iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Afu-008988

Ensembl Protein ID

CADAFUAP00007660

UniProt Accession

Q4WRL2; Q4WRL2_ASPFU

Genbank Protein ID

EAL90920.1

Protein Name

Ubiquitin carboxyl-terminal hydrolase

Genbank Nucleotide ID

AAHF01000004

Gene Name

AFUA_1G15920

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
CADAFUAG00007660	CADAFUAT00007660	CADAFUAP00007660

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/UCH	1.70e-59	200.8	4	244

Active Site

Position(s)	Description	Evidence
93	Nucleophile	{ECO:0000256\|PIRSR:PIRSR038120-1}
176	Proton donor	{ECO:0000256\|PIRSR:PIRSR038120-1}

Domain Profile

DUB/UCH

   S: 5    vkewleLesdPglftllvedfgvkrdiqveelysLdpenlglyqepvegllllFkinekressrksqvtsndlevvdediiktiffakqvigN 97
           + +w ++esd g+ft l+e++gvk++ q+eel sLd ++++++  pv+g+++lFk++ +  s +++q +     +   +  +++ffa q+i+N
   Q: 4    GGGWSTIESDEGVFTSLIENLGVKDV-QFEELISLDADTIRSL-SPVYGVIFLFKWIREPPSTNTTQPLD---GTYITSLPENLFFAAQTIQN 91
           579***********************.****************.********************888764...35556788999********* PP
   S: 98   sCatyAllsvllnc....edkl.ldlGttlsrlkestkaespenkalalgnqqvlecihnslariesrseperqdedneqytkeafhfvsyvn 185
           +C+t+A+lsv+ln     +    +++G++l  +ke+t ++ p+ +++al+n++ ++ +hn++ar  ++  ++ +  ++   + +++hf++y++
   Q: 92   ACGTQAILSVILNQdspaSTPYpINIGPELRSFKEFTAGFPPDLRGEALSNSETIRTAHNAFARASPFVDETVRTTQD--EEADVYHFIAYTP 182
           *************955543344689******************************************98887764443..4899********* PP
   S: 186  ingrlyeldglkpfPldlgkkketeelkdklkvvraflerikllesdeirfnllaivadrrvikt 250
           +ng lyeldgl+p+P+ +g+++ ++  ++ ++v++    ri  + ++e rfnl+a+v d rv   
   Q: 183  VNGVLYELDGLQPYPISHGECNAETFPEKVIEVLQ---RRIARYPEGETRFNLMAVVRDLRVRAR 244
           ********************887777777777777...9********************999765 PP

Organism

Aspergillus fumigatus

Protein Sequence
(Fasta)

MADGGGWSTI ESDEGVFTSL IENLGVKDVQ FEELISLDAD TIRSLSPVYG VIFLFKWIRE 60
PPSTNTTQPL DGTYITSLPE NLFFAAQTIQ NACGTQAILS VILNQDSPAS TPYPINIGPE 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGCCGACG GCGGAGGCTG GAGCACGATC GAGTCGGATG AGGTATGTTC AACCCCTTTC 60
TCCCCCAACA TAAAACCTCA TCCTAACGTG TCCAGGGCGT CTTCACCTCC CTGATCGAGA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0645--Protease
KW-0647--Proteasome
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway

Interpro

IPR001578--Peptidase_C12_UCH
IPR017390--Ubiquitinyl_hydrolase_UCH37

Pfam

PF01088--Peptidase_C12

PRINTS

PR00707--UBCTHYDRLASE

Gene Ontology

GO:0034399--C:nuclear periphery
GO:0031595--C:nuclear proteasome complex
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0016579--P:protein deubiquitination
GO:0006511--P:ubiquitin-dependent protein catabolic process

KEGG

afm:AFUA_1G15920

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000936	Aegilops tauschii	39.89	1.00e-62	231.00
IUUC-Aml-001866	Ailuropoda melanoleuca	38.29	4.00e-57	213.00
IUUC-Atr-002966	Amborella trichopoda	48.85	7.00e-55	206.00
IUUC-Apl-003306	Anas platyrhynchos	35.16	5.00e-48	182.00
IUUC-Aca-004763	Anolis carolinensis	39.56	2.00e-56	211.00
IUUC-Aly-005581	Arabidopsis lyrata	51.48	2.00e-55	207.00
IUUC-Ath-007283	Arabidopsis thaliana	51.05	8.00e-57	212.00
IUUC-Ago-007999	Ashbya gossypii	37.50	3.00e-46	176.00
IUUC-Acl-008231	Aspergillus clavatus	86.08	1.00e-152	530.00
IUUC-Afl-008557	Aspergillus flavus	83.28	1.00e-143	499.00
IUUC-Ani-009420	Aspergillus nidulans	73.44	1.00e-126	443.00
IUUC-Ang-009859	Aspergillus niger	78.93	8.00e-135	471.00
IUUC-Aor-010145	Aspergillus oryzae	83.28	1.00e-143	499.00
IUUC-Ate-010347	Aspergillus terreus	77.48	8.00e-138	481.00
IUUC-Ame-010791	Astyanax mexicanus	39.17	4.00e-58	216.00
IUUC-Bgr-012298	Blumeria graminis	60.46	3.00e-102	362.00
IUUC-Bta-013251	Bos taurus	39.81	3.00e-57	213.00
IUUC-Bci-013786	Botrytis cinerea	66.78	1.00e-118	417.00
IUUC-Bdi-014132	Brachypodium distachyon	46.77	2.00e-60	224.00
IUUC-Bol-015611	Brassica oleracea	41.98	9.00e-58	215.00
IUUC-Bra-017769	Brassica rapa	42.27	3.00e-58	216.00
IUUC-Cel-018604	Caenorhabditis elegans	37.65	8.00e-53	198.00
IUUC-Cja-019768	Callithrix jacchus	34.88	2.00e-51	194.00
IUUC-Cfa-020207	Canis familiaris	38.29	4.00e-57	213.00
IUUC-Cpo-021925	Cavia porcellus	36.51	2.00e-51	194.00
IUUC-Cre-022919	Chlamydomonas reinhardtii	48.28	2.00e-56	210.00
IUUC-Csa-023958	Chlorocebus sabaeus	39.37	4.00e-57	213.00
IUUC-Cho-024928	Choloepus hoffmanni	43.02	2.00e-12	64.70
IUUC-Cin-025771	Ciona intestinalis	35.63	6.00e-53	199.00
IUUC-Csv-026149	Ciona savignyi	38.20	4.00e-56	209.00
IUUC-Cgl-026424	Colletotrichum gloeosporioides	50.33	2.00e-83	300.00
IUUC-Cne-026955	Cryptococcus neoformans	37.50	2.00e-52	197.00
IUUC-Cme-027104	Cyanidioschyzon merolae	34.31	9.00e-41	159.00
IUUC-Dre-027409	Danio rerio	39.68	3.00e-56	209.00
IUUC-Dno-028921	Dasypus novemcinctus	37.97	2.00e-56	210.00
IUUC-Dor-030891	Dipodomys ordii	32.38	5.00e-30	124.00
IUUC-Dse-031170	Dothistroma septosporum	59.87	2.00e-100	357.00
IUUC-Dme-031677	Drosophila melanogaster	39.00	6.00e-56	209.00
IUUC-Ete-032646	Echinops telfairi	40.29	8.00e-34	137.00
IUUC-Eca-033776	Equus caballus	38.23	4.00e-50	189.00
IUUC-Eeu-035305	Erinaceus europaeus	36.55	3.00e-29	120.00
IUUC-Fca-035846	Felis catus	35.28	1.00e-52	198.00
IUUC-Fal-037597	Ficedula albicollis	36.86	2.00e-48	184.00
IUUC-Fox-037670	Fusarium oxysporum	61.67	3.00e-93	332.00
IUUC-Fso-038243	Fusarium solani	61.00	6.00e-92	328.00
IUUC-Gmo-038499	Gadus morhua	35.99	1.00e-48	184.00
IUUC-Ggr-039975	Gaeumannomyces graminis	56.35	1.00e-87	314.00
IUUC-Gga-040904	Gallus gallus	38.61	1.00e-56	211.00
IUUC-Gac-042058	Gasterosteus aculeatus	38.22	1.00e-55	207.00
IUUC-Gma-043030	Glycine max	50.97	2.00e-59	221.00
IUUC-Ggo-044699	Gorilla gorilla	44.81	8.00e-55	205.00
IUUC-Hsa-046227	Homo sapiens	38.29	2.00e-57	213.00
IUUC-Hvu-047359	Hordeum vulgare	40.17	2.00e-62	231.00
IUUC-Itr-048989	Ictidomys tridecemlineatus	35.16	3.00e-52	197.00
IUUC-Lch-049829	Latimeria chalumnae	39.49	2.00e-56	211.00
IUUC-Lpe-050899	Leersia perrieri	50.41	4.00e-61	226.00
IUUC-Loc-052264	Lepisosteus oculatus	39.05	3.00e-55	206.00
IUUC-Lma-053110	Leptosphaeria maculans	62.16	7.00e-93	332.00
IUUC-Laf-053639	Loxodonta africana	38.29	4.00e-57	213.00
IUUC-Mcc-055506	Macaca mulatta	39.37	4.00e-57	213.00
IUUC-Meu-056267	Macropus eugenii	36.92	1.00e-38	152.00
IUUC-Mor-057001	Magnaporthe oryzae	56.33	7.00e-89	318.00
IUUC-Mpo-057608	Magnaporthe poae	58.47	5.00e-55	205.00
IUUC-Mtr-057731	Medicago truncatula	49.81	2.00e-62	230.00
IUUC-Mla-059016	Melampsora laricipopulina	43.27	1.00e-43	167.00
IUUC-Mga-060178	Meleagris gallopavo	37.88	9.00e-50	188.00
IUUC-Mvi-060353	Microbotryum violaceum	36.91	1.00e-50	191.00
IUUC-Mmr-060738	Microcebus murinus	38.29	4.00e-57	213.00
IUUC-Mdo-062266	Monodelphis domestica	44.24	7.00e-46	174.00
IUUC-Mmu-063619	Mus musculus	39.24	2.00e-57	214.00
IUUC-Mac-065301	Musa acuminata	42.99	7.00e-65	238.00
IUUC-Mpu-066058	Mustela putorius furo	38.29	4.00e-57	213.00
IUUC-Mlu-067292	Myotis lucifugus	38.10	2.00e-56	211.00
IUUC-Nfi-068275	Neosartorya fischeri	98.10	0.00e+00	640.00
IUUC-Ncr-068713	Neurospora crassa	59.37	3.00e-110	389.00
IUUC-Nle-069013	Nomascus leucogenys	39.68	3.00e-57	214.00
IUUC-Opr-070628	Ochotona princeps	33.72	2.00e-48	184.00
IUUC-Ont-072688	Oreochromis niloticus	37.26	4.00e-55	206.00
IUUC-Oan-073004	Ornithorhynchus anatinus	44.24	2.00e-47	180.00
IUUC-Ocu-074303	Oryctolagus cuniculus	38.22	3.00e-56	211.00
IUUC-Oba-075002	Oryza barthii	40.29	1.00e-61	228.00
IUUC-Obr-076392	Oryza brachyantha	49.24	8.00e-63	232.00
IUUC-Ogl-077271	Oryza glaberrima	40.29	1.00e-61	228.00
IUUC-Ogu-078493	Oryza glumaepatula	40.57	1.00e-62	231.00
IUUC-Oin-080084	Oryza indica	40.57	1.00e-62	231.00
IUUC-Olo-080803	Oryza longistaminata	40.86	4.00e-63	233.00
IUUC-Ome-081146	Oryza meridionalis	40.86	5.00e-63	232.00
IUUC-Oni-082146	Oryza nivara	40.57	1.00e-62	231.00
IUUC-Opu-083633	Oryza punctata	48.85	4.00e-62	229.00
IUUC-Oru-084789	Oryza rufipogon	40.57	1.00e-62	231.00
IUUC-Osa-086196	Oryza sativa	40.57	1.00e-62	231.00
IUUC-Ola-087126	Oryzias latipes	38.85	4.00e-56	209.00
IUUC-Olu-087665	Ostreococcus lucimarinus	39.44	5.00e-53	199.00
IUUC-Oga-089140	Otolemur garnettii	35.38	2.00e-52	197.00
IUUC-Oar-090296	Ovis aries	38.10	1.00e-55	207.00
IUUC-Ptr-090566	Pan troglodytes	38.29	2.00e-57	213.00
IUUC-Pan-092052	Papio anubis	39.68	4.00e-57	213.00
IUUC-Psi-093723	Pelodiscus sinensis	37.88	2.00e-49	187.00
IUUC-Pma-094568	Petromyzon marinus	44.95	2.00e-48	184.00
IUUC-Pno-095120	Phaeosphaeria nodorum	62.42	2.00e-99	353.00
IUUC-Ppa-095761	Physcomitrella patens	48.47	4.00e-60	223.00
IUUC-Pfo-096210	Poecilia formosa	38.54	2.00e-56	210.00
IUUC-Pab-098463	Pongo abelii	38.29	5.00e-57	213.00
IUUC-Pop-099109	Populus trichocarpa	47.49	2.00e-56	211.00
IUUC-Pca-100108	Procavia capensis	44.03	6.00e-52	196.00
IUUC-Ppe-101176	Prunus persica	38.86	4.00e-56	209.00
IUUC-Pva-102629	Pteropus vampyrus	44.81	7.00e-53	199.00
IUUC-Pgr-103419	Puccinia graminis	35.71	8.00e-47	178.00
IUUC-Pte-104207	Pyrenophora teres	60.80	1.00e-49	186.00
IUUC-Pyt-104471	Pyrenophora triticirepentis	60.91	2.00e-99	353.00
IUUC-Rno-105579	Rattus norvegicus	36.02	4.00e-47	179.00
IUUC-Sha-106894	Sarcophilus harrisii	39.42	1.00e-47	181.00
IUUC-Sja-107732	Schizosaccharomyces japonicus	44.97	7.00e-74	268.00
IUUC-Spo-108371	Schizosaccharomyces pombe	47.60	8.00e-78	281.00
IUUC-Ssl-108467	Sclerotinia sclerotiorum	66.17	1.00e-99	353.00
IUUC-Smo-109396	Selaginella moellendorffii	40.29	3.00e-57	213.00
IUUC-Sit-110630	Setaria italica	49.03	7.00e-63	232.00
IUUC-Sly-110972	Solanum lycopersicum	40.96	5.00e-57	212.00
IUUC-Stu-112185	Solanum tuberosum	42.29	2.00e-64	237.00
IUUC-Sar-113294	Sorex araneus	33.72	4.00e-46	176.00
IUUC-Sbi-113951	Sorghum bicolor	50.38	3.00e-63	233.00
IUUC-Ssc-115501	Sus scrofa	37.42	6.00e-52	195.00
IUUC-Tgu-117152	Taeniopygia guttata	36.86	2.00e-48	184.00
IUUC-Tru-118388	Takifugu rubripes	38.22	1.00e-55	208.00
IUUC-Tsy-119109	Tarsius syrichta	38.29	4.00e-57	213.00
IUUC-Tni-120048	Tetraodon nigroviridis	38.22	4.00e-56	209.00
IUUC-Tca-121750	Theobroma cacao	41.03	1.00e-62	231.00
IUUC-Tre-122130	Trichoderma reesei	60.61	1.00e-100	357.00
IUUC-Tvi-122284	Trichoderma virens	58.67	9.00e-96	341.00
IUUC-Tae-124183	Triticum aestivum	47.55	6.00e-61	226.00
IUUC-Tur-126366	Triticum urartu	40.35	2.00e-41	161.00
IUUC-Tme-127187	Tuber melanosporum	58.84	3.00e-106	375.00
IUUC-Tbe-127705	Tupaia belangeri	37.96	5.00e-38	149.00
IUUC-Ttr-128225	Tursiops truncatus	39.68	2.00e-42	166.00
IUUC-Vda-129912	Verticillium dahliae	55.23	2.00e-85	307.00
IUUC-Vpa-130552	Vicugna pacos	43.64	3.00e-46	177.00
IUUC-Vvi-130881	Vitis vinifera	40.29	3.00e-58	216.00
IUUC-Xtr-131934	Xenopus tropicalis	38.85	2.00e-56	210.00
IUUC-Xma-133312	Xiphophorus maculatus	38.54	2.00e-56	210.00
IUUC-Yli-134487	Yarrowia lipolytica	44.59	3.00e-69	253.00
IUUC-Zma-135639	Zea mays	42.91	1.00e-53	201.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence