iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Pfo-097346

Ensembl Protein ID

ENSPFOP00000014180.2

UniProt Accession

A0A087Y827; A0A087Y827_POEFO

Genbank Protein ID

ENSPFOP00000014180

Protein Name

E3 ubiquitin-protein ligase

Genbank Nucleotide ID

AYCK01018880

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSPFOG00000013961.2	ENSPFOT00000014200.2	ENSPFOP00000014180.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	8.10e-136	453.4	549	881

Active Site

Position(s)	Description	Evidence
850	Glycyl thioester intermediate	{ECO:0000256\|PIRSR:PIRSR001569-1, ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 2    ksdlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlldl 90
           ++dl++rl++ f gEegld+gGv+re+++lls+e+ np+++lf+y  +d++ lq+np+s + np+hlk+F+f+Gr++++al++g+++d+
   Q: 549  PQDLRRRLWIIFPGEEGLDYGGVAREWFFLLSHEVLNPMYCLFEYAGKDNYGLQINPASDI-NPDHLKYFRFIGRFIAMALFHGKFIDT 636
           689*********************************************************9.89************************* PP
   S: 91   plsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvklvve 179
            +s +fyk++l+k+l+l+dle++dpe+y+sl++ik+n   diee+gl++ fsv++e lge++++eLk+gG +i+Vt+eNkeeY+klv+e
   Q: 637  GFSLPFYKRMLNKPLTLNDLESIDPEFYNSLMWIKDN---DIEECGLEMFFSVDKEMLGEISTHELKEGGGDIQVTEENKEEYIKLVAE 722
           ***********************************99...************************************************* PP
   S: 180  yrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerkafLqFv 268
           +rl +g++eq++af eGfnev+p++ l++F+++ele+++cG++e+d+ d++++t y++ yt++s++i wFw+ ++e+++e+r ++LqFv
   Q: 723  WRLSRGVEEQTQAFFEGFNEVLPQQYLQYFDAKELEVMLCGMQELDLGDWQNNTIYRH-YTRTSKQIVWFWQLMKEMDNEKRMRLLQFV 810
           ********************************************************99.****************************** PP
   S: 269  TgssrlPlgGfaelk....prlfvirkdasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFel 335
           Tg++rlP+gGfa+l+    p++f+i+k +++++lP+s+TCfn+L+LP+Y+s+e+lkekL++Aieet+gF++
   Q: 811  TGTCRLPVGGFANLMgsngPQKFCIEKVGKENWLPRSHTCFNRLDLPPYKSYEQLKEKLMFAIEETEGFGQ 881
           *********************************************************************96 PP

Organism

Poecilia formosa

Protein Sequence
(Fasta)

MASGVTKSST SNGYPPKAQL QITVLSAKLK ENKKNWFAPS PYVEVTVDGQ SKKTEKCNST 60
HSPKWKQPLT VIVTPFSKLV FRVWSHQTLK TDVFLGMAML DISETLKSNN MKISDVVQSL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GTGAGAAATG GAGCCGTAAA TGCGTCAGTA TGTTTACTAA TCGCTCATTG GTCCAATCAG 60
TCTGTTATCT GATCCAATCA AAGAGCGAAG GGGGTGACTA ACATGCGCCC CACCTTGTTT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000008--C2_dom
IPR024928--E3_ub_ligase_SMURF1
IPR000569--HECT_dom
IPR001202--WW_dom

PROSITE

PS50004--C2
PS50237--HECT
PS01159--WW_DOMAIN_1
PS50020--WW_DOMAIN_2

Pfam

PF00168--C2
PF00632--HECT
PF00397--WW

SMART

SM00239--C2
SM00119--HECTc
SM00456--WW

Gene Ontology

GO:0004842--F:ubiquitin-protein transferase activity
GO:0048920--P:posterior lateral line neuromast primordium migration

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002302	Ailuropoda melanoleuca	72.90	0.00e+00	1272.00
IUUC-Apl-003752	Anas platyrhynchos	72.20	0.00e+00	1269.00
IUUC-Aca-005338	Anolis carolinensis	71.78	0.00e+00	1278.00
IUUC-Cfa-020648	Canis familiaris	72.59	0.00e+00	1236.00
IUUC-Cpo-022073	Cavia porcellus	73.96	0.00e+00	1277.00
IUUC-Csa-023252	Chlorocebus sabaeus	73.44	0.00e+00	1269.00
IUUC-Cho-024695	Choloepus hoffmanni	67.81	0.00e+00	1207.00
IUUC-Dno-029884	Dasypus novemcinctus	73.51	0.00e+00	1276.00
IUUC-Eca-033793	Equus caballus	72.96	0.00e+00	1274.00
IUUC-Fca-035605	Felis catus	74.57	0.00e+00	1286.00
IUUC-Fal-037126	Ficedula albicollis	72.04	0.00e+00	1268.00
IUUC-Gga-040832	Gallus gallus	72.64	0.00e+00	1281.00
IUUC-Gac-041658	Gasterosteus aculeatus	81.99	0.00e+00	1373.00
IUUC-Ggo-044535	Gorilla gorilla	70.41	0.00e+00	1241.00
IUUC-Kpa-049273	Komagataella pastoris	48.45	8.00e-160	557.00
IUUC-Loc-052647	Lepisosteus oculatus	73.49	0.00e+00	1347.00
IUUC-Laf-054383	Loxodonta africana	73.99	0.00e+00	1273.00
IUUC-Mcc-055532	Macaca mulatta	73.56	0.00e+00	1269.00
IUUC-Mga-059661	Meleagris gallopavo	72.18	0.00e+00	1271.00
IUUC-Mmr-061135	Microcebus murinus	73.76	0.00e+00	1283.00
IUUC-Mdo-062505	Monodelphis domestica	72.53	0.00e+00	1259.00
IUUC-Mpu-066203	Mustela putorius furo	72.68	0.00e+00	1268.00
IUUC-Mlu-067837	Myotis lucifugus	72.56	0.00e+00	1273.00
IUUC-Nle-069244	Nomascus leucogenys	71.32	0.00e+00	1268.00
IUUC-Ont-071822	Oreochromis niloticus	78.99	0.00e+00	1459.00
IUUC-Ola-086526	Oryzias latipes	75.91	0.00e+00	1390.00
IUUC-Oga-088167	Otolemur garnettii	67.85	0.00e+00	1180.00
IUUC-Pan-092454	Papio anubis	73.56	0.00e+00	1269.00
IUUC-Pva-103209	Pteropus vampyrus	72.63	0.00e+00	1228.00
IUUC-Rno-104924	Rattus norvegicus	72.86	0.00e+00	1278.00
IUUC-Sha-107175	Sarcophilus harrisii	71.22	0.00e+00	1274.00
IUUC-Tsy-119198	Tarsius syrichta	66.74	0.00e+00	1144.00
IUUC-Xtr-132885	Xenopus tropicalis	67.97	0.00e+00	1261.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence