iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMMUG00000013069.3	ENSMMUT00000018336.3	ENSMMUP00000017167.2
ENSMMUG00000013069.3	ENSMMUT00000058147.1	ENSMMUP00000058692.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E2/UBC	5.80e-50	169.8	59	194

Active Site

Position(s)	Description	Evidence
139	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00388}

Domain Profile

E2/UBC

   S: 1    RlkkelkelekdppegisakpvdesdltewevlilGpedtpYeggvFkleiefpedYPfkPPkvkfltkifhPnvyenGkvClsilkee 89
           R++kel+e++ dpp+++sa+p+ + +++ew+ +ilGp++++YeggvF l+i+f++dYPfkPPkv+f t+i+h+n++++G +Cl+ilk  
   Q: 59   RIQKELAEITLDPPPNCSAGPKGD-NIYEWRSTILGPPGSVYEGGVFFLDITFSPDYPFKPPKVTFRTRIYHCNINSQGVICLDILK-- 144
           9***********************.9************************************************************9.. PP
   S: 90   ekWspalsvesvllsiqsllaepnpesplneeaaellkknreeykkkvre 139
           ++Wspal++++vllsi+sll+++np++pl  ++a+++ +nr+e+++++r+
   Q: 145  DNWSPALTISKVLLSICSLLTDCNPADPLVGSIATQYMTNRAEHDRMARQ 194
           *********************************************99985 PP

Organism

Macaca mulatta

Protein Sequence
(Fasta)

MSTEAQRVDD SPSTSGGSSD GDQRESVQQE PEREQVQPKK KEGKISSKTA AKLSTSAKRI 60
QKELAEITLD PPPNCSAGPK GDNIYEWRST ILGPPGSVYE GGVFFLDITF SPDYPFKPPK 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGTCCACTG AGGCACAAAG AGTTGATGAC AGTCCAAGCA CTAGTGGAGG AAGTTCCGAT 60
GGAGATCAAC GTGAAAGTGT TCAGCAAGAA CCAGAAAGAG AACAAGTTCA GCCCAAGAAA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0547--Nucleotide-binding
KW-1185--Reference proteome
KW-0833--Ubl conjugation pathway

Interpro

IPR000608--UBQ-conjugat_E2
IPR023313--UBQ-conjugating_AS
IPR016135--UBQ-conjugating_enzyme/RWD

PROSITE

PS00183--UBIQUITIN_CONJUGAT_1
PS50127--UBIQUITIN_CONJUGAT_2

Pfam

PF00179--UQ_con

Gene Ontology

GO:0005524--F:ATP binding
GO:0042296--F:ISG15 transferase activity
GO:0061631--F:ubiquitin conjugating enzyme activity
GO:0006974--P:cellular response to DNA damage stimulus
GO:0032020--P:ISG15-protein conjugation
GO:1900087--P:positive regulation of G1/S transition of mitotic cell cycle
GO:0070979--P:protein K11-linked ubiquitination
GO:0070936--P:protein K48-linked ubiquitination
GO:0070534--P:protein K63-linked ubiquitination

KEGG

mcc:699101

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001532	Ailuropoda melanoleuca	95.48	3.00e-88	317.00
IUUC-Aca-005044	Anolis carolinensis	98.01	1.00e-97	348.00
IUUC-Ame-011419	Astyanax mexicanus	95.80	1.00e-82	298.00
IUUC-Cja-019311	Callithrix jacchus	95.48	4.00e-88	317.00
IUUC-Cfa-020017	Canis familiaris	95.48	4.00e-88	317.00
IUUC-Cpo-022266	Cavia porcellus	95.48	4.00e-88	317.00
IUUC-Cre-022791	Chlamydomonas reinhardtii	80.13	1.00e-71	261.00
IUUC-Csa-023538	Chlorocebus sabaeus	95.48	4.00e-88	317.00
IUUC-Cho-024986	Choloepus hoffmanni	89.55	8.00e-87	312.00
IUUC-Csv-025982	Ciona savignyi	84.52	2.00e-80	291.00
IUUC-Dno-029130	Dasypus novemcinctus	100.00	1.00e-74	271.00
IUUC-Dor-030450	Dipodomys ordii	97.27	2.00e-62	230.00
IUUC-Dme-032042	Drosophila melanogaster	87.65	2.00e-84	305.00
IUUC-Ete-032397	Echinops telfairi	89.71	4.00e-92	330.00
IUUC-Fca-035425	Felis catus	99.50	3.00e-85	307.00
IUUC-Fal-037043	Ficedula albicollis	98.51	2.00e-85	308.00
IUUC-Gmo-039645	Gadus morhua	91.13	7.00e-92	329.00
IUUC-Gga-040236	Gallus gallus	100.00	4.00e-85	306.00
IUUC-Gac-041661	Gasterosteus aculeatus	91.54	3.00e-91	327.00
IUUC-Ggo-045507	Gorilla gorilla	95.48	4.00e-88	317.00
IUUC-Hsa-046767	Homo sapiens	100.00	6.00e-86	309.00
IUUC-Lch-050322	Latimeria chalumnae	87.43	1.00e-89	321.00
IUUC-Loc-052673	Lepisosteus oculatus	94.53	2.00e-94	337.00
IUUC-Laf-054313	Loxodonta africana	95.48	4.00e-88	317.00
IUUC-Meu-056590	Macropus eugenii	97.89	3.00e-83	299.00
IUUC-Mmr-060629	Microcebus murinus	100.00	6.00e-86	309.00
IUUC-Mmu-063733	Mus musculus	99.50	2.00e-99	354.00
IUUC-Mpu-065698	Mustela putorius furo	90.29	6.00e-93	332.00
IUUC-Mlu-067897	Myotis lucifugus	99.50	6.00e-86	309.00
IUUC-Nle-069421	Nomascus leucogenys	100.00	6.00e-86	309.00
IUUC-Ont-071325	Oreochromis niloticus	92.04	4.00e-92	330.00
IUUC-Oan-073704	Ornithorhynchus anatinus	100.00	1.00e-74	270.00
IUUC-Ocu-074055	Oryctolagus cuniculus	95.48	4.00e-88	317.00
IUUC-Ola-086636	Oryzias latipes	95.80	3.00e-82	297.00
IUUC-Oga-088863	Otolemur garnettii	95.48	4.00e-88	317.00
IUUC-Oar-089803	Ovis aries	90.29	6.00e-93	332.00
IUUC-Ptr-090914	Pan troglodytes	95.48	4.00e-88	317.00
IUUC-Pan-092786	Papio anubis	95.48	4.00e-88	317.00
IUUC-Psi-093923	Pelodiscus sinensis	95.48	4.00e-88	317.00
IUUC-Pma-094642	Petromyzon marinus	93.65	1.00e-70	257.00
IUUC-Pfo-096966	Poecilia formosa	95.80	5.00e-82	296.00
IUUC-Pab-098017	Pongo abelii	100.00	6.00e-86	309.00
IUUC-Pva-102561	Pteropus vampyrus	99.50	6.00e-86	309.00
IUUC-Rno-105518	Rattus norvegicus	91.81	3.00e-92	330.00
IUUC-Sha-106897	Sarcophilus harrisii	97.90	6.00e-84	302.00
IUUC-Ssc-116298	Sus scrofa	95.92	4.00e-84	303.00
IUUC-Tgu-116958	Taeniopygia guttata	97.99	5.00e-87	313.00
IUUC-Tru-118527	Takifugu rubripes	95.77	1.00e-81	295.00
IUUC-Tni-120349	Tetraodon nigroviridis	95.10	3.00e-81	293.00
IUUC-Ttr-128358	Tursiops truncatus	100.00	6.00e-86	309.00
IUUC-Vpa-130232	Vicugna pacos	98.58	5.00e-81	293.00
IUUC-Xtr-132547	Xenopus tropicalis	97.93	5.00e-85	306.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence