iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Gac-041398

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Suppressor of cytokine signaling 2

Genbank Nucleotide ID

EF371370

Gene Name

socs2; SOCS2

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSGACG00000000635.1	ENSGACT00000000818.1	ENSGACP00000000818.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/ECS/SOCS_VHL_BC-box	2.50e-12	46.9	150	192

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/ECS/SOCS_VHL_BC-box

   S: 4    lwllrseprSLqhLCRlaIrrclgsqrlkaidkLPLPksLkdYLlyed 51
           ++++ +  ++LqhLCR+aI+r +++     +++LPLP++LkdYL ++ 
   Q: 150  TRPAYTATPPLQHLCRVAINRRTRR-----VEELPLPNRLKDYLTEYG 192
           566778889**************99.....7**************985 PP

Organism

Gasterosteus aculeatus

Protein Sequence
(Fasta)

MTCQSSESTD TIDGDGRAHS TSTSVGSDES RIASAMKDLR NTGWYWGGLT ANEAKEVLQD 60
ASEGTFLVRD SSQRDFLFTI SAMTSAGPTN LRIEYKHGKF KLDSVVLVKP KLRQFDSVVH 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TCCGGGGCCA TTCGGCGGCT CGCTGGCGGC GGTGAGGCCG AGGATCAGCG ACCGGAGGAC 60
GGGCACCGGG CACCGGGAGA CACGCACGGA GCTCCGATAA ATCAGCCCAG TTTGTTTGTT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome

Interpro

IPR000980--SH2
IPR028410--SOCS2
IPR001496--SOCS_box

PROSITE

PS50001--SH2
PS50225--SOCS

Pfam

PF00017--SH2
PF07525--SOCS_box

PRINTS

PR00401--SH2DOMAIN

SMART

SM00252--SH2
SM00253--SOCS
SM00969--SOCS_box

Gene Ontology

GO:0005737--C:cytoplasm
GO:0035556--P:intracellular signal transduction
GO:0046426--P:negative regulation of JAK-STAT cascade
GO:0016567--P:protein ubiquitination
GO:0001558--P:regulation of cell growth

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002075	Ailuropoda melanoleuca	60.37	9.00e-58	216.00
IUUC-Apl-003484	Anas platyrhynchos	60.39	4.00e-53	200.00
IUUC-Aca-004253	Anolis carolinensis	58.18	1.00e-54	205.00
IUUC-Ame-011267	Astyanax mexicanus	70.53	2.00e-78	285.00
IUUC-Bta-013183	Bos taurus	63.23	1.00e-56	212.00
IUUC-Cja-018862	Callithrix jacchus	62.58	3.00e-55	207.00
IUUC-Cfa-020226	Canis familiaris	62.34	2.00e-55	208.00
IUUC-Cpo-022414	Cavia porcellus	62.99	2.00e-55	208.00
IUUC-Csa-023758	Chlorocebus sabaeus	61.94	8.00e-55	206.00
IUUC-Cho-024471	Choloepus hoffmanni	58.17	9.00e-45	172.00
IUUC-Dre-028288	Danio rerio	75.13	7.00e-86	309.00
IUUC-Dno-029036	Dasypus novemcinctus	60.98	8.00e-58	216.00
IUUC-Dor-030447	Dipodomys ordii	61.18	3.00e-53	200.00
IUUC-Ete-033023	Echinops telfairi	55.03	6.00e-58	216.00
IUUC-Fca-036469	Felis catus	62.58	3.00e-56	211.00
IUUC-Fal-036642	Ficedula albicollis	58.39	7.00e-54	202.00
IUUC-Gmo-039331	Gadus morhua	78.69	5.00e-52	195.00
IUUC-Gga-040809	Gallus gallus	59.38	1.00e-54	204.00
IUUC-Ggo-045341	Gorilla gorilla	61.94	4.00e-55	207.00
IUUC-Hsa-046557	Homo sapiens	55.61	3.00e-58	218.00
IUUC-Itr-049013	Ictidomys tridecemlineatus	61.54	2.00e-54	205.00
IUUC-Lch-050160	Latimeria chalumnae	55.93	1.00e-56	211.00
IUUC-Loc-051825	Lepisosteus oculatus	71.28	4.00e-82	296.00
IUUC-Laf-053560	Loxodonta africana	61.94	1.00e-55	209.00
IUUC-Mcc-055890	Macaca mulatta	61.29	3.00e-54	204.00
IUUC-Meu-056218	Macropus eugenii	56.72	5.00e-61	226.00
IUUC-Mga-059755	Meleagris gallopavo	51.30	5.00e-53	200.00
IUUC-Mmr-061387	Microcebus murinus	62.58	3.00e-56	211.00
IUUC-Mdo-062383	Monodelphis domestica	57.43	4.00e-62	230.00
IUUC-Mmu-063443	Mus musculus	61.29	2.00e-54	205.00
IUUC-Mpu-066459	Mustela putorius furo	62.58	2.00e-55	207.00
IUUC-Mlu-068040	Myotis lucifugus	60.98	1.00e-58	218.00
IUUC-Nle-069016	Nomascus leucogenys	58.79	3.00e-55	207.00
IUUC-Opr-071087	Ochotona princeps	62.42	4.00e-59	220.00
IUUC-Ont-072340	Oreochromis niloticus	74.63	5.00e-89	320.00
IUUC-Oan-073443	Ornithorhynchus anatinus	58.29	7.00e-60	223.00
IUUC-Ocu-074539	Oryctolagus cuniculus	62.34	4.00e-55	207.00
IUUC-Ola-087004	Oryzias latipes	77.22	1.00e-71	261.00
IUUC-Oga-088438	Otolemur garnettii	62.58	7.00e-56	209.00
IUUC-Oar-089932	Ovis aries	62.58	2.00e-56	211.00
IUUC-Ptr-091037	Pan troglodytes	61.94	4.00e-55	207.00
IUUC-Pan-092767	Papio anubis	61.94	6.00e-55	206.00
IUUC-Psi-093099	Pelodiscus sinensis	59.38	2.00e-54	204.00
IUUC-Pma-094671	Petromyzon marinus	49.37	1.00e-35	143.00
IUUC-Pfo-097073	Poecilia formosa	72.45	5.00e-80	290.00
IUUC-Pab-098319	Pongo abelii	60.37	2.00e-57	214.00
IUUC-Pca-101117	Procavia capensis	62.58	4.00e-56	210.00
IUUC-Pva-102117	Pteropus vampyrus	62.99	1.00e-55	209.00
IUUC-Rno-105913	Rattus norvegicus	60.65	2.00e-54	205.00
IUUC-Sha-106500	Sarcophilus harrisii	57.07	3.00e-61	227.00
IUUC-Ssc-115252	Sus scrofa	62.58	3.00e-56	211.00
IUUC-Tgu-117524	Taeniopygia guttata	60.62	1.00e-55	208.00
IUUC-Tsy-119335	Tarsius syrichta	62.50	1.00e-53	201.00
IUUC-Tni-120263	Tetraodon nigroviridis	74.63	2.00e-79	287.00
IUUC-Tbe-127915	Tupaia belangeri	63.23	4.00e-57	214.00
IUUC-Ttr-128372	Tursiops truncatus	62.58	3.00e-56	210.00
IUUC-Vpa-130422	Vicugna pacos	62.50	7.00e-55	205.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence