iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000114450.9	ENST00000232564.7	ENSP00000232564.3
ENSG00000114450.9	ENST00000466899.5	ENSP00000420066.1

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
UTRdb	AREsite	circBase	circRNADb
CircNet	miRTarBase	microRNA	TRANSFAC
miRWalk	TargetScan	RepTar	SomamiR
miRcode	RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	HINT
Mentha	InWeb_IM
Disease-associated Variation
ClinVar	GWASdb	OMIM
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	dbPTM
PHOSIDA	BioGRID	mUbiSiDa
DNA Methylation
MethyCancer	TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	2.10e-38	130.3	224	258
UBD/Beta-Prp	1.60e-51	176.9	46	269

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 1    gHtdsvtclaf.sd.tllvsGsdDgtikvWDlrtg 33
           gH +++++++f ++   +++GsdD t++++Dlr +
   Q: 224  GHVSDINAVSFfPNgYAFATGSDDATCRLFDLRAD 258
           8*********99885679**************987 PP

UBD/Beta-Prp

   S: 43   kllrslsgheaevtavkfspdgkilvtgseDrtikvwdlstgkcvhtlkghedsvlslsfspsgdklvsGshdrtirvwdletgqclee... 131
            + r+l gh a+++a+ +  d+ +lv++s+D+ + +wd  t   +h++   ++ v+++++ psg++++ G+ d++  +++l+t++       
   Q: 46   RTRRTLRGHLAKIYAMHWGYDSRLLVSASQDGKLIIWDSYTTNKMHAIPLRSSWVMTCAYAPSGNYVACGGLDNICSIYNLKTREGNVRvsr 137
           446899*****************************************************************************987776677 PP
   S: 132  tlsghdgvvncvvvhpdgnllvsGslDrtvrlWdlktgkllrtltgghtdsvyslsfdsngkelvsgsldgtvklwdlqtgecvrtlnghtd 223
            l gh+g  +c ++ + ++ +v++s D+t+ lWd++t++  +t+tg h ++v sls++++++ +vsg++d + klwd++ g c ++++gh +
   Q: 138  ELPGHTGYLSCCRFLD-DSQIVTSSGDTTCALWDIETAQQTTTFTG-HSGDVMSLSLSPDMRTFVSGACDASSKLWDIRDGMCRQSFTGHVS 227
           9*************99.67789***********************9.********************************************* PP
   S: 224  nvksvrfspnderlvsgssDgsiriWdlrsgdllktlqlhnssv 267
            ++ v f+pn+  +++gs+D + r++dlr ++ l  +++   ++
   Q: 228  DINAVSFFPNGYAFATGSDDATCRLFDLRADQELLLYSHD--NI 269
           ********************************99988874..44 PP

Organism

Homo sapiens

Functional Description
(View)

Strongly expressed in lung and placenta, whereas it is weakly expressed in brain and heart. Abundantly expressed in the axons and Schwann cells of peripheral nerves.

Protein Sequence
(Fasta)

MSELEQLRQE AEQLRNQIQD ARKACNDATL VQITSNMDSV GRIQMRTRRT LRGHLAKIYA 60
MHWGYDSRLL VSASQDGKLI IWDSYTTNKM HAIPLRSSWV MTCAYAPSGN YVACGGLDNI 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CCCCGGCACG TCCCCGCCGG GCCCGCGCGC CTCGTGCCTC GCGCCTCGCG CCTCCAGCCA 60
CGTCCCCGCC CCGGCTCCGG CGCGCCGCGG AGTTGGCTGC TGGGAGGTGC GGGACTGGGT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0007--Acetylation
KW-0144--Charcot-Marie-Tooth disease
KW-0181--Complete proteome
KW-0903--Direct protein sequencing
KW-0225--Disease mutation
KW-0523--Neurodegeneration
KW-0622--Neuropathy
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0807--Transducer
KW-0853--WD repeat

Interpro

IPR020472--G-protein_beta_WD-40_rep
IPR001632--Gprotein_B
IPR016346--Guanine_nucleotide-bd_bsu
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF00400--WD40

PRINTS

PR00319--GPROTEINB
PR00320--GPROTEINBRPT

SMART

SM00320--WD40

Gene Ontology

GO:0005829--C:cytosol
GO:0070062--C:extracellular exosome
GO:0005765--C:lysosomal membrane
GO:0043209--C:myelin sheath
GO:0005886--C:plasma membrane
GO:0032403--F:protein complex binding
GO:0004871--F:signal transducer activity
GO:0071377--P:cellular response to glucagon stimulus
GO:0006457--P:protein folding
GO:0021762--P:substantia nigra development

KEGG

hsa:59345

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001727	Ailuropoda melanoleuca	99.69	0.00e+00	667.00
IUUC-Apl-003923	Anas platyrhynchos	94.75	9.00e-176	608.00
IUUC-Aca-004754	Anolis carolinensis	94.74	3.00e-176	610.00
IUUC-Ate-010520	Aspergillus terreus	61.76	5.00e-110	390.00
IUUC-Bta-013200	Bos taurus	99.69	0.00e+00	665.00
IUUC-Cja-019845	Callithrix jacchus	99.69	0.00e+00	666.00
IUUC-Cfa-020395	Canis familiaris	99.69	0.00e+00	667.00
IUUC-Cpo-021376	Cavia porcellus	99.07	0.00e+00	665.00
IUUC-Csa-023295	Chlorocebus sabaeus	100.00	0.00e+00	667.00
IUUC-Cho-024766	Choloepus hoffmanni	99.38	0.00e+00	668.00
IUUC-Dno-029802	Dasypus novemcinctus	99.34	0.00e+00	627.00
IUUC-Dme-031748	Drosophila melanogaster	81.47	6.00e-173	599.00
IUUC-Ete-032710	Echinops telfairi	96.75	7.00e-180	622.00
IUUC-Eca-033628	Equus caballus	99.38	0.00e+00	664.00
IUUC-Eeu-034978	Erinaceus europaeus	97.44	1.00e-157	548.00
IUUC-Fal-037616	Ficedula albicollis	95.05	7.00e-177	612.00
IUUC-Gmo-039556	Gadus morhua	92.57	1.00e-180	625.00
IUUC-Gga-040249	Gallus gallus	95.05	7.00e-177	612.00
IUUC-Gac-041805	Gasterosteus aculeatus	91.64	1.00e-180	625.00
IUUC-Ggo-044954	Gorilla gorilla	99.69	0.00e+00	666.00
IUUC-Itr-048623	Ictidomys tridecemlineatus	100.00	0.00e+00	664.00
IUUC-Kpa-049192	Komagataella pastoris	38.89	1.00e-62	233.00
IUUC-Mcc-055787	Macaca mulatta	100.00	0.00e+00	667.00
IUUC-Mga-060050	Meleagris gallopavo	94.75	9.00e-176	608.00
IUUC-Mmr-060931	Microcebus murinus	100.00	0.00e+00	667.00
IUUC-Mdo-063055	Monodelphis domestica	94.43	3.00e-176	610.00
IUUC-Mmu-064368	Mus musculus	96.59	0.00e+00	650.00
IUUC-Mpu-066358	Mustela putorius furo	99.69	0.00e+00	667.00
IUUC-Mlu-067328	Myotis lucifugus	98.76	0.00e+00	660.00
IUUC-Nle-069612	Nomascus leucogenys	100.00	0.00e+00	667.00
IUUC-Ont-071287	Oreochromis niloticus	92.57	0.00e+00	625.00
IUUC-Oan-072913	Ornithorhynchus anatinus	95.36	6.00e-178	616.00
IUUC-Ocu-074126	Oryctolagus cuniculus	99.38	0.00e+00	670.00
IUUC-Ola-087297	Oryzias latipes	92.31	0.00e+00	628.00
IUUC-Oar-089360	Ovis aries	99.69	0.00e+00	665.00
IUUC-Ptr-091437	Pan troglodytes	100.00	0.00e+00	667.00
IUUC-Pan-092195	Papio anubis	99.69	0.00e+00	666.00
IUUC-Psi-093718	Pelodiscus sinensis	95.05	7.00e-177	612.00
IUUC-Pfo-096251	Poecilia formosa	92.26	5.00e-180	623.00
IUUC-Sce-106298	Saccharomyces cerevisiae	37.40	2.00e-68	253.00
IUUC-Sha-106534	Sarcophilus harrisii	94.43	2.00e-176	611.00
IUUC-Sja-107891	Schizosaccharomyces japonicus	35.48	9.00e-60	223.00
IUUC-Spo-108352	Schizosaccharomyces pombe	41.69	1.00e-69	256.00
IUUC-Smo-108835	Selaginella moellendorffii	43.58	2.00e-74	272.00
IUUC-Sar-113642	Sorex araneus	99.26	3.00e-161	560.00
IUUC-Tgu-117198	Taeniopygia guttata	95.05	7.00e-177	612.00
IUUC-Tru-118399	Takifugu rubripes	91.95	2.00e-180	624.00
IUUC-Tsy-119354	Tarsius syrichta	96.59	0.00e+00	649.00
IUUC-Ttr-129243	Tursiops truncatus	100.00	0.00e+00	667.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence