iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Xtr-131934

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Ubiquitin carboxyl-terminal hydrolase

Genbank Nucleotide ID

AAMC01088296

Gene Name

uchl5

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSXETG00000017223.3	ENSXETT00000037510.3	ENSXETP00000037510.3

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/UCH	1.10e-92	311.2	1	316

Active Site

Position(s)	Description	Evidence
88	Nucleophile	{ECO:0000256\|PIRSR:PIRSR038120-1}
164	Proton donor	{ECO:0000256\|PIRSR:PIRSR038120-1}

Domain Profile

DUB/UCH

   S: 1    mnsqvkewleLesdPglftllvedfgvkrdiqveelysLdpenlglyqepvegllllFkinekressrksqvtsndlevvdediiktif 89
           m + + ew+ +esdPg+ft+l++ fg+++  qvee++sL++e ++ + +pv+gl++lFk+++ +e +          +vv+++ ++tif
   Q: 1    MAGSAGEWCLMESDPGVFTELIKGFGCRGI-QVEEIWSLEQEHFEDL-QPVQGLIFLFKWQPGEEPAG---------SVVQDSRLDTIF 78
           667789***********************9.****************.9*******************.........899********* PP
   S: 90   fakqvigNsCatyAllsvllncedklldlGttlsrlkestkaespenkalalgnqqvlecihnslariesrseperqdedneqytkeaf 178
           fakqvi+N+Cat+A++s lln ++  ++lG+tls++ke+t+++++ +k+lal+n++v++++hns+ar+++++ + +   +    +++af
   Q: 79   FAKQVINNACATQAIISILLNTTHTDVHLGETLSEFKEFTQSFDAAMKGLALSNSEVIRQVHNSFARQQMFEFDAKSTTK----DDDAF 163
           *************************************************************************9887555....8**** PP
   S: 179  hfvsyvningrlyeldglkpfPldlgkkketeelkdklkvvraflerikllesdeirfnllaivadrrviktlrlnvlkid........ 259
           hfvsyv++ngrlyeldgl+  P+dlg++ke +e+ ++++ v+   +r++++ ++eirfnl+aiv+dr+ i+++++  l+          
   Q: 164  HFVSYVPVNGRLYELDGLRDGPIDLGPCKE-DEWISAARPVI--EKRMQKYCEGEIRFNLMAIVSDRKKIYEQKITDLQRRlaeeepmd 249
           ***************************776.57999******..9*****************************965443366777777 PP
   S: 260  .keLlkLlkdieseeekieaqlddekekrkkfkiddirRtenydeficifikdlaregilrklveet 325
             +   L++ ++se++k++  +++e++k k++ki++irR++ny  fi++++k+la++++l  lve+ 
   Q: 250  tDQGSTLMSSMQSEIAKYQLLIEEENQKIKRYKIENIRRKHNYLPFIMELLKTLAEHQQLIPLVEKA 316
           65556899********************************************************984 PP

Organism

Xenopus tropicalis

Protein Sequence
(Fasta)

MAGSAGEWCL MESDPGVFTE LIKGFGCRGI QVEEIWSLEQ EHFEDLQPVQ GLIFLFKWQP 60
GEEPAGSVVQ DSRLDTIFFA KQVINNACAT QAIISILLNT THTDVHLGET LSEFKEFTQS 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GGTGCTTGTG AGAGATGGCG GGCAGTGCGG GAGAATGGTG CCTGATGGAG AGCGACCCCG 60
GGGTGTTTAC CGAGCTAATC AAAGGCTTTG GTGCGTTGCC TTTCCGGCCT TGTGTGCTTT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway

Interpro

IPR001578--Peptidase_C12_UCH
IPR017390--Ubiquitinyl_hydrolase_UCH37

Pfam

PF01088--Peptidase_C12

PRINTS

PR00707--UBCTHYDRLASE

Gene Ontology

GO:0005737--C:cytoplasm
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0016579--P:protein deubiquitination
GO:0006511--P:ubiquitin-dependent protein catabolic process

KEGG

xtr:100124308

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000936	Aegilops tauschii	47.73	5.00e-85	307.00
IUUC-Aml-001866	Ailuropoda melanoleuca	86.58	4.00e-167	580.00
IUUC-Atr-002966	Amborella trichopoda	47.13	2.00e-81	296.00
IUUC-Apl-003306	Anas platyrhynchos	77.65	8.00e-163	566.00
IUUC-Aca-004763	Anolis carolinensis	88.14	9.00e-169	585.00
IUUC-Aly-005581	Arabidopsis lyrata	49.24	1.00e-81	296.00
IUUC-Ath-007283	Arabidopsis thaliana	48.93	1.00e-83	303.00
IUUC-Ago-007999	Ashbya gossypii	38.56	4.00e-34	138.00
IUUC-Acl-008231	Aspergillus clavatus	44.49	1.00e-52	199.00
IUUC-Afl-008557	Aspergillus flavus	37.05	4.00e-53	201.00
IUUC-Afu-008988	Aspergillus fumigatus	44.92	1.00e-53	202.00
IUUC-Ani-009420	Aspergillus nidulans	38.44	1.00e-51	196.00
IUUC-Ang-009859	Aspergillus niger	40.32	3.00e-49	188.00
IUUC-Aor-010145	Aspergillus oryzae	37.05	4.00e-53	201.00
IUUC-Ate-010347	Aspergillus terreus	41.90	7.00e-52	197.00
IUUC-Ame-010791	Astyanax mexicanus	85.11	8.00e-174	602.00
IUUC-Bgr-012298	Blumeria graminis	39.14	3.00e-51	195.00
IUUC-Bta-013251	Bos taurus	86.58	2.00e-165	574.00
IUUC-Bci-013786	Botrytis cinerea	36.58	3.00e-56	211.00
IUUC-Bdi-014132	Brachypodium distachyon	48.15	2.00e-80	292.00
IUUC-Bol-015611	Brassica oleracea	50.31	5.00e-86	310.00
IUUC-Bra-017769	Brassica rapa	50.31	6.00e-86	310.00
IUUC-Cel-018604	Caenorhabditis elegans	47.60	3.00e-81	294.00
IUUC-Cja-019768	Callithrix jacchus	78.59	3.00e-160	557.00
IUUC-Cfa-020207	Canis familiaris	86.58	4.00e-167	580.00
IUUC-Cpo-021925	Cavia porcellus	83.39	4.00e-159	553.00
IUUC-Cre-022919	Chlamydomonas reinhardtii	44.51	9.00e-74	270.00
IUUC-Csa-023958	Chlorocebus sabaeus	85.94	2.00e-164	571.00
IUUC-Cho-024928	Choloepus hoffmanni	92.21	3.00e-39	155.00
IUUC-Cin-025771	Ciona intestinalis	55.03	1.00e-100	358.00
IUUC-Csv-026149	Ciona savignyi	57.41	2.00e-102	365.00
IUUC-Cgl-026424	Colletotrichum gloeosporioides	37.05	8.00e-51	193.00
IUUC-Cne-026955	Cryptococcus neoformans	36.09	1.00e-52	199.00
IUUC-Cme-027104	Cyanidioschyzon merolae	32.69	6.00e-49	187.00
IUUC-Dre-027409	Danio rerio	84.19	2.00e-169	588.00
IUUC-Dno-028921	Dasypus novemcinctus	86.58	1.00e-166	578.00
IUUC-Dse-031170	Dothistroma septosporum	38.73	9.00e-57	213.00
IUUC-Dme-031677	Drosophila melanogaster	60.00	1.00e-113	402.00
IUUC-Ete-032707	Echinops telfairi	62.38	5.00e-108	384.00
IUUC-Eca-033776	Equus caballus	86.46	4.00e-152	530.00
IUUC-Eeu-035305	Erinaceus europaeus	70.21	2.00e-74	271.00
IUUC-Fca-035846	Felis catus	79.71	6.00e-162	563.00
IUUC-Fal-037597	Ficedula albicollis	86.46	1.00e-147	514.00
IUUC-Fox-037670	Fusarium oxysporum	45.69	8.00e-52	197.00
IUUC-Fso-038243	Fusarium solani	46.98	7.00e-52	197.00
IUUC-Gmo-038499	Gadus morhua	80.19	5.00e-155	540.00
IUUC-Ggr-039975	Gaeumannomyces graminis	41.56	9.00e-46	177.00
IUUC-Gga-040904	Gallus gallus	85.80	6.00e-174	602.00
IUUC-Gac-042058	Gasterosteus aculeatus	84.35	1.00e-163	568.00
IUUC-Gma-043763	Glycine max	48.66	4.00e-86	311.00
IUUC-Ggo-044699	Gorilla gorilla	80.13	1.00e-149	521.00
IUUC-Hsa-046227	Homo sapiens	86.26	1.00e-166	578.00
IUUC-Hvu-047359	Hordeum vulgare	47.87	2.00e-83	301.00
IUUC-Itr-048989	Ictidomys tridecemlineatus	78.78	1.00e-161	562.00
IUUC-Lch-049829	Latimeria chalumnae	86.58	3.00e-166	577.00
IUUC-Lpe-050899	Leersia perrieri	47.32	2.00e-76	279.00
IUUC-Loc-052264	Lepisosteus oculatus	86.31	5.00e-165	573.00
IUUC-Lma-053110	Leptosphaeria maculans	38.08	4.00e-48	185.00
IUUC-Laf-053639	Loxodonta africana	86.58	4.00e-167	580.00
IUUC-Mcc-055506	Macaca mulatta	85.94	2.00e-164	571.00
IUUC-Mor-057001	Magnaporthe oryzae	45.30	1.00e-52	199.00
IUUC-Mpo-057608	Magnaporthe poae	41.18	3.00e-32	130.00
IUUC-Mtr-057731	Medicago truncatula	48.07	3.00e-85	308.00
IUUC-Mla-059016	Melampsora laricipopulina	42.29	3.00e-43	167.00
IUUC-Mga-060178	Meleagris gallopavo	85.53	1.00e-159	555.00
IUUC-Mvi-060353	Microbotryum violaceum	39.20	7.00e-54	204.00
IUUC-Mmr-060738	Microcebus murinus	86.26	7.00e-167	579.00
IUUC-Mdo-062266	Monodelphis domestica	87.25	7.00e-109	385.00
IUUC-Mmu-063619	Mus musculus	85.62	4.00e-165	573.00
IUUC-Mac-065301	Musa acuminata	49.84	4.00e-86	310.00
IUUC-Mpu-066058	Mustela putorius furo	86.90	2.00e-167	581.00
IUUC-Mlu-067292	Myotis lucifugus	86.90	2.00e-165	574.00
IUUC-Nfi-068275	Neosartorya fischeri	37.62	2.00e-54	205.00
IUUC-Ncr-068713	Neurospora crassa	36.79	8.00e-54	203.00
IUUC-Nle-069013	Nomascus leucogenys	85.62	7.00e-164	569.00
IUUC-Opr-070628	Ochotona princeps	75.59	1.00e-150	525.00
IUUC-Ont-072688	Oreochromis niloticus	85.08	3.00e-163	567.00
IUUC-Oan-073004	Ornithorhynchus anatinus	85.19	4.00e-126	443.00
IUUC-Ocu-074303	Oryctolagus cuniculus	86.90	2.00e-167	582.00
IUUC-Oba-075002	Oryza barthii	47.59	1.00e-80	293.00
IUUC-Obr-076392	Oryza brachyantha	48.26	5.00e-79	287.00
IUUC-Ogl-077271	Oryza glaberrima	47.59	1.00e-80	293.00
IUUC-Ogu-078493	Oryza glumaepatula	47.59	2.00e-81	295.00
IUUC-Oin-080084	Oryza indica	47.59	2.00e-81	295.00
IUUC-Olo-080803	Oryza longistaminata	47.29	5.00e-81	294.00
IUUC-Ome-081146	Oryza meridionalis	46.69	1.00e-80	292.00
IUUC-Oni-082146	Oryza nivara	47.59	2.00e-81	295.00
IUUC-Opu-083633	Oryza punctata	47.63	6.00e-78	283.00
IUUC-Oru-084789	Oryza rufipogon	47.59	2.00e-81	295.00
IUUC-Osa-086196	Oryza sativa	47.59	2.00e-81	295.00
IUUC-Ola-087126	Oryzias latipes	84.03	2.00e-159	554.00
IUUC-Olu-087665	Ostreococcus lucimarinus	41.67	7.00e-69	253.00
IUUC-Oga-089140	Otolemur garnettii	78.82	3.00e-161	560.00
IUUC-Oar-090296	Ovis aries	86.26	2.00e-165	574.00
IUUC-Ptr-090566	Pan troglodytes	86.26	1.00e-166	578.00
IUUC-Pan-092052	Papio anubis	85.94	3.00e-164	571.00
IUUC-Psi-093723	Pelodiscus sinensis	86.46	5.00e-153	533.00
IUUC-Pma-094568	Petromyzon marinus	57.99	3.00e-101	360.00
IUUC-Pno-095120	Phaeosphaeria nodorum	45.81	4.00e-49	187.00
IUUC-Ppa-095761	Physcomitrella patens	47.95	3.00e-84	304.00
IUUC-Pfo-096210	Poecilia formosa	84.66	1.00e-163	568.00
IUUC-Pab-098463	Pongo abelii	86.26	2.00e-166	578.00
IUUC-Pop-099109	Populus trichocarpa	46.69	4.00e-82	297.00
IUUC-Pca-100108	Procavia capensis	84.96	4.00e-126	444.00
IUUC-Ppe-101176	Prunus persica	49.11	3.00e-84	305.00
IUUC-Pva-102629	Pteropus vampyrus	84.35	5.00e-133	466.00
IUUC-Pgr-103419	Puccinia graminis	39.63	1.00e-56	213.00
IUUC-Pte-104207	Pyrenophora teres	44.97	1.00e-32	132.00
IUUC-Pyt-104471	Pyrenophora triticirepentis	38.69	1.00e-54	206.00
IUUC-Rno-105579	Rattus norvegicus	75.85	3.00e-144	503.00
IUUC-Sha-106894	Sarcophilus harrisii	84.67	3.00e-142	497.00
IUUC-Sja-107732	Schizosaccharomyces japonicus	41.53	3.00e-61	228.00
IUUC-Spo-108371	Schizosaccharomyces pombe	39.20	1.00e-59	223.00
IUUC-Ssl-108467	Sclerotinia sclerotiorum	36.96	1.00e-46	179.00
IUUC-Smo-109396	Selaginella moellendorffii	50.46	2.00e-87	315.00
IUUC-Sit-110630	Setaria italica	50.00	5.00e-86	310.00
IUUC-Sly-110972	Solanum lycopersicum	49.68	5.00e-83	300.00
IUUC-Stu-112185	Solanum tuberosum	48.66	5.00e-91	327.00
IUUC-Sar-113294	Sorex araneus	73.09	3.00e-148	517.00
IUUC-Sbi-113951	Sorghum bicolor	49.69	1.00e-84	306.00
IUUC-Ssc-115501	Sus scrofa	85.52	2.00e-155	541.00
IUUC-Tgu-117152	Taeniopygia guttata	86.11	1.00e-147	514.00
IUUC-Tru-118388	Takifugu rubripes	84.03	1.00e-163	568.00
IUUC-Tsy-119109	Tarsius syrichta	86.58	4.00e-167	580.00
IUUC-Tni-120048	Tetraodon nigroviridis	84.03	3.00e-164	570.00
IUUC-Tca-121750	Theobroma cacao	48.24	2.00e-87	315.00
IUUC-Tre-122130	Trichoderma reesei	39.00	3.00e-54	204.00
IUUC-Tvi-122284	Trichoderma virens	38.54	3.00e-50	191.00
IUUC-Tae-124082	Triticum aestivum	47.73	3.00e-84	304.00
IUUC-Tur-126366	Triticum urartu	43.58	4.00e-68	251.00
IUUC-Tme-127187	Tuber melanosporum	39.40	4.00e-61	228.00
IUUC-Tbe-127619	Tupaia belangeri	77.70	2.00e-126	444.00
IUUC-Ttr-128867	Tursiops truncatus	76.33	1.00e-108	385.00
IUUC-Vda-129912	Verticillium dahliae	37.16	3.00e-51	194.00
IUUC-Vpa-130552	Vicugna pacos	87.56	2.00e-112	398.00
IUUC-Vvi-130881	Vitis vinifera	49.85	2.00e-84	305.00
IUUC-Xma-133312	Xiphophorus maculatus	84.35	2.00e-162	565.00
IUUC-Yli-134487	Yarrowia lipolytica	32.93	1.00e-45	176.00
IUUC-Zma-135462	Zea mays	43.08	1.00e-72	266.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence