iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Mga-059671

UUCD1 version

UUC-MeG-00215

Ensembl Protein ID

ENSMGAP00000004134.2

UniProt Accession

G1MYS8; G1MYS8_MELGA

Protein Name

Uncharacterized protein

Gene Name

KDM2B

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMGAG00000004301.2	ENSMGAT00000004847.2	ENSMGAP00000004134.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/SCF/F-box	1.30e-06	28.2	919	1007
E3 activity/RING/PHD	3.00e-14	52.7	564	629

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/SCF/F-box

   S: 56   rrtprqpprgpsaaakpkaglrseaaaapap.apaptptpeegpdaglldrlpeeilveilklldkeellraarvcrrwqelasqka 141
           r tpr   r p + + pk+         p p +p p   p    d g  + ++ e+++ ++++l++++l+ + rvc++w++ + +k+
   Q: 919  RSTPRGIARPPPSLSPPKCIQMERHVIRPPPiSPPPDSLPL---DDGAAHVMQREVWMAVFSYLSHRDLCICMRVCKTWNRWCCDKR 1002
           88999999999999999986665555555551344444443...6677788889**************************5555599 PP
   S: 142  lwktv 146
           lw ++
   Q: 1003 LWTKI 1007
           *9986 PP

E3 activity/RING/PHD

   S: 2    kvClvCgeggede.....k.....slveCekCrewfHpaClkls.....veeelpnsekwiCpkCrsk 54
           +vClvCge+g+++     +     +l+eC++C+e++Hp+Clk +     v++elpn+  w+CpkC+++
   Q: 564  AVCLVCGEAGKEDtveeeEskfnlMLMECSICNEIIHPGCLKVKesdgvVNDELPNC--WECPKCNHA 629
           79*********9977766156889*********************************..*******85 PP

Organism

Meleagris gallopavo

Protein Sequence
(Fasta)

DFTFEYVQRE ALRVPLIFRN KDGLGIKMPD PDFTVRDVKL LVGSRRIVDV MDVNTQRGVE 60
MSMSQFVRYY ETPEAQREKL YNVISLEFSH TKLENIVKRP NVVDLVDWVD NMWPQHLKER 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GATTTTACTT TTGAGTATGT GCAAAGAGAA GCCCTCAGAG TTCCACTTAT CTTCAGAAAT 60
AAGGATGGAC TGGGAATTAA GTAAGTTACC ACCAAATCTT GATTAAGAAA CACTTTTATA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0479--Metal-binding
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001810--F-box_dom
IPR003347--JmjC_dom
IPR032675--L_dom-like
IPR006553--Leu-rich_rpt_Cys-con_subtyp
IPR002857--Znf_CXXC
IPR011011--Znf_FYVE_PHD
IPR001965--Znf_PHD
IPR019787--Znf_PHD-finger
IPR013083--Znf_RING/FYVE/PHD

PROSITE

PS51184--JMJC
PS51058--ZF_CXXC
PS50016--ZF_PHD_2

Pfam

PF00646--F-box
PF02373--JmjC
PF16866--PHD_4
PF02008--zf-CXXC

SMART

SM00558--JmjC
SM00367--LRR_CC
SM00249--PHD

Gene Ontology

GO:0031519--C:PcG protein complex
GO:0000979--F:RNA polymerase II core promoter sequence-specific DNA binding
GO:0008270--F:zinc ion binding
GO:0048596--P:embryonic camera-type eye morphogenesis
GO:0021592--P:fourth ventricle development
GO:0035518--P:histone H2A monoubiquitination
GO:0070544--P:histone H3-K36 demethylation
GO:0021993--P:initiation of neural tube closure
GO:0021670--P:lateral ventricle development
GO:0030901--P:midbrain development
GO:0021555--P:midbrain-hindbrain boundary morphogenesis
GO:2000178--P:negative regulation of neural precursor cell proliferation
GO:0043524--P:negative regulation of neuron apoptotic process
GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter
GO:0030307--P:positive regulation of cell growth
GO:1902459--P:positive regulation of stem cell population maintenance
GO:0007283--P:spermatogenesis
GO:0021678--P:third ventricle development

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001358	Ailuropoda melanoleuca	83.82	0.00e+00	1950.00
IUUC-Apl-003787	Anas platyrhynchos	94.51	0.00e+00	2187.00
IUUC-Aca-004247	Anolis carolinensis	80.80	0.00e+00	1800.00
IUUC-Afl-008579	Aspergillus flavus	41.55	4.00e-23	102.00
IUUC-Bta-013531	Bos taurus	84.28	0.00e+00	1958.00
IUUC-Cel-018303	Caenorhabditis elegans	45.34	8.00e-81	295.00
IUUC-Cja-018876	Callithrix jacchus	81.44	0.00e+00	1872.00
IUUC-Cfa-020857	Canis familiaris	84.29	0.00e+00	1949.00
IUUC-Cpo-021967	Cavia porcellus	82.00	0.00e+00	1830.00
IUUC-Csa-023210	Chlorocebus sabaeus	83.00	0.00e+00	1897.00
IUUC-Cme-027118	Cyanidioschyzon merolae	30.91	5.00e-49	188.00
IUUC-Dre-028272	Danio rerio	66.71	0.00e+00	945.00
IUUC-Dno-030034	Dasypus novemcinctus	83.67	0.00e+00	1902.00
IUUC-Dor-030736	Dipodomys ordii	73.63	0.00e+00	837.00
IUUC-Dse-031402	Dothistroma septosporum	42.25	9.00e-61	229.00
IUUC-Eca-034255	Equus caballus	84.24	0.00e+00	1956.00
IUUC-Eeu-035038	Erinaceus europaeus	84.11	0.00e+00	1016.00
IUUC-Fca-035786	Felis catus	84.04	0.00e+00	1966.00
IUUC-Fal-037589	Ficedula albicollis	94.03	0.00e+00	2215.00
IUUC-Gga-041103	Gallus gallus	99.18	0.00e+00	1212.00
IUUC-Gac-041304	Gasterosteus aculeatus	62.79	0.00e+00	1461.00
IUUC-Ggo-044522	Gorilla gorilla	74.00	0.00e+00	1578.00
IUUC-Hsa-045877	Homo sapiens	84.55	0.00e+00	1934.00
IUUC-Itr-049003	Ictidomys tridecemlineatus	85.10	0.00e+00	1157.00
IUUC-Lch-049950	Latimeria chalumnae	82.16	0.00e+00	1953.00
IUUC-Loc-051972	Lepisosteus oculatus	73.58	0.00e+00	1043.00
IUUC-Lma-053190	Leptosphaeria maculans	44.15	1.00e-60	228.00
IUUC-Laf-053623	Loxodonta africana	83.67	0.00e+00	1873.00
IUUC-Mcc-054943	Macaca mulatta	83.43	0.00e+00	1917.00
IUUC-Meu-056259	Macropus eugenii	83.20	0.00e+00	1925.00
IUUC-Mmr-061003	Microcebus murinus	83.53	0.00e+00	1931.00
IUUC-Mmu-063584	Mus musculus	83.08	0.00e+00	1910.00
IUUC-Mpu-066056	Mustela putorius furo	84.05	0.00e+00	1931.00
IUUC-Mlu-067850	Myotis lucifugus	83.84	0.00e+00	1964.00
IUUC-Nle-069837	Nomascus leucogenys	83.46	0.00e+00	1804.00
IUUC-Opr-070943	Ochotona princeps	80.70	0.00e+00	1803.00
IUUC-Ont-071663	Oreochromis niloticus	65.50	0.00e+00	1526.00
IUUC-Oan-072934	Ornithorhynchus anatinus	76.96	0.00e+00	1286.00
IUUC-Ocu-074706	Oryctolagus cuniculus	84.00	0.00e+00	1944.00
IUUC-Ola-086543	Oryzias latipes	63.79	0.00e+00	1492.00
IUUC-Oga-088671	Otolemur garnettii	76.23	0.00e+00	924.00
IUUC-Oar-089560	Ovis aries	79.64	0.00e+00	1871.00
IUUC-Ptr-090875	Pan troglodytes	84.47	0.00e+00	1951.00
IUUC-Pan-091788	Papio anubis	82.23	0.00e+00	1880.00
IUUC-Psi-093382	Pelodiscus sinensis	90.98	0.00e+00	2154.00
IUUC-Pma-094687	Petromyzon marinus	52.53	8.00e-95	340.00
IUUC-Pno-094984	Phaeosphaeria nodorum	45.45	6.00e-62	233.00
IUUC-Pfo-096272	Poecilia formosa	67.21	0.00e+00	942.00
IUUC-Pab-097907	Pongo abelii	79.90	0.00e+00	1783.00
IUUC-Pca-100628	Procavia capensis	75.17	0.00e+00	1557.00
IUUC-Pva-102956	Pteropus vampyrus	76.61	0.00e+00	949.00
IUUC-Ptt-103859	Puccinia triticina	45.49	4.00e-73	268.00
IUUC-Pte-104241	Pyrenophora teres	44.70	8.00e-61	229.00
IUUC-Pyt-104741	Pyrenophora triticirepentis	44.70	6.00e-60	226.00
IUUC-Rno-105722	Rattus norvegicus	82.70	0.00e+00	1601.00
IUUC-Sha-106626	Sarcophilus harrisii	80.08	0.00e+00	1802.00
IUUC-Ssc-115918	Sus scrofa	82.18	0.00e+00	1531.00
IUUC-Tru-118638	Takifugu rubripes	69.44	0.00e+00	936.00
IUUC-Tme-127054	Tuber melanosporum	41.67	3.00e-52	200.00
IUUC-Tbe-127654	Tupaia belangeri	70.29	0.00e+00	1476.00
IUUC-Ttr-128821	Tursiops truncatus	77.24	0.00e+00	1724.00
IUUC-Xtr-131823	Xenopus tropicalis	76.18	0.00e+00	1751.00
IUUC-Xma-133305	Xiphophorus maculatus	66.44	0.00e+00	943.00
IUUC-Yli-134626	Yarrowia lipolytica	42.25	3.00e-54	205.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence