus lucimarinus 36.36 1.00e-13 68.60
IUUC-Oga-088961 Otolemur garnettii 98.67 0.00e+00 1637.00
IUUC-Oar-089755 Ovis aries 97.95 0.00e+00 1607.00
IUUC-Ptr-091602 Pan troglodytes 100.00 0.00e+00 1619.00
IUUC-Pan-092263 Papio anubis 100.00 0.00e+00 1619.00
IUUC-Psi-093554 Pelodiscus sinensis 89.25 0.00e+00 947.00
IUUC-Pab-098598 Pongo abelii 99.79 0.00e+00 1617.00
IUUC-Pca-100157 Procavia capensis 96.15 0.00e+00 996.00
IUUC-Pva-102720 Pteropus vampyrus 97.64 0.00e+00 1578.00
IUUC-Rno-104996 Rattus norvegicus 97.05 0.00e+00 1015.00
IUUC-Sha-107000 Sarcophilus harrisii 94.83 0.00e+00 964.00
IUUC-Sja-107993 Schizosaccharomyces japonicus 45.00 2.00e-12 68.20
IUUC-Spo-108304 Schizosaccharomyces pombe 43.08 8.00e-15 75.90
IUUC-Sar-113349 Sorex araneus 97.07 0.00e+00 941.00
IUUC-Ssc-115723 Sus scrofa 98.26 0.00e+00 1615.00
IUUC-Tgu-116549 Taeniopygia guttata 88.07 0.00e+00 876.00
IUUC-Tsy-118808 Tarsius syrichta 96.08 0.00e+00 1180.00
IUUC-Ttr-128266 Tursiops truncatus 97.85 0.00e+00 1599.00
IUUC-Vpa-130237 Vicugna pacos 98.16 0.00e+00 1654.00
IUUC-Xtr-132589 Xenopus tropicalis 76.33 0.00e+00 710.00
IUUC-Yli-134445 Yarrowia lipolytica 39.06 9.00e-13 68.90
Created Date 25-Jun-2017

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