iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Cne-026950

Ensembl Protein ID

AAW43195

UniProt Accession

P0CN06; Q55UJ4; Q5KHV1; DCN1_CRYNJ

Genbank Protein ID

AAW43195.1

Protein Name

Defective in cullin neddylation protein 1

Genbank Nucleotide ID

AE017344

Gene Name

DCN1; CND05210

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
CND05210	AAW43195	AAW43195

Status

Unreviewed

Classification

Family	Identity	E-Value	Score	Source Orthology
E3 activity/DCUN1	36.47	4.00e-38	155.00	IUUC-Ath-007531
UBD/Alpha-Helix/UBA	25.18	3.00e-15	79.00	IUUC-Cel-018441
E3 activity/DCUN1	31.23	1.00e-28	124.00	IUUC-Hsa-046089
UBD/Alpha-Helix/UBA	31.23	1.00e-28	124.00	IUUC-Hsa-046089
UBD/Alpha-Helix/UBA	32.58	2.00e-30	130.00	IUUC-Mmu-063816
E3 activity/DCUN1	26.18	8.00e-19	89.00	IUUC-Sce-106358
UBD/Alpha-Helix/UBA	26.18	8.00e-19	89.00	IUUC-Sce-106358

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Organism

Cryptococcus neoformans

Functional Description
(View)

May contribute to neddylation of cullin components of SCF-type E3 ubiquitin ligase complexes. Neddylation of cullins play an essential role in the regulation of SCF-type complexes activity (By similarity).

Protein Sequence
(Fasta)

MASIVSPLST KDSLLVTQFR AITGTSSAEA AKYIKRYKHI EAAVDAFYNN EPAPRADPAQ 60
ERKLGEIWEK FKDPSDPKLI KIDGTMELCE ELDIDPGTDA VLFCLAADLG SKATGEWEKA 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGCAAGTA TCGTCTCGGT ATCTCACGGC CACAGCCCAC AGCTCATACT CCACAGCCCC 60
TCTCCACCAA GGACTCGCTC CTCGTCACCC AGTTCAGAGC AATCACAGGC ACATCGTACG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0833--Ubl conjugation pathway

Interpro

IPR014764--DCN-prot
IPR005176--PONY_dom

PROSITE

PS51229--DCUN1

Pfam

PF03556--Cullin_binding

Gene Ontology

GO:0000151--C:ubiquitin ligase complex
GO:0097602--F:cullin family protein binding
GO:0031624--F:ubiquitin conjugating enzyme binding
GO:0032182--F:ubiquitin-like protein binding
GO:0051443--P:positive regulation of ubiquitin-protein transferase activity
GO:0045116--P:protein neddylation

KEGG

cne:CND05210

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000561	Aegilops tauschii	35.63	3.00e-39	153.00
IUUC-Aml-001879	Ailuropoda melanoleuca	31.23	9.00e-31	124.00
IUUC-Atr-002697	Amborella trichopoda	32.09	1.00e-14	70.10
IUUC-Apl-003933	Anas platyrhynchos	32.58	1.00e-31	128.00
IUUC-Aca-005269	Anolis carolinensis	31.97	1.00e-30	124.00
IUUC-Aly-006285	Arabidopsis lyrata	32.71	3.00e-29	119.00
IUUC-Ath-007531	Arabidopsis thaliana	36.47	7.00e-40	155.00
IUUC-Ago-007806	Ashbya gossypii	28.80	2.00e-15	74.30
IUUC-Acl-008172	Aspergillus clavatus	28.52	8.00e-25	105.00
IUUC-Afl-008569	Aspergillus flavus	30.25	2.00e-27	114.00
IUUC-Afu-009005	Aspergillus fumigatus	31.94	3.00e-19	85.90
IUUC-Ani-009241	Aspergillus nidulans	27.53	5.00e-24	102.00
IUUC-Ang-009664	Aspergillus niger	32.35	3.00e-24	103.00
IUUC-Aor-009902	Aspergillus oryzae	34.93	1.00e-16	76.60
IUUC-Ate-010414	Aspergillus terreus	30.14	4.00e-27	112.00
IUUC-Ame-011763	Astyanax mexicanus	31.18	6.00e-30	122.00
IUUC-Bgr-011991	Blumeria graminis	29.66	2.00e-21	94.00
IUUC-Bta-013561	Bos taurus	31.97	2.00e-29	120.00
IUUC-Bci-013824	Botrytis cinerea	29.10	4.00e-24	102.00
IUUC-Bdi-014138	Brachypodium distachyon	35.63	7.00e-39	151.00
IUUC-Bol-016110	Brassica oleracea	35.04	5.00e-37	145.00
IUUC-Bra-017111	Brassica rapa	35.40	6.00e-37	145.00
IUUC-Cel-018441	Caenorhabditis elegans	25.18	8.00e-17	79.00
IUUC-Cja-019502	Callithrix jacchus	31.23	8.00e-31	125.00
IUUC-Cfa-020523	Canis familiaris	31.97	1.00e-29	120.00
IUUC-Cpo-022196	Cavia porcellus	31.60	5.00e-31	125.00
IUUC-Cre-022620	Chlamydomonas reinhardtii	28.26	1.00e-30	125.00
IUUC-Csa-023551	Chlorocebus sabaeus	31.23	1.00e-30	124.00
IUUC-Cho-024373	Choloepus hoffmanni	30.60	3.00e-28	116.00
IUUC-Cin-025269	Ciona intestinalis	29.81	1.00e-29	121.00
IUUC-Csv-025976	Ciona savignyi	29.06	7.00e-20	88.60
IUUC-Cgl-026386	Colletotrichum gloeosporioides	29.06	1.00e-19	87.40
IUUC-Cme-027199	Cyanidioschyzon merolae	32.81	6.00e-09	52.80
IUUC-Dre-028247	Danio rerio	30.80	2.00e-29	120.00
IUUC-Dno-029524	Dasypus novemcinctus	32.79	2.00e-30	124.00
IUUC-Dor-030143	Dipodomys ordii	31.44	2.00e-30	123.00
IUUC-Dse-031365	Dothistroma septosporum	31.48	3.00e-29	119.00
IUUC-Dme-032197	Drosophila melanogaster	30.15	3.00e-29	120.00
IUUC-Ete-032371	Echinops telfairi	31.23	1.00e-30	124.00
IUUC-Eca-033242	Equus caballus	31.23	1.00e-30	124.00
IUUC-Eeu-035317	Erinaceus europaeus	31.60	5.00e-31	125.00
IUUC-Fca-036061	Felis catus	30.50	8.00e-31	125.00
IUUC-Fal-036715	Ficedula albicollis	32.58	9.00e-32	128.00
IUUC-Fox-037884	Fusarium oxysporum	38.03	6.00e-20	88.20
IUUC-Fso-038150	Fusarium solani	26.22	3.00e-18	84.00
IUUC-Gmo-039604	Gadus morhua	33.21	6.00e-31	125.00
IUUC-Ggr-039959	Gaeumannomyces graminis	28.04	1.00e-15	76.30
IUUC-Gga-040224	Gallus gallus	32.95	5.00e-32	129.00
IUUC-Gac-041853	Gasterosteus aculeatus	30.92	3.00e-29	119.00
IUUC-Gma-043516	Glycine max	34.48	1.00e-35	141.00
IUUC-Ggo-044972	Gorilla gorilla	31.06	3.00e-30	123.00
IUUC-Hsa-046089	Homo sapiens	31.23	1.00e-30	124.00
IUUC-Hvu-047636	Hordeum vulgare	25.00	1.00e-10	57.40
IUUC-Itr-047902	Ictidomys tridecemlineatus	31.82	1.00e-28	118.00
IUUC-Kpa-049127	Komagataella pastoris	29.37	2.00e-24	103.00
IUUC-Lch-049751	Latimeria chalumnae	32.58	2.00e-31	127.00
IUUC-Lpe-051540	Leersia perrieri	34.48	5.00e-38	149.00
IUUC-Loc-051976	Lepisosteus oculatus	31.82	4.00e-31	126.00
IUUC-Lma-053103	Leptosphaeria maculans	30.00	3.00e-21	93.60
IUUC-Laf-053527	Loxodonta africana	30.86	2.00e-30	124.00
IUUC-Mcc-054700	Macaca mulatta	31.06	2.00e-30	123.00
IUUC-Meu-056791	Macropus eugenii	26.42	4.00e-20	89.40
IUUC-Mor-056909	Magnaporthe oryzae	29.50	6.00e-27	112.00
IUUC-Mpo-057299	Magnaporthe poae	25.90	1.00e-21	94.70
IUUC-Mtr-057964	Medicago truncatula	33.46	4.00e-34	135.00
IUUC-Mla-058990	Melampsora laricipopulina	29.37	3.00e-21	94.00
IUUC-Mga-060072	Meleagris gallopavo	32.95	7.00e-32	128.00
IUUC-Mvi-060312	Microbotryum violaceum	33.95	7.00e-34	135.00
IUUC-Mmr-060851	Microcebus murinus	31.23	1.00e-30	124.00
IUUC-Mdo-063074	Monodelphis domestica	31.23	5.00e-30	124.00
IUUC-Mmu-063816	Mus musculus	32.58	2.00e-32	130.00
IUUC-Mac-065016	Musa acuminata	36.04	2.00e-29	119.00
IUUC-Mpu-066254	Mustela putorius furo	33.33	1.00e-31	127.00
IUUC-Mlu-067701	Myotis lucifugus	31.23	1.00e-30	124.00
IUUC-Nfi-068610	Neosartorya fischeri	31.94	2.00e-18	83.20
IUUC-Ncr-068780	Neurospora crassa	25.34	4.00e-14	70.10
IUUC-Nle-069291	Nomascus leucogenys	31.23	1.00e-30	124.00
IUUC-Opr-070682	Ochotona princeps	27.27	6.00e-19	86.30
IUUC-Ont-071408	Oreochromis niloticus	31.18	2.00e-30	124.00
IUUC-Oan-073031	Ornithorhynchus anatinus	31.60	5.00e-31	125.00
IUUC-Ocu-074648	Oryctolagus cuniculus	31.23	1.00e-30	124.00
IUUC-Oba-074993	Oryza barthii	34.48	3.00e-38	149.00
IUUC-Obr-076341	Oryza brachyantha	35.63	1.00e-39	154.00
IUUC-Ogl-077099	Oryza glaberrima	34.48	3.00e-38	149.00
IUUC-Ogu-078285	Oryza glumaepatula	34.48	2.00e-37	147.00
IUUC-Oin-079441	Oryza indica	34.48	3.00e-38	149.00
IUUC-Olo-081037	Oryza longistaminata	34.48	3.00e-38	149.00
IUUC-Ome-081357	Oryza meridionalis	34.48	3.00e-38	149.00
IUUC-Oni-082632	Oryza nivara	34.48	3.00e-38	149.00
IUUC-Opu-083351	Oryza punctata	33.98	8.00e-37	144.00
IUUC-Oru-084306	Oryza rufipogon	34.48	3.00e-38	149.00
IUUC-Osa-085307	Oryza sativa	34.48	3.00e-38	149.00
IUUC-Ola-086868	Oryzias latipes	32.83	1.00e-33	134.00
IUUC-Olu-087646	Ostreococcus lucimarinus	30.69	3.00e-22	97.10
IUUC-Oga-088621	Otolemur garnettii	31.82	1.00e-30	124.00
IUUC-Oar-090405	Ovis aries	31.23	1.00e-30	124.00
IUUC-Ptr-090735	Pan troglodytes	31.23	1.00e-30	124.00
IUUC-Pan-092825	Papio anubis	31.06	2.00e-30	124.00
IUUC-Psi-093029	Pelodiscus sinensis	33.05	3.00e-30	122.00
IUUC-Pma-094196	Petromyzon marinus	29.11	4.00e-22	96.70
IUUC-Pno-095145	Phaeosphaeria nodorum	32.58	1.00e-22	98.20
IUUC-Ppa-095321	Physcomitrella patens	37.02	2.00e-39	153.00
IUUC-Pfo-097121	Poecilia formosa	30.68	1.00e-30	125.00
IUUC-Pab-098197	Pongo abelii	31.67	4.00e-29	119.00
IUUC-Pop-098821	Populus trichocarpa	39.23	5.00e-21	90.90
IUUC-Pca-100218	Procavia capensis	30.48	5.00e-30	122.00
IUUC-Ppe-102032	Prunus persica	34.87	2.00e-37	147.00
IUUC-Pva-102691	Pteropus vampyrus	31.82	6.00e-31	125.00
IUUC-Pgr-103633	Puccinia graminis	32.19	8.00e-34	135.00
IUUC-Ptt-103979	Puccinia triticina	30.69	2.00e-13	68.20
IUUC-Pyt-104428	Pyrenophora triticirepentis	27.69	2.00e-20	90.50
IUUC-Rno-105016	Rattus norvegicus	32.20	2.00e-31	126.00
IUUC-Sce-106358	Saccharomyces cerevisiae	26.18	7.00e-20	89.00
IUUC-Sha-106888	Sarcophilus harrisii	31.23	1.00e-30	124.00
IUUC-Sja-107938	Schizosaccharomyces japonicus	26.15	2.00e-14	70.90
IUUC-Spo-108207	Schizosaccharomyces pombe	28.33	2.00e-16	77.00
IUUC-Ssl-108410	Sclerotinia sclerotiorum	29.14	3.00e-26	109.00
IUUC-Smo-108750	Selaginella moellendorffii	32.58	3.00e-32	129.00
IUUC-Sit-110052	Setaria italica	36.02	2.00e-41	159.00
IUUC-Sly-111489	Solanum lycopersicum	35.25	1.00e-37	147.00
IUUC-Stu-112517	Solanum tuberosum	33.72	5.00e-37	145.00
IUUC-Sar-113248	Sorex araneus	30.93	9.00e-20	88.20
IUUC-Sbi-114113	Sorghum bicolor	35.11	5.00e-40	155.00
IUUC-Sre-115221	Sporisorium reilianum	28.34	4.00e-24	103.00
IUUC-Ssc-115547	Sus scrofa	31.23	1.00e-30	124.00
IUUC-Tgu-117196	Taeniopygia guttata	32.20	1.00e-31	127.00
IUUC-Tru-117740	Takifugu rubripes	32.32	1.00e-30	124.00
IUUC-Tsy-119599	Tarsius syrichta	30.86	3.00e-30	123.00
IUUC-Tni-120542	Tetraodon nigroviridis	29.92	4.00e-28	115.00
IUUC-Tca-121033	Theobroma cacao	34.87	6.00e-36	142.00
IUUC-Tre-121986	Trichoderma reesei	24.62	2.00e-18	84.30
IUUC-Tvi-122607	Trichoderma virens	28.83	3.00e-25	106.00
IUUC-Tae-125740	Triticum aestivum	31.44	2.00e-34	137.00
IUUC-Tur-126375	Triticum urartu	28.57	5.00e-31	126.00
IUUC-Tme-126878	Tuber melanosporum	31.87	4.00e-29	120.00
IUUC-Tbe-127937	Tupaia belangeri	29.74	9.00e-20	88.60
IUUC-Ttr-129086	Tursiops truncatus	27.51	8.00e-24	101.00
IUUC-Uma-129364	Ustilago maydis	30.41	4.00e-32	129.00
IUUC-Vda-129929	Verticillium dahliae	31.08	5.00e-18	83.60
IUUC-Vpa-130543	Vicugna pacos	29.47	2.00e-19	87.00
IUUC-Vvi-130834	Vitis vinifera	35.32	7.00e-36	142.00
IUUC-Xtr-131888	Xenopus tropicalis	31.60	8.00e-31	125.00
IUUC-Xma-134122	Xiphophorus maculatus	31.44	2.00e-31	126.00
IUUC-Yli-134595	Yarrowia lipolytica	27.55	1.00e-22	98.20
IUUC-Zma-135864	Zea mays	36.02	1.00e-41	160.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence