iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSXETG00000015806.3	ENSXETT00000034467.2	ENSXETP00000034467.2
ENSXETG00000015806.3	ENSXETT00000034468.2	ENSXETP00000034468.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	7.40e-120	400.5	999	1330

Active Site

Position(s)	Description	Evidence
1298	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 3    sdlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlld 89
           + ++++l+++fvgEegld++G++ref++lls+el+np++glf+ys+nd++t+q++p s +  ++hl  F+f Gr+lg+al ++ lld
   Q: 999  ELQRNKLYITFVGEEGLDYSGPSREFFFLLSQELFNPYYGLFEYSANDTYTVQISPMSAFV-ENHL-EFRFSGRILGLALIHQYLLD 1083
           567899****************************************************985.3666.59****************** PP
   S: 90   lplsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvkl 176
           ++++++fyk ll+ +++l+dle +d+e+++sl+++k+n   di+++ ldltf+v+ee++g+++e+eLk+gG+ni+V ++Nk+eY+++
   Q: 1084 AFFTRPFYKALLRLPCDLSDLEYLDEEFHQSLQWMKDN---DITDI-LDLTFTVNEEVFGQVTERELKSGGANIQVSEKNKKEYIEK 1166
           ************************************99...9***9.**************************************** PP
   S: 177  vveyrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerka 263
           +v++r+++g+ +q+ea+ +Gf+ev++ +l+s+F+++elel+i G++eid++d++++t+y+ggy++ + +i+wFw ++e+f++e+r +
   Q: 1167 MVKWRVERGVVQQTEALVRGFYEVVDSRLVSVFDARELELVIAGTAEIDLNDWRNNTEYRGGYHDGHIVIRWFWAAVERFNNEQRLR 1253
           *************************************************************************************** PP
   S: 264  fLqFvTgssrlPlgGfaelk....prlfvirkdasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFels 336
           +LqFvTg+s++P +Gfa+l+     r+f+i+k+++ ++lP+++TCfn+L+LP+Y+s++ l+ekLl+A+eet+ F+l+
   Q: 1254 LLQFVTGTSSVPYEGFAALRgsngLRRFCIEKWGKITSLPRAHTCFNRLDLPPYPSYSMLHEKLLIAVEETSTFGLE 1330
           ************************999***********************************************985 PP

Organism

Xenopus tropicalis

Protein Sequence
(Fasta)

LFSFVSLPTD VLEIEVKDKF AKSRPIIKRF LGKLSMPVQR LLERHAIGDR VVSYTLGRRL 60
PTDHVSGQLQ FRFEITSSIH PDDEEISVSS DTVPGTASAS PLHNTNEETP IESQRRASVA 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CTTTTCAGTT TTGTCTCCCT TCCAACTGAC GTATTGGAAA TTGAAGTAAA GGATAAATTT 60
GCCAAAAGCC GTCCAATCAT CAAACGATTT TTGGGAAAGC TCTCTATGCC AGTACAGCGC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000008--C2_dom
IPR000569--HECT_dom
IPR001202--WW_dom

PROSITE

PS50237--HECT
PS01159--WW_DOMAIN_1
PS50020--WW_DOMAIN_2

Pfam

PF00632--HECT
PF00397--WW

SMART

SM00119--HECTc
SM00456--WW

Gene Ontology

GO:0004842--F:ubiquitin-protein transferase activity

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001636	Ailuropoda melanoleuca	80.84	0.00e+00	1638.00
IUUC-Apl-003299	Anas platyrhynchos	78.34	0.00e+00	1951.00
IUUC-Aca-005024	Anolis carolinensis	77.69	0.00e+00	1934.00
IUUC-Ame-010893	Astyanax mexicanus	75.73	0.00e+00	1128.00
IUUC-Bta-012604	Bos taurus	80.74	0.00e+00	1677.00
IUUC-Cel-018137	Caenorhabditis elegans	42.55	9.00e-90	324.00
IUUC-Cja-019880	Callithrix jacchus	71.33	0.00e+00	1755.00
IUUC-Cfa-021216	Canis familiaris	80.40	0.00e+00	1656.00
IUUC-Cpo-021466	Cavia porcellus	88.50	0.00e+00	1588.00
IUUC-Csa-023080	Chlorocebus sabaeus	75.54	0.00e+00	1855.00
IUUC-Cho-024740	Choloepus hoffmanni	89.61	0.00e+00	1113.00
IUUC-Csv-026127	Ciona savignyi	70.31	2.00e-148	518.00
IUUC-Dre-028750	Danio rerio	72.11	0.00e+00	1541.00
IUUC-Dno-030019	Dasypus novemcinctus	81.95	0.00e+00	1703.00
IUUC-Dor-031030	Dipodomys ordii	69.60	0.00e+00	1074.00
IUUC-Dme-032217	Drosophila melanogaster	69.32	0.00e+00	634.00
IUUC-Ete-032352	Echinops telfairi	91.04	0.00e+00	1229.00
IUUC-Eca-033948	Equus caballus	80.95	0.00e+00	1636.00
IUUC-Eeu-034474	Erinaceus europaeus	67.98	0.00e+00	818.00
IUUC-Fca-036148	Felis catus	81.80	0.00e+00	1670.00
IUUC-Fal-036957	Ficedula albicollis	78.30	0.00e+00	1951.00
IUUC-Gmo-038714	Gadus morhua	64.09	0.00e+00	1055.00
IUUC-Gga-041194	Gallus gallus	78.25	0.00e+00	1960.00
IUUC-Gac-041366	Gasterosteus aculeatus	71.74	0.00e+00	1435.00
IUUC-Ggo-045442	Gorilla gorilla	66.28	0.00e+00	1616.00
IUUC-Hsa-045730	Homo sapiens	74.06	0.00e+00	1858.00
IUUC-Itr-048439	Ictidomys tridecemlineatus	82.22	0.00e+00	1711.00
IUUC-Lch-050185	Latimeria chalumnae	77.50	0.00e+00	1431.00
IUUC-Loc-052744	Lepisosteus oculatus	73.58	0.00e+00	1767.00
IUUC-Laf-054368	Loxodonta africana	92.52	0.00e+00	1435.00
IUUC-Mcc-055487	Macaca mulatta	74.30	0.00e+00	1857.00
IUUC-Meu-056751	Macropus eugenii	90.03	0.00e+00	715.00
IUUC-Mga-059545	Meleagris gallopavo	78.20	0.00e+00	1953.00
IUUC-Mmr-061078	Microcebus murinus	80.31	0.00e+00	1624.00
IUUC-Mdo-062176	Monodelphis domestica	80.49	0.00e+00	1645.00
IUUC-Mmu-063513	Mus musculus	80.75	0.00e+00	1637.00
IUUC-Mpu-065786	Mustela putorius furo	82.17	0.00e+00	1693.00
IUUC-Mlu-067780	Myotis lucifugus	74.84	0.00e+00	1476.00
IUUC-Nle-069213	Nomascus leucogenys	82.42	0.00e+00	1708.00
IUUC-Opr-070208	Ochotona princeps	92.02	0.00e+00	1431.00
IUUC-Ont-072132	Oreochromis niloticus	76.31	0.00e+00	1364.00
IUUC-Oan-072807	Ornithorhynchus anatinus	84.21	0.00e+00	1710.00
IUUC-Ocu-074745	Oryctolagus cuniculus	74.26	0.00e+00	1823.00
IUUC-Ola-086981	Oryzias latipes	74.23	0.00e+00	1499.00
IUUC-Oga-087965	Otolemur garnettii	82.70	0.00e+00	1656.00
IUUC-Oar-089749	Ovis aries	80.52	0.00e+00	1671.00
IUUC-Ptr-091243	Pan troglodytes	75.31	0.00e+00	1858.00
IUUC-Pan-092201	Papio anubis	75.35	0.00e+00	1858.00
IUUC-Psi-093511	Pelodiscus sinensis	77.49	0.00e+00	1892.00
IUUC-Pfo-097001	Poecilia formosa	67.31	0.00e+00	1648.00
IUUC-Pab-098728	Pongo abelii	71.61	0.00e+00	1744.00
IUUC-Pca-100129	Procavia capensis	75.55	0.00e+00	1172.00
IUUC-Pva-102250	Pteropus vampyrus	69.33	0.00e+00	1650.00
IUUC-Rno-105031	Rattus norvegicus	73.36	0.00e+00	1797.00
IUUC-Sha-106985	Sarcophilus harrisii	65.34	0.00e+00	1202.00
IUUC-Sar-113505	Sorex araneus	74.59	0.00e+00	1184.00
IUUC-Ssc-115534	Sus scrofa	88.40	0.00e+00	674.00
IUUC-Tgu-117515	Taeniopygia guttata	78.08	0.00e+00	1951.00
IUUC-Tru-117914	Takifugu rubripes	76.41	0.00e+00	1375.00
IUUC-Tsy-119379	Tarsius syrichta	76.89	0.00e+00	769.00
IUUC-Tni-120178	Tetraodon nigroviridis	76.57	0.00e+00	1396.00
IUUC-Tbe-127762	Tupaia belangeri	77.59	0.00e+00	1546.00
IUUC-Ttr-128806	Tursiops truncatus	84.78	0.00e+00	1580.00
IUUC-Vpa-130812	Vicugna pacos	78.17	8.00e-171	594.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence