iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Itr-048190

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AGTP01090554

Gene Name

Hectd4

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSSTOG00000026003.1	ENSSTOT00000027732.1	ENSSTOP00000016517.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	3.60e-81	273.1	933	1293

Active Site

Position(s)	Description	Evidence
1267	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 4    dlkkrlevefvgEegldlgGvtreflallskelqnpdlglf.......lysendketlqpnpdsglknpehlklFeflGrllgkalq 83
           d ++ ++++f+gEe+++++G++r+fl++++kelq+++l+l+       ++++++k+ l+p+p ++     +++l +flG+llg+a++
   Q: 933  DPTYAFNIRFTGEEVHGTSGSFRHFLWQVCKELQSSSLSLLllcpssaVNKNKGKYILTPSPITY----GEEQLLHFLGQLLGIAIR 1015
           5667789*********************************9999999888888***********9....789*************** PP
   S: 84   dgrlldlplsksfyklllgkklsl.edleevdpelyks.lkeikenaesdieelgldltfs..vseei...............lget 151
            + +l+l+l +sf+k+l+g++l+  +dl+e d  +y++ +k+ + n+es++e+l+++++++  +  ++                 + 
   Q: 1016 ADVPLPLDLLPSFWKTLVGEPLDPdQDLQEADILTYNYvKKFESINDESELEALCAEIASQhlA--TEspdgpskpccrftylTMTG 1100
           **************************************66666678899999999999999532..33469**********655555 PP
   S: 152  keeeLkpgGenipVtneNkeeYvklvveyrlke.gikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykg 237
           +e+eL+++G++ipV++eNk+ Y  ++ ++rl+e +  e+v+a+r+G+ ++ipl+ll+ +++ e+el +cG ++i++e lk++t+y+ 
   Q: 1101 EEVELCSRGRHIPVAWENKDIYAAAIRSLRLRElQNVECVTAVRAGLGSIIPLQLLTTLSPLEMELRTCGLPYINLEFLKAHTMYQV 1187
           6667*****************************9***************************************************** PP
   S: 238  gytedspaiqwFwevleefsseerkafLqFvTgssrlPl......gGfaelk....prlfvirk...dasddrlPssnTCfnyLkLP 311
           g++e++++i++Fw +le f++ee ++f++F+++++r+P+      gG ++ +    p+++  ++    + d+r+++++TC++++kLP
   Q: 1188 GLMETDQHIEFFWGALETFTQEELCRFIKFACNQERIPFtcpckdGGPDTAHvppyPMKIAPPDgtaGSPDSRYIRVETCMFMIKLP 1274
           *********************************************99999999988888888889955555**************** PP
   S: 312  eYsskeilkekLlyAieet 330
           +Yss ei+ ekL++Ai+++
   Q: 1275 QYSSLEIMLEKLRCAIHYR 1293
           ****************986 PP

Organism

Ictidomys tridecemlineatus

Protein Sequence
(Fasta)

MAFAEQLLSW KSEDGEGKSE DEPDTIPTSV LLQVVELLGN FLWTTDMAAC VKELVFHLLA 60
ELLRTVHALE QRKHPAGLSS SIALQLNPCL AMLMALQSEL HKLYDEETQS WVSGSTCGGS 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGGGCTCC TGCTGGTCTT CCCCCTTATT CAGTCCCAGA GTAGAACAGA TCCTTCTCTC 60
TGTAACATAA CTGCTGAGGT GCTATTGAAC TGTCTTCGTG ACTGCCAGCC TTTGAGCCTG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000569--HECT_dom

PROSITE

PS50237--HECT

Pfam

PF00632--HECT

SMART

SM00119--HECTc

Gene Ontology

GO:0004842--F:ubiquitin-protein transferase activity

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002256	Ailuropoda melanoleuca	96.30	0.00e+00	2131.00
IUUC-Apl-004161	Anas platyrhynchos	89.99	0.00e+00	2070.00
IUUC-Aca-005341	Anolis carolinensis	86.26	0.00e+00	1966.00
IUUC-Ame-011574	Astyanax mexicanus	77.54	0.00e+00	1619.00
IUUC-Bta-012514	Bos taurus	97.16	0.00e+00	1942.00
IUUC-Cja-019148	Callithrix jacchus	96.54	0.00e+00	2155.00
IUUC-Cfa-020499	Canis familiaris	97.23	0.00e+00	2152.00
IUUC-Cpo-021894	Cavia porcellus	94.39	0.00e+00	2179.00
IUUC-Csa-023079	Chlorocebus sabaeus	96.92	0.00e+00	2149.00
IUUC-Cho-024415	Choloepus hoffmanni	89.86	0.00e+00	683.00
IUUC-Dre-027452	Danio rerio	75.51	0.00e+00	1452.00
IUUC-Dno-029595	Dasypus novemcinctus	95.93	0.00e+00	2194.00
IUUC-Dor-030849	Dipodomys ordii	89.58	0.00e+00	1522.00
IUUC-Ete-032563	Echinops telfairi	90.21	0.00e+00	1412.00
IUUC-Eca-034202	Equus caballus	96.77	0.00e+00	2102.00
IUUC-Eeu-035175	Erinaceus europaeus	96.93	0.00e+00	1078.00
IUUC-Fca-036295	Felis catus	96.38	0.00e+00	2201.00
IUUC-Fal-037003	Ficedula albicollis	87.91	0.00e+00	1268.00
IUUC-Gmo-038579	Gadus morhua	81.90	0.00e+00	1122.00
IUUC-Gga-040961	Gallus gallus	89.76	0.00e+00	2057.00
IUUC-Gac-041899	Gasterosteus aculeatus	84.42	0.00e+00	1148.00
IUUC-Ggo-045099	Gorilla gorilla	96.77	0.00e+00	2220.00
IUUC-Hsa-046331	Homo sapiens	96.84	0.00e+00	2198.00
IUUC-Lch-050062	Latimeria chalumnae	80.10	8.00e-160	555.00
IUUC-Loc-052630	Lepisosteus oculatus	75.88	0.00e+00	1602.00
IUUC-Laf-053394	Loxodonta africana	95.92	0.00e+00	2234.00
IUUC-Mcc-055763	Macaca mulatta	96.92	0.00e+00	2149.00
IUUC-Meu-056039	Macropus eugenii	85.92	0.00e+00	1939.00
IUUC-Mga-059500	Meleagris gallopavo	89.25	0.00e+00	2045.00
IUUC-Mmr-060868	Microcebus murinus	93.22	0.00e+00	2090.00
IUUC-Mdo-062772	Monodelphis domestica	91.54	0.00e+00	2099.00
IUUC-Mmu-063606	Mus musculus	95.61	0.00e+00	2125.00
IUUC-Mpu-065860	Mustela putorius furo	96.46	0.00e+00	2130.00
IUUC-Mlu-067376	Myotis lucifugus	96.83	0.00e+00	1834.00
IUUC-Nle-069693	Nomascus leucogenys	96.07	0.00e+00	2187.00
IUUC-Ont-072470	Oreochromis niloticus	75.15	0.00e+00	1818.00
IUUC-Oan-073693	Ornithorhynchus anatinus	88.26	0.00e+00	2102.00
IUUC-Ocu-074032	Oryctolagus cuniculus	94.84	0.00e+00	2153.00
IUUC-Oga-088546	Otolemur garnettii	97.15	0.00e+00	2164.00
IUUC-Oar-089643	Ovis aries	91.15	0.00e+00	761.00
IUUC-Ptr-090504	Pan troglodytes	97.00	0.00e+00	2202.00
IUUC-Pan-092543	Papio anubis	96.92	0.00e+00	2149.00
IUUC-Psi-093952	Pelodiscus sinensis	85.14	0.00e+00	2059.00
IUUC-Pfo-096356	Poecilia formosa	76.02	0.00e+00	1828.00
IUUC-Pab-098240	Pongo abelii	96.84	0.00e+00	2159.00
IUUC-Pca-100994	Procavia capensis	94.32	0.00e+00	1452.00
IUUC-Pva-102263	Pteropus vampyrus	95.30	0.00e+00	2098.00
IUUC-Rno-104888	Rattus norvegicus	95.54	0.00e+00	2103.00
IUUC-Sha-106944	Sarcophilus harrisii	89.69	0.00e+00	2093.00
IUUC-Sar-113556	Sorex araneus	86.98	0.00e+00	969.00
IUUC-Ssc-116187	Sus scrofa	96.92	0.00e+00	2153.00
IUUC-Tgu-116655	Taeniopygia guttata	89.39	0.00e+00	2009.00
IUUC-Tru-118093	Takifugu rubripes	76.62	0.00e+00	1368.00
IUUC-Tni-119665	Tetraodon nigroviridis	71.61	1.00e-139	489.00
IUUC-Tbe-127962	Tupaia belangeri	92.35	0.00e+00	989.00
IUUC-Ttr-128819	Tursiops truncatus	91.36	0.00e+00	1994.00
IUUC-Vpa-130482	Vicugna pacos	96.77	1.00e-65	246.00
IUUC-Xtr-132222	Xenopus tropicalis	81.23	0.00e+00	2033.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence