iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Details
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Basic Information

Integrated Annotations

Tag

Content

iUUCD ID

IUUC-Spo-108060

UUCD1 version

UUC-ScP-00044

Ensembl Protein ID

SPAC17H9.19c.1:pep

UniProt Accession

Q10990; CDT2_SCHPO

Genbank Protein ID

AAA85478.1; CAB11228.1

Protein Name

Cell division cycle protein cdt2

Genbank Nucleotide ID

L75944; CU329670

Gene Name

cdt2; SPAC17H9.19c

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
SPAC17H9.19c	SPAC17H9.19c.1	SPAC17H9.19c.1:pep

Annotation

mRNA Expression
GEO
Protein-protein Interaction
iRefIndex	Mentha
Protein Expression/Proteomics

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E3 adaptor/Cullin RING/DCX/DWD	WD_repeat	21215368; 21123655

Classification

Family	E-value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	4.10e-25	85.0	227	262

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 2    Htdsvtclaf.sd.tl.lvsGsdDgtikvWDlrtgv 34
           H+ sv  ++f +d ++ lvs+s+Dg+i  WD+rt+ 
   Q: 227  HSHSVKQVNFcNDsPYnLVSCSRDGSIIFWDMRTHG 262
           999********7776669**************9986 PP

Organism

Schizosaccharomyces pombe

Functional Description
(View)

Substrate-specific adapter of a DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex required for DNA replication during mitosis and meiosis. The DCX(DTL) complex, also named CRL4(CDT2) complex, mediates the polyubiquitination and subsequent degradation of cdt1 and spd1. Involved in the regulation of mitotic and pre-meiotic S-phase progression.

Protein Sequence
(Fasta)

MNMDIGKALS DVGGLRDITS RANNSLPPTP DSSPAAPSKK HKLYDFLESR GKIETPRKRI 60
VFEKKPLLHK PVHIQKKPAQ LCKELLIRQL GGSRSHPFST KTSRHVGGRL NLETYYSRPS 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AAATTAAGAT TCATGATTAT ACCATGAATA TGGACATTGG AAAAGCTTTG AGTGATGTTG 60
GTGGGCTTCG AGATATTACC TCACGTGCAA ATAACTCATT ACCTCCGACT CCTGATTCTT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0131--Cell cycle
KW-0132--Cell division
KW-0181--Complete proteome
KW-0469--Meiosis
KW-0498--Mitosis
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0677--Repeat
KW-0833--Ubl conjugation pathway
KW-0853--WD repeat

Interpro

IPR020472--G-protein_beta_WD-40_rep
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF00400--WD40

PRINTS

PR00320--GPROTEINBRPT

SMART

SM00320--WD40

Gene Ontology

GO:0080008--C:Cul4-RING E3 ubiquitin ligase complex
GO:0005634--C:nucleus
GO:0030674--F:protein binding, bridging
GO:0032403--F:protein complex binding
GO:0051301--P:cell division
GO:0007067--P:mitotic nuclear division
GO:0006279--P:premeiotic DNA replication
GO:0016567--P:protein ubiquitination
GO:2000058--P:regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process

KEGG

spo:SPAC17H9.19c

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002111	Ailuropoda melanoleuca	26.80	3.00e-23	101.00
IUUC-Atr-003097	Amborella trichopoda	28.93	2.00e-34	138.00
IUUC-Apl-004088	Anas platyrhynchos	26.67	2.00e-23	102.00
IUUC-Aca-004732	Anolis carolinensis	26.59	4.00e-28	117.00
IUUC-Aly-005686	Arabidopsis lyrata	31.09	5.00e-33	133.00
IUUC-Ath-006970	Arabidopsis thaliana	31.20	3.00e-30	124.00
IUUC-Acl-008219	Aspergillus clavatus	28.41	1.00e-43	169.00
IUUC-Afl-008558	Aspergillus flavus	31.06	1.00e-23	101.00
IUUC-Afu-008784	Aspergillus fumigatus	27.86	2.00e-37	149.00
IUUC-Ani-009304	Aspergillus nidulans	27.10	3.00e-36	144.00
IUUC-Ang-009842	Aspergillus niger	28.52	4.00e-42	164.00
IUUC-Aor-009883	Aspergillus oryzae	27.06	8.00e-39	153.00
IUUC-Ate-010454	Aspergillus terreus	33.11	4.00e-33	133.00
IUUC-Ame-010949	Astyanax mexicanus	26.65	2.00e-25	108.00
IUUC-Bta-012333	Bos taurus	25.98	5.00e-22	97.80
IUUC-Bci-013733	Botrytis cinerea	26.10	7.00e-28	117.00
IUUC-Bdi-014494	Brachypodium distachyon	31.94	2.00e-35	141.00
IUUC-Bol-015301	Brassica oleracea	29.64	9.00e-35	139.00
IUUC-Bra-017691	Brassica rapa	30.81	8.00e-36	142.00
IUUC-Cel-018498	Caenorhabditis elegans	26.78	1.00e-24	105.00
IUUC-Cja-019534	Callithrix jacchus	26.49	6.00e-22	97.40
IUUC-Cfa-020847	Canis familiaris	26.26	8.00e-23	100.00
IUUC-Cpo-021695	Cavia porcellus	26.52	1.00e-21	96.30
IUUC-Cre-022762	Chlamydomonas reinhardtii	28.05	1.00e-19	91.30
IUUC-Csa-023748	Chlorocebus sabaeus	26.52	2.00e-22	99.00
IUUC-Cho-024445	Choloepus hoffmanni	26.94	5.00e-15	74.30
IUUC-Cgl-026664	Colletotrichum gloeosporioides	25.34	1.00e-21	96.30
IUUC-Cne-027008	Cryptococcus neoformans	27.47	8.00e-17	81.60
IUUC-Dre-027536	Danio rerio	27.20	1.00e-26	112.00
IUUC-Dno-030035	Dasypus novemcinctus	26.82	2.00e-24	105.00
IUUC-Dse-031354	Dothistroma septosporum	28.95	4.00e-40	157.00
IUUC-Dme-031691	Drosophila melanogaster	27.15	1.00e-24	106.00
IUUC-Ete-032814	Echinops telfairi	25.19	2.00e-11	62.40
IUUC-Eca-033332	Equus caballus	26.26	7.00e-23	100.00
IUUC-Fca-035571	Felis catus	25.98	6.00e-23	100.00
IUUC-Fal-037421	Ficedula albicollis	27.09	3.00e-24	104.00
IUUC-Fox-038069	Fusarium oxysporum	27.74	1.00e-29	122.00
IUUC-Fso-038192	Fusarium solani	25.52	2.00e-25	108.00
IUUC-Gmo-039365	Gadus morhua	27.97	2.00e-25	108.00
IUUC-Ggr-039904	Gaeumannomyces graminis	28.53	4.00e-23	101.00
IUUC-Gga-041153	Gallus gallus	26.57	5.00e-25	107.00
IUUC-Gac-041984	Gasterosteus aculeatus	26.89	3.00e-25	108.00
IUUC-Gma-043734	Glycine max	30.66	6.00e-32	129.00
IUUC-Ggo-044419	Gorilla gorilla	26.63	3.00e-22	98.60
IUUC-Hsa-045862	Homo sapiens	26.52	2.00e-22	99.40
IUUC-Hvu-047728	Hordeum vulgare	33.05	5.00e-39	153.00
IUUC-Itr-048786	Ictidomys tridecemlineatus	26.52	6.00e-23	100.00
IUUC-Lch-050616	Latimeria chalumnae	25.42	6.00e-24	103.00
IUUC-Lpe-051222	Leersia perrieri	31.48	2.00e-34	138.00
IUUC-Loc-052564	Lepisosteus oculatus	27.08	1.00e-24	106.00
IUUC-Lma-053098	Leptosphaeria maculans	29.07	2.00e-31	129.00
IUUC-Laf-053892	Loxodonta africana	25.42	2.00e-21	95.90
IUUC-Mcc-055854	Macaca mulatta	26.52	2.00e-22	99.00
IUUC-Mor-057144	Magnaporthe oryzae	25.56	4.00e-21	94.70
IUUC-Mpo-057501	Magnaporthe poae	28.91	1.00e-16	79.70
IUUC-Mtr-058510	Medicago truncatula	31.00	5.00e-39	153.00
IUUC-Mla-058823	Melampsora laricipopulina	29.18	3.00e-34	137.00
IUUC-Mga-060128	Meleagris gallopavo	26.94	6.00e-24	103.00
IUUC-Mvi-060475	Microbotryum violaceum	34.43	2.00e-48	184.00
IUUC-Mmr-061331	Microcebus murinus	25.97	1.00e-22	99.80
IUUC-Mdo-063020	Monodelphis domestica	26.59	4.00e-24	104.00
IUUC-Mmu-063713	Mus musculus	26.26	2.00e-21	95.50
IUUC-Mac-064653	Musa acuminata	30.96	2.00e-34	138.00
IUUC-Mpu-066490	Mustela putorius furo	26.26	3.00e-23	101.00
IUUC-Mlu-067900	Myotis lucifugus	25.69	3.00e-21	95.10
IUUC-Nfi-068433	Neosartorya fischeri	27.55	9.00e-39	153.00
IUUC-Ncr-068776	Neurospora crassa	30.38	5.00e-33	134.00
IUUC-Nle-069675	Nomascus leucogenys	26.61	4.00e-20	91.30
IUUC-Ont-071441	Oreochromis niloticus	26.58	1.00e-23	102.00
IUUC-Oan-072757	Ornithorhynchus anatinus	25.58	1.00e-22	99.80
IUUC-Ocu-074670	Oryctolagus cuniculus	26.52	7.00e-22	97.10
IUUC-Oba-075844	Oryza barthii	32.59	3.00e-35	141.00
IUUC-Obr-076625	Oryza brachyantha	32.58	3.00e-36	144.00
IUUC-Ogl-077771	Oryza glaberrima	32.59	3.00e-35	140.00
IUUC-Ogu-078475	Oryza glumaepatula	31.39	3.00e-28	117.00
IUUC-Oin-079958	Oryza indica	32.59	3.00e-35	140.00
IUUC-Olo-080311	Oryza longistaminata	33.55	3.00e-31	127.00
IUUC-Ome-081985	Oryza meridionalis	32.03	4.00e-35	140.00
IUUC-Oni-082921	Oryza nivara	32.59	3.00e-35	140.00
IUUC-Opu-083174	Oryza punctata	31.69	7.00e-34	136.00
IUUC-Oru-084338	Oryza rufipogon	32.59	3.00e-35	140.00
IUUC-Oga-088358	Otolemur garnettii	26.24	1.00e-22	99.80
IUUC-Oar-089994	Ovis aries	26.26	7.00e-23	100.00
IUUC-Ptr-091338	Pan troglodytes	26.52	2.00e-22	99.00
IUUC-Pan-091759	Papio anubis	26.63	4.00e-22	98.20
IUUC-Psi-093211	Pelodiscus sinensis	27.07	7.00e-24	103.00
IUUC-Pma-094588	Petromyzon marinus	27.51	3.00e-18	84.00
IUUC-Pno-094964	Phaeosphaeria nodorum	27.56	2.00e-38	152.00
IUUC-Ppa-095159	Physcomitrella patens	32.09	5.00e-33	133.00
IUUC-Pfo-096592	Poecilia formosa	26.30	7.00e-22	97.10
IUUC-Pab-098597	Pongo abelii	25.73	3.00e-13	68.60
IUUC-Pop-099255	Populus trichocarpa	29.70	2.00e-33	134.00
IUUC-Ppe-101333	Prunus persica	29.30	9.00e-38	149.00
IUUC-Pva-102283	Pteropus vampyrus	24.76	7.00e-19	87.00
IUUC-Pgr-103383	Puccinia graminis	28.69	1.00e-25	108.00
IUUC-Ptt-103974	Puccinia triticina	33.02	4.00e-24	103.00
IUUC-Pte-104329	Pyrenophora teres	31.45	5.00e-31	127.00
IUUC-Pyt-104424	Pyrenophora triticirepentis	30.79	5.00e-31	127.00
IUUC-Rno-105720	Rattus norvegicus	26.54	3.00e-22	98.60
IUUC-Sha-106891	Sarcophilus harrisii	25.07	1.00e-19	90.10
IUUC-Sja-107723	Schizosaccharomyces japonicus	60.04	6.00e-171	591.00
IUUC-Ssl-108481	Sclerotinia sclerotiorum	31.85	2.00e-24	105.00
IUUC-Sit-109862	Setaria italica	32.77	4.00e-36	144.00
IUUC-Sly-111468	Solanum lycopersicum	32.33	5.00e-35	140.00
IUUC-Stu-112346	Solanum tuberosum	32.77	4.00e-32	130.00
IUUC-Sbi-114076	Sorghum bicolor	33.33	2.00e-38	151.00
IUUC-Ssc-115561	Sus scrofa	25.55	1.00e-22	99.80
IUUC-Tgu-117011	Taeniopygia guttata	27.00	4.00e-24	104.00
IUUC-Tru-118411	Takifugu rubripes	26.43	3.00e-19	88.20
IUUC-Tni-120301	Tetraodon nigroviridis	26.11	3.00e-22	98.20
IUUC-Tca-121265	Theobroma cacao	31.48	1.00e-30	125.00
IUUC-Tre-121997	Trichoderma reesei	25.99	7.00e-29	120.00
IUUC-Tvi-122292	Trichoderma virens	25.68	4.00e-30	124.00
IUUC-Tae-123660	Triticum aestivum	33.89	5.00e-40	156.00
IUUC-Tur-126794	Triticum urartu	34.00	2.00e-31	127.00
IUUC-Tme-127090	Tuber melanosporum	31.63	1.00e-31	128.00
IUUC-Tbe-127646	Tupaia belangeri	24.59	6.00e-16	77.40
IUUC-Ttr-128171	Tursiops truncatus	26.26	5.00e-23	100.00
IUUC-Vda-129871	Verticillium dahliae	26.84	6.00e-29	120.00
IUUC-Vpa-130554	Vicugna pacos	31.51	9.00e-12	63.50
IUUC-Vvi-131698	Vitis vinifera	30.27	5.00e-38	150.00
IUUC-Xtr-131962	Xenopus tropicalis	25.12	4.00e-27	114.00
IUUC-Xma-133803	Xiphophorus maculatus	26.85	6.00e-23	100.00
IUUC-Zma-135693	Zea mays	31.78	4.00e-34	137.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence