iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Basic Information

Integrated Annotations

Tag

Content

UUCD2 ID

IUUC-Rno-106087

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

ERCC excision repair 8, CSA ubiquitin ligase complex subunit; Excision repair cross-complementing rodent repair deficiency, complementation group 8 (Predicted), isoform CRA_c

Genbank Nucleotide ID

AABR07008024

Gene Name

Ercc8; Ercc8_predicted; rCG_44836

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSRNOG00000009968.5	ENSRNOT00000013598.5	ENSRNOP00000013598.5
ENSRNOG00000009968.5	ENSRNOT00000077938.1	ENSRNOP00000075729.1

Annotation

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress
DNA & RNA Element
TRANSFAC	RAID2
Protein-protein Interaction
IID
Protein Expression/Proteomics

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	2.20e-31	106.9	184	218
UBD/Beta-Prp	8.80e-49	166.7	42	280

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 1    gHtdsvtclaf...sdtllvsGsdDgtikvWDlrt 32
           gH  ++ ++++    d +l+++s D  +k+WD+r+
   Q: 184  GHRQEILAVSWsprYDYILATASADSRVKLWDVRR 218
           8**********96543678*************986 PP

UBD/Beta-Prp

   S: 51   heaevtavkfspdgk.ilvtgseDrtikvwdls........tgkcvhtlk.....ghedsvlslsfsp.sgdklvsGshdrtirvwdle 124
           h ++v++++++p +  ++++g++D++i ++dl+        t+k v ++       h++sv +++++p ++  + s s d+t++vwd++
   Q: 42   HCSGVNTLDIEPVEGrYMLSGGSDGVIVLYDLEnasrqpyyTCKAVCSVGrshpdVHKYSVETVQWYPhDTGMFTSSSFDKTLKVWDTN 130
           6678999999998777999***********999998888887777766666777789999999*****7779***************** PP
   S: 125  tgqcleetlsghdgv.vncvvvhpdg.nllvsGslDrtvrlWdlktgkllrtltgghtdsvyslsfdsng.kelvsgsldgtvklwdlq 210
           t q    +++ ++ v   +++   ++ +l++ G+   +v+l dlk+g++ + l+g h + +  +s+++     l+++s d++vklwd++
   Q: 131  TLQAAD-VFNFEETVySHHMSPAATKhCLVAVGTRGPKVQLCDLKSGSCSHILQG-HRQEILAVSWSPRYdYILATASADSRVKLWDVR 217
           ***998.555555440455555566678889999999****************99.*********99987677889999*********9 PP
   S: 211  ................tgecvrtlnghtdnvksvrfspnderlvsgssDgsiriWdlrsgdll 257
                           ++ +  + ++h+  v+ + f++++ +l++++ D+  r+W++ sgd++
   Q: 218  rasgclltldqhngkkSQAVESANTAHNGKVNGLCFTSDGLHLLTVGTDNRMRLWNSSSGDNT 280
           97666666666655544444666677779***************************9999987 PP

Organism

Rattus norvegicus

Protein Sequence
(Fasta)

MLSFLSARQS GLEDPLRLRR AQSTRRVLGL ELNKDRDVER VHCSGVNTLD IEPVEGRYML 60
SGGSDGVIVL YDLENASRQP YYTCKAVCSV GRSHPDVHKY SVETVQWYPH DTGMFTSSSF 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATCCGTTCCA AGCTCTGTCA TGGCGGCATC CCGGCCTCAA GCCGGTGTGT GGAACCGAGA 60
TGTTGAGCTT TTTGTCCGCT CGACAGTCAG GGTTGGAGGA CCCTCTTCGC TTGCGTAGAG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0853--WD repeat

Interpro

IPR020472--G-protein_beta_WD-40_rep
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF00400--WD40

PRINTS

PR00320--GPROTEINBRPT

SMART

SM00320--WD40

Gene Ontology

GO:0031464--C:Cul4A-RING E3 ubiquitin ligase complex
GO:0016363--C:nuclear matrix
GO:0000109--C:nucleotide-excision repair complex
GO:0004842--F:ubiquitin-protein transferase activity
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0051865--P:protein autoubiquitination
GO:0000209--P:protein polyubiquitination
GO:0006979--P:response to oxidative stress
GO:0009411--P:response to UV
GO:0010165--P:response to X-ray
GO:0006283--P:transcription-coupled nucleotide-excision repair

KEGG

rno:310071

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-001170	Aegilops tauschii	31.03	1.00e-36	148.00
IUUC-Aml-002201	Ailuropoda melanoleuca	89.67	0.00e+00	753.00
IUUC-Atr-002784	Amborella trichopoda	36.60	4.00e-40	159.00
IUUC-Apl-003202	Anas platyrhynchos	79.47	0.00e+00	642.00
IUUC-Aca-004708	Anolis carolinensis	81.90	2.00e-178	617.00
IUUC-Aly-006144	Arabidopsis lyrata	30.71	1.00e-44	173.00
IUUC-Ath-006673	Arabidopsis thaliana	41.15	8.00e-46	177.00
IUUC-Acl-008195	Aspergillus clavatus	39.39	5.00e-43	168.00
IUUC-Afl-008406	Aspergillus flavus	37.65	1.00e-38	154.00
IUUC-Afu-008759	Aspergillus fumigatus	34.34	4.00e-40	159.00
IUUC-Ani-009380	Aspergillus nidulans	37.41	4.00e-41	162.00
IUUC-Ang-009820	Aspergillus niger	37.15	1.00e-38	154.00
IUUC-Aor-010092	Aspergillus oryzae	38.26	9.00e-44	171.00
IUUC-Ate-010491	Aspergillus terreus	35.44	6.00e-45	175.00
IUUC-Bta-012825	Bos taurus	91.18	0.00e+00	766.00
IUUC-Bci-013856	Botrytis cinerea	32.41	2.00e-52	200.00
IUUC-Bdi-014899	Brachypodium distachyon	33.99	2.00e-65	243.00
IUUC-Bol-015337	Brassica oleracea	31.93	1.00e-53	203.00
IUUC-Bra-018089	Brassica rapa	38.36	3.00e-45	176.00
IUUC-Cja-018725	Callithrix jacchus	90.18	0.00e+00	754.00
IUUC-Cfa-021162	Canis familiaris	90.68	0.00e+00	758.00
IUUC-Cpo-022190	Cavia porcellus	89.17	0.00e+00	752.00
IUUC-Cre-022960	Chlamydomonas reinhardtii	36.09	5.00e-39	155.00
IUUC-Csa-023610	Chlorocebus sabaeus	90.43	0.00e+00	760.00
IUUC-Cho-024689	Choloepus hoffmanni	89.22	0.00e+00	690.00
IUUC-Cin-025324	Ciona intestinalis	38.90	1.00e-80	293.00
IUUC-Csv-026059	Ciona savignyi	37.72	3.00e-73	268.00
IUUC-Cgl-026384	Colletotrichum gloeosporioides	34.18	2.00e-38	153.00
IUUC-Cme-027182	Cyanidioschyzon merolae	28.05	3.00e-13	70.50
IUUC-Dre-028696	Danio rerio	71.32	2.00e-174	604.00
IUUC-Dno-029102	Dasypus novemcinctus	89.67	0.00e+00	753.00
IUUC-Dor-030361	Dipodomys ordii	73.30	7.00e-169	586.00
IUUC-Dse-031167	Dothistroma septosporum	30.87	1.00e-46	181.00
IUUC-Ete-032856	Echinops telfairi	74.81	2.00e-173	601.00
IUUC-Eca-033611	Equus caballus	91.15	0.00e+00	650.00
IUUC-Eeu-034583	Erinaceus europaeus	67.25	6.00e-151	526.00
IUUC-Fca-036481	Felis catus	90.18	0.00e+00	755.00
IUUC-Fal-037327	Ficedula albicollis	77.65	4.00e-164	570.00
IUUC-Fox-037684	Fusarium oxysporum	33.45	1.00e-42	167.00
IUUC-Fso-038306	Fusarium solani	34.31	1.00e-53	203.00
IUUC-Gmo-039043	Gadus morhua	67.42	1.00e-161	562.00
IUUC-Ggr-039783	Gaeumannomyces graminis	33.79	9.00e-38	151.00
IUUC-Gga-041085	Gallus gallus	83.33	7.00e-180	623.00
IUUC-Gac-042328	Gasterosteus aculeatus	67.41	2.00e-158	551.00
IUUC-Gma-042916	Glycine max	32.17	8.00e-56	211.00
IUUC-Ggo-045627	Gorilla gorilla	82.09	0.00e+00	686.00
IUUC-Hsa-046028	Homo sapiens	90.43	0.00e+00	760.00
IUUC-Hvu-047678	Hordeum vulgare	28.43	7.00e-30	124.00
IUUC-Itr-048648	Ictidomys tridecemlineatus	89.42	0.00e+00	752.00
IUUC-Kpa-049386	Komagataella pastoris	30.52	1.00e-44	174.00
IUUC-Lch-050590	Latimeria chalumnae	77.87	5.00e-159	553.00
IUUC-Lpe-051725	Leersia perrieri	33.12	2.00e-35	143.00
IUUC-Loc-051788	Lepisosteus oculatus	75.26	0.00e+00	629.00
IUUC-Lma-053082	Leptosphaeria maculans	34.37	1.00e-54	207.00
IUUC-Laf-053809	Loxodonta africana	91.44	0.00e+00	767.00
IUUC-Mcc-054998	Macaca mulatta	93.59	2.00e-160	558.00
IUUC-Meu-055929	Macropus eugenii	75.38	0.00e+00	627.00
IUUC-Mor-057003	Magnaporthe oryzae	33.83	1.00e-47	184.00
IUUC-Mtr-057921	Medicago truncatula	32.79	8.00e-57	214.00
IUUC-Mga-059449	Meleagris gallopavo	63.64	4.00e-121	427.00
IUUC-Mmr-061609	Microcebus murinus	86.73	0.00e+00	701.00
IUUC-Mdo-062564	Monodelphis domestica	83.42	0.00e+00	711.00
IUUC-Mmu-063904	Mus musculus	94.96	0.00e+00	780.00
IUUC-Mac-064716	Musa acuminata	31.42	2.00e-51	196.00
IUUC-Mpu-066617	Mustela putorius furo	89.92	0.00e+00	750.00
IUUC-Mlu-067054	Myotis lucifugus	87.41	0.00e+00	731.00
IUUC-Nfi-068467	Neosartorya fischeri	36.84	6.00e-34	138.00
IUUC-Nle-069731	Nomascus leucogenys	90.43	0.00e+00	760.00
IUUC-Opr-070297	Ochotona princeps	66.53	1.00e-85	309.00
IUUC-Ont-072558	Oreochromis niloticus	69.73	2.00e-161	561.00
IUUC-Oan-072864	Ornithorhynchus anatinus	87.72	1.00e-26	110.00
IUUC-Ocu-074415	Oryctolagus cuniculus	90.43	0.00e+00	758.00
IUUC-Oba-075759	Oryza barthii	42.11	9.00e-43	167.00
IUUC-Obr-076387	Oryza brachyantha	30.62	3.00e-53	202.00
IUUC-Ogl-077924	Oryza glaberrima	41.13	9.00e-18	83.20
IUUC-Ogu-078186	Oryza glumaepatula	35.23	1.00e-61	230.00
IUUC-Oin-079389	Oryza indica	34.52	3.00e-45	175.00
IUUC-Olo-080916	Oryza longistaminata	30.94	5.00e-16	77.00
IUUC-Ome-081471	Oryza meridionalis	41.05	5.00e-40	158.00
IUUC-Oni-082449	Oryza nivara	40.31	7.00e-40	158.00
IUUC-Opu-083210	Oryza punctata	31.16	2.00e-52	199.00
IUUC-Oru-085159	Oryza rufipogon	42.11	6.00e-43	168.00
IUUC-Osa-085926	Oryza sativa	42.57	2.00e-32	132.00
IUUC-Ola-087084	Oryzias latipes	67.84	1.00e-164	572.00
IUUC-Olu-087853	Ostreococcus lucimarinus	28.50	6.00e-33	134.00
IUUC-Oga-089008	Otolemur garnettii	88.47	0.00e+00	740.00
IUUC-Oar-089259	Ovis aries	90.93	0.00e+00	764.00
IUUC-Ptr-091112	Pan troglodytes	89.85	0.00e+00	751.00
IUUC-Pan-092303	Papio anubis	82.95	2.00e-62	230.00
IUUC-Psi-093050	Pelodiscus sinensis	81.20	0.00e+00	689.00
IUUC-Pma-094259	Petromyzon marinus	56.44	2.00e-126	445.00
IUUC-Pno-094798	Phaeosphaeria nodorum	32.58	4.00e-51	195.00
IUUC-Ppa-095477	Physcomitrella patens	31.91	6.00e-54	204.00
IUUC-Pfo-096855	Poecilia formosa	67.74	8.00e-163	566.00
IUUC-Pab-098096	Pongo abelii	89.67	0.00e+00	754.00
IUUC-Pop-098800	Populus trichocarpa	36.84	3.00e-45	176.00
IUUC-Pca-100187	Procavia capensis	92.72	8.00e-114	403.00
IUUC-Ppe-101759	Prunus persica	29.60	5.00e-52	198.00
IUUC-Pva-102438	Pteropus vampyrus	77.56	1.00e-90	326.00
IUUC-Pte-104197	Pyrenophora teres	33.62	3.00e-49	189.00
IUUC-Pyt-104421	Pyrenophora triticirepentis	34.18	6.00e-49	188.00
IUUC-Sce-106276	Saccharomyces cerevisiae	27.32	3.00e-13	69.70
IUUC-Sha-106831	Sarcophilus harrisii	80.65	0.00e+00	685.00
IUUC-Sja-107681	Schizosaccharomyces japonicus	34.19	2.00e-56	212.00
IUUC-Spo-108294	Schizosaccharomyces pombe	37.14	7.00e-65	241.00
IUUC-Ssl-108613	Sclerotinia sclerotiorum	32.95	1.00e-51	197.00
IUUC-Smo-109008	Selaginella moellendorffii	38.28	7.00e-72	264.00
IUUC-Sit-110300	Setaria italica	30.99	3.00e-52	199.00
IUUC-Sly-111441	Solanum lycopersicum	29.95	3.00e-47	182.00
IUUC-Stu-111995	Solanum tuberosum	29.63	2.00e-47	182.00
IUUC-Sar-113196	Sorex araneus	77.95	1.00e-119	422.00
IUUC-Sbi-113790	Sorghum bicolor	32.38	5.00e-52	198.00
IUUC-Ssc-115609	Sus scrofa	90.68	0.00e+00	758.00
IUUC-Tgu-116927	Taeniopygia guttata	78.45	0.00e+00	654.00
IUUC-Tru-118164	Takifugu rubripes	69.40	4.00e-171	593.00
IUUC-Tsy-119151	Tarsius syrichta	84.38	0.00e+00	697.00
IUUC-Tni-120896	Tetraodon nigroviridis	68.83	2.00e-161	561.00
IUUC-Tca-121592	Theobroma cacao	37.50	8.00e-45	174.00
IUUC-Tre-122023	Trichoderma reesei	34.24	3.00e-48	186.00
IUUC-Tvi-122507	Trichoderma virens	35.11	9.00e-49	187.00
IUUC-Tae-125730	Triticum aestivum	31.02	2.00e-53	202.00
IUUC-Tur-126092	Triticum urartu	31.27	1.00e-34	140.00
IUUC-Tbe-127422	Tupaia belangeri	67.39	1.00e-141	495.00
IUUC-Ttr-129097	Tursiops truncatus	87.15	0.00e+00	732.00
IUUC-Vda-130014	Verticillium dahliae	35.62	6.00e-48	184.00
IUUC-Vpa-130782	Vicugna pacos	90.18	0.00e+00	759.00
IUUC-Vvi-131494	Vitis vinifera	29.89	1.00e-52	200.00
IUUC-Xtr-132165	Xenopus tropicalis	77.57	0.00e+00	627.00
IUUC-Xma-133205	Xiphophorus maculatus	68.41	8.00e-167	579.00
IUUC-Yli-134614	Yarrowia lipolytica	35.01	1.00e-59	223.00
IUUC-Zma-135861	Zea mays	34.55	1.00e-58	220.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence