iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMMUG00000000238.3	ENSMMUT00000000351.3	ENSMMUP00000000328.2
ENSMMUG00000000238.3	ENSMMUT00000057537.1	ENSMMUP00000054541.1
ENSMMUG00000000238.3	ENSMMUT00000070463.1	ENSMMUP00000045336.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	1.50e-102	344.6	442	780

Active Site

Position(s)	Description	Evidence
748	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 2    ksdlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlldl 90
           ++dlkk+l+v+fvgE+gld+gG+t+e++ ll++++++pd+g+f+y+++++++++ + +      ++ + F+++G+l+g+a++++  ld+
   Q: 442  RADLKKKLKVTFVGEAGLDMGGLTKEWFLLLIRQIFHPDYGMFTYHKDSHCHWFSSFKC-----DNYSEFRLVGILMGLAVYNSITLDI 525
           589***************************************************87766.....789********************** PP
   S: 91   plsksfyklllgk..............klsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipV 165
           ++++++yk+ll+               +++++dl +++pel++ l e++++ e ++ee  +  tf+v +e++g +k+++LkpgG++i+V
   Q: 526  RFPPCCYKKLLSPpiipsdqnipvgicSVTVDDLCQIMPELAHGLSELLSH-EGNVEED-FYSTFQVFQEEFGIIKSYNLKPGGDKISV 612
           *************666666666666555*********************98.6788885.***************************** PP
   S: 166  tneNkeeYvklvveyrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevle 254
           tn+N++eYv+l++++ l+++i +q++af+ Gf++v+  + l l+++ee+e+l+cG++++d+++l++ t+y+g y +++ +i++Fw+v+ 
   Q: 613  TNQNRKEYVQLYTDFLLNKSIYKQFAAFYYGFHSVCASNALMLLRPEEVEILVCGSPDLDMHALQRSTQYDG-YAKTDLTIKYFWDVVL 700
           **********************************************************************76.**************** PP
   S: 255  efsseerkafLqFvTgssrlPlgGfaelkprlfvirk.dasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFels 336
           +f  + +k++L+F+Tgs+r+P+gG+a+l+   f i+k ++s+++lP ++TCfn+L+LP+Y+sk+ lk+kL++ i++++gF+l+
   Q: 701  GFPLDLQKKLLHFTTGSDRVPVGGMADLN---FKISKnETSTNWLPVAHTCFNQLCLPPYKSKKDLKQKLIIGISNSEGFGLE 780
           *****************************...9999967777**************************************985 PP

Organism

Macaca mulatta

Protein Sequence
(Fasta)

MSEAGRVPSP ATPLVVAAAA PEERKGKEPE REKLPPIVSA GAGATAGLDR GAKGQISTFS 60
SFISAISPKK EAAENRSSPA HLVFPNIKNV RDQPPICLDV RQKQRVSMDA SSSEMKAPVL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GTCCGCGGGC CTGGCGCGCG CGGGGGCGGC CGGCGGGGTC GCGCGGCCTC GGGCTCGCGC 60
GCAGAGGCGC GGGCGCGGGC GGGGGCGGAG TGGCGGCGGC GGCGGCGGCG GCGGCGGCAG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000569--HECT_dom

PROSITE

PS50237--HECT

Pfam

PF00632--HECT

SMART

SM00119--HECTc

Gene Ontology

GO:0004842--F:ubiquitin-protein transferase activity

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001266	Ailuropoda melanoleuca	95.78	0.00e+00	1452.00
IUUC-Apl-003589	Anas platyrhynchos	84.76	0.00e+00	1264.00
IUUC-Aca-004350	Anolis carolinensis	79.92	0.00e+00	1186.00
IUUC-Ago-007908	Ashbya gossypii	34.86	3.00e-80	293.00
IUUC-Acl-008288	Aspergillus clavatus	34.91	1.00e-93	338.00
IUUC-Afl-008402	Aspergillus flavus	33.94	3.00e-87	316.00
IUUC-Afu-008762	Aspergillus fumigatus	34.09	2.00e-90	327.00
IUUC-Ani-009176	Aspergillus nidulans	34.93	1.00e-88	321.00
IUUC-Ang-009791	Aspergillus niger	35.63	2.00e-89	323.00
IUUC-Aor-009921	Aspergillus oryzae	33.77	5.00e-87	315.00
IUUC-Ate-010295	Aspergillus terreus	35.25	2.00e-96	347.00
IUUC-Ame-010660	Astyanax mexicanus	81.94	3.00e-152	530.00
IUUC-Bgr-011981	Blumeria graminis	32.24	2.00e-91	330.00
IUUC-Bta-012945	Bos taurus	93.68	0.00e+00	1405.00
IUUC-Bci-013697	Botrytis cinerea	37.04	5.00e-78	286.00
IUUC-Cja-019263	Callithrix jacchus	98.21	0.00e+00	1472.00
IUUC-Cfa-020486	Canis familiaris	96.61	0.00e+00	1291.00
IUUC-Cpo-021755	Cavia porcellus	93.03	0.00e+00	1424.00
IUUC-Csa-023814	Chlorocebus sabaeus	99.33	0.00e+00	1405.00
IUUC-Cho-024980	Choloepus hoffmanni	78.08	0.00e+00	1147.00
IUUC-Cgl-026526	Colletotrichum gloeosporioides	42.05	2.00e-95	344.00
IUUC-Dre-028551	Danio rerio	74.44	0.00e+00	1138.00
IUUC-Dno-029497	Dasypus novemcinctus	92.94	0.00e+00	1269.00
IUUC-Dor-030867	Dipodomys ordii	81.86	0.00e+00	1191.00
IUUC-Dse-031239	Dothistroma septosporum	29.24	2.00e-86	314.00
IUUC-Ete-032902	Echinops telfairi	79.10	0.00e+00	1171.00
IUUC-Eca-033678	Equus caballus	95.10	0.00e+00	1414.00
IUUC-Eeu-035262	Erinaceus europaeus	77.83	0.00e+00	1045.00
IUUC-Fca-035590	Felis catus	95.37	0.00e+00	1444.00
IUUC-Fal-037123	Ficedula albicollis	80.24	0.00e+00	1217.00
IUUC-Fox-037941	Fusarium oxysporum	39.88	9.00e-98	352.00
IUUC-Fso-038388	Fusarium solani	40.08	3.00e-99	357.00
IUUC-Gmo-039553	Gadus morhua	65.74	0.00e+00	840.00
IUUC-Ggr-040110	Gaeumannomyces graminis	40.48	3.00e-96	347.00
IUUC-Gga-040406	Gallus gallus	84.13	0.00e+00	1303.00
IUUC-Gac-042141	Gasterosteus aculeatus	75.18	0.00e+00	1101.00
IUUC-Ggo-045504	Gorilla gorilla	97.99	0.00e+00	1482.00
IUUC-Hsa-045786	Homo sapiens	97.99	0.00e+00	1471.00
IUUC-Itr-048050	Ictidomys tridecemlineatus	88.87	0.00e+00	1219.00
IUUC-Kpa-049152	Komagataella pastoris	33.98	1.00e-74	275.00
IUUC-Lch-049824	Latimeria chalumnae	80.00	0.00e+00	1084.00
IUUC-Loc-052173	Lepisosteus oculatus	77.20	0.00e+00	1186.00
IUUC-Laf-054017	Loxodonta africana	94.50	0.00e+00	1327.00
IUUC-Meu-056212	Macropus eugenii	68.50	7.00e-115	407.00
IUUC-Mor-057045	Magnaporthe oryzae	36.40	4.00e-89	323.00
IUUC-Mla-059187	Melampsora laricipopulina	43.52	7.00e-85	307.00
IUUC-Mga-059884	Meleagris gallopavo	78.40	0.00e+00	1155.00
IUUC-Mmr-061344	Microcebus murinus	93.22	0.00e+00	1403.00
IUUC-Mdo-062653	Monodelphis domestica	87.52	0.00e+00	1315.00
IUUC-Mmu-063775	Mus musculus	89.05	0.00e+00	1284.00
IUUC-Mpu-066069	Mustela putorius furo	96.55	0.00e+00	1321.00
IUUC-Mlu-067925	Myotis lucifugus	94.14	0.00e+00	1376.00
IUUC-Nfi-068439	Neosartorya fischeri	34.09	2.00e-90	327.00
IUUC-Ncr-068903	Neurospora crassa	37.27	1.00e-90	328.00
IUUC-Nle-070046	Nomascus leucogenys	98.53	0.00e+00	1496.00
IUUC-Opr-071085	Ochotona princeps	79.53	7.00e-138	484.00
IUUC-Ont-072126	Oreochromis niloticus	71.94	0.00e+00	1149.00
IUUC-Oan-072933	Ornithorhynchus anatinus	88.79	0.00e+00	1169.00
IUUC-Ocu-073800	Oryctolagus cuniculus	96.10	0.00e+00	1297.00
IUUC-Ola-086988	Oryzias latipes	75.40	0.00e+00	1101.00
IUUC-Oga-088117	Otolemur garnettii	95.86	0.00e+00	1130.00
IUUC-Oar-089371	Ovis aries	93.60	0.00e+00	1366.00
IUUC-Ptr-090551	Pan troglodytes	97.86	0.00e+00	1428.00
IUUC-Pan-092067	Papio anubis	99.49	0.00e+00	1458.00
IUUC-Psi-092963	Pelodiscus sinensis	85.01	0.00e+00	1258.00
IUUC-Pfo-096562	Poecilia formosa	69.74	0.00e+00	1110.00
IUUC-Pab-098680	Pongo abelii	98.39	0.00e+00	1476.00
IUUC-Pca-100986	Procavia capensis	75.17	0.00e+00	884.00
IUUC-Pva-102219	Pteropus vampyrus	79.59	0.00e+00	1069.00
IUUC-Pgr-103315	Puccinia graminis	36.10	1.00e-93	337.00
IUUC-Ptt-103736	Puccinia triticina	41.28	1.00e-92	334.00
IUUC-Rno-105270	Rattus norvegicus	88.06	0.00e+00	1295.00
IUUC-Sce-106306	Saccharomyces cerevisiae	34.25	4.00e-67	249.00
IUUC-Sha-106819	Sarcophilus harrisii	90.05	0.00e+00	1364.00
IUUC-Spo-108271	Schizosaccharomyces pombe	32.83	3.00e-86	313.00
IUUC-Ssl-108657	Sclerotinia sclerotiorum	30.92	1.00e-81	298.00
IUUC-Sar-113134	Sorex araneus	84.88	0.00e+00	1219.00
IUUC-Ssc-115441	Sus scrofa	94.63	0.00e+00	1384.00
IUUC-Tgu-117166	Taeniopygia guttata	83.40	0.00e+00	1239.00
IUUC-Tsy-118898	Tarsius syrichta	82.50	0.00e+00	1128.00
IUUC-Tre-122108	Trichoderma reesei	38.57	5.00e-87	316.00
IUUC-Tvi-122644	Trichoderma virens	38.31	3.00e-91	330.00
IUUC-Tme-127004	Tuber melanosporum	34.65	8.00e-100	359.00
IUUC-Tbe-127292	Tupaia belangeri	78.20	0.00e+00	1068.00
IUUC-Ttr-128352	Tursiops truncatus	90.74	0.00e+00	1330.00
IUUC-Vda-129969	Verticillium dahliae	40.66	5.00e-92	333.00
IUUC-Vpa-130218	Vicugna pacos	91.90	0.00e+00	996.00
IUUC-Xtr-132594	Xenopus tropicalis	77.59	0.00e+00	1171.00
IUUC-Xma-134157	Xiphophorus maculatus	74.39	0.00e+00	1029.00
IUUC-Yli-134470	Yarrowia lipolytica	34.55	2.00e-75	277.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence