iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMMUG00000013812.3	ENSMMUT00000077012.1	ENSMMUP00000047839.1
ENSMMUG00000013812.3	ENSMMUT00000019393.3	ENSMMUP00000018162.3

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	3.40e-96	323.5	273	678

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrellle............kkkeklneenp................................... 42
           tGl+NlgNtCYmNSvLQ+Ls++  +r+++l+            +         +                                   
   Q: 273  TGLRNLGNTCYMNSVLQVLSHLLIFRQCFLKldlnqwlavtasE---------Kkrsfckhppvtdtvvyqmnecqekdtgfvrsrqss 352
           7******************************8777665555542.........133444555689999999999988888999998888 PP
   S: 43   .......................kepkgellkslqklfeelwkskkkavsprellkalkkeaeefsgyeqqDaqEflaflldqleeelk 108
                                  +++  +l+++l++lf+ +w++k+  vsp ++l++++++ + f+gy+qqDaqEfl+ lld+++ el 
   Q: 353  lssglsggasksrkmeliqprepTSQYLSLCHELHTLFQVMWSGKWALVSPFAMLHSVWRLIPAFRGYAQQDAQEFLCELLDKIQHEL- 440
           8888888888777777777766655666************************************************************. PP
   S: 109  keknkpkeeeeeedkselsdeaeekkkkknkslisdlFqgqlksqikclecdnvssreepfldlslpvpgkeetkke.......slqdc 190
                   e+++++  +l   +++k  k+  ++++++F+gql sq++cl+cdn+s++ epf+dlsl++p++ +++ +        ++++
   Q: 441  --------ETTGTSLPALIPTSQRKLIKQVLNVVNNIFHGQLLSQVTCLACDNKSNTIEPFWDLSLEFPERYQCSGKdiasqpcLVTEM 521
           ........7889999999999************************************************9998877788888889**** PP
   S: 191  Lesftkeeelegenkyycekckkkqe...........aekklklkklPevLilhLkRfsfseeqksrekinkkvefpleLdlspfctsp 268
           L++ft++e leg+  y ce+c++k++           a+k+l++ +lP+vL lhLkRf++s   ++reki  +v f + L+++p+c+++
   Q: 522  LAKFTETEALEGKI-YVCEQCNSKRRrfsskpvvlteAQKQLMICHLPQVLRLHLKRFRWSGC-NNREKIGVHVGFEEVLNMEPYCCRE 608
           ***********965.*******999999999999999***********************998.7778*********99*********9 PP
   S: 269  eekqke..kkkYeLiavvvHsG.slssGHYvayvknekgk.WllfdDskVtevkeeevleetgstaYvlfYkr 337
           + k+ +  + +Y+L+avv+H+G +++sGHY+ay++n++g+ W++++Dsk + ++++ev++   ++aY+lfY++
   Q: 609  TLKSLRpeCFIYDLSAVVMHHGkGFGSGHYTAYCYNSEGGfWVHCNDSKLSMCTMDEVCK---AQAYILFYTQ 678
           988876779***************************9999********************...********98 PP

Organism

Macaca mulatta

Protein Sequence
(Fasta)

MLTMDKCKHV GQLRLAQDHS SLNPQKWHCV DCNTTESIWA CLSCSHVACG RYIEEHALKH 60
FQESSHPVAL EVNEMYVFCY LCDDYVLNDN ATGDLKLLRS TLSAIKSQNY HCMTRSGMVL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CGAGCGTCGC GGAGAGGCTG GCGCGGGCTG GGTGCTGTGT GGAGCACGCA CTGCCCGGGT 60
CCAGCCGCAT CCTTCCCGCT GCCCGGATTA CCGCGAGGGG ATGCTCGAAG CCCCAGGGCG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0479--Metal-binding
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001394--Peptidase_C19_UCH
IPR018200--USP_CS
IPR028889--USP_dom
IPR013083--Znf_RING/FYVE/PHD
IPR001607--Znf_UBP

PROSITE

PS00972--USP_1
PS00973--USP_2
PS50235--USP_3
PS50271--ZF_UBP

Pfam

PF00443--UCH
PF02148--zf-UBP

SMART

SM00290--ZnF_UBP

Gene Ontology

GO:0036459--F:thiol-dependent ubiquitinyl hydrolase activity
GO:0008270--F:zinc ion binding
GO:0016579--P:protein deubiquitination
GO:0006511--P:ubiquitin-dependent protein catabolic process

KEGG

mcc:712480

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001220	Ailuropoda melanoleuca	91.44	0.00e+00	1313.00
IUUC-Apl-003673	Anas platyrhynchos	75.35	0.00e+00	1049.00
IUUC-Aca-004434	Anolis carolinensis	73.32	0.00e+00	1001.00
IUUC-Ame-010986	Astyanax mexicanus	64.48	0.00e+00	872.00
IUUC-Bta-012774	Bos taurus	89.48	0.00e+00	1271.00
IUUC-Cja-019619	Callithrix jacchus	92.99	0.00e+00	1317.00
IUUC-Cfa-020957	Canis familiaris	90.04	0.00e+00	1312.00
IUUC-Csa-023177	Chlorocebus sabaeus	98.04	0.00e+00	1380.00
IUUC-Cho-024877	Choloepus hoffmanni	88.47	0.00e+00	844.00
IUUC-Csv-025814	Ciona savignyi	44.51	4.00e-150	525.00
IUUC-Dre-027878	Danio rerio	63.73	0.00e+00	845.00
IUUC-Dno-029832	Dasypus novemcinctus	91.30	0.00e+00	1320.00
IUUC-Ete-032627	Echinops telfairi	86.13	0.00e+00	1239.00
IUUC-Eca-033863	Equus caballus	86.34	0.00e+00	1211.00
IUUC-Eeu-035225	Erinaceus europaeus	86.26	0.00e+00	1195.00
IUUC-Fca-036288	Felis catus	91.16	0.00e+00	1313.00
IUUC-Fal-037207	Ficedula albicollis	74.23	0.00e+00	1011.00
IUUC-Gga-040457	Gallus gallus	73.94	0.00e+00	1016.00
IUUC-Ggo-044926	Gorilla gorilla	95.23	0.00e+00	1340.00
IUUC-Hsa-046079	Homo sapiens	94.95	0.00e+00	1337.00
IUUC-Itr-048737	Ictidomys tridecemlineatus	90.60	0.00e+00	1291.00
IUUC-Lch-050260	Latimeria chalumnae	66.67	0.00e+00	916.00
IUUC-Laf-054491	Loxodonta africana	88.12	0.00e+00	1213.00
IUUC-Mga-059523	Meleagris gallopavo	73.77	0.00e+00	1029.00
IUUC-Mmr-060885	Microcebus murinus	93.97	0.00e+00	1341.00
IUUC-Mdo-063018	Monodelphis domestica	79.21	0.00e+00	1114.00
IUUC-Mmu-064012	Mus musculus	79.80	0.00e+00	1093.00
IUUC-Mpu-066207	Mustela putorius furo	89.62	0.00e+00	1315.00
IUUC-Mlu-066929	Myotis lucifugus	86.19	0.00e+00	1175.00
IUUC-Nle-069313	Nomascus leucogenys	84.88	0.00e+00	1159.00
IUUC-Opr-070375	Ochotona princeps	81.79	0.00e+00	1116.00
IUUC-Ont-071637	Oreochromis niloticus	63.52	0.00e+00	855.00
IUUC-Oan-073030	Ornithorhynchus anatinus	78.52	0.00e+00	857.00
IUUC-Ocu-074836	Oryctolagus cuniculus	87.89	0.00e+00	1255.00
IUUC-Oga-088367	Otolemur garnettii	92.85	0.00e+00	1308.00
IUUC-Oar-089953	Ovis aries	90.76	0.00e+00	1310.00
IUUC-Ptr-090980	Pan troglodytes	95.09	0.00e+00	1339.00
IUUC-Pan-092748	Papio anubis	99.02	0.00e+00	1387.00
IUUC-Psi-094078	Pelodiscus sinensis	75.86	0.00e+00	838.00
IUUC-Pab-098514	Pongo abelii	95.65	0.00e+00	1348.00
IUUC-Pva-102984	Pteropus vampyrus	88.64	0.00e+00	1238.00
IUUC-Rno-106019	Rattus norvegicus	79.89	0.00e+00	1130.00
IUUC-Sha-106965	Sarcophilus harrisii	77.89	0.00e+00	1106.00
IUUC-Ssc-115299	Sus scrofa	91.02	0.00e+00	1323.00
IUUC-Tgu-117160	Taeniopygia guttata	73.14	0.00e+00	1005.00
IUUC-Tru-118156	Takifugu rubripes	60.54	0.00e+00	828.00
IUUC-Tni-119733	Tetraodon nigroviridis	62.12	0.00e+00	844.00
IUUC-Tbe-128084	Tupaia belangeri	85.39	0.00e+00	1207.00
IUUC-Ttr-128928	Tursiops truncatus	92.29	0.00e+00	1335.00
IUUC-Vpa-130706	Vicugna pacos	91.02	0.00e+00	1311.00
IUUC-Xtr-132061	Xenopus tropicalis	70.93	0.00e+00	916.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence