iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSRNOG00000012734.7	ENSRNOT00000068334.2	ENSRNOP00000059805.1
ENSRNOG00000012734.7	ENSRNOT00000080100.1	ENSRNOP00000074566.1

Annotation

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress
DNA & RNA Element
RAID2
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/DCUN1	4.40e-91	304.5	75	261
UBD/Alpha-Helix/UBA	5.40e-07	29.9	21	59

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/DCUN1

   S: 2    skkkleelferYkdpqed.ligieglekfcedlgvdpediavLvlawkleaatlcefsreefldgltalgcdsieklqeklktleselk 89
           ++kkle+l++rYkdpq++ +igi+g+++fc+dl++dp++i+vL++awk++aat+cefs++ef+dg+t+lgcds+ekl+++++++e+elk
   Q: 75   DRKKLEQLYNRYKDPQDEnKIGIDGIQQFCDDLALDPASISVLIIAWKFRAATQCEFSKQEFMDGMTELGCDSVEKLKAQIPKMEQELK 163
           78**************999********************************************************************** PP
   S: 90   deqkfkdiYrfafnfakdkgqksldldtaialwkLllaerefklldawlkfLeeekkksiskDtWnllLefskviakdlsnYdeegaWP 178
           +  +fkd+Y+f+fnfak++gqk+ldl++aia+w+L+l++r fk+ld+w+kfL e++k+si+kDtWnllL+fs +ia+d+snYdeegaWP
   Q: 164  EPGRFKDFYQFTFNFAKNPGQKGLDLEMAIAYWNLVLNGR-FKFLDLWNKFLLEHHKRSIPKDTWNLLLDFSSMIADDMSNYDEEGAWP 251
           ***************************************9.************************************************ PP
   S: 179  vliDefveyl 188
           vliD+fve++
   Q: 252  VLIDDFVEFA 261
           ********97 PP

UBD/Alpha-Helix/UBA

   S: 2    ededkleqlve.MGFdreealqaLraannnleaAveyLl 39
           +++dk++q++  +  ++++a+ +L ++++ l++A+++++
   Q: 21   SQKDKVRQFMIfTQSSEKTAVSCLSQNDWKLDVATDNFF 59
           699********9999999*******************99 PP

Organism

Rattus norvegicus

Protein Sequence
(Fasta)

MWRKESQAVI PSASLNKLKS SQKDKVRQFM IFTQSSEKTA VSCLSQNDWK LDVATDNFFQ 60
NPELYIRESV KGSLDRKKLE QLYNRYKDPQ DENKIGIDGI QQFCDDLALD PASISVLIIA 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CTTCGAATGG TTCCGAATGT GGAGGAAAGA GTCCCAGGCA GTCATTCCTT CAGCTTCACT 60
GGTAATGTGT ACGGGGGCAG GGGACAGCAG AGGCTTTTAT TTCTAAGCCT ACTCTTACAA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1267--Proteomics identification
KW-1185--Reference proteome

Interpro

IPR014764--DCN-prot
IPR005176--PONY_dom
IPR009060--UBA-like

PROSITE

PS51229--DCUN1

Pfam

PF03556--Cullin_binding

Gene Ontology

GO:0005829--C:cytosol
GO:0005634--C:nucleus
GO:0000151--C:ubiquitin ligase complex
GO:0097602--F:cullin family protein binding
GO:0031624--F:ubiquitin conjugating enzyme binding
GO:0032182--F:ubiquitin-like protein binding
GO:0051443--P:positive regulation of ubiquitin-protein transferase activity
GO:0045116--P:protein neddylation

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001879	Ailuropoda melanoleuca	98.45	3.00e-152	530.00
IUUC-Apl-003451	Anas platyrhynchos	96.55	1.00e-149	521.00
IUUC-Aca-005269	Anolis carolinensis	94.25	4.00e-149	520.00
IUUC-Ago-007806	Ashbya gossypii	23.74	5.00e-20	91.30
IUUC-Acl-008172	Aspergillus clavatus	27.80	1.00e-22	100.00
IUUC-Afl-008569	Aspergillus flavus	28.97	4.00e-29	121.00
IUUC-Ani-009241	Aspergillus nidulans	26.37	1.00e-24	107.00
IUUC-Ang-009664	Aspergillus niger	28.40	1.00e-23	103.00
IUUC-Ate-010414	Aspergillus terreus	30.23	1.00e-30	126.00
IUUC-Ame-011763	Astyanax mexicanus	87.64	1.00e-136	478.00
IUUC-Bgr-011991	Blumeria graminis	32.23	8.00e-26	110.00
IUUC-Bta-013561	Bos taurus	98.36	3.00e-144	503.00
IUUC-Bci-013824	Botrytis cinerea	32.68	7.00e-31	127.00
IUUC-Cel-018441	Caenorhabditis elegans	36.56	2.00e-51	196.00
IUUC-Cja-019502	Callithrix jacchus	98.45	4.00e-152	530.00
IUUC-Cfa-020523	Canis familiaris	98.77	9.00e-145	505.00
IUUC-Cpo-022196	Cavia porcellus	97.67	4.00e-151	526.00
IUUC-Csa-023551	Chlorocebus sabaeus	98.46	7.00e-153	532.00
IUUC-Cho-024373	Choloepus hoffmanni	96.90	3.00e-145	507.00
IUUC-Cin-025269	Ciona intestinalis	60.85	2.00e-99	355.00
IUUC-Csv-026372	Ciona savignyi	41.80	4.00e-51	194.00
IUUC-Dre-028247	Danio rerio	84.13	1.00e-137	481.00
IUUC-Dno-028974	Dasypus novemcinctus	98.46	7.00e-153	532.00
IUUC-Dor-030696	Dipodomys ordii	87.98	2.00e-131	461.00
IUUC-Dme-032197	Drosophila melanogaster	61.48	9.00e-93	333.00
IUUC-Ete-032371	Echinops telfairi	98.45	3.00e-152	530.00
IUUC-Eca-033242	Equus caballus	98.84	1.00e-152	531.00
IUUC-Eeu-035317	Erinaceus europaeus	98.45	2.00e-152	530.00
IUUC-Fca-036061	Felis catus	98.08	2.00e-153	534.00
IUUC-Fal-037372	Ficedula albicollis	96.55	1.00e-149	521.00
IUUC-Gmo-038885	Gadus morhua	87.26	2.00e-136	478.00
IUUC-Gga-040935	Gallus gallus	97.30	8.00e-152	528.00
IUUC-Gac-041937	Gasterosteus aculeatus	86.87	3.00e-135	473.00
IUUC-Ggo-044468	Gorilla gorilla	97.69	3.00e-150	523.00
IUUC-Hsa-046089	Homo sapiens	98.46	7.00e-153	532.00
IUUC-Lch-050600	Latimeria chalumnae	93.82	8.00e-148	515.00
IUUC-Loc-052509	Lepisosteus oculatus	93.44	4.00e-145	506.00
IUUC-Lma-053103	Leptosphaeria maculans	31.56	1.00e-32	133.00
IUUC-Laf-053527	Loxodonta africana	98.84	1.00e-152	531.00
IUUC-Mcc-055699	Macaca mulatta	88.54	3.00e-146	511.00
IUUC-Meu-056626	Macropus eugenii	77.52	1.00e-111	395.00
IUUC-Mor-056909	Magnaporthe oryzae	28.37	9.00e-25	107.00
IUUC-Mla-058990	Melampsora laricipopulina	28.62	1.00e-18	87.40
IUUC-Mga-059379	Meleagris gallopavo	97.85	4.00e-136	476.00
IUUC-Mmr-060851	Microcebus murinus	98.84	3.00e-152	530.00
IUUC-Mdo-063074	Monodelphis domestica	98.45	9.00e-155	541.00
IUUC-Mmu-063954	Mus musculus	98.46	2.00e-152	531.00
IUUC-Mpu-066870	Mustela putorius furo	98.77	9.00e-145	505.00
IUUC-Mlu-067701	Myotis lucifugus	98.45	1.00e-151	528.00
IUUC-Ncr-068780	Neurospora crassa	25.09	3.00e-23	102.00
IUUC-Nle-069291	Nomascus leucogenys	98.46	7.00e-153	532.00
IUUC-Opr-070265	Ochotona princeps	72.09	5.00e-95	340.00
IUUC-Ont-071408	Oreochromis niloticus	87.98	3.00e-135	474.00
IUUC-Oan-073031	Ornithorhynchus anatinus	98.45	6.00e-152	529.00
IUUC-Ocu-074648	Oryctolagus cuniculus	98.84	1.00e-152	531.00
IUUC-Olu-087646	Ostreococcus lucimarinus	36.84	9.00e-45	173.00
IUUC-Oga-089015	Otolemur garnettii	98.45	5.00e-152	529.00
IUUC-Oar-090405	Ovis aries	98.45	5.00e-152	529.00
IUUC-Ptr-090735	Pan troglodytes	98.84	1.00e-152	531.00
IUUC-Pan-092186	Papio anubis	97.69	2.00e-149	521.00
IUUC-Psi-093110	Pelodiscus sinensis	97.95	6.00e-143	499.00
IUUC-Pno-095145	Phaeosphaeria nodorum	32.54	9.00e-25	107.00
IUUC-Pfo-096813	Poecilia formosa	81.41	2.00e-133	468.00
IUUC-Pca-100218	Procavia capensis	96.12	7.00e-150	522.00
IUUC-Pva-102983	Pteropus vampyrus	93.02	2.00e-138	484.00
IUUC-Pgr-103633	Puccinia graminis	27.53	2.00e-24	106.00
IUUC-Pyt-104428	Pyrenophora triticirepentis	31.48	8.00e-30	123.00
IUUC-Sce-106358	Saccharomyces cerevisiae	25.19	5.00e-20	91.30
IUUC-Sha-106888	Sarcophilus harrisii	98.45	2.00e-152	531.00
IUUC-Sja-107938	Schizosaccharomyces japonicus	30.65	3.00e-23	101.00
IUUC-Smo-108750	Selaginella moellendorffii	42.11	2.00e-50	191.00
IUUC-Sly-111489	Solanum lycopersicum	44.72	4.00e-60	224.00
IUUC-Stu-112517	Solanum tuberosum	43.55	1.00e-59	222.00
IUUC-Sar-113509	Sorex araneus	98.26	2.00e-98	351.00
IUUC-Sre-115221	Sporisorium reilianum	27.40	1.00e-25	110.00
IUUC-Ssc-115547	Sus scrofa	98.46	7.00e-153	532.00
IUUC-Tgu-117147	Taeniopygia guttata	97.67	2.00e-151	527.00
IUUC-Tru-117740	Takifugu rubripes	85.27	3.00e-133	467.00
IUUC-Tsy-119599	Tarsius syrichta	98.45	3.00e-152	530.00
IUUC-Tme-126878	Tuber melanosporum	32.70	5.00e-40	158.00
IUUC-Ttr-129086	Tursiops truncatus	87.98	2.00e-131	461.00
IUUC-Uma-129364	Ustilago maydis	29.37	5.00e-34	138.00
IUUC-Vpa-130048	Vicugna pacos	86.05	2.00e-127	447.00
IUUC-Xtr-131888	Xenopus tropicalis	97.29	1.00e-150	525.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence