iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSBTAG00000013057.5	ENSBTAT00000017358.4	ENSBTAP00000017358.4
ENSBTAG00000013057.5	ENSBTAT00000062945.1	ENSBTAP00000055296.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/RING/RING	9.60e-08	32.6	373	412

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/RING

   S: 1    CaiCledfkdgplvlpCgHvfhadClqkwpglknssskefrCPlCr 46
           C iC e  kd +++ pCgH+++++Cl +w    ++s ++  CP Cr
   Q: 373  CKICAENDKD-VKIEPCGHLMCTSCLTAW----QESDGQ-GCPFCR 412
           99********.******************....555555.5****8 PP

Organism

Bos taurus

Protein Sequence
(Fasta)

MANSMNGRNP GGRGGNPRKG RILGIIDAIQ DAVGPPKQAA ADRRTVEKTW KLMDKVVRLC 60
QNPKLQLKNS PPYILDILPD TYQHLRLILS KYDDNQKLAQ LSENEYFKIY IDSLMKKSKR 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGCAAATT CTATGAATGG CAGAAACCCT GGTGGTCGAG GAGGAAACCC CCGAAAAGGA 60
CGGATTTTGG GTATTATTGA TGCTATTCAA GATGCAGTTG GACCCCCTAA GCAAGCCGCA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome

Interpro

IPR024162--Adaptor_Cbl
IPR014741--Adaptor_Cbl_EF_hand-like
IPR003153--Adaptor_Cbl_N_hlx
IPR014742--Adaptor_Cbl_SH2-like
IPR024159--Cbl_PTB
IPR011992--EF-hand-dom_pair
IPR000980--SH2
IPR015940--UBA
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS

PROSITE

PS51506--CBL_PTB
PS50030--UBA
PS00518--ZF_RING_1
PS50089--ZF_RING_2

Pfam

PF02262--Cbl_N
PF02761--Cbl_N2
PF02762--Cbl_N3

SMART

SM00184--RING
SM00165--UBA

Gene Ontology

GO:0005829--C:cytosol
GO:0045121--C:membrane raft
GO:0005654--C:nucleoplasm
GO:0005886--C:plasma membrane
GO:0005509--F:calcium ion binding
GO:0030971--F:receptor tyrosine kinase binding
GO:0017124--F:SH3 domain binding
GO:0004871--F:signal transducer activity
GO:0061630--F:ubiquitin protein ligase activity
GO:0008270--F:zinc ion binding
GO:0007173--P:epidermal growth factor receptor signaling pathway
GO:0007175--P:negative regulation of epidermal growth factor-activated receptor activity
GO:0006508--P:proteolysis

KEGG

bta:525906

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001412	Ailuropoda melanoleuca	97.86	0.00e+00	1677.00
IUUC-Apl-004148	Anas platyrhynchos	86.78	0.00e+00	1506.00
IUUC-Aca-005204	Anolis carolinensis	83.08	0.00e+00	1440.00
IUUC-Ame-011919	Astyanax mexicanus	64.52	0.00e+00	1044.00
IUUC-Cel-018674	Caenorhabditis elegans	56.92	1.00e-133	469.00
IUUC-Cja-018813	Callithrix jacchus	88.54	0.00e+00	1540.00
IUUC-Cfa-021054	Canis familiaris	97.76	0.00e+00	1742.00
IUUC-Cpo-022514	Cavia porcellus	91.15	0.00e+00	1636.00
IUUC-Csa-024110	Chlorocebus sabaeus	97.25	0.00e+00	1693.00
IUUC-Cho-024886	Choloepus hoffmanni	80.98	0.00e+00	1142.00
IUUC-Dre-027480	Danio rerio	64.54	0.00e+00	1038.00
IUUC-Dno-028923	Dasypus novemcinctus	97.25	0.00e+00	1671.00
IUUC-Dor-031040	Dipodomys ordii	89.98	0.00e+00	811.00
IUUC-Ete-032406	Echinops telfairi	91.91	0.00e+00	1521.00
IUUC-Eca-033849	Equus caballus	97.15	0.00e+00	1699.00
IUUC-Fca-036224	Felis catus	98.37	0.00e+00	1717.00
IUUC-Fal-036860	Ficedula albicollis	96.89	0.00e+00	1006.00
IUUC-Gga-040159	Gallus gallus	83.35	0.00e+00	1434.00
IUUC-Gac-042312	Gasterosteus aculeatus	59.64	0.00e+00	984.00
IUUC-Ggo-045175	Gorilla gorilla	88.83	0.00e+00	1542.00
IUUC-Hsa-046306	Homo sapiens	97.15	0.00e+00	1690.00
IUUC-Lch-049931	Latimeria chalumnae	61.26	0.00e+00	873.00
IUUC-Loc-052524	Lepisosteus oculatus	69.53	0.00e+00	1103.00
IUUC-Laf-053635	Loxodonta africana	93.80	0.00e+00	1611.00
IUUC-Mcc-055536	Macaca mulatta	97.15	0.00e+00	1691.00
IUUC-Meu-056045	Macropus eugenii	79.11	0.00e+00	1294.00
IUUC-Mga-060177	Meleagris gallopavo	92.80	0.00e+00	1112.00
IUUC-Mmr-061088	Microcebus murinus	97.97	0.00e+00	1709.00
IUUC-Mdo-062020	Monodelphis domestica	92.00	0.00e+00	1583.00
IUUC-Mmu-063114	Mus musculus	90.23	0.00e+00	1595.00
IUUC-Mpu-066632	Mustela putorius furo	98.68	0.00e+00	1756.00
IUUC-Mlu-067145	Myotis lucifugus	97.15	0.00e+00	1700.00
IUUC-Ont-072323	Oreochromis niloticus	84.63	0.00e+00	896.00
IUUC-Oan-073165	Ornithorhynchus anatinus	89.54	0.00e+00	1615.00
IUUC-Ocu-074723	Oryctolagus cuniculus	97.25	0.00e+00	1704.00
IUUC-Oga-088021	Otolemur garnettii	96.24	0.00e+00	1674.00
IUUC-Oar-089809	Ovis aries	99.59	0.00e+00	1711.00
IUUC-Ptr-090834	Pan troglodytes	97.05	0.00e+00	1687.00
IUUC-Pan-092225	Papio anubis	97.15	0.00e+00	1691.00
IUUC-Psi-093317	Pelodiscus sinensis	87.13	0.00e+00	1555.00
IUUC-Pma-094249	Petromyzon marinus	77.61	5.00e-127	446.00
IUUC-Pab-097595	Pongo abelii	97.15	0.00e+00	1690.00
IUUC-Pca-100844	Procavia capensis	80.67	0.00e+00	1327.00
IUUC-Pva-103216	Pteropus vampyrus	89.93	0.00e+00	1587.00
IUUC-Rno-105381	Rattus norvegicus	94.71	0.00e+00	1684.00
IUUC-Sha-107574	Sarcophilus harrisii	91.81	0.00e+00	1577.00
IUUC-Sar-113500	Sorex araneus	85.08	0.00e+00	1361.00
IUUC-Ssc-115856	Sus scrofa	97.42	0.00e+00	1462.00
IUUC-Tgu-116866	Taeniopygia guttata	86.23	0.00e+00	1490.00
IUUC-Tru-118579	Takifugu rubripes	86.34	0.00e+00	891.00
IUUC-Tsy-119167	Tarsius syrichta	85.45	0.00e+00	1450.00
IUUC-Tni-120788	Tetraodon nigroviridis	85.21	0.00e+00	902.00
IUUC-Tbe-127830	Tupaia belangeri	93.92	0.00e+00	1162.00
IUUC-Ttr-128631	Tursiops truncatus	98.58	0.00e+00	1726.00
IUUC-Vpa-130713	Vicugna pacos	97.21	0.00e+00	1483.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence