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Basic Information Integrated Annotations

Tag Content
iUUCD ID IUUC-Hsa-046345
UUCD1 version UUC-HoS-00032
Ensembl Protein ID ENSP00000348299.4
UniProt Accession O60858; B2RB49; Q5UBW0; Q5W0U8; Q5W0U9; Q9BQ47; Q9C021; TRI13_HUMAN
Genbank Protein ID CAA12136.1; AAK13059.1; AAG53500.1; AAG53501.1; AAO38979.1; AAK51624.1; AAF91315.1; AAR31110.1; AAV51406.1; BAG37096.1; CAC43391.1; CAH72825.1; CAH72826.1; EAX08844.1; EAX08845.1; AAH03579.1; AAH63407.1
Protein Name E3 ubiquitin-protein ligase TRIM13; B-cell chronic lymphocytic leukemia tumor suppressor Leu5; Leukemia-associated protein 5; Putative tumor suppressor RFP2; RING finger protein 77; RING-type E3 ubiquitin transferase TRIM13; Ret finger protein 2; Tripartite motif-containing protein 13
Genbank Nucleotide ID AJ224819; AF279660; AF220127; AF220128; AY191002; AF241849; AF241850; AY455758; AY764035; AK314496; AL137060; AL137060; AL137060; CH471075; CH471075; BC003579; BC063407
Gene Name TRIM13; LEU5; RFP2; RNF77
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000204977.9 ENST00000356017.8 ENSP00000348299.4
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPM
DNA & RNA Element
UTRdbAREsitecircBaseCircNet
miRTarBasemicroRNATRANSFACRepTar
miRcodeRAID2
Protein-protein Interaction
IIDPINAHINTMentha
InWeb_IM
Disease-associated Information
OMIM
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
BioGRIDmUbiSiDa
Protein Expression/Proteomics
THPAHPMGPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
E3 activity/RING/RING RING 18248090; 21333377; 20100910; 17314412
Classification
Family E-value Score Start End
E3 activity/RING/RING 6.80e-08 34.6 13 61
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 activity/RING/RING

   S: 1    CaiCledfkdgplvlpCgHvfhadClqkw....pglknssskefrCPlCr 46
    C+iC++ f+d p+vlpC H f+++Cl+ + + + f+CP+Cr
   Q: 13 CPICCSLFDD-PRVLPCSHNFCKKCLEGIlegsVRNSLWRPAPFKCPTCR 61
    ********99.**************97776666666666999999****8 PP
   

Organism Homo sapiens
Functional Description
(View)

Functional Description



     E3 ubiquitin ligase involved in the retrotranslocation and turnover of membrane and secretory proteins from the ER through a set of processes named ER-associated degradation (ERAD). This process acts on misfolded proteins as well as in the regulated degradation of correctly folded proteins. Enhances ionizing radiation-induced p53/TP53 stability and apoptosis via ubiquitinating MDM2 and AKT1 and decreasing AKT1 kinase activity through MDM2 and AKT1 proteasomal degradation. Regulates ER stress-induced autophagy, and may act as a tumor suppressor.
E3 ubiquitin ligase involved in the retrotranslocation and turnover of membrane and secretory proteins from the ER through a set of processes named ER-associated degradation (ERAD). This process acts on misfolded proteins as well as in the regulated degradation of correctly folded proteins. Enhances ionizing radiation-induced p53/TP53 stability and apoptosis via ubiquitinating MDM2 and AKT1 and decreasing AKT1 kinase activity through MDM2 and AKT1 proteasomal degradation. Regulates ER stress-induced autophagy, and may act as a tumor suppressor.
Protein Sequence
(Fasta)
MDVMELLEED LTCPICCSLF DDPRVLPCSH NFCKKCLEGI LEGSVRNSLW RPAPFKCPTC 60
RKETSATGIN SLQVNYSLKG IVEKYNKIKI SPKMPVCKGH LGQPLNIFCL TDMQLICGIC 120
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Protein Fasta Sequence



>IUUC-Hsa-046345|E3,RING|Homo sapiens
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Nucleotide Sequence
(Fasta)
ACTTCTCCCA AGATCGTAAA TTCTGGAGGA GCCATTCCTT CATCATCCAT GTTTGCATCC 60
TTCACACCGT TCACTGGTTA AGTGCTTAGT ACGTTTGCTA TTGGGCAAGG TCCTCAAACG 120
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Nucleotide Fasta Sequence



>IUUC-Hsa-046345|E3,RING|Homo sapiens
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Sequence Source Ensembl
Keyword

KW-0025--Alternative splicing
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0256--Endoplasmic reticulum
KW-0472--Membrane
KW-0479--Metal-binding
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0808--Transferase
KW-0812--Transmembrane
KW-1133--Transmembrane helix
KW-0832--Ubl conjugation
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR027370--Znf-RING_LisH
IPR000315--Znf_B-box
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS

PROSITE

PS50119--ZF_BBOX
PS00518--ZF_RING_1
PS50089--ZF_RING_2

Pfam

PF00643--zf-B_box
PF13445--zf-RING_UBOX

SMART

SM00336--BBOX
SM00184--RING

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005789--C:endoplasmic reticulum membrane
GO:0044322--C:endoplasmic reticulum quality control compartment
GO:0016021--C:integral component of membrane
GO:0097038--C:perinuclear endoplasmic reticulum
GO:0004871--F:signal transducer activity
GO:1904264--F:ubiquitin protein ligase activity involved in ERAD pathway
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0009653--P:anatomical structure morphogenesis
GO:1904380--P:endoplasmic reticulum mannose trimming
GO:0045087--P:innate immune response
GO:1902187--P:negative regulation of viral release from host cell
GO:0032897--P:negative regulation of viral transcription
GO:0010942--P:positive regulation of cell death
GO:0043123--P:positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0016239--P:positive regulation of macroautophagy
GO:0051092--P:positive regulation of NF-kappaB transcription factor activity
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0051865--P:protein autoubiquitination
GO:0010332--P:response to gamma radiation
GO:0030433--P:ubiquitin-dependent ERAD pathway

KEGG hsa:10206
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-002269 Ailuropoda melanoleuca 92.67 0.00e+00 743.00
IUUC-Apl-004168 Anas platyrhynchos 76.23 0.00e+00 635.00
IUUC-Aca-004395 Anolis carolinensis 70.10 3.00e-165 574.00
IUUC-Ame-011325 Astyanax mexicanus 46.44 3.00e-68 252.00
IUUC-Bta-012613 Bos taurus 92.63 0.00e+00 738.00
IUUC-Cja-018856 Callithrix jacchus 96.58 0.00e+00 798.00
IUUC-Cfa-021019 Canis familiaris 92.18 0.00e+00 736.00
IUUC-Cpo-021845 Cavia porcellus 92.14 0.00e+00 728.00
IUUC-Csa-023380 Chlorocebus sabaeus 97.54 0.00e+00 761.00
IUUC-Cho-024733 Choloepus hoffmanni 83.26 2.00e-89 323.00
IUUC-Dre-028675 Danio rerio 59.80 4.00e-109 388.00
IUUC-Dno-030018 Dasypus novemcinctus 90.44 0.00e+00 720.00
IUUC-Dor-030599 Dipodomys ordii 89.14 3.00e-126 444.00
IUUC-Dse-031522 Dothistroma septosporum 35.53 2.00e-06 46.60
IUUC-Ete-033134 Echinops telfairi 88.29 0.00e+00 728.00
IUUC-Eca-033931 Equus caballus 93.64 0.00e+00 738.00
IUUC-Eeu-034903 Erinaceus europaeus 90.46 0.00e+00 722.00
IUUC-Fca-035642 Felis catus 92.87 0.00e+00 734.00
IUUC-Fal-037108 Ficedula albicollis 76.72 0.00e+00 639.00
IUUC-Gga-040903 Gallus gallus 74.50 2.00e-177 615.00
IUUC-Ggo-044635 Gorilla gorilla 99.51 0.00e+00 772.00
IUUC-Itr-048220 Ictidomys tridecemlineatus 90.98 0.00e+00 704.00
IUUC-Lch-050599 Latimeria chalumnae 61.14 7.00e-138 483.00
IUUC-Loc-052378 Lepisosteus oculatus 64.71 3.00e-119 421.00
IUUC-Laf-053332 Loxodonta africana 91.67 0.00e+00 728.00
IUUC-Mcc-054705 Macaca mulatta 96.83 0.00e+00 765.00
IUUC-Meu-056825 Macropus eugenii 83.66 0.00e+00 697.00
IUUC-Mga-059528 Meleagris gallopavo 75.25 0.00e+00 629.00
IUUC-Mmr-060688 Microcebus murinus 94.13 0.00e+00 742.00
IUUC-Mdo-061882 Monodelphis domestica 82.89 0.00e+00 701.00
IUUC-Mmu-064352 Mus musculus 88.94 0.00e+00 742.00
IUUC-Mpu-066712 Mustela putorius furo 92.08 0.00e+00 679.00
IUUC-Mlu-068093 Myotis lucifugus 90.66 0.00e+00 719.00
IUUC-Nle-069310 Nomascus leucogenys 98.53 0.00e+00 763.00
IUUC-Ont-071759 Oreochromis niloticus 58.96 7.00e-110 390.00
IUUC-Oan-073673 Ornithorhynchus anatinus 80.73 0.00e+00 682.00
IUUC-Ocu-074192 Oryctolagus cuniculus 91.69 0.00e+00 740.00
IUUC-Ola-087424 Oryzias latipes 58.44 4.00e-108 384.00
IUUC-Oga-088808 Otolemur garnettii 93.37 0.00e+00 743.00
IUUC-Oar-089553 Ovis aries 92.67 0.00e+00 741.00
IUUC-Ptr-090518 Pan troglodytes 99.27 0.00e+00 769.00
IUUC-Pan-092781 Papio anubis 96.58 0.00e+00 761.00
IUUC-Psi-093914 Pelodiscus sinensis 75.79 0.00e+00 626.00
IUUC-Ppa-095862 Physcomitrella patens 37.33 6.00e-06 44.30
IUUC-Pfo-096346 Poecilia formosa 57.32 1.00e-108 386.00
IUUC-Pca-100914 Procavia capensis 89.51 0.00e+00 741.00
IUUC-Pva-102728 Pteropus vampyrus 92.42 0.00e+00 734.00
IUUC-Rno-105922 Rattus norvegicus 87.47 0.00e+00 685.00
IUUC-Sha-107124 Sarcophilus harrisii 83.86 0.00e+00 710.00
IUUC-Sar-113607 Sorex araneus 88.26 0.00e+00 704.00
IUUC-Ssc-116355 Sus scrofa 93.12 0.00e+00 741.00
IUUC-Tgu-116476 Taeniopygia guttata 76.96 0.00e+00 637.00
IUUC-Tru-118737 Takifugu rubripes 59.93 3.00e-112 398.00
IUUC-Tsy-118908 Tarsius syrichta 93.64 0.00e+00 749.00
IUUC-Tbe-127258 Tupaia belangeri 94.87 0.00e+00 753.00
IUUC-Vpa-130138 Vicugna pacos 91.93 0.00e+00 741.00
IUUC-Xtr-132100 Xenopus tropicalis 59.56 4.00e-136 477.00
Created Date 25-Jun-2017

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