iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Mga-059427

Ensembl Protein ID

ENSMGAP00000015024.1

UniProt Accession

G1NN27; G1NN27_MELGA

Protein Name

Tyrosine-protein kinase

Gene Name

BLK

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMGAG00000014205.1	ENSMGAT00000015970.1	ENSMGAP00000015024.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/SH3	1.30e-14	53.6	5	60

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/SH3

   S: 5    kvqvlydyeaqnddeLtlkkGdvvlviekeeqdegWlkgvkelegkrGlfPenFvekle 63
            v++lyd+ a++d +L+l kG++++++   +++++W+ +++  +gk+G +P+nFv+ ++
   Q: 5    IVIALYDFAASSDRDLELVKGEKLQIL---SNEGDWWLAKSLRSGKKGYIPSNFVALVD 60
           699************************...99***********************9886 PP

Organism

Meleagris gallopavo

Protein Sequence
(Fasta)

ADDIIVIALY DFAASSDRDL ELVKGEKLQI LSNEGDWWLA KSLRSGKKGY IPSNFVALVD 60
SLEQEKWFFK TLSRKDAERL LLSSGNKIGS FLVRESETST GAYSLSVRDS DSAHGDIIKH 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GCAGATGACA TCATTGTGAT TGCACTGTAT GACTTTGCTG CTTCAAGTGA CCGTGATCTG 60
GAGCTGGTCA AGGGGGAGAA ACTTCAGATC CTCTCCAAGT AAGGGATGCT TAAAGTCGAG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0418--Kinase
KW-0547--Nucleotide-binding
KW-1185--Reference proteome
KW-0728--SH3 domain
KW-0808--Transferase
KW-0829--Tyrosine-protein kinase

Interpro

IPR011009--Kinase-like_dom
IPR000719--Prot_kinase_dom
IPR017441--Protein_kinase_ATP_BS
IPR001245--Ser-Thr/Tyr_kinase_cat_dom
IPR000980--SH2
IPR001452--SH3_domain
IPR020635--Tyr_kinase_cat_dom

PROSITE

PS00107--PROTEIN_KINASE_ATP
PS50011--PROTEIN_KINASE_DOM
PS50001--SH2
PS50002--SH3

Pfam

PF07714--Pkinase_Tyr
PF00017--SH2
PF00018--SH3_1

PRINTS

PR00401--SH2DOMAIN
PR00452--SH3DOMAIN
PR00109--TYRKINASE

SMART

SM00252--SH2
SM00326--SH3
SM00219--TyrKc

Gene Ontology

GO:0005524--F:ATP binding
GO:0004715--F:non-membrane spanning protein tyrosine kinase activity
GO:0050853--P:B cell receptor signaling pathway
GO:0032024--P:positive regulation of insulin secretion

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002133	Ailuropoda melanoleuca	75.50	0.00e+00	732.00
IUUC-Apl-003307	Anas platyrhynchos	93.53	0.00e+00	879.00
IUUC-Aca-004357	Anolis carolinensis	75.23	0.00e+00	715.00
IUUC-Ame-010642	Astyanax mexicanus	71.65	0.00e+00	696.00
IUUC-Bta-012400	Bos taurus	75.06	0.00e+00	724.00
IUUC-Cfa-021056	Canis familiaris	75.28	0.00e+00	729.00
IUUC-Cpo-021779	Cavia porcellus	75.28	0.00e+00	736.00
IUUC-Csa-023557	Chlorocebus sabaeus	75.28	0.00e+00	734.00
IUUC-Dre-027517	Danio rerio	71.21	0.00e+00	698.00
IUUC-Eca-034218	Equus caballus	75.28	0.00e+00	731.00
IUUC-Eeu-035095	Erinaceus europaeus	56.57	9.00e-148	516.00
IUUC-Fca-036015	Felis catus	73.72	0.00e+00	713.00
IUUC-Fal-036946	Ficedula albicollis	90.58	0.00e+00	857.00
IUUC-Gmo-038861	Gadus morhua	66.97	0.00e+00	637.00
IUUC-Gga-040822	Gallus gallus	98.44	0.00e+00	919.00
IUUC-Ggo-044608	Gorilla gorilla	73.83	0.00e+00	687.00
IUUC-Hsa-046719	Homo sapiens	74.16	0.00e+00	724.00
IUUC-Itr-048323	Ictidomys tridecemlineatus	75.34	0.00e+00	725.00
IUUC-Lch-050114	Latimeria chalumnae	74.55	0.00e+00	729.00
IUUC-Loc-052326	Lepisosteus oculatus	74.33	0.00e+00	716.00
IUUC-Laf-053387	Loxodonta africana	74.16	0.00e+00	721.00
IUUC-Mcc-055026	Macaca mulatta	75.50	0.00e+00	736.00
IUUC-Mmr-061660	Microcebus murinus	75.78	0.00e+00	735.00
IUUC-Mdo-062318	Monodelphis domestica	75.40	0.00e+00	722.00
IUUC-Mmu-063325	Mus musculus	74.83	0.00e+00	730.00
IUUC-Mpu-066582	Mustela putorius furo	75.06	0.00e+00	729.00
IUUC-Nle-069624	Nomascus leucogenys	75.56	0.00e+00	732.00
IUUC-Ont-072266	Oreochromis niloticus	70.31	0.00e+00	686.00
IUUC-Ocu-073907	Oryctolagus cuniculus	76.01	0.00e+00	730.00
IUUC-Ola-086668	Oryzias latipes	69.96	0.00e+00	672.00
IUUC-Oga-088057	Otolemur garnettii	75.56	0.00e+00	728.00
IUUC-Oar-089332	Ovis aries	71.05	0.00e+00	678.00
IUUC-Ptr-091551	Pan troglodytes	73.26	0.00e+00	687.00
IUUC-Pan-092173	Papio anubis	76.01	0.00e+00	735.00
IUUC-Psi-093895	Pelodiscus sinensis	83.30	0.00e+00	798.00
IUUC-Pfo-096608	Poecilia formosa	70.98	0.00e+00	688.00
IUUC-Pab-097598	Pongo abelii	76.40	0.00e+00	736.00
IUUC-Pva-102135	Pteropus vampyrus	75.06	0.00e+00	723.00
IUUC-Rno-104891	Rattus norvegicus	74.83	0.00e+00	733.00
IUUC-Sha-107192	Sarcophilus harrisii	76.58	0.00e+00	730.00
IUUC-Ssc-115696	Sus scrofa	75.50	0.00e+00	731.00
IUUC-Tgu-117056	Taeniopygia guttata	90.32	0.00e+00	845.00
IUUC-Tru-117621	Takifugu rubripes	67.79	0.00e+00	661.00
IUUC-Ttr-128457	Tursiops truncatus	75.28	0.00e+00	723.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence