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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Hsa-046261
UUCD1 version UUC-HoS-00300
Ensembl Protein ID ENSP00000351789.4
UniProt Accession Q96FA3; Q96SM0; Q9GZY5; Q9HCX0; PELI1_HUMAN
Genbank Protein ID CAC04320.1; AAG15393.1; AAG17451.1; AAH11419.1; AAH50019.1; AAH63611.1; BAB55280.1
Protein Name E3 ubiquitin-protein ligase pellino homolog 1; Pellino-related intracellular-signaling molecule; RING-type E3 ubiquitin transferase pellino homolog 1
Genbank Nucleotide ID AJ278859; AF302505; AF300987; BC011419; BC050019; BC063611; AK027668
Gene Name PELI1; PRISM
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000197329.11 ENST00000358912.4 ENSP00000351789.4
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPA
DNA & RNA Element
UTRdbAREsitecircRNADbCircNet
miRTarBasemicroRNATRANSFACTargetScan
RepTarmiRNAMapmiRcodeRAID2
Protein-protein Interaction
IIDPINAHINTMentha
InWeb_IM
Disease-associated Information
GWASdbGWAS CentralOMIM
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
BioGRIDmUbiSiDa
DNA Methylation
TCGAICGCCOSMIC
Protein Expression/Proteomics
THPAGPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
E3 activity/RING/RING RING 16884718
Classification
Family E-value Score Start End
E3 activity/RING/RING 0.16 14.1 282 337
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 activity/RING/RING
   S: 1    CaiCledf.............kdgplvlpCgHvfhadClqkwpglknssskefrCPlCr 46
           C++ ++ +             k++++ l+CgHv   +  ++w ++     k   CP Cr
   Q: 282  CPVGFNTLafpsmkrkdvvdeKQPWVYLNCGHV---HGYHNWGNKEERDGKDRECPMCR 337
           555555555555555555554556888****98...445689777777788888****8 PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. Involved in the TLR and IL-1 signaling pathways via interaction with the complex containing IRAK kinases and TRAF6. Mediates 'Lys-63'-linked polyubiquitination of IRAK1 allowing subsequent NF-kappa-B activation.
 E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. Involved in the TLR and IL-1 signaling pathways via interaction with the complex containing IRAK kinases and TRAF6. Mediates 'Lys-63'-linked polyubiquitination of IRAK1 allowing subsequent NF-kappa-B activation.
Protein Sequence
(Fasta)
MFSPDQENHP SKAPVKYGEL IVLGYNGSLP NGDRGRRKSR FALFKRPKAN GVKPSTVHIA 60
CTPQAAKAIS NKDQHSISYT LSRAQTVVVE YTHDSNTDMF QIGRSTESPI DFVVTDTVPG 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-046261|E3,RING|Homo sapiens
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Nucleotide Sequence
(Fasta)
GGCTAGACCC CTCCCCTCCT TGCGAGTGTA TGTCAGTGAC CCAGAGGCGG TGTGAGGCGG 60
AGGGACCGTC GGGGGGCGCC GCCGCCGCCT CCACTAGCAG CAGCGGCAGC AGCCCTAGTC 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-046261|E3,RING|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0181--Complete proteome
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0808--Transferase
KW-0832--Ubl conjugation
KW-0833--Ubl conjugation pathway
Interpro

IPR006800--Pellino_fam
IPR013083--Znf_RING/FYVE/PHD
Pfam

PF04710--Pellino
Gene Ontology

GO:0005829--C:cytosol
GO:0005634--C:nucleus
GO:0004674--F:protein serine/threonine kinase activity
GO:0061630--F:ubiquitin protein ligase activity
GO:0034450--F:ubiquitin-ubiquitin ligase activity
GO:0006955--P:immune response
GO:0032088--P:negative regulation of NF-kappaB transcription factor activity
GO:0042130--P:negative regulation of T cell proliferation
GO:0030890--P:positive regulation of B cell proliferation
GO:0001819--P:positive regulation of cytokine production
GO:0043123--P:positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0031398--P:positive regulation of protein ubiquitination
GO:0034141--P:positive regulation of toll-like receptor 3 signaling pathway
GO:0034145--P:positive regulation of toll-like receptor 4 signaling pathway
GO:0070936--P:protein K48-linked ubiquitination
GO:0043331--P:response to dsRNA
GO:0032496--P:response to lipopolysaccharide
GO:0008063--P:Toll signaling pathway
KEGG hsa:57162
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001486 Ailuropoda melanoleuca 100.00 0.00e+00 881.00
IUUC-Apl-003642 Anas platyrhynchos 99.28 0.00e+00 877.00
IUUC-Aca-004878 Anolis carolinensis 97.85 0.00e+00 864.00
IUUC-Ame-011117 Astyanax mexicanus 85.38 0.00e+00 771.00
IUUC-Bta-012657 Bos taurus 99.52 0.00e+00 877.00
IUUC-Bci-013893 Botrytis cinerea 28.89 1.60e-01 30.80
IUUC-Cel-018562 Caenorhabditis elegans 44.36 9.00e-101 360.00
IUUC-Cja-019539 Callithrix jacchus 99.76 0.00e+00 880.00
IUUC-Cfa-020479 Canis familiaris 99.76 0.00e+00 880.00
IUUC-Cpo-021657 Cavia porcellus 99.52 0.00e+00 874.00
IUUC-Csa-023842 Chlorocebus sabaeus 100.00 0.00e+00 881.00
IUUC-Cho-025068 Choloepus hoffmanni 99.43 0.00e+00 739.00
IUUC-Cin-025429 Ciona intestinalis 56.24 3.00e-137 481.00
IUUC-Csv-026180 Ciona savignyi 57.52 1.00e-136 479.00
IUUC-Dre-028217 Danio rerio 89.18 0.00e+00 791.00
IUUC-Dno-029357 Dasypus novemcinctus 80.62 0.00e+00 741.00
IUUC-Dor-030597 Dipodomys ordii 99.52 0.00e+00 879.00
IUUC-Dse-031384 Dothistroma septosporum 25.66 4.00e-03 36.20
IUUC-Ete-032925 Echinops telfairi 99.52 0.00e+00 876.00
IUUC-Eca-034037 Equus caballus 99.76 0.00e+00 879.00
IUUC-Fca-036415 Felis catus 100.00 0.00e+00 881.00
IUUC-Fal-037444 Ficedula albicollis 99.28 0.00e+00 874.00
IUUC-Fox-037816 Fusarium oxysporum 34.04 3.20e-02 32.70
IUUC-Gmo-039248 Gadus morhua 78.55 0.00e+00 692.00
IUUC-Gga-040551 Gallus gallus 99.28 0.00e+00 874.00
IUUC-Gac-041981 Gasterosteus aculeatus 72.13 0.00e+00 654.00
IUUC-Ggo-045270 Gorilla gorilla 100.00 0.00e+00 881.00
IUUC-Itr-047919 Ictidomys tridecemlineatus 100.00 0.00e+00 881.00
IUUC-Kpa-049153 Komagataella pastoris 31.15 1.60e+00 29.60
IUUC-Loc-052528 Lepisosteus oculatus 92.14 0.00e+00 825.00
IUUC-Laf-054201 Loxodonta africana 99.28 0.00e+00 877.00
IUUC-Mga-059547 Meleagris gallopavo 99.04 0.00e+00 875.00
IUUC-Mdo-062133 Monodelphis domestica 99.28 0.00e+00 877.00
IUUC-Mmu-063411 Mus musculus 99.76 0.00e+00 879.00
IUUC-Mac-065171 Musa acuminata 27.69 2.10e-01 29.60
IUUC-Mpu-066566 Mustela putorius furo 100.00 0.00e+00 881.00
IUUC-Mlu-067015 Myotis lucifugus 99.76 0.00e+00 879.00
IUUC-Nle-069510 Nomascus leucogenys 100.00 0.00e+00 881.00
IUUC-Ont-072324 Oreochromis niloticus 87.09 0.00e+00 776.00
IUUC-Oan-073059 Ornithorhynchus anatinus 99.28 0.00e+00 878.00
IUUC-Ocu-073888 Oryctolagus cuniculus 99.70 0.00e+00 706.00
IUUC-Ola-086600 Oryzias latipes 86.15 0.00e+00 769.00
IUUC-Oga-088926 Otolemur garnettii 99.76 0.00e+00 880.00
IUUC-Oar-089559 Ovis aries 100.00 0.00e+00 880.00
IUUC-Ptr-090954 Pan troglodytes 99.52 0.00e+00 876.00
IUUC-Pan-092719 Papio anubis 100.00 0.00e+00 881.00
IUUC-Psi-093982 Pelodiscus sinensis 99.04 0.00e+00 873.00
IUUC-Pno-095123 Phaeosphaeria nodorum 32.69 3.60e-02 32.30
IUUC-Pfo-097047 Poecilia formosa 88.26 0.00e+00 784.00
IUUC-Pab-097906 Pongo abelii 100.00 0.00e+00 881.00
IUUC-Pca-101126 Procavia capensis 98.48 0.00e+00 813.00
IUUC-Rno-105984 Rattus norvegicus 99.76 0.00e+00 879.00
IUUC-Sar-112939 Sorex araneus 99.50 0.00e+00 843.00
IUUC-Ssc-115320 Sus scrofa 100.00 0.00e+00 880.00
IUUC-Tgu-116492 Taeniopygia guttata 98.80 0.00e+00 874.00
IUUC-Tru-118750 Takifugu rubripes 86.62 0.00e+00 766.00
IUUC-Tsy-119254 Tarsius syrichta 100.00 0.00e+00 845.00
IUUC-Tni-119865 Tetraodon nigroviridis 87.44 0.00e+00 728.00
IUUC-Tre-122231 Trichoderma reesei 34.00 1.60e-01 30.80
IUUC-Tae-124278 Triticum aestivum 31.73 2.20e-02 34.30
IUUC-Tbe-127454 Tupaia belangeri 91.87 0.00e+00 800.00
IUUC-Ttr-129040 Tursiops truncatus 99.52 0.00e+00 876.00
IUUC-Vpa-130078 Vicugna pacos 99.76 0.00e+00 874.00
IUUC-Xtr-131992 Xenopus tropicalis 97.13 0.00e+00 860.00
Created Date 25-Jun-2017

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