iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Mcc-054661

UUCD1 version

UUC-MaM-01106

Ensembl Protein ID

ENSMMUP00000004034.2

UniProt Accession

F6VN92; F6VN92_MACMU

Genbank Protein ID

AFE76303.1; AFE76304.1; AFH30824.1; AFI36021.1

Protein Name

Ubiquitin carboxyl-terminal hydrolase 16; Deubiquitinating enzyme 16; Ubiquitin thioesterase 16; Ubiquitin-specific-processing protease 16

Genbank Nucleotide ID

JSUE03027257; JU332549; JU474020; JV045950

Gene Name

USP16

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMMUG00000003020.3	ENSMMUT00000004279.3	ENSMMUP00000004034.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	4.90e-90	303.2	196	824

Active Site

Position(s)	Description	Evidence
205	Nucleophile	ECO:0000256\|HAMAP-Rule:MF_03062}
761	Proton acceptor	ECO:0000256\|HAMAP-Rule:MF_03062}

Domain Profile

DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrellle..........kkkeklneenp............kepkgellkslqklfeelwkskkka 67
           +Gl+NlgNtC++N+v+Q Ls++p lrell+e          +         p             ep g+l+ ++ ++++e++++kk+ 
   Q: 196  KGLSNLGNTCFFNAVMQNLSQTPVLRELLKEvkmsgtivkiE---------PpdlaltepleinLEPPGPLTLAMSQFLNEMQETKKGI 275
           5******************************86555555540.........24555555555658899********************* PP
   S: 68   vsprellkalkkeaeefsgyeqqDaqEflaflldqleeelkkeknkpkeeeeeedkselsde.....aeekkkkknkslisdlFqgqlk 151
           v+p+el+++++k+a++f+gy+qqD+qE+l++lld+++ e +++ +k + +++++++++l++e     ++++kkk+ +s+++++F+g+l+
   Q: 276  VTPKELFSQVCKKAVRFKGYQQQDSQELLRYLLDGMRAEEHQRVSKGILKAFGNSTEKLDEElknkvKDYEKKKSIPSFVDRIFGGELT 364
           *************************************************************99999999999***************** PP
   S: 152  sqikclecdnvssreepfldlslpvpgkeetkke....................................................... 185
           s+i+c +c++vs  +e+fldlslpv ++++ kk+                                                       
   Q: 365  STIMCDQCRTVSLVHESFLDLSLPVLDDQSGKKSvndknlkktmededqdseeekdndsyikersdipsgtskhlqkkakkqakkqakn 453
           *****************************99999******************************************************* PP
   S: 186  ......................................................................................... 185
                                                                                                    
   Q: 454  qrrqqkiqgkvlhlndictidhpedneyeaemslqgevniksnhisqegvmhkeycvnqkdlngqekmiesvtdnqksteevdmkninm 542
           ***************************************************************************************** PP
   S: 186  ......................................................................................... 185
                                                                                                    
   Q: 543  dndlevltssptectrnlngaylteasngevdisngfknlnlnaalhpdeinieilndshtpgtkvyevvnedpetafctlanrevfnt 631
           ***************************************************************************************** PP
   S: 186  ...slqdcLesftkeeelegenkyycekckkkqe.................aekklklkklPevLilhLkRfsfseeqksrekinkkve 254
              s+q+cL +ft++e+l+++nk+ ce c+++q                  a+k++ ++  P+vL+lhLkRf  ++++ + +k+nk+++
   Q: 632  decSIQHCLYQFTRNEKLRDANKLLCEVCTRRQCngpkanmkgerkhvytnAKKQMLISLAPPVLTLHLKRF--QQAGFNLRKVNKHIK 718
           ******************************888899999999999999999*********************..9999*********** PP
   S: 255  fpleLdlspfctspeekqke...kkkYeLiavvvHsGslssGHYvayvkn.......................ekgkWllfdDskVtev 317
           fp+ Ldl+pfct ++++++e   ++ Y+L++vv HsG+++sGHY+ay+k                        +kg+W++++D++V++v
   Q: 719  FPEILDLAPFCTLKCKNVAEentRVLYSLYGVVEHSGTMRSGHYTAYAKArtanshlsnlvlhgdipqdfemeSKGQWFHISDTHVQAV 807
           *************9999887777999************************999999999999999999999888999************ PP
   S: 318  keeevleetgstaYvlfYkr 337
           + ++vl+   s+aY+lfY+r
   Q: 808  PTTKVLN---SQAYLLFYER 824
           *******...********98 PP

Organism

Macaca mulatta

Functional Description
(View)

Specifically deubiquitinates 'Lys-120' of histone H2A (H2AK119Ub), a specific tag for epigenetic transcriptional repression, thereby acting as a coactivator. Deubiquitination of histone H2A is a prerequisite for subsequent phosphorylation at 'Ser-11' of histone H3 (H3S10ph), and is required for chromosome segregation when cells enter into mitosis. In resting B- and T-lymphocytes, phosphorylation by AURKB leads to enhance its activity, thereby maintaining transcription in resting lymphocytes. Regulates Hox gene expression via histone H2A deubiquitination. Prefers nucleosomal substrates. Does not deubiquitinate histone H2B.

Protein Sequence
(Fasta)

MGKKRTKGKT VPIDDSSETL EPMCRHIRKG LEQGNLKKAL VNVEWNICQD CKTDNKVKDK 60
AEEETEEKPS VWLCLKCGHQ GCGRNSQEQH ALKHYLTPRS EPHCLVLSLD NWSVWCYICD 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GGAGGTGGTG GCCTAGCCAC TTCCCATAAT GCCGCGTTCC GGAAGTTGTT GCTTTCCAGG 60
GGTCACTCTG GCTTCTGCTC CGTCGCTCTC AATTCGTCAC CAGGAGGAAG ACGGAGCTGG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0010--Activator
KW-0131--Cell cycle
KW-0132--Cell division
KW-0156--Chromatin regulator
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0479--Metal-binding
KW-0498--Mitosis
KW-0539--Nucleus
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001394--Peptidase_C19_UCH
IPR030849--UBP16
IPR018200--USP_CS
IPR028889--USP_dom
IPR013083--Znf_RING/FYVE/PHD
IPR001607--Znf_UBP

PROSITE

PS00972--USP_1
PS00973--USP_2
PS50235--USP_3
PS50271--ZF_UBP

Pfam

PF00443--UCH
PF02148--zf-UBP

SMART

SM00290--ZnF_UBP

Gene Ontology

GO:0005634--C:nucleus
GO:0004197--F:cysteine-type endopeptidase activity
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0003713--F:transcription coactivator activity
GO:0008270--F:zinc ion binding
GO:0051301--P:cell division
GO:0006974--P:cellular response to DNA damage stimulus
GO:0070537--P:histone H2A K63-linked deubiquitination
GO:0007067--P:mitotic nuclear division
GO:0035522--P:monoubiquitinated histone H2A deubiquitination
GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter
GO:0045901--P:positive regulation of translational elongation
GO:0051289--P:protein homotetramerization
GO:0051726--P:regulation of cell cycle
GO:0006351--P:transcription, DNA-templated
GO:0006511--P:ubiquitin-dependent protein catabolic process

KEGG

mcc:706403

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000997	Aegilops tauschii	36.28	3.00e-28	120.00
IUUC-Aml-001931	Ailuropoda melanoleuca	92.74	0.00e+00	1428.00
IUUC-Atr-003015	Amborella trichopoda	31.41	2.00e-35	144.00
IUUC-Apl-004145	Anas platyrhynchos	63.79	0.00e+00	922.00
IUUC-Aca-004314	Anolis carolinensis	59.62	0.00e+00	896.00
IUUC-Aly-006422	Arabidopsis lyrata	28.75	3.00e-29	124.00
IUUC-Ath-006732	Arabidopsis thaliana	32.94	2.00e-32	134.00
IUUC-Afl-008729	Aspergillus flavus	28.72	5.00e-14	72.80
IUUC-Aor-009965	Aspergillus oryzae	28.72	2.00e-14	74.70
IUUC-Ame-011659	Astyanax mexicanus	49.55	1.00e-110	394.00
IUUC-Bta-013362	Bos taurus	91.66	0.00e+00	1422.00
IUUC-Bdi-014465	Brachypodium distachyon	32.22	2.00e-30	128.00
IUUC-Bol-015941	Brassica oleracea	30.00	7.00e-33	136.00
IUUC-Bra-016751	Brassica rapa	29.36	1.00e-30	129.00
IUUC-Cja-019177	Callithrix jacchus	96.73	0.00e+00	1542.00
IUUC-Cfa-020051	Canis familiaris	92.87	0.00e+00	1445.00
IUUC-Cpo-021886	Cavia porcellus	82.17	0.00e+00	1311.00
IUUC-Csa-024103	Chlorocebus sabaeus	99.64	0.00e+00	1588.00
IUUC-Cho-024315	Choloepus hoffmanni	79.17	2.00e-131	462.00
IUUC-Cin-025775	Ciona intestinalis	51.77	2.00e-39	154.00
IUUC-Csv-026075	Ciona savignyi	51.67	5.00e-60	225.00
IUUC-Cme-027348	Cyanidioschyzon merolae	39.46	4.00e-20	93.20
IUUC-Dre-028388	Danio rerio	46.36	0.00e+00	647.00
IUUC-Dno-029409	Dasypus novemcinctus	89.96	0.00e+00	1424.00
IUUC-Dor-030443	Dipodomys ordii	79.36	0.00e+00	662.00
IUUC-Ete-032807	Echinops telfairi	83.97	0.00e+00	691.00
IUUC-Eca-033479	Equus caballus	92.87	0.00e+00	1471.00
IUUC-Eeu-034835	Erinaceus europaeus	85.02	0.00e+00	677.00
IUUC-Fca-036320	Felis catus	92.99	0.00e+00	1487.00
IUUC-Fal-037029	Ficedula albicollis	60.95	0.00e+00	856.00
IUUC-Gmo-039480	Gadus morhua	53.32	2.00e-115	409.00
IUUC-Gga-040527	Gallus gallus	63.86	0.00e+00	912.00
IUUC-Gac-042343	Gasterosteus aculeatus	46.68	0.00e+00	642.00
IUUC-Gma-044402	Glycine max	27.62	1.00e-31	132.00
IUUC-Ggo-045598	Gorilla gorilla	98.43	0.00e+00	1566.00
IUUC-Hsa-046598	Homo sapiens	98.18	0.00e+00	1557.00
IUUC-Hvu-047146	Hordeum vulgare	35.90	3.00e-27	117.00
IUUC-Itr-047951	Ictidomys tridecemlineatus	92.74	0.00e+00	1469.00
IUUC-Lch-050536	Latimeria chalumnae	53.08	0.00e+00	754.00
IUUC-Lpe-050703	Leersia perrieri	36.92	2.00e-27	118.00
IUUC-Loc-051814	Lepisosteus oculatus	57.00	9.00e-127	447.00
IUUC-Laf-053732	Loxodonta africana	87.71	0.00e+00	1421.00
IUUC-Meu-055967	Macropus eugenii	73.12	2.00e-159	556.00
IUUC-Mga-059551	Meleagris gallopavo	62.57	0.00e+00	926.00
IUUC-Mvi-060391	Microbotryum violaceum	32.31	3.00e-19	90.90
IUUC-Mmr-061747	Microcebus murinus	94.55	0.00e+00	1460.00
IUUC-Mdo-062220	Monodelphis domestica	69.29	0.00e+00	1055.00
IUUC-Mmu-063582	Mus musculus	83.35	0.00e+00	1285.00
IUUC-Mac-064941	Musa acuminata	33.03	2.00e-37	150.00
IUUC-Mpu-066339	Mustela putorius furo	92.02	0.00e+00	1473.00
IUUC-Mlu-067511	Myotis lucifugus	86.46	0.00e+00	1355.00
IUUC-Nle-069252	Nomascus leucogenys	99.15	0.00e+00	1579.00
IUUC-Opr-070969	Ochotona princeps	87.20	0.00e+00	1331.00
IUUC-Ont-071786	Oreochromis niloticus	51.53	2.00e-117	416.00
IUUC-Ocu-074704	Oryctolagus cuniculus	92.71	0.00e+00	1433.00
IUUC-Oba-075094	Oryza barthii	30.49	2.00e-30	128.00
IUUC-Obr-076743	Oryza brachyantha	30.86	1.00e-30	128.00
IUUC-Ogl-077739	Oryza glaberrima	30.49	1.00e-30	128.00
IUUC-Ogu-078851	Oryza glumaepatula	30.49	2.00e-30	128.00
IUUC-Oin-079402	Oryza indica	30.49	2.00e-30	128.00
IUUC-Olo-080431	Oryza longistaminata	30.49	2.00e-30	128.00
IUUC-Ome-081580	Oryza meridionalis	30.49	2.00e-30	127.00
IUUC-Oni-082644	Oryza nivara	30.49	2.00e-30	128.00
IUUC-Opu-083452	Oryza punctata	29.57	7.00e-30	126.00
IUUC-Oru-084546	Oryza rufipogon	30.49	2.00e-30	128.00
IUUC-Osa-085858	Oryza sativa	30.49	2.00e-30	128.00
IUUC-Ola-086795	Oryzias latipes	49.78	2.00e-112	399.00
IUUC-Oga-088713	Otolemur garnettii	91.90	0.00e+00	1459.00
IUUC-Oar-089887	Ovis aries	92.26	0.00e+00	1439.00
IUUC-Ptr-091670	Pan troglodytes	98.55	0.00e+00	1568.00
IUUC-Pan-092293	Papio anubis	100.00	0.00e+00	1591.00
IUUC-Psi-093101	Pelodiscus sinensis	66.95	0.00e+00	956.00
IUUC-Pfo-097202	Poecilia formosa	50.43	2.00e-117	416.00
IUUC-Pab-098773	Pongo abelii	97.83	0.00e+00	1216.00
IUUC-Pop-099136	Populus trichocarpa	29.72	2.00e-38	154.00
IUUC-Pca-101069	Procavia capensis	68.92	0.00e+00	1141.00
IUUC-Ppe-101794	Prunus persica	30.32	7.00e-34	139.00
IUUC-Pva-103092	Pteropus vampyrus	89.33	0.00e+00	696.00
IUUC-Rno-105237	Rattus norvegicus	84.32	0.00e+00	1297.00
IUUC-Sha-106889	Sarcophilus harrisii	73.52	0.00e+00	1131.00
IUUC-Spo-108149	Schizosaccharomyces pombe	34.74	5.00e-20	93.60
IUUC-Ssl-108648	Sclerotinia sclerotiorum	27.62	2.00e-12	67.40
IUUC-Sit-110283	Setaria italica	32.36	4.00e-30	127.00
IUUC-Sly-111487	Solanum lycopersicum	29.46	8.00e-39	155.00
IUUC-Stu-112820	Solanum tuberosum	29.64	3.00e-37	150.00
IUUC-Sar-113530	Sorex araneus	83.82	0.00e+00	1323.00
IUUC-Sbi-113785	Sorghum bicolor	38.31	1.00e-24	108.00
IUUC-Ssc-116091	Sus scrofa	91.58	0.00e+00	1410.00
IUUC-Tgu-117478	Taeniopygia guttata	60.31	0.00e+00	879.00
IUUC-Tru-118640	Takifugu rubripes	53.64	1.00e-119	424.00
IUUC-Tsy-119042	Tarsius syrichta	80.89	0.00e+00	947.00
IUUC-Tni-120015	Tetraodon nigroviridis	47.10	0.00e+00	633.00
IUUC-Tca-121701	Theobroma cacao	27.92	1.00e-36	149.00
IUUC-Tae-125305	Triticum aestivum	36.41	7.00e-26	112.00
IUUC-Tur-126788	Triticum urartu	28.70	2.00e-26	114.00
IUUC-Tbe-127309	Tupaia belangeri	78.66	0.00e+00	1133.00
IUUC-Ttr-128271	Tursiops truncatus	92.02	0.00e+00	1462.00
IUUC-Vpa-130674	Vicugna pacos	92.15	0.00e+00	1351.00
IUUC-Xtr-131869	Xenopus tropicalis	52.27	0.00e+00	795.00
IUUC-Xma-134195	Xiphophorus maculatus	53.21	5.00e-117	415.00
IUUC-Zma-135157	Zea mays	30.86	2.00e-27	117.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence