iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Pan-091802

Ensembl Protein ID

ENSPANP00000002064.1

UniProt Accession

A0A096MQN1; A0A096MQN1_PAPAN

Genbank Protein ID

ENSPANP00000002064

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AHZZ01065677

Gene Name

HERC6

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSPANG00000021686.1	ENSPANT00000003301.1	ENSPANP00000002064.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	4.90e-91	305.6	698	1017

Active Site

Position(s)	Description	Evidence
988	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 3    sdlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlld 89
            d++k+l vef +E   + gGv++ef++++++e+ +p++g+f+y e ++++++p++ +     e+ ++F ++G+l+g++l++ ++ +
   Q: 698  TDFRKVLVVEFIEEIRPESGGVSSEFFHCMFEEMTKPEYGMFMYPEMGSCMWFPAKPKL----EKKRYF-LFGMLCGLSLFNLNVAN 779
           6899****************************************************998....677888.55*************** PP
   S: 90   lplsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvkl 176
           lp++ ++yk+ll++k sledl+e+ p l ksl+e+++ + +di ++ l+++fs++     ++++++L+p+G +ipV ++Nk++Yv++
   Q: 780  LPFPLALYKKLLDQKPSLEDLKELSPRLGKSLQEVLNDDADDIGDA-LCIRFSIH----WDQNDVDLIPNGISIPVDQTNKKDYVSK 861
           ************************************9999999997.*****855....5779999********************* PP
   S: 177  vveyrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerka 263
           +++y+++ ++k  +e+f++Gf++v+++e+l+ F +eel + i G++++d+++++++ ky++gy++++p+i+ Fw+++++++ +e+k+
   Q: 862  YIDYIFNVSVKAVYEEFQRGFYRVCEKEILRHFYPEELMTAIIGNTDYDWKQFEQNSKYEQGYQKSHPTIRLFWKAFHKLTLDEKKK 948
           *************************************************************************************** PP
   S: 264  fLqFvTgssrlPlgGfaelkprlfvirkdasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgF 333
           fL F+Tg++rl ++G+++++  +f +++  s+++ P+s TC + L LP+Ys++e ++e L++Ai++++gF
   Q: 949  FLLFLTGRDRLHARGIQKME-IVFRCPETFSERDHPTSITCHHILYLPKYSTMERMEEALQVAINNNRGF 1017
           ********************.77888889****************************************9 PP

Organism

Papio anubis

Protein Sequence
(Fasta)

MYFCWGTDSR ELQRRRTERS PGAELLQAAS GERHSLLLLT NHRVLSCGDN SRGQLGRRSA 60
PRGELPEPIQ ALETLNVDLV SCGKEHSLAV CHKGRVFAWG AGSEGQLGIG EFKEISFTPT 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ACTGTATTTG CAGGTCGGGC GCGGAGGCTC AGGCCTGTAA TCCCTGCACT TTGGGAAGCT 60
GAGGGGGGTG GATCACTTGA GGTCAGGAGT TCGAGACCAG CCTGGCCAAC ATGAGGAAAC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0677--Repeat
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000569--HECT_dom
IPR009091--RCC1/BLIP-II
IPR000408--Reg_chr_condens

PROSITE

PS50237--HECT
PS00626--RCC1_2
PS50012--RCC1_3

Pfam

PF00632--HECT
PF00415--RCC1

PRINTS

PR00633--RCCNDNSATION

SMART

SM00119--HECTc

Gene Ontology

GO:0005829--C:cytosol
GO:0005634--C:nucleus
GO:0004842--F:ubiquitin-protein transferase activity
GO:0002244--P:hematopoietic progenitor cell differentiation

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001374	Ailuropoda melanoleuca	68.85	0.00e+00	1314.00
IUUC-Aca-004663	Anolis carolinensis	43.76	0.00e+00	800.00
IUUC-Bta-013080	Bos taurus	68.49	0.00e+00	1343.00
IUUC-Cja-018891	Callithrix jacchus	82.71	0.00e+00	1694.00
IUUC-Cfa-020763	Canis familiaris	68.30	0.00e+00	1276.00
IUUC-Cpo-022346	Cavia porcellus	65.50	0.00e+00	1352.00
IUUC-Csa-023049	Chlorocebus sabaeus	93.15	0.00e+00	1967.00
IUUC-Dno-029093	Dasypus novemcinctus	71.60	0.00e+00	1449.00
IUUC-Eca-034098	Equus caballus	72.38	0.00e+00	1372.00
IUUC-Eeu-035028	Erinaceus europaeus	50.57	6.00e-133	468.00
IUUC-Fca-036283	Felis catus	69.75	0.00e+00	1337.00
IUUC-Ggo-045553	Gorilla gorilla	86.61	0.00e+00	1752.00
IUUC-Hsa-046396	Homo sapiens	89.82	0.00e+00	1838.00
IUUC-Loc-052700	Lepisosteus oculatus	38.78	0.00e+00	724.00
IUUC-Laf-054433	Loxodonta africana	67.30	0.00e+00	1411.00
IUUC-Mcc-055014	Macaca mulatta	88.70	0.00e+00	1887.00
IUUC-Mdo-061839	Monodelphis domestica	53.46	0.00e+00	967.00
IUUC-Mmu-064378	Mus musculus	62.39	0.00e+00	1208.00
IUUC-Mpu-066293	Mustela putorius furo	67.25	0.00e+00	1266.00
IUUC-Mlu-067407	Myotis lucifugus	68.12	0.00e+00	1346.00
IUUC-Nle-069978	Nomascus leucogenys	89.53	0.00e+00	1889.00
IUUC-Opr-070190	Ochotona princeps	53.41	1.00e-174	607.00
IUUC-Ocu-074640	Oryctolagus cuniculus	71.18	0.00e+00	885.00
IUUC-Oga-088780	Otolemur garnettii	66.57	0.00e+00	1339.00
IUUC-Oar-090307	Ovis aries	69.25	0.00e+00	1358.00
IUUC-Ptr-091567	Pan troglodytes	89.53	0.00e+00	1832.00
IUUC-Pab-098024	Pongo abelii	74.32	0.00e+00	1470.00
IUUC-Pca-100315	Procavia capensis	60.70	0.00e+00	872.00
IUUC-Pva-102382	Pteropus vampyrus	64.38	0.00e+00	1245.00
IUUC-Rno-105768	Rattus norvegicus	58.88	0.00e+00	1150.00
IUUC-Sha-106525	Sarcophilus harrisii	50.91	0.00e+00	1007.00
IUUC-Sar-113014	Sorex araneus	50.30	5.00e-125	441.00
IUUC-Ssc-116223	Sus scrofa	75.14	2.00e-158	551.00
IUUC-Tsy-119565	Tarsius syrichta	78.65	1.00e-177	617.00
IUUC-Vpa-130214	Vicugna pacos	66.81	0.00e+00	1205.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence