iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Mpu-066889

Ensembl Protein ID

ENSMPUP00000010427.1

UniProt Accession

M3YGH0; M3YGH0_MUSPF

Genbank Protein ID

ENSMPUP00000010427

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AEYP01069257

Gene Name

TRIM21

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMPUG00000010504.1	ENSMPUT00000010595.1	ENSMPUP00000010427.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/RING/U-box	8.70e-08	32.1	12	75
E3 activity/RING/RING	8.40e-08	32.6	16	55

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/U-box

   S: 4    eeflCpIslelMrdPvvlpsGitydrssIekwlasggktcPvtrqplteedlvPnltlrrliqa 67
           ee  CpI l++M +P+ + +G+ +  ++I +  ++gg  cPv+++ +  ++l Pn  l +++++
   Q: 12   EEVTCPICLDPMVEPMSIDCGHNFCHECISEVGKDGGGVCPVCKHNFLLQNLRPNWPLANMVDN 75
           6889***************************9999999*****************988887765 PP

E3 activity/RING/RING

   S: 1    CaiCledfkdgplvlpCgHvfhadClqkwpglknssskefrCPlCr 46
           C+iCl+++ + p++ +CgH f+++C+  +      + +   CP+C+
   Q: 16   CPICLDPMVE-PMSIDCGHNFCHECISEV-----GKDGGGVCPVCK 55
           *********9.***************999.....7889999****6 PP

Organism

Mustela putorius furo

Protein Sequence
(Fasta)

MASVAPLAMM WEEVTCPICL DPMVEPMSID CGHNFCHECI SEVGKDGGGV CPVCKHNFLL 60
QNLRPNWPLA NMVDNLKQMA QSAKEDTQGD RCKVHGEKLH LFCEEDGKTL CWVCSQSQRH 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CGCCTCTGAC GGGAAATCGA AAGTGAAATA GGCAACTTGC CGCCAGCTGG TGAGTACCCT 60
TAAAAGGTAA GTGACTTGCC CCGACCCTAG TGGCCCAGAA ACAGGGGGAC CTCTTTCCCC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0479--Metal-binding
KW-1185--Reference proteome
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001870--B30.2/SPRY
IPR003879--Butyrophylin
IPR013320--ConA-like_dom
IPR006574--PRY
IPR003877--SPRY_dom
IPR000315--Znf_B-box
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS

PROSITE

PS50188--B302_SPRY
PS50119--ZF_BBOX
PS00518--ZF_RING_1
PS50089--ZF_RING_2

Pfam

PF13765--PRY
PF00622--SPRY
PF00643--zf-B_box

PRINTS

PR01407--BUTYPHLNCDUF

SMART

SM00336--BBOX
SM00589--PRY
SM00184--RING
SM00449--SPRY

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005654--C:nucleoplasm
GO:0019005--C:SCF ubiquitin ligase complex
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0032088--P:negative regulation of NF-kappaB transcription factor activity
GO:0090086--P:negative regulation of protein deubiquitination
GO:1902187--P:negative regulation of viral release from host cell
GO:0032897--P:negative regulation of viral transcription
GO:0010508--P:positive regulation of autophagy
GO:0045787--P:positive regulation of cell cycle
GO:0051091--P:positive regulation of sequence-specific DNA binding transcription factor activity
GO:0046598--P:positive regulation of viral entry into host cell
GO:0051865--P:protein autoubiquitination
GO:0031648--P:protein destabilization
GO:0006513--P:protein monoubiquitination
GO:0000209--P:protein polyubiquitination
GO:0070206--P:protein trimerization
GO:0034341--P:response to interferon-gamma

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001896	Ailuropoda melanoleuca	92.09	0.00e+00	904.00
IUUC-Ang-009772	Aspergillus niger	38.57	4.00e-08	50.80
IUUC-Bta-013083	Bos taurus	71.80	0.00e+00	678.00
IUUC-Cja-019002	Callithrix jacchus	75.85	0.00e+00	728.00
IUUC-Cfa-020415	Canis familiaris	83.12	0.00e+00	818.00
IUUC-Cpo-021948	Cavia porcellus	69.87	0.00e+00	671.00
IUUC-Csa-023135	Chlorocebus sabaeus	76.50	0.00e+00	676.00
IUUC-Cho-024493	Choloepus hoffmanni	66.20	6.00e-99	353.00
IUUC-Dno-030061	Dasypus novemcinctus	71.00	0.00e+00	697.00
IUUC-Ete-033168	Echinops telfairi	67.16	3.00e-166	577.00
IUUC-Eca-033578	Equus caballus	76.87	0.00e+00	737.00
IUUC-Eeu-034749	Erinaceus europaeus	55.51	4.00e-132	464.00
IUUC-Fca-035468	Felis catus	80.00	0.00e+00	776.00
IUUC-Ggo-045190	Gorilla gorilla	76.07	0.00e+00	705.00
IUUC-Hsa-046583	Homo sapiens	76.50	0.00e+00	708.00
IUUC-Itr-048632	Ictidomys tridecemlineatus	72.77	0.00e+00	672.00
IUUC-Laf-053455	Loxodonta africana	74.22	0.00e+00	677.00
IUUC-Mcc-054609	Macaca mulatta	76.28	0.00e+00	673.00
IUUC-Mtr-058638	Medicago truncatula	44.90	8.00e-09	53.90
IUUC-Mmr-061369	Microcebus murinus	72.14	1.00e-177	615.00
IUUC-Mmu-063166	Mus musculus	69.41	0.00e+00	640.00
IUUC-Mlu-067647	Myotis lucifugus	77.94	0.00e+00	698.00
IUUC-Nle-069567	Nomascus leucogenys	75.21	0.00e+00	697.00
IUUC-Opr-071178	Ochotona princeps	66.03	1.00e-174	605.00
IUUC-Oar-090413	Ovis aries	75.70	0.00e+00	695.00
IUUC-Ptr-091187	Pan troglodytes	76.50	0.00e+00	708.00
IUUC-Pan-092231	Papio anubis	76.28	0.00e+00	672.00
IUUC-Pfo-096972	Poecilia formosa	32.11	6.00e-64	238.00
IUUC-Pab-098079	Pongo abelii	72.24	8.00e-141	493.00
IUUC-Pca-100639	Procavia capensis	72.42	1.00e-147	516.00
IUUC-Pva-102476	Pteropus vampyrus	77.56	0.00e+00	742.00
IUUC-Rno-105054	Rattus norvegicus	68.45	1.00e-164	572.00
IUUC-Sar-113204	Sorex araneus	73.09	0.00e+00	654.00
IUUC-Ssc-116291	Sus scrofa	75.43	0.00e+00	708.00
IUUC-Tsy-118803	Tarsius syrichta	72.89	3.00e-128	451.00
IUUC-Tbe-127337	Tupaia belangeri	60.78	6.00e-105	373.00
IUUC-Ttr-128914	Tursiops truncatus	73.93	0.00e+00	650.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence