iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSCAFG00000010598.4	ENSCAFT00000045557.2	ENSCAFP00000036179.1
ENSCAFG00000010598.4	ENSCAFT00000016899.3	ENSCAFP00000015639.3

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	4.80e-96	322.4	1632	2011

Active Site

Position(s)	Description	Evidence
1978	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 6    kkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlq..pnpdsglknp.....................ehlk 69
           ++ le+++++E g++l G+t+ef+al+s+elq++dlgl++ +e   ++ +   + +++                         ++  
   Q: 1632 RAMLEIQYENEVGTGL-GPTLEFYALVSQELQRADLGLWRGEEVTLSNPKgsQEGTKY---IqnlqglfalpfgrtakpahiaKVKM 1714
           56899***********.**********************6665533332200222333...14458888999**********9999* PP
   S: 70   lFeflGrllgkalqdgrlldlplsksfyklllgkklsl..edleevdpelykslkeikena......es.................. 130
            F+flG+l++ka++d rl+dlpl  +fyk +l+++ sl  +dl ++dp +++s+  +++ +      e+                  
   Q: 1715 KFRFLGKLMAKAIMDFRLVDLPLGLPFYKWMLRQETSLtsHDLFDIDPVVARSVYHLEDIVrqkkrlEQdksqtkeslqyaletltm 1801
           **********************************654444**************999999855555511555666666554444444 PP
   S: 131  ...dieelgldltfsvseei.....lgetkeeeLkpgGenipVtneNkeeYvklvveyrlkegikeqveafreGfneviplellslF 209
              ++e+            +     l+   + eLk gG++ipVt+ N+eeY +lv+ + l+eg+ +q+++fr+Gf++v+pl++l++F
   Q: 1802 ngcSVED------------LgldftLPGFPNIELKKGGKDIPVTIHNLEEYLRLVIFWALNEGVSRQFDSFRDGFESVFPLSHLQYF 1876
           4444444............25555578999********************************************************* PP
   S: 210  teeelellicGe..eeidvedlkketkykggytedspaiqwFwevleefsseerkafLqFvTgssrlPlgGfaelkprlfvirk... 291
            +eel++l+cG+  +++d+++l + ++ ++gyt+ds+a+++++e+l++f++e+++ fLqFvTgs+rlP+gGf++l+p l+++rk   
   Q: 1877 YPEELDQLLCGSkaDTWDAKTLMECCRPDHGYTHDSRAVKFLFEILSSFDNEQQRLFLQFVTGSPRLPVGGFRSLNPPLTIVRKtfe 1963
           ************7778999999999999*********************************************************** PP
   S: 292  ..dasddrlPssnTCfnyLkLPeYsskeilkekLlyAieet.kgFels 336
             ++ dd lPs++TC+nyLkLP+Yss +i++ekLl+A +e+ ++F+ls
   Q: 1964 stENPDDFLPSVMTCVNYLKLPDYSSIDIMREKLLIAAREGqQSFHLS 2011
           988888***************************************985 PP

Organism

Canis familiaris

Protein Sequence
(Fasta)

MSNRPNNNPG GSLRRSQRNT AGAQPQDDSI GGRSHLGQAK HKGYSPPESR KSNSKAPKVQ 60
SNTTSELSRG HLSKRSCSSS SAVIVPQPED PDRANTSERQ KTGQVPKKDN SRGVKRSASP 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TGAATGGTAG TGTCTAGAAA GGGTATGTCC CTTCAAGAGA GAGGTGCCAA TGTCCAACCG 60
GCCTAATAAC AATCCAGGGG GGTCACTGCG ACGTTCACAG AGGAACACTG CCGGGGCCCA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR011989--ARM-like
IPR016024--ARM-type_fold
IPR000569--HECT_dom
IPR004170--WWE-dom

PROSITE

PS50237--HECT
PS50918--WWE

Pfam

PF00632--HECT

SMART

SM00119--HECTc

Gene Ontology

GO:0016607--C:nuclear speck
GO:0004842--F:ubiquitin-protein transferase activity
GO:0006974--P:cellular response to DNA damage stimulus
GO:0009790--P:embryo development
GO:2000780--P:negative regulation of double-strand break repair
GO:1901315--P:negative regulation of histone H2A K63-linked ubiquitination
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000750	Aegilops tauschii	38.54	2.00e-126	447.00
IUUC-Aml-001502	Ailuropoda melanoleuca	98.14	0.00e+00	3651.00
IUUC-Atr-002821	Amborella trichopoda	37.30	7.00e-117	416.00
IUUC-Apl-003531	Anas platyrhynchos	91.19	0.00e+00	3320.00
IUUC-Aly-005962	Arabidopsis lyrata	38.80	1.00e-114	409.00
IUUC-Ath-006636	Arabidopsis thaliana	38.52	5.00e-114	406.00
IUUC-Ago-007875	Ashbya gossypii	36.01	2.00e-81	298.00
IUUC-Acl-008242	Aspergillus clavatus	35.85	2.00e-114	407.00
IUUC-Afl-008736	Aspergillus flavus	39.01	3.00e-111	397.00
IUUC-Afu-008812	Aspergillus fumigatus	34.95	5.00e-114	406.00
IUUC-Ani-009407	Aspergillus nidulans	36.97	2.00e-111	397.00
IUUC-Ang-009763	Aspergillus niger	40.18	8.00e-107	382.00
IUUC-Aor-009941	Aspergillus oryzae	30.77	2.00e-113	404.00
IUUC-Ate-010459	Aspergillus terreus	37.31	1.00e-85	312.00
IUUC-Ame-011761	Astyanax mexicanus	86.03	0.00e+00	2882.00
IUUC-Bgr-012265	Blumeria graminis	34.70	4.00e-104	373.00
IUUC-Bta-013070	Bos taurus	96.62	0.00e+00	3491.00
IUUC-Bci-013890	Botrytis cinerea	39.92	4.00e-103	370.00
IUUC-Bdi-014046	Brachypodium distachyon	38.33	2.00e-121	431.00
IUUC-Bol-015942	Brassica oleracea	44.04	4.00e-114	406.00
IUUC-Bra-016849	Brassica rapa	44.04	9.00e-114	405.00
IUUC-Cja-019046	Callithrix jacchus	96.62	0.00e+00	3586.00
IUUC-Cpo-021639	Cavia porcellus	93.54	0.00e+00	3506.00
IUUC-Cre-022767	Chlamydomonas reinhardtii	39.88	1.00e-89	323.00
IUUC-Csa-023231	Chlorocebus sabaeus	96.52	0.00e+00	3584.00
IUUC-Cho-024380	Choloepus hoffmanni	89.41	0.00e+00	3271.00
IUUC-Cin-025482	Ciona intestinalis	51.21	8.00e-160	556.00
IUUC-Csv-026121	Ciona savignyi	49.21	0.00e+00	1549.00
IUUC-Cgl-026716	Colletotrichum gloeosporioides	34.94	7.00e-111	396.00
IUUC-Cne-026857	Cryptococcus neoformans	39.58	3.00e-94	340.00
IUUC-Cme-027226	Cyanidioschyzon merolae	34.94	4.00e-74	273.00
IUUC-Dre-028174	Danio rerio	85.39	0.00e+00	2906.00
IUUC-Dor-030939	Dipodomys ordii	88.39	0.00e+00	2783.00
IUUC-Dse-031444	Dothistroma septosporum	39.52	4.00e-106	380.00
IUUC-Dme-032162	Drosophila melanogaster	63.41	7.00e-158	553.00
IUUC-Ete-032345	Echinops telfairi	92.69	0.00e+00	2311.00
IUUC-Eca-033229	Equus caballus	97.50	0.00e+00	3544.00
IUUC-Eeu-035205	Erinaceus europaeus	84.56	0.00e+00	3023.00
IUUC-Fca-036444	Felis catus	97.26	0.00e+00	3591.00
IUUC-Fal-037131	Ficedula albicollis	91.68	0.00e+00	3393.00
IUUC-Fox-038035	Fusarium oxysporum	36.12	1.00e-109	390.00
IUUC-Fso-038320	Fusarium solani	37.07	2.00e-110	395.00
IUUC-Gmo-039497	Gadus morhua	86.42	0.00e+00	2935.00
IUUC-Ggr-040057	Gaeumannomyces graminis	35.05	4.00e-109	390.00
IUUC-Gga-041021	Gallus gallus	92.12	0.00e+00	3401.00
IUUC-Gac-042474	Gasterosteus aculeatus	80.44	0.00e+00	2981.00
IUUC-Gma-043060	Glycine max	38.78	9.00e-122	432.00
IUUC-Ggo-044855	Gorilla gorilla	96.67	0.00e+00	3590.00
IUUC-Hsa-046147	Homo sapiens	94.17	0.00e+00	3492.00
IUUC-Hvu-047775	Hordeum vulgare	38.54	1.00e-124	441.00
IUUC-Itr-048131	Ictidomys tridecemlineatus	93.81	0.00e+00	3397.00
IUUC-Kpa-049098	Komagataella pastoris	37.90	2.00e-85	311.00
IUUC-Lch-049818	Latimeria chalumnae	82.39	0.00e+00	2975.00
IUUC-Lpe-051017	Leersia perrieri	38.30	3.00e-118	420.00
IUUC-Loc-051777	Lepisosteus oculatus	85.70	0.00e+00	3247.00
IUUC-Lma-052990	Leptosphaeria maculans	39.55	1.00e-111	399.00
IUUC-Laf-053727	Loxodonta africana	97.35	0.00e+00	3590.00
IUUC-Mcc-055799	Macaca mulatta	97.94	0.00e+00	3582.00
IUUC-Meu-056065	Macropus eugenii	94.58	0.00e+00	2110.00
IUUC-Mor-057054	Magnaporthe oryzae	38.86	2.00e-107	385.00
IUUC-Mpo-057417	Magnaporthe poae	39.36	4.00e-109	390.00
IUUC-Mtr-057849	Medicago truncatula	37.22	1.00e-113	405.00
IUUC-Mla-058870	Melampsora laricipopulina	42.77	2.00e-107	384.00
IUUC-Mga-059580	Meleagris gallopavo	92.85	0.00e+00	2944.00
IUUC-Mvi-060507	Microbotryum violaceum	39.82	1.00e-112	402.00
IUUC-Mmr-060816	Microcebus murinus	96.37	0.00e+00	3575.00
IUUC-Mdo-062866	Monodelphis domestica	95.10	0.00e+00	3410.00
IUUC-Mmu-063906	Mus musculus	93.18	0.00e+00	3462.00
IUUC-Mac-064675	Musa acuminata	38.92	7.00e-112	398.00
IUUC-Mpu-066199	Mustela putorius furo	97.99	0.00e+00	3575.00
IUUC-Mlu-067110	Myotis lucifugus	93.76	0.00e+00	3467.00
IUUC-Nfi-068482	Neosartorya fischeri	35.10	9.00e-114	405.00
IUUC-Ncr-068906	Neurospora crassa	39.13	2.00e-109	391.00
IUUC-Nle-069410	Nomascus leucogenys	97.40	0.00e+00	3578.00
IUUC-Opr-070401	Ochotona princeps	84.87	0.00e+00	3008.00
IUUC-Ont-072100	Oreochromis niloticus	81.12	0.00e+00	3014.00
IUUC-Oan-073121	Ornithorhynchus anatinus	91.59	0.00e+00	3536.00
IUUC-Ocu-074623	Oryctolagus cuniculus	97.15	0.00e+00	3581.00
IUUC-Oba-075380	Oryza barthii	36.66	2.00e-114	407.00
IUUC-Obr-076915	Oryza brachyantha	37.62	6.00e-119	422.00
IUUC-Ogl-077055	Oryza glaberrima	38.56	4.00e-118	420.00
IUUC-Ogu-078892	Oryza glumaepatula	40.54	2.00e-113	404.00
IUUC-Oin-079256	Oryza indica	38.38	7.00e-117	416.00
IUUC-Olo-080343	Oryza longistaminata	38.38	3.00e-117	417.00
IUUC-Ome-081422	Oryza meridionalis	38.10	1.00e-116	415.00
IUUC-Oni-083047	Oryza nivara	36.81	2.00e-115	410.00
IUUC-Opu-083641	Oryza punctata	36.59	6.00e-112	399.00
IUUC-Oru-084439	Oryza rufipogon	40.54	4.00e-114	406.00
IUUC-Osa-085972	Oryza sativa	38.30	4.00e-116	412.00
IUUC-Ola-087173	Oryzias latipes	79.19	0.00e+00	2949.00
IUUC-Olu-087871	Ostreococcus lucimarinus	36.70	1.00e-88	320.00
IUUC-Oga-087908	Otolemur garnettii	96.38	0.00e+00	3582.00
IUUC-Oar-090277	Ovis aries	95.06	0.00e+00	3476.00
IUUC-Ptr-091543	Pan troglodytes	94.90	0.00e+00	3496.00
IUUC-Pan-092243	Papio anubis	97.89	0.00e+00	3582.00
IUUC-Psi-093150	Pelodiscus sinensis	93.88	0.00e+00	3520.00
IUUC-Pno-094891	Phaeosphaeria nodorum	41.28	1.00e-113	405.00
IUUC-Ppa-095181	Physcomitrella patens	41.94	4.00e-107	382.00
IUUC-Pfo-096267	Poecilia formosa	80.41	0.00e+00	2966.00
IUUC-Pab-098072	Pongo abelii	97.70	0.00e+00	3591.00
IUUC-Pop-099190	Populus trichocarpa	40.88	1.00e-115	412.00
IUUC-Pca-100311	Procavia capensis	90.15	0.00e+00	3208.00
IUUC-Ppe-101284	Prunus persica	37.37	3.00e-116	414.00
IUUC-Pva-102215	Pteropus vampyrus	94.74	0.00e+00	1305.00
IUUC-Pgr-103694	Puccinia graminis	40.88	7.00e-105	376.00
IUUC-Ptt-103916	Puccinia triticina	39.19	7.00e-99	356.00
IUUC-Pte-104346	Pyrenophora teres	39.59	3.00e-110	394.00
IUUC-Pyt-104508	Pyrenophora triticirepentis	39.66	2.00e-110	394.00
IUUC-Rno-105315	Rattus norvegicus	96.91	0.00e+00	3514.00
IUUC-Sce-106273	Saccharomyces cerevisiae	35.19	1.00e-71	265.00
IUUC-Sha-106835	Sarcophilus harrisii	94.15	0.00e+00	3565.00
IUUC-Sja-107943	Schizosaccharomyces japonicus	37.37	4.00e-94	340.00
IUUC-Spo-108081	Schizosaccharomyces pombe	38.34	3.00e-94	340.00
IUUC-Ssl-108560	Sclerotinia sclerotiorum	40.12	1.00e-106	382.00
IUUC-Smo-108776	Selaginella moellendorffii	43.10	8.00e-112	399.00
IUUC-Sit-110717	Setaria italica	37.94	4.00e-120	426.00
IUUC-Sly-111469	Solanum lycopersicum	39.22	1.00e-122	435.00
IUUC-Stu-112896	Solanum tuberosum	38.07	1.00e-105	377.00
IUUC-Sar-113224	Sorex araneus	86.02	0.00e+00	1836.00
IUUC-Sbi-114313	Sorghum bicolor	38.02	8.00e-124	439.00
IUUC-Sre-114993	Sporisorium reilianum	34.24	6.00e-101	363.00
IUUC-Ssc-115535	Sus scrofa	89.97	0.00e+00	3348.00
IUUC-Tgu-117493	Taeniopygia guttata	92.47	0.00e+00	2684.00
IUUC-Tru-118669	Takifugu rubripes	80.99	0.00e+00	3009.00
IUUC-Tsy-119373	Tarsius syrichta	94.75	0.00e+00	1868.00
IUUC-Tni-120049	Tetraodon nigroviridis	77.98	0.00e+00	867.00
IUUC-Tca-121779	Theobroma cacao	38.61	2.00e-115	411.00
IUUC-Tre-122195	Trichoderma reesei	35.65	3.00e-105	377.00
IUUC-Tvi-122650	Trichoderma virens	36.08	1.00e-109	392.00
IUUC-Tae-123580	Triticum aestivum	38.44	3.00e-124	439.00
IUUC-Tur-126295	Triticum urartu	38.39	4.00e-125	443.00
IUUC-Tme-126964	Tuber melanosporum	40.28	3.00e-105	377.00
IUUC-Tbe-128149	Tupaia belangeri	81.95	0.00e+00	1468.00
IUUC-Ttr-128165	Tursiops truncatus	96.58	0.00e+00	3070.00
IUUC-Uma-129365	Ustilago maydis	36.25	2.00e-89	325.00
IUUC-Vda-129725	Verticillium dahliae	41.28	1.00e-109	392.00
IUUC-Vpa-130678	Vicugna pacos	99.13	0.00e+00	2691.00
IUUC-Vvi-131147	Vitis vinifera	39.09	3.00e-122	433.00
IUUC-Xtr-132636	Xenopus tropicalis	85.70	0.00e+00	3183.00
IUUC-Xma-133458	Xiphophorus maculatus	80.93	0.00e+00	3008.00
IUUC-Yli-134481	Yarrowia lipolytica	39.36	3.00e-97	350.00
IUUC-Zma-135782	Zea mays	37.87	4.00e-118	420.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence