iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Nle-068981

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Ribosome biogenesis protein WDR12; WD repeat-containing protein 12

Genbank Nucleotide ID

ADFV01059938

Gene Name

WDR12

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSNLEG00000007018.1	ENSNLET00000008969.1	ENSNLEP00000008564.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	5.10e-43	143.2	341	376
UBD/Beta-Prp	9.50e-47	159.6	246	412

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 2    Htdsvtclaf..sd.tllvsGsdDgtikvWDlrtgv 34
           Ht++vt++++  +    l+sGs D+ +k+WD+r+++
   Q: 341  HTGWVTSVKWspTHeQQLISGSLDNIVKLWDTRSCK 376
           **********9533678**************99876 PP

UBD/Beta-Prp

   S: 83   tgkcvhtlkghedsvlslsfspsgdklvsGshdrtirvwdletgqcleetlsghdgvvncvvvhpdgnllvsGslDrtvrlWdl..ktg 169
           t+++++tl+gh + v s+ +s+  + + s+s+d tirvwd+e+g+  + tl+g++ v nc++++p ++ l+sGs+Dr +rlWd   k g
   Q: 246  TRTPIVTLSGHMEAVSSVLWSE-AEEICSASWDHTIRVWDVESGSLKS-TLTGNK-VFNCISYSPLCKRLASGSTDRHIRLWDPrtKDG 331
           67899*****************.99**********************9.***987.99**************************54456 PP
   S: 170  kllrtl.tgghtdsvyslsfdsng.kelvsgsldgtvklwdlq.tgecvrtlnghtdnvksvrfspnderlvsgssDgsiriW 249
           +l+    t+ ht+ v+s++++++  ++l+sgsld+ vklwd +  +  ++ l +h+d v+sv+ + ++ +l+sg++D+ ++ +
   Q: 332  SLVSLSlTS-HTGWVTSVKWSPTHeQQLISGSLDNIVKLWDTRsCKAPLYDLAAHEDKVLSVDWT-DTGLLLSGGADNKLYSY 412
           666644366.************9889*****************54566****************9.999********998765 PP

Organism

Nomascus leucogenys

Functional Description
(View)

Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome.

Protein Sequence
(Fasta)

MAQLQTRFYT DNKKYAVDDV PFSIPAASEI ADLSNIINKL LKDKNEFHKH VEFDFLIKGQ 60
FLRMPLDKHM ELENISSEEV VEIEYVEKYT APQPEQCMFH DDWISSIKGA EEWILTGSYD 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATCGGCCACC GTCGACCGTT TCCTCTTTCA TCCGTTCTTT TTTTCGTATT TCCGCCTCTC 60
GCCTCTGTAA AACCCGCAGT TAGAGGCGAG ACTTAGGAAA AACCTCTGCC GAGTGAGAAT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0677--Repeat
KW-0690--Ribosome biogenesis
KW-0698--rRNA processing
KW-0853--WD repeat

Interpro

IPR020472--G-protein_beta_WD-40_rep
IPR012972--NLE
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom
IPR028599--WDR12/Ytm1

PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF08154--NLE
PF00400--WD40

PRINTS

PR00320--GPROTEINBRPT

SMART

SM00320--WD40

Gene Ontology

GO:0005654--C:nucleoplasm
GO:0070545--C:PeBoW complex
GO:0030687--C:preribosome, large subunit precursor
GO:0043021--F:ribonucleoprotein complex binding
GO:0008283--P:cell proliferation
GO:0000466--P:maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GO:0000463--P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)

KEGG

nle:100602443

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000532	Aegilops tauschii	33.25	5.00e-55	208.00
IUUC-Aml-001997	Ailuropoda melanoleuca	96.59	0.00e+00	724.00
IUUC-Atr-002544	Amborella trichopoda	33.57	2.00e-54	206.00
IUUC-Apl-003981	Anas platyrhynchos	86.44	3.00e-179	620.00
IUUC-Aca-004370	Anolis carolinensis	84.47	0.00e+00	696.00
IUUC-Aly-006455	Arabidopsis lyrata	34.48	3.00e-57	215.00
IUUC-Ath-006669	Arabidopsis thaliana	33.91	2.00e-53	202.00
IUUC-Ago-007864	Ashbya gossypii	29.09	5.00e-35	142.00
IUUC-Acl-008177	Aspergillus clavatus	29.71	1.00e-35	144.00
IUUC-Afl-008617	Aspergillus flavus	28.90	1.00e-33	137.00
IUUC-Afu-008752	Aspergillus fumigatus	28.29	5.00e-33	135.00
IUUC-Ani-009136	Aspergillus nidulans	29.74	5.00e-35	142.00
IUUC-Ang-009701	Aspergillus niger	28.39	2.00e-32	133.00
IUUC-Aor-009884	Aspergillus oryzae	28.90	8.00e-34	138.00
IUUC-Ame-011432	Astyanax mexicanus	75.65	0.00e+00	644.00
IUUC-Bgr-012218	Blumeria graminis	28.37	2.00e-32	133.00
IUUC-Bta-012829	Bos taurus	95.74	0.00e+00	748.00
IUUC-Bci-013953	Botrytis cinerea	30.08	8.00e-35	141.00
IUUC-Bdi-014351	Brachypodium distachyon	35.78	8.00e-54	204.00
IUUC-Bol-016190	Brassica oleracea	35.48	1.00e-52	200.00
IUUC-Bra-017876	Brassica rapa	33.99	7.00e-55	207.00
IUUC-Cel-018569	Caenorhabditis elegans	31.62	4.00e-45	175.00
IUUC-Cja-019468	Callithrix jacchus	97.87	0.00e+00	743.00
IUUC-Cfa-020471	Canis familiaris	95.04	0.00e+00	739.00
IUUC-Cpo-022260	Cavia porcellus	95.51	0.00e+00	734.00
IUUC-Cre-022614	Chlamydomonas reinhardtii	31.22	8.00e-39	154.00
IUUC-Csa-023989	Chlorocebus sabaeus	98.82	0.00e+00	751.00
IUUC-Cho-024426	Choloepus hoffmanni	91.75	3.00e-152	531.00
IUUC-Cin-025789	Ciona intestinalis	43.17	4.00e-93	334.00
IUUC-Cne-027063	Cryptococcus neoformans	23.93	6.00e-20	92.00
IUUC-Dre-027907	Danio rerio	76.60	0.00e+00	660.00
IUUC-Dno-029225	Dasypus novemcinctus	94.33	0.00e+00	741.00
IUUC-Dor-031082	Dipodomys ordii	78.49	7.00e-162	563.00
IUUC-Dse-031308	Dothistroma septosporum	27.79	1.00e-34	140.00
IUUC-Dme-032189	Drosophila melanogaster	41.26	1.00e-89	323.00
IUUC-Ete-032247	Echinops telfairi	88.18	0.00e+00	683.00
IUUC-Eca-034285	Equus caballus	95.74	0.00e+00	748.00
IUUC-Eeu-035322	Erinaceus europaeus	85.18	2.00e-179	621.00
IUUC-Fca-036114	Felis catus	95.27	0.00e+00	745.00
IUUC-Fal-036891	Ficedula albicollis	85.59	2.00e-166	577.00
IUUC-Fox-037965	Fusarium oxysporum	25.16	1.00e-32	134.00
IUUC-Fso-038244	Fusarium solani	26.43	6.00e-32	131.00
IUUC-Gmo-039040	Gadus morhua	75.41	0.00e+00	653.00
IUUC-Ggr-040093	Gaeumannomyces graminis	23.39	4.00e-10	59.30
IUUC-Gga-040610	Gallus gallus	83.22	0.00e+00	683.00
IUUC-Gac-042117	Gasterosteus aculeatus	74.47	0.00e+00	628.00
IUUC-Gma-043146	Glycine max	36.78	3.00e-63	235.00
IUUC-Ggo-045179	Gorilla gorilla	98.58	0.00e+00	749.00
IUUC-Hsa-046114	Homo sapiens	99.29	0.00e+00	754.00
IUUC-Hvu-047331	Hordeum vulgare	33.85	1.00e-50	193.00
IUUC-Itr-048275	Ictidomys tridecemlineatus	95.74	0.00e+00	746.00
IUUC-Kpa-049304	Komagataella pastoris	28.44	7.00e-40	158.00
IUUC-Lch-050655	Latimeria chalumnae	77.01	2.00e-141	494.00
IUUC-Lpe-051675	Leersia perrieri	35.08	2.00e-56	213.00
IUUC-Loc-052868	Lepisosteus oculatus	79.91	0.00e+00	659.00
IUUC-Lma-053258	Leptosphaeria maculans	26.04	2.00e-31	131.00
IUUC-Laf-053993	Loxodonta africana	94.33	0.00e+00	744.00
IUUC-Mcc-055128	Macaca mulatta	79.67	4.00e-167	580.00
IUUC-Meu-056501	Macropus eugenii	78.28	1.00e-154	539.00
IUUC-Mor-057114	Magnaporthe oryzae	26.48	8.00e-26	111.00
IUUC-Mtr-058367	Medicago truncatula	36.45	3.00e-57	216.00
IUUC-Mla-059107	Melampsora laricipopulina	26.78	1.00e-26	114.00
IUUC-Mga-059745	Meleagris gallopavo	81.18	0.00e+00	657.00
IUUC-Mvi-060362	Microbotryum violaceum	29.09	4.00e-32	132.00
IUUC-Mdo-062257	Monodelphis domestica	85.68	0.00e+00	696.00
IUUC-Mmu-063546	Mus musculus	93.62	0.00e+00	737.00
IUUC-Mac-065540	Musa acuminata	34.68	7.00e-55	207.00
IUUC-Mpu-066284	Mustela putorius furo	96.69	0.00e+00	754.00
IUUC-Mlu-067241	Myotis lucifugus	95.98	0.00e+00	750.00
IUUC-Nfi-068260	Neosartorya fischeri	28.54	7.00e-34	138.00
IUUC-Ncr-068719	Neurospora crassa	26.00	2.00e-26	114.00
IUUC-Opr-071218	Ochotona princeps	87.44	0.00e+00	666.00
IUUC-Ont-071646	Oreochromis niloticus	77.11	0.00e+00	645.00
IUUC-Oan-073453	Ornithorhynchus anatinus	88.65	0.00e+00	727.00
IUUC-Ocu-074008	Oryctolagus cuniculus	96.45	0.00e+00	753.00
IUUC-Oba-075712	Oryza barthii	30.77	1.00e-39	157.00
IUUC-Obr-076721	Oryza brachyantha	34.52	6.00e-56	211.00
IUUC-Ogl-077229	Oryza glaberrima	34.61	2.00e-55	209.00
IUUC-Ogu-078977	Oryza glumaepatula	30.77	6.00e-40	158.00
IUUC-Oin-079683	Oryza indica	34.61	2.00e-55	209.00
IUUC-Olo-080291	Oryza longistaminata	30.64	5.00e-27	114.00
IUUC-Ome-081834	Oryza meridionalis	34.84	2.00e-56	213.00
IUUC-Oni-082507	Oryza nivara	33.49	1.00e-51	197.00
IUUC-Opu-083396	Oryza punctata	34.84	1.00e-56	214.00
IUUC-Oru-085220	Oryza rufipogon	34.05	3.00e-51	195.00
IUUC-Osa-085767	Oryza sativa	34.61	2.00e-55	209.00
IUUC-Ola-087420	Oryzias latipes	77.30	0.00e+00	660.00
IUUC-Olu-087740	Ostreococcus lucimarinus	28.12	6.00e-35	141.00
IUUC-Oga-088264	Otolemur garnettii	95.98	0.00e+00	753.00
IUUC-Oar-089335	Ovis aries	95.27	0.00e+00	745.00
IUUC-Ptr-091320	Pan troglodytes	99.29	0.00e+00	754.00
IUUC-Pan-092833	Papio anubis	98.35	0.00e+00	747.00
IUUC-Psi-093504	Pelodiscus sinensis	86.76	0.00e+00	704.00
IUUC-Pma-094189	Petromyzon marinus	68.16	1.00e-165	575.00
IUUC-Pno-094929	Phaeosphaeria nodorum	25.93	2.00e-33	136.00
IUUC-Ppa-095429	Physcomitrella patens	35.87	1.00e-63	236.00
IUUC-Pfo-096337	Poecilia formosa	74.94	0.00e+00	650.00
IUUC-Pab-097571	Pongo abelii	98.82	0.00e+00	753.00
IUUC-Pop-099977	Populus trichocarpa	35.58	3.00e-61	229.00
IUUC-Pca-100394	Procavia capensis	88.75	0.00e+00	662.00
IUUC-Ppe-101848	Prunus persica	35.90	1.00e-58	220.00
IUUC-Pva-102921	Pteropus vampyrus	94.74	2.00e-113	402.00
IUUC-Pgr-103637	Puccinia graminis	28.39	1.00e-31	130.00
IUUC-Ptt-103781	Puccinia triticina	28.39	1.00e-31	131.00
IUUC-Pte-104135	Pyrenophora teres	25.83	3.00e-32	134.00
IUUC-Pyt-104609	Pyrenophora triticirepentis	25.71	8.00e-31	127.00
IUUC-Rno-105114	Rattus norvegicus	93.38	0.00e+00	737.00
IUUC-Sce-106401	Saccharomyces cerevisiae	29.52	4.00e-37	149.00
IUUC-Sha-107122	Sarcophilus harrisii	86.13	0.00e+00	668.00
IUUC-Sja-107766	Schizosaccharomyces japonicus	32.01	4.00e-48	185.00
IUUC-Spo-108134	Schizosaccharomyces pombe	29.59	3.00e-38	152.00
IUUC-Ssl-108398	Sclerotinia sclerotiorum	28.19	2.00e-35	143.00
IUUC-Smo-108720	Selaginella moellendorffii	33.10	4.00e-54	205.00
IUUC-Sit-110311	Setaria italica	35.81	3.00e-54	205.00
IUUC-Sly-111178	Solanum lycopersicum	33.83	8.00e-55	207.00
IUUC-Stu-112778	Solanum tuberosum	35.08	3.00e-58	219.00
IUUC-Sar-113596	Sorex araneus	78.49	3.00e-167	580.00
IUUC-Sbi-114193	Sorghum bicolor	35.22	2.00e-55	209.00
IUUC-Sre-115002	Sporisorium reilianum	25.00	1.00e-10	61.60
IUUC-Ssc-116066	Sus scrofa	95.98	0.00e+00	747.00
IUUC-Tgu-117048	Taeniopygia guttata	84.31	8.00e-177	612.00
IUUC-Tsy-119573	Tarsius syrichta	62.92	2.00e-131	461.00
IUUC-Tni-119820	Tetraodon nigroviridis	75.77	0.00e+00	648.00
IUUC-Tca-121605	Theobroma cacao	36.30	5.00e-59	221.00
IUUC-Tre-121947	Trichoderma reesei	26.07	3.00e-32	132.00
IUUC-Tvi-122481	Trichoderma virens	26.28	1.00e-33	137.00
IUUC-Tae-125861	Triticum aestivum	33.49	4.00e-55	208.00
IUUC-Tur-126586	Triticum urartu	34.10	8.00e-53	200.00
IUUC-Tme-126900	Tuber melanosporum	31.91	3.00e-48	186.00
IUUC-Tbe-127736	Tupaia belangeri	72.86	1.00e-145	509.00
IUUC-Ttr-129041	Tursiops truncatus	83.45	0.00e+00	653.00
IUUC-Vpa-130260	Vicugna pacos	96.45	0.00e+00	753.00
IUUC-Vvi-131009	Vitis vinifera	35.00	2.00e-58	219.00
IUUC-Xtr-132083	Xenopus tropicalis	81.32	0.00e+00	668.00
IUUC-Xma-133094	Xiphophorus maculatus	74.23	0.00e+00	643.00
IUUC-Yli-134531	Yarrowia lipolytica	24.69	2.00e-17	84.00
IUUC-Zma-135509	Zea mays	33.81	3.00e-55	209.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence