iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Mpu-066359

Ensembl Protein ID

ENSMPUP00000017978.1

UniProt Accession

M3Z316; M3Z316_MUSPF

Genbank Protein ID

ENSMPUP00000017978

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AEYP01032587

Gene Name

PHIP

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMPUG00000018090.1	ENSMPUT00000018241.1	ENSMPUP00000017978.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	4.40e-35	118.2	9	46
UBD/Beta-Prp	3.20e-52	177.6	108	369

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 1    gHtdsvtclaf.sd.tllvsGsdDgtikvWDlrtgvll 36
           gH +sv+c+ f  + +++ +GsdD+ +k+W +++g+ll
   Q: 9    GHLSSVYCVTFdRTgRRIFTGSDDCLVKIWATDDGRLL 46
           8**********955599*****************9987 PP

UBD/Beta-Prp

   S: 19   spdksllatgsrdgtikvwdvttgkl.....lrsl.sgheaevtavk..fspdgkilvtgseDrtikvw..dlstgkcvhtlkghedsv 97
           s +k++l ++++dgti  w ++ g+l      +++ +   ++v+ ++  fs  g +l+tgs+D++i+v+     +++ ++ l+ h+d+v
   Q: 108  SGSKRYLSSTGADGTICFWLWDAGTLkinprPAKFtERPRPGVQMICssFSAGGMFLATGSTDHIIRVYffGSGQPEKISELEFHTDKV 196
           67899***********999999999988988555547777888765522777888**************777779999*********** PP
   S: 98   lslsfspsgdklvsGshdrtirvwdletgqclee................tlsghdgvvncvvvhpdgnllvsGslDrtvrlWdlktgk 170
            s++fs +++++vsGs+d t+r+w+ + +++ +                  +++++  v++v+++  +n ++++ ++ t+++W++ tg+
   Q: 197  DSIQFSNTSNRFVSGSRDGTARIWQFKRREWKSIlldmatrpagqnlqgiEDKITKMKVTMVAWDRHDNTVITAVNNMTLKVWNSYTGQ 285
           ********************************99***************888899999******************************* PP
   S: 171  llrtltgghtdsvysls...fdsngkelvsgsldgtvklwdlqtgecvrtlnght.....dnvksvrfspnderlvsgssDgsiriW 249
           l++ l g h+d v  l+   fd+  + l s+++dg v++wdl +g  +r++ +         v + + sp++++++++ s+g + i+
   Q: 286  LIHVLMG-HEDEVFVLEphpFDP--RVLFSAGHDGNVIVWDLARGVKIRSYFNMIegqghGAVFDCKCSPDGQHFACTDSHGHLLIF 369
           ******9.*********999999..89******************999998875544445666667777999999999999988887 PP

Organism

Mustela putorius furo

Protein Sequence
(Fasta)

MKMHKRILGH LSSVYCVTFD RTGRRIFTGS DDCLVKIWAT DDGRLLATLR GHAAEISDMA 60
VNYENTMIAA GSCDKMIRVW CLRTCAPLAV LQGHSASITS LQFSPLCSGS KRYLSSTGAD 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGAAAATGC ATAAACGAAT TCTTGGACAC TTGTCATCTG TGTACTGCGT AACTTTTGAT 60
CGAACTGGCA GACGGATATT TACTGTAAGT AATTTTTGAA GTATTATCTT AATTCATATA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0103--Bromodomain
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0677--Repeat
KW-0853--WD repeat

Interpro

IPR001487--Bromodomain
IPR018359--Bromodomain_CS
IPR028738--PHIP
IPR027295--Quinoprotein_ADH-like_fam
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS00633--BROMODOMAIN_1
PS50014--BROMODOMAIN_2
PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF00439--Bromodomain
PF00400--WD40

PRINTS

PR00503--BROMODOMAIN

SMART

SM00297--BROMO
SM00320--WD40

Gene Ontology

GO:0070062--C:extracellular exosome
GO:0007010--P:cytoskeleton organization
GO:0008286--P:insulin receptor signaling pathway
GO:2001237--P:negative regulation of extrinsic apoptotic signaling pathway
GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter
GO:0022604--P:regulation of cell morphogenesis

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002299	Ailuropoda melanoleuca	98.42	0.00e+00	2997.00
IUUC-Apl-003700	Anas platyrhynchos	85.77	0.00e+00	2651.00
IUUC-Aca-004474	Anolis carolinensis	81.54	0.00e+00	2512.00
IUUC-Bta-013125	Bos taurus	96.36	0.00e+00	2916.00
IUUC-Bdi-014797	Brachypodium distachyon	33.40	7.00e-56	213.00
IUUC-Cja-018868	Callithrix jacchus	93.57	0.00e+00	2959.00
IUUC-Cfa-021179	Canis familiaris	98.85	0.00e+00	2926.00
IUUC-Cpo-022077	Cavia porcellus	90.21	0.00e+00	2833.00
IUUC-Csa-023618	Chlorocebus sabaeus	96.30	0.00e+00	2992.00
IUUC-Cho-024794	Choloepus hoffmanni	90.32	0.00e+00	873.00
IUUC-Dno-030048	Dasypus novemcinctus	96.43	0.00e+00	2934.00
IUUC-Dor-030195	Dipodomys ordii	88.02	0.00e+00	1226.00
IUUC-Ete-032748	Echinops telfairi	84.37	0.00e+00	1167.00
IUUC-Eca-034274	Equus caballus	97.45	0.00e+00	2969.00
IUUC-Eeu-034688	Erinaceus europaeus	86.00	0.00e+00	1432.00
IUUC-Fca-035451	Felis catus	97.69	0.00e+00	2893.00
IUUC-Fal-037465	Ficedula albicollis	85.23	0.00e+00	2605.00
IUUC-Gmo-039451	Gadus morhua	68.38	0.00e+00	723.00
IUUC-Gga-040798	Gallus gallus	85.16	0.00e+00	2640.00
IUUC-Gma-043340	Glycine max	34.74	4.00e-65	244.00
IUUC-Ggo-045347	Gorilla gorilla	98.84	0.00e+00	1387.00
IUUC-Hsa-046757	Homo sapiens	96.36	0.00e+00	2966.00
IUUC-Hvu-047706	Hordeum vulgare	31.84	1.00e-37	150.00
IUUC-Itr-048843	Ictidomys tridecemlineatus	92.76	0.00e+00	1173.00
IUUC-Laf-054140	Loxodonta africana	96.37	0.00e+00	3004.00
IUUC-Mcc-055061	Macaca mulatta	96.48	0.00e+00	2999.00
IUUC-Mmr-060837	Microcebus murinus	95.64	0.00e+00	2955.00
IUUC-Mdo-061903	Monodelphis domestica	91.05	0.00e+00	2847.00
IUUC-Mmu-063772	Mus musculus	94.12	0.00e+00	2921.00
IUUC-Mlu-067928	Myotis lucifugus	95.15	0.00e+00	2952.00
IUUC-Nle-070094	Nomascus leucogenys	96.54	0.00e+00	2970.00
IUUC-Opr-070971	Ochotona princeps	74.53	0.00e+00	957.00
IUUC-Oan-073185	Ornithorhynchus anatinus	86.90	0.00e+00	2638.00
IUUC-Ocu-074033	Oryctolagus cuniculus	93.95	0.00e+00	2633.00
IUUC-Ogu-078641	Oryza glumaepatula	24.08	1.00e-29	125.00
IUUC-Oin-079669	Oryza indica	31.13	4.00e-52	199.00
IUUC-Olo-080755	Oryza longistaminata	31.65	2.00e-54	208.00
IUUC-Oni-082991	Oryza nivara	27.78	2.00e-39	159.00
IUUC-Oga-088578	Otolemur garnettii	95.94	0.00e+00	2939.00
IUUC-Oar-090247	Ovis aries	96.66	0.00e+00	2920.00
IUUC-Ptr-091266	Pan troglodytes	96.18	0.00e+00	2948.00
IUUC-Pan-092734	Papio anubis	96.54	0.00e+00	2998.00
IUUC-Pab-098402	Pongo abelii	96.42	0.00e+00	2968.00
IUUC-Pop-099185	Populus trichocarpa	35.52	3.00e-69	258.00
IUUC-Pca-101128	Procavia capensis	85.86	0.00e+00	2638.00
IUUC-Pva-103058	Pteropus vampyrus	96.25	0.00e+00	1598.00
IUUC-Rno-106013	Rattus norvegicus	92.97	0.00e+00	2909.00
IUUC-Sha-107496	Sarcophilus harrisii	91.61	0.00e+00	2858.00
IUUC-Sar-113520	Sorex araneus	91.93	0.00e+00	1549.00
IUUC-Ssc-115461	Sus scrofa	92.97	0.00e+00	2829.00
IUUC-Tgu-116821	Taeniopygia guttata	85.11	0.00e+00	2605.00
IUUC-Tsy-119132	Tarsius syrichta	83.63	0.00e+00	2421.00
IUUC-Tae-123136	Triticum aestivum	32.47	7.00e-59	223.00
IUUC-Tbe-127479	Tupaia belangeri	91.78	0.00e+00	1445.00
IUUC-Ttr-128427	Tursiops truncatus	92.24	0.00e+00	2787.00
IUUC-Vpa-130160	Vicugna pacos	93.27	0.00e+00	2823.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence