iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Cfa-020763

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AAEX03016750

Gene Name

HERC6

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSCAFG00000009781.3	ENSCAFT00000015531.3	ENSCAFP00000014370.3

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	1.30e-85	288.1	691	1010

Active Site

Position(s)	Description	Evidence
981	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 3    sdlkkrlevefvgEe.gldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrll 88
            dl+k ++vef +E   +++ Gv++ef++ +++e+ n ++g+f+y e+++++++p+++++    ++ ++F ++G+l+g++l++ ++ 
   Q: 691  TDLHKAFMVEFIKEIrSIGY-GVKSEFFYSIFEEMTNIEYGMFMYPEEGSYMWFPAKSKF----KKKRYF-LFGILCGLSLYNLNPA 771
           68999999******846677.************************************998....678888.55************** PP
   S: 89   dlplsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvk 175
           +lp++ +++k+ll++k s++dl+e+ p l k+l+ei++n+  d +e+ l + fs    i+ + ++++L+p+G ++pV ++Nk+eYv+
   Q: 772  NLPFPLALFKKLLDQKPSFQDLKELSPLLGKNLQEILDNEA-DDTEE-LYIYFS----IYWDKNNVNLIPNGISVPVDQTNKKEYVS 852
           ***************************************54.44443.788886....79999************************ PP
   S: 176  lvveyrlkegikeqveafreGfneviple.llslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseer 261
           + ++y++++++k  +e+f++Gf++v+++e l++lF++eel + + G++++d++ ++++ +y +gy++++p+i +Fw+++++++ ee+
   Q: 853  ACIDYIFNTSVKAVYEEFQRGFYKVCDKEiLVKLFQPEELMTALVGNNDYDWKYFEENSQYGQGYHKSHPTILMFWKAFHKLTLEEK 939
           *****************************778******************************************************* PP
   S: 262  kafLqFvTgssrlPlgGfaelkprlfvirkdasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgF 333
           k+fL F+ g++rlPl G +e+   +f +++  s++++P++ TC n L+LP+Ys++e+++e L++Ai+++kgF
   Q: 940  KKFLFFLRGNDRLPLSGKQEIG-IKFRCPETFSEADYPRALTCHNILDLPQYSTMEKVEEALQVAINSNKGF 1010
           **********************.55777777****************************************9 PP

Organism

Canis familiaris

Protein Sequence
(Fasta)

MYLSWGPGPR GPVSRRRVGL GGVELRQAAS GERHSLLLLS NGQVHSCGDN GRGQLGQRGA 60
PCSAQLKERI RALETLHVDL VSCGKEHSLA VCHKGRVFAW GAGSEGQLGT GEFKETNLIP 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGTACCTCT CGTGGGGCCC CGGCCCCCGC GGGCCCGTGA GCCGGAGGCG GGTCGGCCTG 60
GGGGGCGTGG AGCTGCGACA GGCGGCCTCC GGGGAGCGGC ACTCGCTGCT GCTGCTGAGC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0677--Repeat
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000569--HECT_dom
IPR009091--RCC1/BLIP-II
IPR000408--Reg_chr_condens

PROSITE

PS50237--HECT
PS00626--RCC1_2
PS50012--RCC1_3

Pfam

PF00632--HECT
PF00415--RCC1

PRINTS

PR00633--RCCNDNSATION

SMART

SM00119--HECTc

Gene Ontology

GO:0005829--C:cytosol
GO:0005634--C:nucleus
GO:0004842--F:ubiquitin-protein transferase activity
GO:0002244--P:hematopoietic progenitor cell differentiation

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001374	Ailuropoda melanoleuca	81.71	0.00e+00	1572.00
IUUC-Aca-004663	Anolis carolinensis	46.28	0.00e+00	835.00
IUUC-Bta-013080	Bos taurus	71.62	0.00e+00	1396.00
IUUC-Cja-018891	Callithrix jacchus	70.57	0.00e+00	1402.00
IUUC-Cpo-022346	Cavia porcellus	68.10	0.00e+00	1366.00
IUUC-Csa-023049	Chlorocebus sabaeus	72.49	0.00e+00	1488.00
IUUC-Dno-029093	Dasypus novemcinctus	71.48	0.00e+00	1426.00
IUUC-Dor-030422	Dipodomys ordii	51.11	9.00e-114	404.00
IUUC-Eca-034098	Equus caballus	74.45	0.00e+00	1408.00
IUUC-Eeu-035028	Erinaceus europaeus	65.00	8.00e-146	511.00
IUUC-Fca-036283	Felis catus	79.68	0.00e+00	1536.00
IUUC-Ggo-045553	Gorilla gorilla	70.26	0.00e+00	1389.00
IUUC-Hsa-046396	Homo sapiens	72.49	0.00e+00	1465.00
IUUC-Loc-052700	Lepisosteus oculatus	41.03	0.00e+00	757.00
IUUC-Laf-054433	Loxodonta africana	68.77	0.00e+00	1458.00
IUUC-Mcc-055014	Macaca mulatta	68.53	0.00e+00	1411.00
IUUC-Mdo-061839	Monodelphis domestica	54.87	0.00e+00	984.00
IUUC-Mmu-064378	Mus musculus	63.20	0.00e+00	1229.00
IUUC-Mpu-066293	Mustela putorius furo	78.42	0.00e+00	1495.00
IUUC-Mlu-067407	Myotis lucifugus	71.71	0.00e+00	1413.00
IUUC-Nle-069978	Nomascus leucogenys	71.89	0.00e+00	1473.00
IUUC-Opr-070190	Ochotona princeps	58.97	0.00e+00	688.00
IUUC-Oga-088780	Otolemur garnettii	64.03	0.00e+00	1267.00
IUUC-Oar-090307	Ovis aries	73.35	0.00e+00	1434.00
IUUC-Ptr-091567	Pan troglodytes	72.39	0.00e+00	1449.00
IUUC-Pan-091802	Papio anubis	68.30	0.00e+00	1389.00
IUUC-Pab-098024	Pongo abelii	58.00	0.00e+00	1082.00
IUUC-Pva-102382	Pteropus vampyrus	68.12	0.00e+00	1328.00
IUUC-Rno-105768	Rattus norvegicus	60.54	0.00e+00	1202.00
IUUC-Sha-106525	Sarcophilus harrisii	52.24	0.00e+00	1016.00
IUUC-Sar-113014	Sorex araneus	61.03	1.00e-158	553.00
IUUC-Vpa-130214	Vicugna pacos	70.61	0.00e+00	1273.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence