iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Fal-037207

Ensembl Protein ID

ENSFALP00000011256.1

UniProt Accession

U3K8A2; U3K8A2_FICAL

Genbank Protein ID

ENSFALP00000011256

Protein Name

Ubiquitinyl hydrolase 1

Genbank Nucleotide ID

AGTO01010177

Gene Name

USP44

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSFALG00000010789.1	ENSFALT00000011301.1	ENSFALP00000011256.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	2.20e-98	329.3	272	678

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrellle...kkkeklneenp............................................ 42
           tGl+NlgNtCYmNSvLQ+Ls++  +re++l+   ++++      +                                            
   Q: 272  TGLRNLGNTCYMNSVLQVLSHLLIFRECFLKldlNQTQ------Ellatatngktrssskhlsiaastlrvnenqekvrgsysvrrpsl 354
           7******************************5552222......22234557888888999999999999999999************* PP
   S: 43   ....................kepkgellkslqklfeelwkskkkavsprellkalkkeaeefsgyeqqDaqEflaflldqleeelkkek 111
                               ++++ +l+++l++lf+ +w++k+  vsp ++l++++++ + f+gy+qqDaqEfl+ lld++++el    
   Q: 355  ssglsggasksmeliqprepSSKHISLCHELHTLFQVMWSGKWALVSPFAMLHSVWRLIPAFRGYAQQDAQEFLCELLDKVQKEL---- 439
           ********99999999999999999************************************************************.... PP
   S: 112  nkpkeeeeeedkselsdeaeekkkkknkslisdlFqgqlksqikclecdnvssreepfldlslpvpgkeetkke........slqdcLe 192
                e+++++  +l   ++++  k+  ++++++F+gql sq++cl+cdn+s++ epf+dlsl++p++ +++ +         l+++L+
   Q: 440  -----ETTGTRYPALIPASQRRLIKQVLNVVNNIFHGQLLSQVTCLTCDNKSNTIEPFWDLSLEFPERYHCNGKemssqypcLLTEMLA 523
           .....77888888999999***********************************************9999887789999999******* PP
   S: 193  sftkeeelegenkyycekckkkqe...........aekklklkklPevLilhLkRfsfseeqksrekinkkvefpleLdlspfctspee 270
           +ft++e leg+  y c++c+ k++           a+k+l++ +lP+vL lhLkRf++s + ++reki  +v+f ++L+++p+c++++ 
   Q: 524  KFTETEALEGKI-YACDQCNTKRRkfsskpvilteAQKQLMVCRLPQVLRLHLKRFRWSGR-NHREKIGVHVSFDQMLNMEPYCCRESL 610
           *********965.*******999999999999999***********************997.8889********************887 PP
   S: 271  kqke..kkkYeLiavvvHsG.slssGHYvayvknekgk.WllfdDskVtevkeeevleetgstaYvlfYkr 337
           k+    + +Y+L+avv+H+G +++sGHY+ay++n++g+ W++++Dsk + +++eev++   ++aY+lfY +
   Q: 611  KSLLpdCFIYDLSAVVMHHGkGFGSGHYTAYCYNSEGGfWVHCNDSKLNMCTMEEVCK---AQAYILFYSQ 678
           7654669***************************9999********************...********87 PP

Organism

Ficedula albicollis

Protein Sequence
(Fasta)

MDKCKHVGRL RLAQDHSILN PQKWHCMDCN TTESVWACLS CSHVACGRYI EEHALKHFQE 60
SSHPVALEVN ELYVFCYLCD DYVLNDNATG DLKLLRSTLS AIKSQNYECT TRSGRTLRST 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TCTTTTAACA AAATCAGTGC CCTTAATAAA AAAAAAATAA ACCAGGCCTA GAGTATAGCT 60
CGTGTGCTTC AGTCCTGAGC CACAAAGCAC TGGGACTATA AACAGCGGTA GCAGGCAATT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0479--Metal-binding
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001394--Peptidase_C19_UCH
IPR018200--USP_CS
IPR028889--USP_dom
IPR013083--Znf_RING/FYVE/PHD
IPR001607--Znf_UBP

PROSITE

PS00972--USP_1
PS00973--USP_2
PS50235--USP_3
PS50271--ZF_UBP

Pfam

PF00443--UCH
PF02148--zf-UBP

SMART

SM00290--ZnF_UBP

Gene Ontology

GO:0005634--C:nucleus
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0008270--F:zinc ion binding
GO:1904667--P:negative regulation of ubiquitin protein ligase activity
GO:0016579--P:protein deubiquitination
GO:0090231--P:regulation of spindle checkpoint
GO:0006511--P:ubiquitin-dependent protein catabolic process

KEGG

fab:101815183

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001220	Ailuropoda melanoleuca	76.03	0.00e+00	1056.00
IUUC-Apl-003673	Anas platyrhynchos	91.33	0.00e+00	1261.00
IUUC-Aca-004434	Anolis carolinensis	81.68	0.00e+00	1149.00
IUUC-Ame-010986	Astyanax mexicanus	68.47	0.00e+00	917.00
IUUC-Bta-012774	Bos taurus	74.93	0.00e+00	1054.00
IUUC-Cja-019619	Callithrix jacchus	73.44	0.00e+00	1041.00
IUUC-Cfa-020957	Canis familiaris	75.18	0.00e+00	1057.00
IUUC-Csa-023177	Chlorocebus sabaeus	72.39	0.00e+00	1037.00
IUUC-Cho-024877	Choloepus hoffmanni	68.67	0.00e+00	641.00
IUUC-Cin-025587	Ciona intestinalis	47.97	3.00e-114	406.00
IUUC-Csv-025814	Ciona savignyi	44.64	6.00e-157	547.00
IUUC-Dre-027878	Danio rerio	68.70	0.00e+00	888.00
IUUC-Dno-029832	Dasypus novemcinctus	74.93	0.00e+00	1056.00
IUUC-Ete-032627	Echinops telfairi	72.47	0.00e+00	1034.00
IUUC-Eca-033863	Equus caballus	73.93	0.00e+00	1036.00
IUUC-Eeu-035225	Erinaceus europaeus	69.55	0.00e+00	988.00
IUUC-Fca-036288	Felis catus	74.47	0.00e+00	1040.00
IUUC-Gga-040457	Gallus gallus	88.95	0.00e+00	1201.00
IUUC-Ggo-044926	Gorilla gorilla	73.12	0.00e+00	1035.00
IUUC-Hsa-046079	Homo sapiens	72.97	0.00e+00	1033.00
IUUC-Itr-048737	Ictidomys tridecemlineatus	74.68	0.00e+00	1038.00
IUUC-Lch-050260	Latimeria chalumnae	75.54	0.00e+00	1008.00
IUUC-Loc-051981	Lepisosteus oculatus	80.46	0.00e+00	716.00
IUUC-Laf-054491	Loxodonta africana	74.93	0.00e+00	1031.00
IUUC-Mcc-055694	Macaca mulatta	72.68	0.00e+00	1038.00
IUUC-Mga-059523	Meleagris gallopavo	89.51	0.00e+00	1227.00
IUUC-Mmr-060885	Microcebus murinus	74.72	0.00e+00	1069.00
IUUC-Mdo-063018	Monodelphis domestica	84.29	0.00e+00	1140.00
IUUC-Mmu-064012	Mus musculus	68.32	0.00e+00	924.00
IUUC-Mpu-066207	Mustela putorius furo	75.32	0.00e+00	1063.00
IUUC-Mlu-066929	Myotis lucifugus	72.51	0.00e+00	996.00
IUUC-Nle-069313	Nomascus leucogenys	64.39	0.00e+00	872.00
IUUC-Opr-070375	Ochotona princeps	69.32	0.00e+00	946.00
IUUC-Oan-073030	Ornithorhynchus anatinus	81.58	0.00e+00	915.00
IUUC-Ocu-074836	Oryctolagus cuniculus	71.77	0.00e+00	1006.00
IUUC-Oga-088367	Otolemur garnettii	73.24	0.00e+00	1035.00
IUUC-Oar-089953	Ovis aries	75.11	0.00e+00	1067.00
IUUC-Ptr-090980	Pan troglodytes	73.12	0.00e+00	1036.00
IUUC-Pan-092748	Papio anubis	73.06	0.00e+00	1048.00
IUUC-Psi-094078	Pelodiscus sinensis	87.52	0.00e+00	957.00
IUUC-Pma-094155	Petromyzon marinus	56.90	4.00e-84	303.00
IUUC-Pab-098514	Pongo abelii	73.97	0.00e+00	1048.00
IUUC-Pva-102984	Pteropus vampyrus	75.87	0.00e+00	1069.00
IUUC-Rno-106019	Rattus norvegicus	68.97	0.00e+00	962.00
IUUC-Sha-106965	Sarcophilus harrisii	83.86	0.00e+00	1130.00
IUUC-Ssc-115299	Sus scrofa	75.46	0.00e+00	1077.00
IUUC-Tgu-117160	Taeniopygia guttata	93.57	0.00e+00	1251.00
IUUC-Tru-118156	Takifugu rubripes	63.57	0.00e+00	852.00
IUUC-Tni-119733	Tetraodon nigroviridis	64.13	0.00e+00	889.00
IUUC-Tbe-128084	Tupaia belangeri	71.41	0.00e+00	1009.00
IUUC-Ttr-128928	Tursiops truncatus	76.45	0.00e+00	1071.00
IUUC-Vpa-130706	Vicugna pacos	73.80	0.00e+00	1055.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence