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Basic Information Integrated Annotations
Tag Content
UUCD2 ID IUUC-Hsa-046063
UUCD1 version UUC-HoS-00625
Ensembl Protein ID ENSP00000315659.4
UniProt Accession Q6XZF7; Q8IVY3; Q9Y2L3; DNMBP_HUMAN
Genbank Protein ID AAP34307.1; BAA76854.1; AAH41628.1
Protein Name Dynamin-binding protein; Scaffold protein Tuba
Genbank Nucleotide ID AY196211; AB023227; BC041628
Gene Name DNMBP; KIAA1010
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000107554.16 ENST00000543621.6 ENSP00000443657.2
ENSG00000107554.16 ENST00000636706.1 ENSP00000489875.1
ENSG00000107554.16 ENST00000324109.8 ENSP00000315659.4
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPM
DNA & RNA Element
UTRdbAREsitecircBasecircRNADb
CircNetmiRTarBasemicroRNATRANSFAC
TargetScanRepTarSomamiRmiRcode
RAID2
Protein-protein Interaction
IIDiRefIndexPINAHINT
MenthaInWeb_IM
Protein 3D Structure
PDBMMDB
Disease-associated Variation
GWASdbOMIM
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
HPRDPhospho.ELMUniProtPHOSIDA
BioGRIDmUbiSiDa
DNA Methylation
TCGAICGCCOSMIC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
UBD/SH3 7.50e-49 165.2 248 298
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   UBD/SH3
   S: 6    vqvlydyeaqnddeLtlkkGdvvlviekeeqdegWlkgvkelegkrGlfPenFve 60
             +ly ++a + +eL ++ Gd+++++  ++ + gWl+g   l+g+ G+fP  Fv+
   Q: 248  GVALYRFQALEPNELDFEVGDKIRIL--ATLEDGWLEG--SLKGRTGIFPYRFVK 298
           579***********************..999*******..9*************8 PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     Scaffold protein that links dynamin with actin-regulating proteins. May play a role in membrane trafficking between the cell surface and the Golgi (By similarity).
 Scaffold protein that links dynamin with actin-regulating proteins. May play a role in membrane trafficking between the cell surface and the Golgi (By similarity).
Protein Sequence
(Fasta)
MEAGSVVRAI FDFCPSVSEE LPLFVGDIIE VLAVVDEFWL LGKKEDVTGQ FPSSFVEIVT 60
IPSLKEGERL FVCICEFTSQ ELDNLPLHRG DLVILDGIPT AGWLQGRSCW GARGFFPSSC 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-046063|UBD,SH3|Homo sapiens
Please wait for a moment...
Nucleotide Sequence
(Fasta)
AGGGGCGGAG GTGACAGCGG GCTGGGGACT GGCGGCTGCA ACTGCCTGCC GCGCCGAGGG 60
ACCGCCGGGC GGCGGAAAGC AGGTCAGAGG CCGGGCCAGG CCGGAGCCGG GCGGGGGCCG 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-046063|UBD,SH3|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0007--Acetylation
KW-0025--Alternative splicing
KW-0965--Cell junction
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0206--Cytoskeleton
KW-0333--Golgi apparatus
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0677--Repeat
KW-0728--SH3 domain
KW-0770--Synapse
Interpro

IPR027267--AH/BAR-dom
IPR004148--BAR_dom
IPR000219--DH-domain
IPR001331--GDS_CDC24_CS
IPR011511--SH3_2
IPR001452--SH3_domain
PROSITE

PS51021--BAR
PS00741--DH_1
PS50010--DH_2
PS50002--SH3
Pfam

PF03114--BAR
PF00621--RhoGEF
PF00018--SH3_1
PF07653--SH3_2
PF14604--SH3_9
SMART

SM00721--BAR
SM00325--RhoGEF
SM00326--SH3
Gene Ontology

GO:0030054--C:cell junction
GO:0005856--C:cytoskeleton
GO:0005795--C:Golgi stack
GO:0045202--C:synapse
GO:0005089--F:Rho guanyl-nucleotide exchange factor activity
GO:0043547--P:positive regulation of GTPase activity
GO:0035023--P:regulation of Rho protein signal transduction
GO:0007264--P:small GTPase mediated signal transduction
KEGG hsa:23268
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-002128 Ailuropoda melanoleuca 82.74 0.00e+00 2364.00
IUUC-Apl-003934 Anas platyrhynchos 81.02 0.00e+00 1063.00
IUUC-Aca-005005 Anolis carolinensis 64.25 0.00e+00 1229.00
IUUC-Ame-011361 Astyanax mexicanus 60.09 0.00e+00 979.00
IUUC-Bta-013210 Bos taurus 83.90 0.00e+00 2395.00
IUUC-Cel-018396 Caenorhabditis elegans 27.12 1.00e-30 129.00
IUUC-Cja-019104 Callithrix jacchus 92.14 0.00e+00 2649.00
IUUC-Cfa-020960 Canis familiaris 82.90 0.00e+00 2352.00
IUUC-Cpo-022440 Cavia porcellus 81.17 0.00e+00 2360.00
IUUC-Csa-023391 Chlorocebus sabaeus 96.07 0.00e+00 2833.00
IUUC-Cho-024795 Choloepus hoffmanni 74.39 0.00e+00 2013.00
IUUC-Cin-025137 Ciona intestinalis 33.16 1.00e-30 126.00
IUUC-Dre-027932 Danio rerio 65.69 0.00e+00 880.00
IUUC-Dno-029750 Dasypus novemcinctus 82.55 0.00e+00 2449.00
IUUC-Dor-031109 Dipodomys ordii 77.08 0.00e+00 2155.00
IUUC-Ete-032660 Echinops telfairi 74.94 0.00e+00 1836.00
IUUC-Eca-033433 Equus caballus 84.70 0.00e+00 2348.00
IUUC-Eeu-034929 Erinaceus europaeus 76.33 0.00e+00 1383.00
IUUC-Fca-035859 Felis catus 84.80 0.00e+00 2457.00
IUUC-Fal-036653 Ficedula albicollis 72.37 0.00e+00 1164.00
IUUC-Gmo-038948 Gadus morhua 60.08 0.00e+00 792.00
IUUC-Gga-040279 Gallus gallus 71.41 0.00e+00 1142.00
IUUC-Gac-041641 Gasterosteus aculeatus 56.59 0.00e+00 948.00
IUUC-Ggo-045005 Gorilla gorilla 99.23 2.00e-59 221.00
IUUC-Itr-049071 Ictidomys tridecemlineatus 82.57 0.00e+00 2448.00
IUUC-Lch-049865 Latimeria chalumnae 48.98 0.00e+00 1167.00
IUUC-Lpe-050758 Leersia perrieri 56.52 6.20e-02 32.70
IUUC-Loc-051754 Lepisosteus oculatus 61.43 0.00e+00 1091.00
IUUC-Laf-054037 Loxodonta africana 82.96 0.00e+00 2485.00
IUUC-Mcc-055002 Macaca mulatta 96.51 0.00e+00 2846.00
IUUC-Meu-056420 Macropus eugenii 64.69 0.00e+00 1367.00
IUUC-Mga-059868 Meleagris gallopavo 71.94 0.00e+00 1154.00
IUUC-Mmr-060767 Microcebus murinus 86.36 0.00e+00 2538.00
IUUC-Mdo-061939 Monodelphis domestica 68.52 0.00e+00 1909.00
IUUC-Mmu-063980 Mus musculus 75.49 0.00e+00 2163.00
IUUC-Mpu-065913 Mustela putorius furo 82.05 0.00e+00 2389.00
IUUC-Mlu-067340 Myotis lucifugus 83.41 0.00e+00 2347.00
IUUC-Nle-069343 Nomascus leucogenys 97.72 0.00e+00 2845.00
IUUC-Opr-070694 Ochotona princeps 76.91 0.00e+00 2200.00
IUUC-Ont-071844 Oreochromis niloticus 65.32 0.00e+00 846.00
IUUC-Oan-073605 Ornithorhynchus anatinus 41.73 5.00e-64 238.00
IUUC-Ocu-074406 Oryctolagus cuniculus 82.20 0.00e+00 2357.00
IUUC-Ola-087343 Oryzias latipes 59.80 0.00e+00 689.00
IUUC-Oga-088847 Otolemur garnettii 86.73 0.00e+00 2493.00
IUUC-Oar-089817 Ovis aries 81.93 0.00e+00 2339.00
IUUC-Pan-092104 Papio anubis 96.07 0.00e+00 2840.00
IUUC-Psi-094045 Pelodiscus sinensis 46.95 0.00e+00 632.00
IUUC-Pma-094663 Petromyzon marinus 47.25 2.00e-131 464.00
IUUC-Pfo-096714 Poecilia formosa 61.82 0.00e+00 854.00
IUUC-Pab-097918 Pongo abelii 97.53 0.00e+00 2872.00
IUUC-Pca-101096 Procavia capensis 77.42 0.00e+00 1307.00
IUUC-Pva-102490 Pteropus vampyrus 82.40 0.00e+00 2442.00
IUUC-Rno-105908 Rattus norvegicus 74.91 0.00e+00 2092.00
IUUC-Sha-107509 Sarcophilus harrisii 69.26 0.00e+00 1820.00
IUUC-Ssc-115250 Sus scrofa 82.32 0.00e+00 2307.00
IUUC-Tru-118279 Takifugu rubripes 56.30 0.00e+00 972.00
IUUC-Tni-120459 Tetraodon nigroviridis 63.80 0.00e+00 758.00
IUUC-Tbe-127753 Tupaia belangeri 69.83 0.00e+00 1080.00
IUUC-Ttr-129096 Tursiops truncatus 83.55 0.00e+00 1715.00
IUUC-Vpa-130643 Vicugna pacos 80.91 0.00e+00 1999.00
IUUC-Xtr-131979 Xenopus tropicalis 55.80 0.00e+00 1590.00
Created Date 25-Jun-2017

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