iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Cfa-020642

Ensembl Protein ID

ENSCAFP00000014740.3

UniProt Accession

F1PEG8; F1PEG8_CANLF

Genbank Protein ID

ENSCAFP00000014740

Protein Name

E3 ubiquitin-protein ligase

Genbank Nucleotide ID

AAEX03001637

Gene Name

SIAH1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSCAFG00000010013.3	ENSCAFT00000015934.3	ENSCAFP00000014740.3

Status

Unreviewed

Classification

Family	Identity	E-Value	Score	Source Orthology
E3 activity/RING/RING	81.96	4.00e-126	447.00	IUUC-Dme-031700
E3 activity/RING/RING	96.30	1.00e-170	596.00	IUUC-Hsa-046357
E3 activity/RING/RING	99.29	8.00e-169	590.00	IUUC-Mmu-064129

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Organism

Canis familiaris

Functional Description
(View)

E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates.

Protein Sequence
(Fasta)

MGTEMDTHSK KAAQSKTRMK QMPSKEMSRQ TATALPTGTS KCTPSQRVPA LTGTTASNND 60
LASLFECPVC FDYVLPPILQ CQSGHLVCSN CRPKLTCCPT CRGPLGSIRN LAMEKVANSV 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGGAACAG AAATGGACAC ACATTCTAAG AAAGCTGCCC AAAGCAAAAC AAGGATGAAG 60
CAAATGCCCT CTAAAGGTAC GTGTGAAGAT GCCTGAGAGT TTGCATCCAG GCCCAGCCCT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0479--Metal-binding
KW-1185--Reference proteome
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR018121--7-in-absentia-prot_TRAF-dom
IPR004162--SINA-like
IPR008974--TRAF-like
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR013010--Znf_SIAH

PROSITE

PS50089--ZF_RING_2
PS51081--ZF_SIAH

Pfam

PF03145--Sina

Gene Ontology

GO:0030877--C:beta-catenin destruction complex
GO:0005634--C:nucleus
GO:0061630--F:ubiquitin protein ligase activity
GO:0008270--F:zinc ion binding
GO:0007275--P:multicellular organism development
GO:2001244--P:positive regulation of intrinsic apoptotic signaling pathway
GO:0006511--P:ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000061	Aegilops tauschii	37.09	9.00e-45	173.00
IUUC-Aml-001186	Ailuropoda melanoleuca	100.00	1.00e-172	598.00
IUUC-Atr-002857	Amborella trichopoda	36.06	1.00e-44	173.00
IUUC-Apl-003813	Anas platyrhynchos	100.00	2.00e-171	594.00
IUUC-Aca-005014	Anolis carolinensis	100.00	3.00e-172	597.00
IUUC-Aly-006207	Arabidopsis lyrata	33.94	6.00e-42	164.00
IUUC-Ath-007049	Arabidopsis thaliana	33.45	6.00e-42	164.00
IUUC-Ame-011196	Astyanax mexicanus	96.83	3.00e-169	587.00
IUUC-Bta-012887	Bos taurus	99.65	5.00e-172	596.00
IUUC-Bdi-014200	Brachypodium distachyon	37.73	2.00e-45	175.00
IUUC-Bol-015523	Brassica oleracea	36.36	4.00e-42	164.00
IUUC-Bra-017336	Brassica rapa	36.29	4.00e-41	161.00
IUUC-Cel-018320	Caenorhabditis elegans	62.78	2.00e-115	409.00
IUUC-Cja-019796	Callithrix jacchus	99.65	1.00e-171	595.00
IUUC-Cpo-022348	Cavia porcellus	99.65	1.00e-170	591.00
IUUC-Csa-023974	Chlorocebus sabaeus	96.30	4.00e-172	596.00
IUUC-Cin-025674	Ciona intestinalis	78.01	2.00e-135	474.00
IUUC-Csv-026233	Ciona savignyi	84.25	8.00e-133	466.00
IUUC-Dre-028041	Danio rerio	93.24	1.00e-169	588.00
IUUC-Dno-029764	Dasypus novemcinctus	99.30	1.00e-172	598.00
IUUC-Dme-031700	Drosophila melanogaster	83.87	2.00e-120	425.00
IUUC-Ete-032423	Echinops telfairi	98.89	5.00e-162	563.00
IUUC-Eca-033536	Equus caballus	100.00	2.00e-171	594.00
IUUC-Eeu-035314	Erinaceus europaeus	98.89	1.00e-162	565.00
IUUC-Fca-035362	Felis catus	100.00	9.00e-173	598.00
IUUC-Fal-037487	Ficedula albicollis	98.62	9.00e-173	598.00
IUUC-Gga-040269	Gallus gallus	100.00	2.00e-171	594.00
IUUC-Gac-042282	Gasterosteus aculeatus	97.16	1.00e-167	582.00
IUUC-Gma-042926	Glycine max	34.44	8.00e-41	160.00
IUUC-Ggo-045444	Gorilla gorilla	96.30	4.00e-172	596.00
IUUC-Hsa-046357	Homo sapiens	96.30	4.00e-172	596.00
IUUC-Hvu-047574	Hordeum vulgare	36.73	1.00e-44	173.00
IUUC-Itr-048046	Ictidomys tridecemlineatus	99.65	1.00e-170	591.00
IUUC-Lch-049504	Latimeria chalumnae	98.94	6.00e-170	589.00
IUUC-Lpe-050879	Leersia perrieri	40.25	7.00e-43	167.00
IUUC-Loc-052191	Lepisosteus oculatus	98.94	8.00e-171	592.00
IUUC-Laf-053668	Loxodonta africana	100.00	2.00e-171	594.00
IUUC-Mcc-054640	Macaca mulatta	96.30	4.00e-172	596.00
IUUC-Mtr-058747	Medicago truncatula	34.81	3.00e-42	165.00
IUUC-Mga-059503	Meleagris gallopavo	100.00	4.00e-172	596.00
IUUC-Mmr-060794	Microcebus murinus	99.65	1.00e-170	591.00
IUUC-Mmu-064129	Mus musculus	99.29	4.00e-170	590.00
IUUC-Mac-065014	Musa acuminata	36.64	3.00e-42	165.00
IUUC-Mpu-066488	Mustela putorius furo	100.00	1.00e-172	598.00
IUUC-Mlu-067207	Myotis lucifugus	100.00	2.00e-172	597.00
IUUC-Nle-069706	Nomascus leucogenys	99.65	7.00e-172	595.00
IUUC-Ont-071849	Oreochromis niloticus	97.17	2.00e-168	584.00
IUUC-Ocu-074876	Oryctolagus cuniculus	99.65	1.00e-171	595.00
IUUC-Oba-075454	Oryza barthii	40.66	8.00e-43	167.00
IUUC-Obr-076037	Oryza brachyantha	35.43	2.00e-40	159.00
IUUC-Ogl-077712	Oryza glaberrima	40.66	8.00e-43	167.00
IUUC-Ogu-078910	Oryza glumaepatula	40.83	1.00e-42	167.00
IUUC-Oin-079749	Oryza indica	40.66	8.00e-43	167.00
IUUC-Olo-080244	Oryza longistaminata	35.43	2.00e-40	160.00
IUUC-Ome-081318	Oryza meridionalis	40.66	8.00e-43	167.00
IUUC-Oni-083109	Oryza nivara	40.66	8.00e-43	167.00
IUUC-Opu-084065	Oryza punctata	41.08	4.00e-43	168.00
IUUC-Oru-084785	Oryza rufipogon	40.66	8.00e-43	167.00
IUUC-Osa-085610	Oryza sativa	40.66	8.00e-43	167.00
IUUC-Ola-086814	Oryzias latipes	97.16	1.00e-167	582.00
IUUC-Oga-088399	Otolemur garnettii	99.65	1.00e-170	591.00
IUUC-Oar-089323	Ovis aries	99.65	8.00e-172	595.00
IUUC-Ptr-090692	Pan troglodytes	99.65	2.00e-171	594.00
IUUC-Pan-092012	Papio anubis	96.30	4.00e-172	596.00
IUUC-Psi-093687	Pelodiscus sinensis	98.62	5.00e-173	599.00
IUUC-Pma-094387	Petromyzon marinus	94.01	8.00e-162	562.00
IUUC-Ppa-095212	Physcomitrella patens	36.19	4.00e-41	161.00
IUUC-Pfo-097134	Poecilia formosa	97.16	1.00e-167	582.00
IUUC-Pab-097555	Pongo abelii	96.30	4.00e-172	596.00
IUUC-Pop-099970	Populus trichocarpa	34.90	2.00e-44	172.00
IUUC-Ppe-101760	Prunus persica	36.10	3.00e-44	172.00
IUUC-Rno-104866	Rattus norvegicus	99.29	4.00e-170	590.00
IUUC-Sha-106547	Sarcophilus harrisii	97.62	5.00e-173	599.00
IUUC-Smo-109412	Selaginella moellendorffii	34.69	4.00e-39	155.00
IUUC-Sit-110595	Setaria italica	37.45	1.00e-41	163.00
IUUC-Sly-111259	Solanum lycopersicum	38.04	2.00e-41	162.00
IUUC-Stu-112571	Solanum tuberosum	38.04	2.00e-41	163.00
IUUC-Sbi-114090	Sorghum bicolor	37.11	2.00e-42	166.00
IUUC-Tgu-116579	Taeniopygia guttata	100.00	2.00e-171	594.00
IUUC-Tru-118250	Takifugu rubripes	92.91	2.00e-159	554.00
IUUC-Tni-120488	Tetraodon nigroviridis	96.81	5.00e-164	569.00
IUUC-Tca-121228	Theobroma cacao	35.50	2.00e-41	162.00
IUUC-Tae-123647	Triticum aestivum	37.09	9.00e-45	173.00
IUUC-Tur-126049	Triticum urartu	35.04	7.00e-39	154.00
IUUC-Ttr-129166	Tursiops truncatus	99.17	5.00e-144	503.00
IUUC-Vvi-131233	Vitis vinifera	35.45	8.00e-43	167.00
IUUC-Xtr-132553	Xenopus tropicalis	98.94	3.00e-170	590.00
IUUC-Xma-133670	Xiphophorus maculatus	97.16	1.00e-167	582.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence