iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMPUG00000002406.1	ENSMPUT00000002428.1	ENSMPUP00000002379.1
ENSMPUG00000002406.1	ENSMPUT00000002429.1	ENSMPUP00000002380.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	6.60e-80	269.0	3632	3992

Active Site

Position(s)	Description	Evidence
3966	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 4    dlkkrlevefvgEegldlgGvtreflallskelqnpdlglf.......lysendketlqpnpdsglknpehlklFeflGrllgkalq 83
           d ++ ++++f+gEe+++++G++r+fl++++kelq+++l+l+       ++++++k+ l+p+p ++     +++l +flG+llg+a++
   Q: 3632 DPTYAFNIRFTGEEVHGTSGSFRHFLWQVCKELQSSSLSLLllcpssaVNKNKGKYILTPSPITY----GEEQLLHFLGQLLGIAIR 3714
           5667788*********************************9999999888888***********9....789*************** PP
   S: 84   dgrlldlplsksfyklllgkklsl.edleevdpelyks.lkeikenaesdieelgldltfs..vseei...............lget 151
            + +l+l+l +sf+k+l+g++l+  +dl+e d  +y++ +k+ + n+e+++e+l+++++++  +  ++                 + 
   Q: 3715 ADVPLPLDLLPSFWKTLVGEPLDPdQDLQEADILTYNYvKKFESINDETELEALCAEIASQhlA--TEspegpnkpccrftylTMTG 3799
           **************************************56666677799999999999999532..334699*********655555 PP
   S: 152  keeeLkpgGenipVtneNkeeYvklvveyrlke.gikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykg 237
           +e+eL+++G++ipV++eNk+ Y  ++  +rl+e + +e+++a+r+G+  +ipl+ll+ +++ e+el +cG ++i++e lk++t+y+ 
   Q: 3800 EEVELCSRGRHIPVAWENKDIYAAAIRGLRLRElQNAECMTAVRAGLGAIIPLQLLTTLSPLEMELRTCGLPYINLEFLKAHTMYQV 3886
           6667*****************************9***************************************************** PP
   S: 238  gytedspaiqwFwevleefsseerkafLqFvTgssrlPl......gGfaelk....prlfvirk...dasddrlPssnTCfnyLkLP 311
           g++e++++i++Fw +le+f +ee ++f++F+++++r+P+      gG ++ +    p+++  ++    + d+r+++++TC++++kLP
   Q: 3887 GLMETDQHIEFFWGALEMFAQEELCKFIKFACNQERIPFtcpckdGGPDTAHvppyPMKIAPPDgtaGSPDSRYIRVETCMFMIKLP 3973
           *********************************************99999999988888888889955555**************** PP
   S: 312  eYsskeilkekLlyAieet 330
           +Yss ei+ ekL++Ai+++
   Q: 3974 QYSSLEIMLEKLRCAIHYR 3992
           ****************986 PP

Organism

Mustela putorius furo

Protein Sequence
(Fasta)

MPANHLPVGS TMSTVHLSSD GTYFYWIWSP ASLNEKTPKG HSVFMDIFEL VVENGVFVAN 60
PLQERTILMR KEGESAKSIN EMLLSRLSRY RASPSATLAA LTGSTISNTL KEDQAACYTS 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN 60
NNNNNNNGAG ACCATCTTCC TGCACGACGG GCTGATCCGG GTCACCGACC TGGCTGAGCT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000569--HECT_dom

PROSITE

PS50237--HECT

Pfam

PF00632--HECT

SMART

SM00119--HECTc

Gene Ontology

GO:0004842--F:ubiquitin-protein transferase activity

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002256	Ailuropoda melanoleuca	96.85	0.00e+00	7168.00
IUUC-Apl-004161	Anas platyrhynchos	91.44	0.00e+00	5071.00
IUUC-Aca-005341	Anolis carolinensis	87.75	0.00e+00	6501.00
IUUC-Ame-011574	Astyanax mexicanus	78.98	0.00e+00	4364.00
IUUC-Bta-012514	Bos taurus	97.76	0.00e+00	1948.00
IUUC-Cja-019148	Callithrix jacchus	95.60	0.00e+00	5199.00
IUUC-Cfa-020499	Canis familiaris	95.99	0.00e+00	7125.00
IUUC-Cpo-021894	Cavia porcellus	95.19	0.00e+00	2691.00
IUUC-Csa-023079	Chlorocebus sabaeus	95.02	0.00e+00	7117.00
IUUC-Cho-024415	Choloepus hoffmanni	91.50	0.00e+00	4947.00
IUUC-Dre-027452	Danio rerio	77.62	0.00e+00	4373.00
IUUC-Dno-029595	Dasypus novemcinctus	94.44	0.00e+00	7077.00
IUUC-Dor-030849	Dipodomys ordii	93.07	0.00e+00	1700.00
IUUC-Ete-032563	Echinops telfairi	89.67	0.00e+00	1597.00
IUUC-Eca-034202	Equus caballus	96.20	0.00e+00	7038.00
IUUC-Eeu-035175	Erinaceus europaeus	97.65	0.00e+00	1080.00
IUUC-Fca-036295	Felis catus	97.17	0.00e+00	6912.00
IUUC-Fal-037003	Ficedula albicollis	90.01	0.00e+00	6066.00
IUUC-Gmo-038579	Gadus morhua	82.79	0.00e+00	2771.00
IUUC-Gga-040961	Gallus gallus	90.38	0.00e+00	6837.00
IUUC-Gac-041899	Gasterosteus aculeatus	82.51	0.00e+00	2799.00
IUUC-Ggo-045099	Gorilla gorilla	96.73	0.00e+00	6329.00
IUUC-Hsa-046331	Homo sapiens	95.35	0.00e+00	7190.00
IUUC-Itr-048190	Ictidomys tridecemlineatus	96.46	0.00e+00	2148.00
IUUC-Lch-049923	Latimeria chalumnae	82.03	0.00e+00	2518.00
IUUC-Loc-052630	Lepisosteus oculatus	83.89	0.00e+00	4028.00
IUUC-Laf-053394	Loxodonta africana	94.53	0.00e+00	7148.00
IUUC-Mcc-055763	Macaca mulatta	95.00	0.00e+00	7109.00
IUUC-Meu-056039	Macropus eugenii	87.96	0.00e+00	4974.00
IUUC-Mga-059500	Meleagris gallopavo	90.67	0.00e+00	6806.00
IUUC-Mmr-060868	Microcebus murinus	92.13	0.00e+00	6918.00
IUUC-Mdo-062772	Monodelphis domestica	91.69	0.00e+00	6924.00
IUUC-Mmu-063606	Mus musculus	93.74	0.00e+00	7050.00
IUUC-Mlu-067376	Myotis lucifugus	95.17	0.00e+00	5250.00
IUUC-Nle-069693	Nomascus leucogenys	94.51	0.00e+00	7043.00
IUUC-Opr-071065	Ochotona princeps	94.41	0.00e+00	1214.00
IUUC-Ont-072470	Oreochromis niloticus	81.44	0.00e+00	4505.00
IUUC-Oan-073693	Ornithorhynchus anatinus	91.16	0.00e+00	5112.00
IUUC-Ocu-074032	Oryctolagus cuniculus	93.31	0.00e+00	7061.00
IUUC-Ola-087433	Oryzias latipes	79.82	0.00e+00	1496.00
IUUC-Oga-088546	Otolemur garnettii	96.53	0.00e+00	6866.00
IUUC-Oar-089643	Ovis aries	91.65	0.00e+00	761.00
IUUC-Ptr-090504	Pan troglodytes	95.95	0.00e+00	7177.00
IUUC-Pan-092543	Papio anubis	94.93	0.00e+00	7110.00
IUUC-Psi-093952	Pelodiscus sinensis	88.61	0.00e+00	6714.00
IUUC-Pfo-096356	Poecilia formosa	78.92	0.00e+00	6101.00
IUUC-Pab-098240	Pongo abelii	95.02	0.00e+00	7104.00
IUUC-Pca-100994	Procavia capensis	94.95	0.00e+00	2908.00
IUUC-Pva-102263	Pteropus vampyrus	94.75	0.00e+00	7002.00
IUUC-Rno-104888	Rattus norvegicus	93.64	0.00e+00	7027.00
IUUC-Sha-106944	Sarcophilus harrisii	92.09	0.00e+00	6972.00
IUUC-Sar-113556	Sorex araneus	83.88	0.00e+00	985.00
IUUC-Ssc-116187	Sus scrofa	96.88	0.00e+00	5103.00
IUUC-Tgu-116655	Taeniopygia guttata	91.27	0.00e+00	5036.00
IUUC-Tru-118093	Takifugu rubripes	81.67	0.00e+00	2900.00
IUUC-Tni-119739	Tetraodon nigroviridis	79.66	0.00e+00	1509.00
IUUC-Tbe-127962	Tupaia belangeri	91.63	0.00e+00	1204.00
IUUC-Ttr-128819	Tursiops truncatus	93.04	0.00e+00	2873.00
IUUC-Vpa-130482	Vicugna pacos	92.70	0.00e+00	4313.00
IUUC-Xtr-132222	Xenopus tropicalis	85.34	0.00e+00	6471.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence