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Tag Content
iUUCD ID IUUC-Pfo-097202
Ensembl Protein ID ENSPFOP00000002515.2
UniProt Accession A0A087X9R2; A0A087X9R2_POEFO
Genbank Protein ID ENSPFOP00000002515
Protein Name Ubiquitin carboxyl-terminal hydrolase 16; Deubiquitinating enzyme 16; Ubiquitin thioesterase 16; Ubiquitin-specific-processing protease 16
Genbank Nucleotide ID AYCK01012638
Gene Name usp16; USP16
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSPFOG00000002484.2 ENSPFOT00000002519.2 ENSPFOP00000002515.2
Status Unreviewed
Classification
Family E-Value Score Start End
DUB/USP 6.10e-82 276.1 218 833
Active Site
Position(s) Description Evidence
227 Nucleophile ECO:0000256|HAMAP-Rule:MF_03062}
775 Proton acceptor ECO:0000256|HAMAP-Rule:MF_03062}
Domain Profile

   DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrelllekkkeklneenp.............kepkgellkslqklfeelwkskkkavsprellka 76
    +Gl+NlgNtC++N+vLQ Ls+++ lr+ l++ ++ek++ + + ++ g+l+ ++ kl++e+++sk+++v+prel+++
   Q: 218 KGLSNLGNTCFFNAVLQNLSQTQLLRQILNKVTEEKMSLDIKpdaslnlepilvqLDQPGSLTLAMCKLLNEIQESKRGVVTPRELFTQ 306
    5******************************66666655544557777777888888888***************************** PP
   S: 77 lkkeaeefsgyeqqDaqEflaflldqleeelkk.......eknkpkeeeeeedkselsde.....aeekkkkknkslisdlFqgqlksq 153
    ++k+a +f+g++qqD+qE+l++lld+++ e k e+ k+ ++ ++ed + +e++k+ k++++++F+g+++s+
   Q: 307 VCKKAARFKGFQQQDSQELLRYLLDGMRAEELKrvsmgiaESLKQSSKVTDED------KikaavKEYEKNGVPKNFVDQVFGGEMTST 389
    ***************************97664435555543333444444444......2444446899999999************** PP
   S: 154 ikclecdnvssreepfldlslpvpgkeetkke......................................................... 185
    i+c++c++vs+ +e fldlslpv+++ +kk+
   Q: 390 IMCQQCKTVSVVTEMFLDLSLPVSDEAYRKKKtqkvlprtsessqderngsdlirenddsttggsskyqqkkakkqakkqakkrqhkle 478
    ************************9999988899******************************************************* PP
   S: 186 ......................................................................................... 185
   
   Q: 479 tritlgnltspsnadgdqidvtedakdtenadqmpheevslneqdpkpvcefeqdqnveqengedkdspsddvsladssvsnrftvlse 567
    ***************************************************************************************** PP
   S: 186 ...................................................................................slqdcL 191
    s+q+cL
   Q: 568 eqhshdstscnetsntdlegeldtqladqlqqvtlndafiedldsmdpaeesedeveytiinqdpelafntlstrtspekqecSVQSCL 656
    ***************************************************************************************** PP
   S: 192 esftkeeelegenkyycekckkkqe...............aekklklkklPevLilhLkRfsfseeqksrekinkkvefpleLdlspfc 265
    +ft+ e+l+++n + c c+k+ + a k++ +++ P vL+lh+kRf +++++s k+n++v+fpl Ldl+p+c
   Q: 657 FQFTEVETLTQNNSLLCVACTKRHKkgektggskkniytdALKQMLISSPPSVLTLHMKRF--QQNGYSICKVNRHVQFPLILDLAPYC 743
    *********************9888999999999999999*********************..88889999****************** PP
   S: 266 tspeekqke...kkkYeLiavvvHsGslssGHYvayvkn..................ekgkWllfdDskVtevkeeevleetgstaYvl 333
    + ++++ +e + Y+L++vv HsG+++sGHY+ayvk +g+W++++D++V++v+e++v++ ++aY+l
   Q: 744 AAKCKNISEgdtQILYSLYGVVEHSGTMRSGHYTAYVKTrpdslksssngkqgetdlPRGSWFHISDTSVQPVSESKVQS---CQAYLL 829
    **999988888899*************************9999999988877766666777*******************...****** PP
   S: 334 fYkr 337
    fY+r
   Q: 830 FYER 833
    **98 PP
   

Organism Poecilia formosa
Functional Description
(View)

Functional Description



     Specifically deubiquitinates 'Lys-120' of histone H2A (H2AK119Ub), a specific tag for epigenetic transcriptional repression, thereby acting as a coactivator. Deubiquitination of histone H2A is a prerequisite for subsequent phosphorylation at 'Ser-11' of histone H3 (H3S10ph), and is required for chromosome segregation when cells enter into mitosis. Regulates Hox gene expression via histone H2A deubiquitination. Prefers nucleosomal substrates. Does not deubiquitinate histone H2B.
Specifically deubiquitinates 'Lys-120' of histone H2A (H2AK119Ub), a specific tag for epigenetic transcriptional repression, thereby acting as a coactivator. Deubiquitination of histone H2A is a prerequisite for subsequent phosphorylation at 'Ser-11' of histone H3 (H3S10ph), and is required for chromosome segregation when cells enter into mitosis. Regulates Hox gene expression via histone H2A deubiquitination. Prefers nucleosomal substrates. Does not deubiquitinate histone H2B.
Protein Sequence
(Fasta)
MGKKRGKDRS CREDEDVEFT GPSCRHIRKG TDQTLIKKLP AVSDWTRCQE CKPEDNKENI 60
SMTKSEESEE ETVPLWMCLK CGHRGCGRNS ENQHAIKHYE TPRSDPHCLV VGLDNWSVWC 120
It may take some time, please wait.

Protein Fasta Sequence



>IUUC-Pfo-097202|DUB,USP|Poecilia formosa
Please wait for a moment...
Nucleotide Sequence
(Fasta)
TTCTTCAATA AAAAAATGCC ACTCACAATA TGGGGGGCGT CATTCACGTT CGATCCCGGA 60
AGTTCATGTG GCTTCTTTCA CACACATCAC ATTTTTGTTC CTCTCCTGGC CGCATGTGTG 120
It may take some time, please wait.

Nucleotide Fasta Sequence



>IUUC-Pfo-097202|DUB,USP|Poecilia formosa
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0010--Activator
KW-0131--Cell cycle
KW-0132--Cell division
KW-0156--Chromatin regulator
KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0479--Metal-binding
KW-0498--Mitosis
KW-0539--Nucleus
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001394--Peptidase_C19_UCH
IPR030849--UBP16
IPR018200--USP_CS
IPR028889--USP_dom
IPR013083--Znf_RING/FYVE/PHD
IPR001607--Znf_UBP

PROSITE

PS00972--USP_1
PS00973--USP_2
PS50235--USP_3
PS50271--ZF_UBP

Pfam

PF00443--UCH
PF02148--zf-UBP

SMART

SM00290--ZnF_UBP

Gene Ontology

GO:0005634--C:nucleus
GO:0004197--F:cysteine-type endopeptidase activity
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0003713--F:transcription coactivator activity
GO:0008270--F:zinc ion binding
GO:0051301--P:cell division
GO:0016578--P:histone deubiquitination
GO:0007067--P:mitotic nuclear division
GO:0045893--P:positive regulation of transcription, DNA-templated
GO:0051289--P:protein homotetramerization
GO:0051726--P:regulation of cell cycle
GO:0006351--P:transcription, DNA-templated
GO:0006511--P:ubiquitin-dependent protein catabolic process

Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-000997 Aegilops tauschii 35.35 3.00e-25 111.00
IUUC-Aml-001931 Ailuropoda melanoleuca 51.78 1.00e-111 397.00
IUUC-Atr-003015 Amborella trichopoda 27.73 3.00e-33 137.00
IUUC-Apl-004145 Anas platyrhynchos 53.62 3.00e-108 386.00
IUUC-Aly-006422 Arabidopsis lyrata 35.75 3.00e-23 104.00
IUUC-Ath-006732 Arabidopsis thaliana 36.53 9.00e-28 119.00
IUUC-Ame-011659 Astyanax mexicanus 54.49 3.00e-132 466.00
IUUC-Bta-013362 Bos taurus 45.78 0.00e+00 633.00
IUUC-Bdi-014624 Brachypodium distachyon 35.75 3.00e-24 107.00
IUUC-Bol-015853 Brassica oleracea 41.84 9.00e-26 112.00
IUUC-Bra-016751 Brassica rapa 36.73 1.00e-23 105.00
IUUC-Cja-019177 Callithrix jacchus 45.70 0.00e+00 636.00
IUUC-Cfa-020051 Canis familiaris 52.38 2.00e-111 397.00
IUUC-Cpo-021886 Cavia porcellus 43.86 5.00e-180 624.00
IUUC-Csa-024103 Chlorocebus sabaeus 46.00 0.00e+00 638.00
IUUC-Cho-024315 Choloepus hoffmanni 46.70 2.00e-47 184.00
IUUC-Cin-025775 Ciona intestinalis 43.26 2.00e-35 140.00
IUUC-Csv-026075 Ciona savignyi 46.19 6.00e-48 185.00
IUUC-Cme-027348 Cyanidioschyzon merolae 35.21 1.00e-16 82.00
IUUC-Dre-028388 Danio rerio 55.07 0.00e+00 811.00
IUUC-Dno-029409 Dasypus novemcinctus 46.24 0.00e+00 641.00
IUUC-Dor-030443 Dipodomys ordii 45.69 8.00e-82 298.00
IUUC-Dme-031870 Drosophila melanogaster 46.20 1.00e-34 142.00
IUUC-Eca-033479 Equus caballus 45.15 0.00e+00 642.00
IUUC-Eeu-034835 Erinaceus europaeus 57.08 2.00e-68 254.00
IUUC-Fal-037029 Ficedula albicollis 47.61 2.00e-105 377.00
IUUC-Gmo-039480 Gadus morhua 61.36 1.00e-150 526.00
IUUC-Gga-040527 Gallus gallus 49.56 7.00e-111 395.00
IUUC-Gac-042343 Gasterosteus aculeatus 64.78 0.00e+00 1051.00
IUUC-Gma-044402 Glycine max 27.46 4.00e-31 130.00
IUUC-Ggo-045598 Gorilla gorilla 45.60 0.00e+00 632.00
IUUC-Hsa-046598 Homo sapiens 46.05 0.00e+00 637.00
IUUC-Hvu-047146 Hordeum vulgare 35.20 3.00e-25 111.00
IUUC-Itr-047951 Ictidomys tridecemlineatus 46.46 0.00e+00 642.00
IUUC-Lch-050536 Latimeria chalumnae 43.46 4.00e-177 615.00
IUUC-Lpe-050703 Leersia perrieri 35.71 6.00e-25 110.00
IUUC-Loc-051814 Lepisosteus oculatus 61.81 1.00e-146 513.00
IUUC-Laf-053732 Loxodonta africana 44.10 1.00e-179 623.00
IUUC-Mcc-054661 Macaca mulatta 45.77 0.00e+00 636.00
IUUC-Meu-055967 Macropus eugenii 48.67 4.00e-97 349.00
IUUC-Mtr-057945 Medicago truncatula 30.46 2.00e-31 131.00
IUUC-Mga-059551 Meleagris gallopavo 53.08 6.00e-115 408.00
IUUC-Mmr-061747 Microcebus murinus 46.01 0.00e+00 630.00
IUUC-Mdo-062220 Monodelphis domestica 52.88 6.00e-117 415.00
IUUC-Mmu-063582 Mus musculus 48.72 6.00e-103 369.00
IUUC-Mac-064941 Musa acuminata 38.69 7.00e-31 129.00
IUUC-Mpu-066339 Mustela putorius furo 45.50 0.00e+00 631.00
IUUC-Mlu-067511 Myotis lucifugus 49.05 1.00e-110 394.00
IUUC-Nle-069252 Nomascus leucogenys 45.72 0.00e+00 635.00
IUUC-Opr-070969 Ochotona princeps 45.31 4.00e-176 612.00
IUUC-Ont-071786 Oreochromis niloticus 69.85 0.00e+00 1050.00
IUUC-Ocu-074704 Oryctolagus cuniculus 45.58 1.00e-179 623.00
IUUC-Oba-075094 Oryza barthii 34.69 3.00e-24 107.00
IUUC-Obr-076743 Oryza brachyantha 34.18 2.00e-25 111.00
IUUC-Ogl-077739 Oryza glaberrima 34.69 2.00e-24 108.00
IUUC-Ogu-078851 Oryza glumaepatula 33.67 2.00e-24 108.00
IUUC-Oin-079402 Oryza indica 33.67 2.00e-24 108.00
IUUC-Olo-080431 Oryza longistaminata 33.67 2.00e-24 108.00
IUUC-Ome-081580 Oryza meridionalis 33.67 3.00e-24 107.00
IUUC-Oni-082644 Oryza nivara 33.67 2.00e-24 108.00
IUUC-Opu-083452 Oryza punctata 34.69 1.00e-24 108.00
IUUC-Oru-084546 Oryza rufipogon 33.67 2.00e-24 108.00
IUUC-Osa-085858 Oryza sativa 33.67 2.00e-24 108.00
IUUC-Ola-086795 Oryzias latipes 61.83 0.00e+00 942.00
IUUC-Oga-088713 Otolemur garnettii 44.21 8.00e-178 617.00
IUUC-Oar-089887 Ovis aries 45.32 0.00e+00 632.00
IUUC-Ptr-091670 Pan troglodytes 45.72 0.00e+00 636.00
IUUC-Pan-092293 Papio anubis 45.77 0.00e+00 636.00
IUUC-Psi-093101 Pelodiscus sinensis 50.00 1.00e-108 387.00
IUUC-Ppa-095622 Physcomitrella patens 28.33 3.00e-32 134.00
IUUC-Pop-099136 Populus trichocarpa 30.45 6.00e-36 146.00
IUUC-Pca-101069 Procavia capensis 50.19 3.00e-67 250.00
IUUC-Ppe-101794 Prunus persica 32.61 2.00e-36 147.00
IUUC-Rno-105237 Rattus norvegicus 48.93 5.00e-103 369.00
IUUC-Sha-106889 Sarcophilus harrisii 53.24 2.00e-113 403.00
IUUC-Spo-108149 Schizosaccharomyces pombe 33.83 4.00e-22 100.00
IUUC-Sit-110283 Setaria italica 29.82 2.00e-25 111.00
IUUC-Sly-111491 Solanum lycopersicum 28.86 6.00e-35 143.00
IUUC-Stu-112820 Solanum tuberosum 29.44 4.00e-39 157.00
IUUC-Sar-113530 Sorex araneus 51.66 4.00e-113 402.00
IUUC-Sbi-113785 Sorghum bicolor 37.76 3.00e-22 100.00
IUUC-Ssc-116091 Sus scrofa 44.69 3.00e-179 622.00
IUUC-Tru-118640 Takifugu rubripes 60.52 0.00e+00 950.00
IUUC-Tsy-119042 Tarsius syrichta 36.91 6.00e-105 375.00
IUUC-Tni-120015 Tetraodon nigroviridis 58.27 0.00e+00 932.00
IUUC-Tca-121701 Theobroma cacao 30.02 5.00e-38 153.00
IUUC-Tae-125351 Triticum aestivum 36.22 3.00e-24 107.00
IUUC-Tur-126788 Triticum urartu 36.22 3.00e-24 107.00
IUUC-Tbe-127309 Tupaia belangeri 42.61 2.00e-67 251.00
IUUC-Ttr-128271 Tursiops truncatus 45.39 2.00e-179 622.00
IUUC-Vpa-130674 Vicugna pacos 44.69 5.00e-165 575.00
IUUC-Xtr-131869 Xenopus tropicalis 48.14 4.00e-113 402.00
IUUC-Xma-134195 Xiphophorus maculatus 91.76 0.00e+00 1512.00
Created Date 25-Jun-2017

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