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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Mmu-063725
UUCD1 version UUC-MuM-00008
Ensembl Protein ID ENSMUSP00000146244.1
UniProt Accession P22682; Q3U527; Q8CEA1; CBL_MOUSE
Genbank Protein ID CAA40394.1; BAC26087.1; BAE32253.1; AAI25286.1
Protein Name E3 ubiquitin-protein ligase CBL; Casitas B-lineage lymphoma proto-oncogene; Proto-oncogene c-Cbl; RING-type E3 ubiquitin transferase CBL; Signal transduction protein CBL
Genbank Nucleotide ID X57111; AK028730; AK153915; BC125285
Gene Name Cbl
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSMUSG00000034342.9 ENSMUST00000206720.1 ENSMUSP00000146244.1
ENSMUSG00000034342.9 ENSMUST00000206147.1 ENSMUSP00000145827.1
ENSMUSG00000034342.9 ENSMUST00000037644.7 ENSMUSP00000041902.7
ENSMUSG00000034342.9 ENSMUST00000205968.1 ENSMUSP00000146287.1
ENSMUSG00000034342.9 ENSMUST00000206258.1 ENSMUSP00000145538.1
ENSMUSG00000034342.9 ENSMUST00000206540.1 ENSMUSP00000145889.1
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressGXD
DNA & RNA Element
AREsitemiRTarBasemicroRNATRANSFAC
RepTarRAID2
Protein-protein Interaction
IIDiRefIndexPINAHINT
Mentha
Protein 3D Structure
PDBMMDB
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
Phospho.ELMUniProtPHOSIDAmUbiSiDa
Protein Expression/Proteomics
GPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
E3 activity/RING/RING RING 20682791
UBD/Alpha-Helix/UBA UBA 9653117; 10393178; 20100865
Classification
Family E-value Score Start End
E3 activity/RING/RING 4.30e-07 31.5 379 418
UBD/Alpha-Helix/UBA 3.00e-05 25.1 864 899
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 activity/RING/RING
   S: 1    CaiCledfkdgplvlpCgHvfhadClqkwpglknssskefrCPlCr 46
           C iC e  kd +++ pCgH+++++Cl  w    + +s  + CP Cr
   Q: 379  CKICAENDKD-VKIEPCGHLMCTSCLTSW----Q-ESEGQGCPFCR 418
           99********.******************....5.555555****8 PP
   

   UBD/Alpha-Helix/UBA
   S: 3    dedkleqlveMGFdreealqaLraannnleaAveyL 38
           +++ +e l+++G++ +++++aL  a+nn+e+A + L
   Q: 864  LSSEIERLMSQGYSYQDIQKALVIAHNNIEMAKNIL 899
           67889***************************9988 PP
   
Organism Mus musculus
Functional Description
(View)

Functional Description


     Adapter protein that functions as a negative regulator of many signaling pathways that are triggered by activation of cell surface receptors. Acts as an E3 ubiquitin-protein ligase, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and then transfers it to substrates promoting their degradation by the proteasome. Recognizes activated receptor tyrosine kinases, including KIT, FLT1, FGFR1, FGFR2, PDGFRA, PDGFRB, EGFR, CSF1R, EPHA8 and KDR and terminates signaling. Recognizes membrane-bound HCK, SRC and other kinases of the SRC family and mediates their ubiquitination and degradation. Participates in signal transduction in hematopoietic cells. Plays an important role in the regulation of osteoblast differentiation and apoptosis. Essential for osteoclastic bone resorption. The 'Tyr-737' phosphorylated form induces the activation and recruitment of phosphatidylinositol 3-kinase to the cell membrane in a signaling pathway that is critical for osteoclast function. May be functionally coupled with the E2 ubiquitin-protein ligase UB2D3.
 Adapter protein that functions as a negative regulator of many signaling pathways that are triggered by activation of cell surface receptors. Acts as an E3 ubiquitin-protein ligase, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and then transfers it to substrates promoting their degradation by the proteasome. Recognizes activated receptor tyrosine kinases, including KIT, FLT1, FGFR1, FGFR2, PDGFRA, PDGFRB, EGFR, CSF1R, EPHA8 and KDR and terminates signaling. Recognizes membrane-bound HCK, SRC and other kinases of the SRC family and mediates their ubiquitination and degradation. Participates in signal transduction in hematopoietic cells. Plays an important role in the regulation of osteoblast differentiation and apoptosis. Essential for osteoclastic bone resorption. The 'Tyr-737' phosphorylated form induces the activation and recruitment of phosphatidylinositol 3-kinase to the cell membrane in a signaling pathway that is critical for osteoclast function. May be functionally coupled with the E2 ubiquitin-protein ligase UB2D3.
Protein Sequence
(Fasta)
MAGNVKKSSG AGGGGSGGSG AGGLIGLMKD AFQPHHHHHH LSPHPPCTVD KKMVEKCWKL 60
MDKVVRLCQN PKLALKNSPP YILDLLPDTY QHLRTVLSRY EGKMETLGEN EYFRVFMENL 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Mmu-063725|E3,RING;UBD,UBA|Mus musculus
Please wait for a moment...
Nucleotide Sequence
(Fasta)
GGCCGCGCTC GCGCCCGCGC AGGGGCGCGC CTCAGGGCGG GCGCCTCCCT CTCACTCCCT 60
GGGCTGCGAG CGCCGGCGGT GGTTGCCGGA GAGGCCCCTC CTTCTCGCCC GGCTCCATTC 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Mmu-063725|E3,RING;UBD,UBA|Mus musculus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0106--Calcium
KW-1003--Cell membrane
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0472--Membrane
KW-0479--Metal-binding
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-0656--Proto-oncogene
KW-1185--Reference proteome
KW-0677--Repeat
KW-0808--Transferase
KW-0832--Ubl conjugation
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR024162--Adaptor_Cbl
IPR014741--Adaptor_Cbl_EF_hand-like
IPR003153--Adaptor_Cbl_N_hlx
IPR014742--Adaptor_Cbl_SH2-like
IPR024159--Cbl_PTB
IPR011992--EF-hand-dom_pair
IPR000980--SH2
IPR015940--UBA
IPR009060--UBA-like
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS
PROSITE

PS51506--CBL_PTB
PS50030--UBA
PS00518--ZF_RING_1
PS50089--ZF_RING_2
Pfam

PF02262--Cbl_N
PF02761--Cbl_N2
PF02762--Cbl_N3
PF00627--UBA
SMART

SM00184--RING
SM00165--UBA
Gene Ontology

GO:0030424--C:axon
GO:0005913--C:cell-cell adherens junction
GO:0005829--C:cytosol
GO:0005925--C:focal adhesion
GO:0030426--C:growth cone
GO:0042629--C:mast cell granule
GO:0045121--C:membrane raft
GO:0005634--C:nucleus
GO:0048471--C:perinuclear region of cytoplasm
GO:0005886--C:plasma membrane
GO:0098641--F:cadherin binding involved in cell-cell adhesion
GO:0005509--F:calcium ion binding
GO:0046875--F:ephrin receptor binding
GO:0030971--F:receptor tyrosine kinase binding
GO:0017124--F:SH3 domain binding
GO:0004871--F:signal transducer activity
GO:0061630--F:ubiquitin protein ligase activity
GO:0008270--F:zinc ion binding
GO:0045453--P:bone resorption
GO:0006974--P:cellular response to DNA damage stimulus
GO:0071364--P:cellular response to epidermal growth factor stimulus
GO:1990090--P:cellular response to nerve growth factor stimulus
GO:0090650--P:cellular response to oxygen-glucose deprivation
GO:0036120--P:cellular response to platelet-derived growth factor stimulus
GO:0007173--P:epidermal growth factor receptor signaling pathway
GO:0008584--P:male gonad development
GO:0043303--P:mast cell degranulation
GO:0043066--P:negative regulation of apoptotic process
GO:0042059--P:negative regulation of epidermal growth factor receptor signaling pathway
GO:0007175--P:negative regulation of epidermal growth factor-activated receptor activity
GO:1901215--P:negative regulation of neuron death
GO:0070997--P:neuron death
GO:0014068--P:positive regulation of phosphatidylinositol 3-kinase signaling
GO:0048260--P:positive regulation of receptor-mediated endocytosis
GO:0006513--P:protein monoubiquitination
GO:0006468--P:protein phosphorylation
GO:0000209--P:protein polyubiquitination
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0006508--P:proteolysis
GO:0014823--P:response to activity
GO:0046677--P:response to antibiotic
GO:0045471--P:response to ethanol
GO:0010332--P:response to gamma radiation
GO:0042594--P:response to starvation
GO:0033574--P:response to testosterone
KEGG mmu:12402
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-002357 Ailuropoda melanoleuca 90.50 0.00e+00 1472.00
IUUC-Apl-004041 Anas platyrhynchos 84.28 0.00e+00 1388.00
IUUC-Aca-004899 Anolis carolinensis 81.67 0.00e+00 1273.00
IUUC-Ame-010746 Astyanax mexicanus 58.95 0.00e+00 630.00
IUUC-Bta-012759 Bos taurus 90.58 0.00e+00 1523.00
IUUC-Cja-019207 Callithrix jacchus 90.63 0.00e+00 1541.00
IUUC-Cfa-020897 Canis familiaris 90.63 0.00e+00 1503.00
IUUC-Cpo-021453 Cavia porcellus 91.55 0.00e+00 1518.00
IUUC-Csa-023136 Chlorocebus sabaeus 90.95 0.00e+00 1524.00
IUUC-Cho-024282 Choloepus hoffmanni 83.30 0.00e+00 1233.00
IUUC-Cin-025574 Ciona intestinalis 71.28 4.00e-178 617.00
IUUC-Csv-025938 Ciona savignyi 69.62 2.00e-173 601.00
IUUC-Dre-027644 Danio rerio 68.54 0.00e+00 1035.00
IUUC-Dno-030025 Dasypus novemcinctus 92.72 0.00e+00 1497.00
IUUC-Dme-032213 Drosophila melanogaster 74.55 0.00e+00 645.00
IUUC-Ete-033118 Echinops telfairi 78.07 0.00e+00 793.00
IUUC-Eca-033900 Equus caballus 93.09 0.00e+00 1500.00
IUUC-Eeu-035142 Erinaceus europaeus 85.91 0.00e+00 957.00
IUUC-Fca-035455 Felis catus 90.33 0.00e+00 1508.00
IUUC-Fal-037182 Ficedula albicollis 94.80 0.00e+00 902.00
IUUC-Gmo-038698 Gadus morhua 86.83 0.00e+00 869.00
IUUC-Gga-040438 Gallus gallus 83.67 0.00e+00 1413.00
IUUC-Gac-042166 Gasterosteus aculeatus 76.53 0.00e+00 888.00
IUUC-Ggo-045618 Gorilla gorilla 90.94 0.00e+00 1537.00
IUUC-Hsa-046177 Homo sapiens 91.16 0.00e+00 1533.00
IUUC-Itr-048795 Ictidomys tridecemlineatus 96.47 0.00e+00 1011.00
IUUC-Lch-050095 Latimeria chalumnae 73.62 0.00e+00 1177.00
IUUC-Loc-052570 Lepisosteus oculatus 71.99 0.00e+00 1117.00
IUUC-Laf-054008 Loxodonta africana 89.93 0.00e+00 1513.00
IUUC-Mcc-054676 Macaca mulatta 90.84 0.00e+00 1521.00
IUUC-Mga-059239 Meleagris gallopavo 83.07 0.00e+00 1411.00
IUUC-Mmr-060907 Microcebus murinus 90.38 0.00e+00 1508.00
IUUC-Mdo-062595 Monodelphis domestica 88.21 0.00e+00 1426.00
IUUC-Mpu-066771 Mustela putorius furo 89.86 0.00e+00 1510.00
IUUC-Mlu-067206 Myotis lucifugus 77.25 0.00e+00 1097.00
IUUC-Nle-069285 Nomascus leucogenys 88.45 0.00e+00 1439.00
IUUC-Opr-071026 Ochotona princeps 91.66 0.00e+00 1484.00
IUUC-Ont-071954 Oreochromis niloticus 69.07 0.00e+00 1042.00
IUUC-Ocu-074657 Oryctolagus cuniculus 91.67 0.00e+00 1468.00
IUUC-Ola-087165 Oryzias latipes 66.70 0.00e+00 1068.00
IUUC-Oga-088198 Otolemur garnettii 81.08 0.00e+00 1320.00
IUUC-Oar-090258 Ovis aries 90.99 0.00e+00 1456.00
IUUC-Ptr-090710 Pan troglodytes 91.16 0.00e+00 1533.00
IUUC-Pan-092785 Papio anubis 90.84 0.00e+00 1522.00
IUUC-Psi-093431 Pelodiscus sinensis 74.55 0.00e+00 721.00
IUUC-Pfo-096990 Poecilia formosa 90.11 0.00e+00 817.00
IUUC-Pab-098526 Pongo abelii 91.69 0.00e+00 1533.00
IUUC-Pca-100984 Procavia capensis 76.26 3.00e-162 565.00
IUUC-Pva-102352 Pteropus vampyrus 95.40 0.00e+00 893.00
IUUC-Rno-105876 Rattus norvegicus 97.70 0.00e+00 1675.00
IUUC-Sha-107588 Sarcophilus harrisii 86.39 0.00e+00 1235.00
IUUC-Sar-112959 Sorex araneus 87.31 0.00e+00 1427.00
IUUC-Ssc-115261 Sus scrofa 91.82 0.00e+00 1536.00
IUUC-Tgu-116580 Taeniopygia guttata 81.37 0.00e+00 1321.00
IUUC-Tru-118731 Takifugu rubripes 67.40 0.00e+00 1030.00
IUUC-Tsy-118982 Tarsius syrichta 84.88 0.00e+00 1032.00
IUUC-Tni-120725 Tetraodon nigroviridis 68.71 0.00e+00 1038.00
IUUC-Tbe-128018 Tupaia belangeri 95.27 0.00e+00 1155.00
IUUC-Ttr-128927 Tursiops truncatus 91.72 0.00e+00 1554.00
IUUC-Vpa-130369 Vicugna pacos 91.32 0.00e+00 1421.00
IUUC-Xtr-132474 Xenopus tropicalis 73.33 0.00e+00 1154.00
Created Date 25-Jun-2017

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